The fellowship is a part of a 5-year project “ Co-evolution of metacaspase structure and biological function in Arabidopsis”, which aims to advance our mechanistic understanding of metacaspase family proteases in close cooperation between five research groups located in Uppsala BioCenter at SLU, Umeå SLU and Umeå University. The successful candidate for this fellowship will join the group of Hannele Tuominen at UPSC in Umeå, Sweden.

Umeå Plant Science Centre (UPSC) is a research centre in Umeå, Sweden (www.upsc.se) where research of both basic and strategic importance is conducted. The research at UPSC is carried out on all organization levels of the plant with a common goal to understand the plant as a complex organism in dynamic interaction with its environment.

Previous studies carried out by the host and other laboratories have linked metacaspases to regulation of aging and cell death in diverse organisms (Escamez et al., 2020). The Arabidopsis thaliana Metacaspase9 (MC9) is required for the rapid autolysis of the xylem vessel elements (Bollhöner et al., 2013), but the underlying mechanism as well as the proteolytic substrates of MC9 remain poorly understood. The main purpose of this project is to study MC9-mediated cleavage of target proteins which results in production of biologically active peptides, including the previously identified Bia and Kratos peptides (Escamez et al., 2019, J Exp Bot. 70:2199-2210). The function of the peptides is investigated in vascular differentiation of Arabidopsis using genetic, proteomic and biochemical methods. Other aspects of the project can be developed according to the interests of the candidate.

• Bollhöner B, Zhang B, Stael S, Denancé N, Overmyer K, Goffner D, van Breusegem F and Tuominen H 2013. Post mortem function of AtMC9 in xylem vessel elements. New Phytologist 200:498-510.
• Escamez S, Stael S, Vainonen J, Willems P, Jin H, Kimura S, Van Breusegem F, Gevaert K_, Wrzaczek M, and Tuominen H. 2019. Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis. Journal of Experimental botany 70: 2199–2210.
• Escamez S, André D, Sztojka B, Bollhöner B, Hall H, Berthet B, Voss U, Lers A, Maizel A, Andersson M, Bennett M, Tuominen H. 2020. Cell death in cells overlying lateral root primordia contributes to organ growth in Arabidopsis. Current Biology 30: 1–10.

We are looking for a highly motivated plant biologist with a keen interest in understanding mechanisms and role of proteolysis in a developmental context. Successful candidates are expected to have a PhD degree, experience in cell and molecular biology and genetics, and a proven research track record.

A stipend is granted for 2 years starting in August 1, 2020 or by agreement. The tax-free stipend is financed by the Wallenberg foundation and amounts to 288 000 SEK per year. The fellowship can be prolonged by a two-year University employment after positive evaluation. The project involves visits to collaborating laboratories.

Please send you application, including a personal letter, CV, and contact information of three references by e-mail to Hannele.tuominen@slu.se latest 30 April 2020.

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DanStem
The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem) addresses fundamental research questions in stem cell and developmental biology and seeks to develop translational activities based on this fundamental discovery science, producing new therapeutic strategies for chronic diseases. Current focus at DanStem is predominantly on fundamental research at the highest level, and the Center also offers investigators the opportunity to develop their work in the translational arena, providing opportunities for strategic development aiming at clinical application. DanStem is a vibrant, internationally diverse and ambitious research center with state-of-the-art facilities located at the Faculty of Health and Medical Sciences, University of Copenhagen. The setting is ideally situated for seamless collaboration and exchange with other centers and departments of the Faculty and the surrounding hospitals
DanStem is dedicated to promoting research in stem cell and developmental biology within Denmark and throughout Europe. A part of this commitment involves the training og the next generation of stem cell scientist. To this end DanStem engages in pre-graduate training, operates a four-year PhD program, offers a broad spectrum of post-graduate teaching and a number of out-reach activities. DanStem also engages in active post-doctoral t5raining and mentorship programs. Together with its large post-graduate and post-doctoral population, DanStem represents a major European hub for training in contemporary stem cell biology.

Learn more about DanStem at https://danstem.ku.dk/.

DanStem is a part of the NNF Center Cluster, that also contains the Centers for Protein Research (CPR), Basic Metabolic Research (CBMR) and Biosustainability. Three of these centers are located in the Faculty of Health and Medical Science at the University of Copenhagen. DanStem is situated in the Panum building along with CPR, with whom it shares research technology platforms. DanStem is also on the same campus as CBMR and a number of other relevant departments in biomedical sciences. A short walking distance from DanStem is the Biotech Research and Innovation Center (BRIC), a high-profile, vibrant and international center for cancer and epigenetics research at the Faculty, where some of the DanStem research programs are based.  As a result of DanStem’s proximity, there is ample opportunity for educational and research collaborations. DanStem is well integrated into European science and recognized internationally as a key player in stem cell research.

DanStem is a highly international and rewarding workplace with a staff of 250, placing high value on diversity and synergistic approaches to solving the challenges of developmental and stem cell biology. As DanStem has evolved in the last ten years its research approaches have become increasingly interdisciplinary and quantitative. Its location next to the Niels Bohr Institute and in close proximity to Denmark’s leading technical university (Danish Technical University) has helped enable this transition. Importantly, while DanStem will continue solving fundamental questions in stem cell biology, the future will emphasize and strengthen translational stem cell-based applications. This will be enabled through the Faculty’s strong collaboration with the hospitals.

DanStem Executive Directorship
Qualified Executive Director candidates will be visionary scientific leaders of international stature with a strong track record of innovative research in developmental and stem cell biology. They will also have the vision to identify and support new translational programs aiming at clinical application. They are expected to have a strong track record of collaboration and a history in building interdisciplinary academic research in a collaborative environment. The Executive Director will lead the overall research directions at the Center and promote the research carried out by DanStem’s faculty. A management team and Scientific Advisory Board support the Executive Director.

Expectations
The Executive Director will:

• Be responsible for development of the Center, including producing and implementing a vision for future scientific growth as well as the recruitment of a new generation of outstanding and highly interactive researchers
• Lead her/his own research group
• Develop new strategic initiatives and support existing and future translational programs
• Participate in fostering new collaborations
• Work closely with key scientific and administrative staff to develop a comprehensive research strategy and guide the future direction of DanStem’s research portfolio
• Collaborate on cross center initiatives with CPR and CBMR, as well as other national and international research centers
• Report to the Dean of the Faculty of Health and Medical Sciences and work closely with Dean’s office in a variety of joint efforts including educational activities
• Lead the writing of the strategic application to NNF for funding of the renewal period (8 years).

Qualifications and experience
The successful candidate will:

• Hold an appropriate doctoral degree
• Have an outstanding record of scientific discovery and accomplishment, including a track record of substantial external competitive funding and proven success in collaborations
• Present a clear vision of future directions in areas related to developmental and stem cell biology, including how fundamental science can provide technological innovation and clinical translation
• Demonstrate excellent interpersonal and leadership skills, especially with regard to successful leadership of international and diverse teams
• Proven management skills
• Show a commitment to foster and promote excellence in scientific research and education

Inquiries
For informal inquiries and more information about position, you are welcome to contact Dean Ulla Wewer (dekan@sund.ku.dk),  Professor Tor Henrik Semb (semb@sund.ku.dk) or Perrett Laver (see contact information below).

Submitting letter of interest
Perrett Laver is assisting the search committee with the recruitment process. Perrett Laver may also be contacted for informal inquiries and questions on Jack.Bircher@perrettlaver.com or +44 (0)20 7340 6275. Further information, including details on how to apply, can be downloaded at https://candidates.perrettlaver.com/vacancies/ quoting reference 4558.

Please include the following documents, when submitting your letter of interest:

• Your curriculum vitae, detailing employment history, and academic and professional qualifications (max. 4 pages including bio sketch)
• A description of your vision for the future of developmental and stem cell biology and how you believe DanStem could contribute to this  (max. 5 pages)
• A list of not more than 10 selected publications
• A link or reference to a complete list of publications (e.g. ORCID).

Deadline for submitting letters of interest: April 15th 2020 at 23:59 CET.

For further information about

• DanStem, please visit https://danstem.ku.dk
• Copenhagen Bioscience Cluster, a Novo Nordisk Foundation initiative, please visit https://cph–bioscience.com/en/
• University of Copenhagen, Faculty of Health and Medical Sciences, please visit https://healthsciences.ku.dk

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

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The Danish Stem Cell Center (DanStem) at Faculty of Health & Medical Sciences at the University of Copenhagen is looking for a Postdoctoral candidate to join the Żylicz group starting July 2020 or upon agreement with the chosen candidate.

A postdoctoral position is available in the group of Jan Żylicz at DanStem. The team studies fundamental mechanisms of early mouse development and stem cell biology. The Żylicz group wants to understand how metabolic and epigenetic mechanisms cooperate to regulate transcription during early development. In particular the team is interested in how metabolism regulates histone modifiers, and how these in turn affect lineage choice and embryo growth at around the time of implantation. To achieve this, the group utilizes both in vivo mouse models as well as in vitro stem cell culture systems and state-of the-art ultrasensitive transcriptomic, epigenomic and metabolomic techniques. This research project will employ high-throughput screening methods to uncover metallic regulators underpinning chromatin states of mouse stem cell models. Starting date for this position is the 1 June 2020, or upon agreement with the chosen candidate.

Job description:
We are seeking a highly motivated and ambitious post-doctoral candidate with a strong background in either stem cell and developmental biology and/or metabolomic research. The candidate implement high-throughput screening techniques to identify key metabolic players regulating chromatin states in vitro and in vivo. By using functional assays in combination with live imaging and ultra-sensitive chromatin mapping and metabolomic techniques the candidate will get at the underlying principles of epi-metabolic regulation.

About DanStem
The Novo Nordisk Foundation Center for Stem Cell Biology – DanStem – addresses basic research questions in stem cell and developmental biology and translates results from basic research into new strategies and targets for the development of new therapies for diabetes and cancer. DanStem was established as a result of a series of international recruitments coupled with internationally recognized research groups focused on insulin producing beta cells and cancer research already located at the University of Copenhagen.

Qualifications:

• Candidates must hold a PhD degree in cell/developmental/stem cell biology/metabolomics or similar, with a track-record of successful scientific work.
• Candidates should have a strong background in mouse genetics, cell biology and/or live cell imaging. Alternatively candidates with a background in metabolomics applied to animal models are also encouraged to apply.
• Previous experience in metabolomics, bioinformatics, next-generation sequencing, mouse embryology and/or stem cell culture are considered an advantage.
• Good English communication skills, both oral and written, are prerequisite for the successful candidate.

Terms of salary, work, and employment :
The employment is planned to start 1 July 2020 or upon agreement with the chosen candidate. The employment is initially for 2 years. The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. The position will be at the level of postdoctoral fellow and the basic salary according to seniority. Currently, the salary starts at 34.360 DKK/approx. 4,.590 Euro (October 2019-level). A supplement could be negotiated, dependent on the candidate ́s experiences and qualifications. In addition a monthly contribution of 17.1% of the salary is paid into a pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of December 11, 2019.

Questions:
For further information contact Associate Professor Jan Żylicz, jan.zylicz@sund.ku.dk.

Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk.

How to apply
The application, in English, must be submitted electronically by clicking APPLY below.

The application must include:

1. Motivation letter
2. Curriculum vitae incl. education, experience, previous employments, language skills and other relevant skills
3. List of two references (full address, incl. email and phone number)
4. List of publications
5. Copy of diplomas/degree certificate(s)

Application deadline: April 14, 2020

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.

Only applications received in time and consisting of the above listed documents will be considered.

Applications and/or any material received after deadline will not be taken into consideration.

The application will be assessed according to the Ministerial Order no. 284 of 25 April 2008 on the Appointment of Academic Staff at Universities.

Assessment procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

Interviews are expected to be held in weeks 20

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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An interdiciplenary collaboration of scientists from the Novo Nordisk Foundation Center for Stem Cell Biology and animators in Denmark is aiming to facilitate a dialogue between the two diciplines, and ultimately disseminate stem cell research to different segments of the society.

The primary objectives are:

1. To train scientists to pitch scientific stories to non-scientists, and in particular to visual story-tellers.
2. To introduce visual story-tellers to stem cell research and to how science is conducted.
3. To establish a common language between these professionals.

In May 2019, a few scientists from DanStem went to a match-making event in Viborg, and in August the painter and animator Cosimo Miorelli visited DanStem to meet with scientists and platform specialists.

Following these interactions, Cosimo conducted the animation ‘Cells of Knowledge’; a short introduction to stem cells research and to the techniques used in research.

More specilized animations are currently in the pipeline.

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The DanStem podcast team had the privilege to host Uri Manor from Salk Institute for Biological Studies in an inspiring podcast https://lnkd.in/ezVrBNV about deep-learning, image analysis, science communication and a few good tips to junior investigators. 

Uri Manor’s primary focus is the integration and application of optical and charged particle detection technologies to study problems of critical biological significance. His current research focuses on developing deep learning-based computational approaches to increase the resolution, sensitivity and speed of the next generation of microscopes, as well as designing nanoprobes for high spatiotemporal resolution imaging of subcellular dynamics.

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We seek a candidate for a Wellcome Trust-funded Research Associate position working on an interdisciplinary project investigating the role of cell shape in controlling asymmetric cell divisions, fate decisions and tissue morphogenesis. This project is based in the laboratory of Dr Shane Herbert (University of Manchester, UK) and builds upon our recent work revealing that asymmetric divisions fundamentally coordinate tissue morphogenesis during blood vessel formation (Costa. G., et. al. 2016. Nat. Cell Biol. and unpublished work). In particular, we aim to determine how and why acquisition of specific interphase cell geometries modifies the biomechanics of cell division to trigger asymmetric divisions, both during blood vessel formation and development of other tissues. Using in vitro micropatterning to modulate cell shape, omics techniques and live cell imaging approaches, both in vitro and in vivo during zebrafish embryonic development, we aim to define how cell shape globally impacts cellular transcription, translation, actomyosin dynamics, chromosome segregation and DNA damage to drive asymmetric division in diverse tissue contexts in vivo.

The successful applicant will already hold (or have nearly completed) a PhD in a relevant discipline and have experience of either live cell imaging, the mechanisms of cell division, micropatterning tools and/or the zebrafish model system.

The position is available from 1^st April 2020 and is tenable for up to 60 months full time (later start dates are negotiable). For more details of the laboratory, please see www.herbertlab.com.

Informal enquiries can be made to Dr. S. Herbert.

Tel: 0161 275 1140

Email shane.herbert@manchester.ac.uk

Application forms and further particulars can be obtained at http://www.manchester.ac.uk/aboutus/jobs/

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We seek a candidate for a Wellcome Trust-funded Research Associate position working on an interdisciplinary project investigating the roles of subcellular targeting of mRNAs in the spatial control of local cell shape remodelling and tissue morphogenesis. This project is based in the laboratory of Dr Shane Herbert (University of Manchester, UK) and builds upon our recent work revealing that the precise subcellular targeting of mRNAs and resulting local protein translation acts as a molecular compass that drives local cell shape changes, orients motile cell polarity and spatially directs tissue movement during blood vessel formation in vivo (Costa. G., et. al. 2019. bioRxiv). In particular, this project will exploit novel optogenetic tools to achieve light-induced dynamic modulation of mRNA subcellular localisation, both in vitro and in vivo during zebrafish embryonic development, with an aim to define the fundamental mechanisms and function of mRNA targeting in the control of broad aspects of in vivo tissue behaviour.

The successful applicant will already hold (or have nearly completed) a PhD in a relevant discipline and have experience of either live cell imaging, optogenetics, CRISPR gene-editing and/or the zebrafish model system.

The position is available from 1st April 2020 and is tenable for up to 60 months full time (Later start dates are negotiable). For more details of the laboratory, please see www.herbertlab.com.

Informal enquiries can be made to Dr. S. Herbert.
Tel: 0161 275 1140
Email shane.herbert@manchester.ac.uk

Application forms and further particulars can be obtained at http://www.manchester.ac.uk/aboutus/jobs/

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