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The story of my heart, from the bottom of my heart (says the Zebrafish)

Posted by on June 23rd, 2020

I started off as quite little—just one cell, in fact. No heart, no brain, no blood flowed in me and yet, somehow I found the motivation in me to divide. One me made two and two mes made four, till many tiny mes made me a full-fledged embryo with a heart full of hope. As[…]

A Madrid-Washington synergy for mouse embryo live-imaging

Posted by on April 23rd, 2019

One of the things I learned during my stay in another lab is that you can’t succeed completely by yourself. You can try, sure, but a relevant unanswered question in biology is a hard nut to crack. It usually takes a multidisciplinary approach and great ideas coming from more than one brain. Collaborations are key[…]

Research Associate – Cardiac morphogenesis and development

Posted by on September 30th, 2018

The Bloomekatz laboratory in the Department of Biology at the University of Mississippi in Oxford, MS is seeking a research associate to assist in our investigations of the fundamental mechanisms underlying cardiac morphogenesis and disease using zebrafish. Please see our website thebloomekatzlaboratory.org for further details on our research. The successful candidate will have an opportunity[…]

Dating with cells – finding the right match

Posted by on August 23rd, 2018

It’s an age-old mystery of the heart: do opposites attract, or will like do better with like? We can now answer this pressing question, at least for Drosophila cardioblasts: cells prefer to ‘swipe right’ on a shared transcriptional profile, but the resulting relationships are stronger if there are some unattractive alternatives around to remind them[…]

Postdoctoral Position in Cardiovascular Development

Posted by on July 16th, 2018

A postdoctoral position is available in the laboratory of Dr. Sophie Astrof at Thomas Jefferson University to study roles of cell-extracellular matrix (ECM) interactions in cardiovascular development and congenital heart disease. We have recently discovered that progenitors within the second heart field (SHF) give rise to endothelial cells composing pharyngeal arch arteries. Projects in the[…]

Looking back on the adventure: exploring cell fate conversion with single cell RNA-seq

Posted by on November 21st, 2017

The story behind our recent paper: Liu Z*, Wang L*, Welch JD*, Ma H, Zhou Y, Vaseghi HR, Yu S, Wall JB, Alimohamadi S, Zheng M, Yin CY, Shen WN, Prins JF, Liu JD, Qian L (2017). Single cell transcriptomics reconstructs lineage conversion from fibroblast to cardiomyocyte. Nature, 551, 100-104 *: co-first author. https://www.nature.com/articles/nature24454  […]

Mechanisms for asymmetric heart morphogenesis: About Nodal and tissue intrinsic forces

Posted by on December 11th, 2013

Although we all appear symmetrical from the outside, the organization of our internal organs and organ structure are highly asymmetric. Proper asymmetric positioning and patterning of our organs is very important for correct function, and loss of this asymmetry during organ formation can lead to a variety of serious congenital diseases.  Our recent study identifies[…]

Proepicardial cells go for a swim: how fluid flows guide epicardial progenitors to the heart

Posted by on September 12th, 2013

The epicardium, the layer of cells covering the myocardium, plays an essential role in heart maturation and formation of the heart valves and coronary vasculature. It derives from the proepicardium (PE), a cluster of cells emerging from the inner lining of the pericardial wall, in which the heart is located. During development, PE cells need[…]

CNIC conference: Cardiovascular Development, Disease and Repair

Posted by on September 10th, 2013

CNIC conference: Cardiovascular Development, Disease and Repair 8-9th November 2013 Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain. Abstract submission deadline: 20th October 2013 For more information and registration please visit the following webpage: http://www.cnic-conference.com/     Cardiovascular diseases are the leading cause of death worldwide and their treatment is associated with an enormous economic[…]

Postdoc position

Posted by on January 4th, 2013

A postdoctoral position is available in the laboratory of Dr. Sophie Astrof to study roles of cell-extracellular matrix interactions in cardiovascular development and disease using mouse model system. The research will involve investigation of the role of extracellular matrix in orchestrating signaling/communication between various progenitor cell populations during morphogenesis of the aortic arch arteries.  In[…]