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developmental and stem cell biologists
Posted by the Node Interviews, on 12 June 2018
Somites are segmented structures which give rise to numerous tissues in the vertebrate body. It has long been observed that somites scale in size with the overall size of the ...Posted by the Node Interviews, on 25 May 2018
Short CLE peptides regulate a wide variety of processes during plant development. In the developing root, the receptors and co-receptors for CLEs have remained largely unclear, as have the relationships ...Posted by the Node Interviews, on 22 May 2018
The vertebrate lymphatic vascular network provides crucial circulatory and immune functions but its developmental origin has been a contentious issue, in particular the question of whether lymphatic endothelial cells have ...Posted by the Node Interviews, on 21 May 2018
Intrahepatic bile ducts (IHBDs) are epithelial tubular structures that transport bile from the liver to the intestine, but the molecules and mechanisms controlling IHBD morphogenesis have remained largely unclear. A a ...Posted by the Node Interviews, on 19 April 2018
The transition to multicellularity in eukaryotes appears to be intimately linked to the transition from isogamy (gametes of the same size) to anisogamy (gametes of distinct sizes), and indeed to ...Posted by the Node Interviews, on 9 April 2018
Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the ...Posted by the Node Interviews, on 5 April 2018
Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. A recent paper in Development explores how cell identity is ...Posted by the Node Interviews, on 12 March 2018
Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on ...Posted by the Node Interviews, on 19 February 2018
Vertebrate segmentation involves the periodic formation of somites from the presomitic mesoderm, in a manner controlled by oscillating gene expression (the oscillations of the segmentation clock must be one of the ...Posted by the Node Interviews, on 18 January 2018
Vertebrate brain development is characterised by cell migration, as neurons are often born far from where they need to end up. Migration is regulated by guidance cues and their receptors, ...