the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by Garcia Lab on June 19th, 2018
We recently published a manuscript in Cell that describes a method to image transcription factor concentration dynamics in real time, in living embryos, using a nanobody-based protein tag that we call the “LlamaTag.” We were particularly excited about these investigations because this new technology overcomes a major technical obstacle to understanding how gene-expression dynamics are[…]
Posted by the Node Interviews on September 29th, 2017
Cell polarisation is crucial for normal development and controlled by complex molecular interactions in the cytoplasm and at the membrane. Today we feature a paper recently published in Developmental Cell that describes a single-cell biochemistry technique and its insights into polarity protein dynamics the developing worm embryo. We caught up with first author Dan Dickinson, who carried out the work as a postdoc[…]
Posted by Gary McDowell on August 20th, 2014
I previously wrote a post about the development of a 4-D X-Ray Tomography technique for imaging early Xenopus embryos. Frog embryos are opaque due to their yolky composition and this has proved a challenge for traditional optical microscopy of events in the early stages of Xenopus embryo development. However Julian Moosmann, Ralf Hofmann and Jubin[…]
Posted by Kota Miura on August 30th, 2013
Image analysis is powerful and essential in modern biology. However, many people working on image analysis might be struggling with following problems: Which tool is appropriate to address my question? Who should I ask my very specific question about image analysis? I want to increase my skills, but I do not know how. I became[…]
Posted by wongmi22 on August 13th, 2012
48 anatomical structures of the presented mouse embryo atlas are shown in 3D. Here is the backdrop for our recent paper in Development, “A novel 3D mouse embryo atlas based on micro-CT”. With the human genome project complete, the sequence and the location of each gene in the genome is understood. However, the understanding of[…]
Posted by Erin M Campbell on June 13th, 2011
The Drosophila ovary is stunningly beautiful, and a playground of wonderful biological questions. Within the germarium alone, developmental biologists can look at asymmetric division, stem cells and their niches, cell migration, and cell specification. A recent paper in Development describes a technique allowing the in vitro imaging of a fruit fly ovary, and opens the[…]
