We are looking for: Enthusiastic researchers with a BSc or Master Degree in biomedical sciences with interest in Developmental Neurobiology. Good academic records are required, as well as good spoken and written command of English.
We offer: A highly multidisciplinary and competitive training programme in biomedical research. Access to state-of-the-art infrastructures.
The selected candidate will investigate growth of the central nervous system and associated primary microcephaly, with the aim to understand the mechanisms that control cell numbers and brain size at birth. We recently demonstrated that the activity of classical growth factors such as Sonic hedgehog and BMPs is required for the expansion of the pool of neural progenitors by maintaining symmetric divisions. We are now combining high resolution imaging and data from transcriptomics and functional genetics, to describe the mechanisms downstream these growth factors that regulate neural stem cell maintenance.
Those interested please send CV, a cover letter justifying the interest of the applicant in the project, and the names of two referees toemgbmc@ibmb.csic.es
The Royal Society is organising the upcoming Single cell ecology meeting on 10-11 December 2018 in London, UK, on behalf of Professor Thomas Richards, Dr Ramon Massana and Professor Neil Hall.
This will be an interdisciplinary meeting to explore the use of single cell technologies to understand the function, diversity and interactions of microbes. This meeting aims to bring together physicists who manipulate cells; microbiologists who seek to understand the nature of microbial communities; genomicists who are developing new approaches to study individual cells; and evolutionary biologists who are trying to sample microbes and understand where they branch on the tree of life.
This two-day symposium will showcase the best in developmental biology across the life course. From embryogenesis through to ageing, areas of current excitement in the field will be highlighted by plenary talks from 15 internationally renowned speakers, along with selected short talks from abstracts.
The symposium will honour the memory of Rosa Beddington, a leading UK embryologist who was Head of the Division of Mammalian Development at the MRC National Institute for Medical Research from 1993-2001. Many of Rosa’s colleagues and lab alumni will be attending the symposium.
We invite submissions for short talks (15 minutes) from early-career researchers (PhD students, postdocs and recently-established PIs). Please submit your abstracts to events@crick.ac.uk by 1 December 2018. Abstracts should be no more than 500 words including the title, authors and institution information. The presenter for short talks must have registered their attendance to the conference by 1 December 2018. Please ensure the presenter’s name is underlined on your submission.
We look forward to seeing you at the Crick in February,
The Organising Committee (James Briscoe, Alex Gould, Rita Sousa-Nunes and Jean-Paul Vincent)
Several MRC-funded positions are available in the Scholpp lab in the Living Systems Institute (LSI) at the University of Exeter to elucidate various aspects of cytoneme-mediated Wnt trafficking in vertebrates.
We are looking for
a Postdoc (3years, starting in Spring 2019), two PhD students (3.5years, starting in Autumn 2019, UK/EU only), and a Tech (2years, starting in Spring 2019)
Application deadlines: November / December 2018!
More information about the lab, about the LSI, and about our recent research in The Node.
Several postdoctoral positions are available in the group of Taija Mäkinen at Uppsala University. The lab studies fundamental mechanisms of tissue morphogenesis in the vascular system. The aim is to understand how endothelial cells communicate with each other and the tissue environment to co-ordinate vascular morphogenesis and formation of functionally specialised blood and lymphatic vessel types. To do so, the group utilises advanced mouse genetic tools and state-of-the-art cell and molecular biology techniques (including single cell RNA sequencing, flow cytometry, confocal, light-sheet and super-resolution microscopy). For more details about the group’s research please see: http://www.makinenlab.com/
Selected recent publications from the laboratory:
Zhang et al, Nat Commun 2018; Frye et al, Nat Commun 2018; Zhang et al, Development 2018; Wang et al, Development 2017; Martina-Almedina et al, J Clin Invest 2016; Martinez-Corral et al, Circ Res 2015; Stanczuk et al, Cell Rep 2015; Tatin et al, Dev Cell 2013; Lutter et al, J Cell Biol 2012; Bazigou et al, J Clin Invest 2011.
Work description:
The selected candidate(s) will work on one of the following topics: 1) functional characterisation of tissue-specific lymphatic endothelial progenitor cells (as part of an ERC-funded project), 2) identification and functional characterisation of vascular-bed specific genes, or 3) elucidation of disease mechanisms in vascular malformations. In addition, one position will be in collaboration with the group of Ingvar Ferby at Uppsala University (http://www.imbim.uu.se/forskargrupper/cancer/ferby-ingvar/), exploring how vesicular trafficking and compartmentalisation of growth factor receptors instruct behaviour of epithelial and endothelial cells using e.g. live-cell imaging approaches.
Qualifications:
We are looking for highly motivated individuals with a PhD and research background in molecular or cell biology, developmental biology or biochemistry, and a proven track record of successful scientific work. Strong background in molecular/cell biology, mouse genetics, flow cytometry and/or imaging is required.
How to apply:
To apply, please send your CV together with the names of three references and a short description of yourself and the motivation to join the group to: taija.makinen@igp.uu.se
The position is open until 28 December 2018, or until suitable candidate(s) is found.
Are you interested in applying mathematics, statistics or deep learning/machine learning to biomedical problems? Apply now for a MRC WIMM Prize Studentship, to start in October 2019. The studentship is fully-funded for four years, including a stipend of £18,000 p.a. and all University and College fees paid.
Applicants with a background in Physics, Mathematics, Engineering, Statistics or Computer Science are encouraged to apply. To be eligible for a full award, applicants must have no restrictions on how long they can stay in the UK and must have been ordinarily resident in the UK for at least 3 years prior to the start of the studentship. Further details about residence requirements may be obtained here.
For further information on how to apply can be found here.
All applications must be received by 12 noon (UK time) on Friday, 11 January 2019
Interviews will take place the week commencing 28 January 2019.
The Zebrafish Interest Group at the University of Utah held its first Utah Fish Conference (UFC) on October 8, 2018. The conference was organized by pre- and post-doctoral trainees to celebrate the University’s Zebrafish Interest Group (ZIG), as well as to unite the Mountain West fish community. This 1-day event hosted over 80 attendees from 6 institutes. UFC was sponsored by the University’s ZIG, as well as Tecniplast USA, Aquatic Enterprises, IDT, Aquaneering, wFluidx, NCI, NEB, Zeiss, ThermoFisher by Life Technologies, and Developmental Dynamics.
UFC was held at the Crocker Science Center at the University of Utah. The talks were well-attended by an active audience.
The event featured two excellent keynotes, Trista E. North at Boston Children’s Hospital, and Bruce Draper at University of California-Davis. Dr. North jump-started the day’s event with a stimulating talk on the hematopoietic signaling connectome. She was followed by two hour-long sessions of trainee talks, which represented labs across the University and trainees from outside institutes. There was an active poster session comprising 30 posters from 16 labs, with presenters from all career stages, from undergraduate to faculty researchers.
Members of the Organizing Committee (Left to Right: Chelsea Herdman, Alexis Fulbright, and Penny Lam) caught chatting with Dr. North during a coffee break.
An “Ask Me Anything” panel followed the poster session and featured both senior and junior faculty from the University, as well as Dr. North. A pre-doctoral trainee, Deeptha Vasudevan, moderated questions from the audience, and the panel covered topics from how to settle on a career path to advice on how to start your lab. The AMA was followed by an exciting evening talk from Dr. Bruce Draper about sex determination.
The poster session featured 30 posters from a diverse group of labs.
During dinner, the awards for best talk and best posters were announced. Robert Mackin (U of Idaho) won the Outstanding Young Investigator award for his excellent talk. Poster awards were given to 2 trainees in each category: undergraduate, graduate, or post-doctoral trainee. Awards went to: Jeffrey Dunn (BYU) and Samuel Caton (BYU) in the undergraduate category; Dana Klatt Shaw (U of Utah) and Srishti Kotiyal (U of Utah) in the graduate category; and Chelsea Herdman (U of Utah) and Angie Serrano (U of Utah) in the post-doctoral category. Awards were cash prizes sponsored by Developmental Dynamics. Following dinner, an after-party was hosted at The Porcupine Pub, sponsored by ThermoFisher by Life Technologies. The conversation was lively and offered more opportunities for trainees to intermix and mingle with faculty, Dr. North, and Dr. Draper.
The UFC was an invigorating moment for the University’s ZIG community, as well as for the Mountain West fish community. It was an excellent way to highlight the working happening within the region, and unite different institutes.
UFC2018 Organizing Committee:
Gabriel Bossé, PhD, @GabrielBosse1 (Randall Peterson Lab)
Join us for the Conference on Cell Competition in Development & Disease, in Tahoe, California!
February 24–28, 2019
Granlibakken Tahoe – Lake Tahoe, California, USA
Cell competition is a highly conserved process that promotes the context-dependent elimination of less fit cells and stimulates growth of more fit cells during growth and homeostasis. It has long been known that the basis of competition is the ability of growing cells to monitor their fitness and that of their neighbors, but only recently have signaling and effector mechanisms been identified. New technologies have uncovered the prevalence of cell competition in humans, with surprising outcomes and implications for human disease. This conference aims to bring together, for the first time, researchers from diverse fields who study competitive and cooperative interactions between cells.
Plenary Session Topics:
• Evolution of Competition and Cooperation • Stem Cell Competition • The Germline • Mosaicism and Selection in Normal Tissues • Cell Selection in Human Disease • Aging and Pre-Malignancy • Competition in Cancer
Plus workshops on technologies for clonal tracking, oncogenes and tumor suppressors as drivers of competition, and computational modeling of cell competition
Scientific Organizers: Margaret A. Goodell, Baylor College of Medicine, USA Laura A. Johnston, Columbia University, USA Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Scholarship/Discounted Abstract Deadline: Oct 24, 2018; Abstract Deadline: Nov 28, 2018; Discounted Registration Deadline: Jan 8, 2019
A postdoctoral position is available in the Developmental Mechanobiology and Regeneration lab of Joel Boerckel at the University of Pennsylvania in Philadelphia, PA, USA (http://www.med.upenn.edu/orl/boerckellab/). Our laboratory is housed in the Departments of Orthopaedic Surgery and Bioengineering and studies how mechanical cues direct morphogenesis, repair, and regeneration. A major focus of the lab is understanding how the transcriptional co-activators YAP and TAZ mediate progenitor cell mechanosensation, motility, and differentiation during development and regeneration.
We are looking for postdoctoral fellows with backgrounds in either cell and developmental biology or bioengineering to join our multidisciplinary team. NIH-funded projects are available to define the roles of YAP and TAZ in osteoprogenitor cell mobilization, mechanical regulation of endochondral ossification, and development-mimetic tissue engineering. Projects feature a combination of cell and bioreactor culture, biomaterials, and animal modeling using transgenic mice and rats.
What we offer:
Highly collaborative and collegial environment in the McKay Orthopaedic Research Labs (http://www.med.upenn.edu/orl)
Regular interactions with world-class colleagues and visiting speakers through the Penn Center for Musculoskeletal Diseases (https://www.med.upenn.edu/pcmd) and the Center for Engineering Mechanobiology (https://cemb.upenn.edu/) at UPenn.
Supportive mentorship for multi-faceted career development and opportunities tailored towards individual career goals.
A stimulating environment with freedom to develop new research directions.
An NIH funded position at NRSA postdoctoral stipend levels (with potential for renewal up to four additional years).
A department located in a dynamic East-coast city with affordable cost of living.
What we’re looking for:
Enthusiastic and ambitious individuals with a strong interest in our research and a collaborative and collegial laboratory environment.
Fearlessness in learning new techniques and designing projects independently.
Willingness to apply for applicable postdoctoral fellowships and eagerness to take advantage of other career development opportunities.
Interest in working with junior lab members and summer undergraduates.
Strong verbal and written communication skills.
Start date immediately or upon mutual agreement.
Application materials (email to boerckel@pennmedicine.upenn.edu):
Cover letter outlining relevant expertise and scientific interests
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