In this episode we’re taking a look at the story and the characters behind one of the most transformative – and ubiquitous – techniques in modern molecular biology: the polymerase chain reaction.
The genetic code is written in just four ‘letters – A, C, T and G, short for adenine, cytosine, thymine and guanine. But where did they come from? To find out, we need to go back to the Bird Poop Boom of the 1840s.
In this episode we’re looking at the genetics of failure – why we fail to lose weight thanks to our genes, and why ignoring genetic information and DNA diversity leads to billions of dollars being wasted on drugs that don’t work. Cambridge University neuroscientist Giles Yeo talks about his new book, Gene Eating: The science[…]
Checkpoints ensure that mouse oocytes with DNA damage arrest in meiosis I, preventing non-viable embryo formation, however the mechanisms which activate this checkpoint have so far eluded researchers. This week we feature a paper published in the latest issue of Development that reveals that the unique ability of mouse oocytes to sense DNA damage by[…]
The Mouse ENCODE Project released a slew of papers late last month reporting findings from a three-year effort to comprehensively map functional elements in the mouse genome. Their major findings are summarized in an integrative paper in Nature (Yue, F. et. al., 2014). Similar to the goals of the human ENCODE project (The ENCODE Project Consortium,[…]