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developmental and stem cell biologists
Posted by the Node Interviews, on 20 December 2017
Neuromesoderm progenitors are a population of stem cells that contribute to the neural tube and somite-forming paraxial mesoderm, and promote axial growth of the vertebrate embryo. In the latest issue ...Posted by the Node Interviews, on 29 November 2017
Pavement cells in plant leaves were identified as a puzzle which deviated from normal cell shape rules by D’Arcy Thompson in his classic text On Growth and Form. Now modern approaches ...Posted by the Node Interviews, on 16 November 2017
Zika infection in humans is associated with birth defects including microcephaly. Zika has two major lineages – the Asian lineage, which has been associated with birth defects, and the African lineage, ...Posted by the Node Interviews, on 6 November 2017
Embryonic patterning is dependent on the establishment of the anteroposterior (AP) and dorsoventral axes early in development. In mammals this occurs by a breaking of symmetry in the epiblast, however ...Posted by the Node Interviews, on 18 October 2017
During spermatogenesis, progenitor cells must undergo tightly regulated changes to produce functional gametes. However, the genetic control of this process in humans has eluded researchers. This week we feature a ...Posted by the Node Interviews, on 4 October 2017
Checkpoints ensure that mouse oocytes with DNA damage arrest in meiosis I, preventing non-viable embryo formation, however the mechanisms which activate this checkpoint have so far eluded researchers. This week ...Posted by the Node Interviews, on 29 September 2017
Cell polarisation is crucial for normal development and controlled by complex molecular interactions in the cytoplasm and at the membrane. Today we feature a paper recently published in Developmental Cell that describes a single-cell biochemistry technique ...Posted by the Node Interviews, on 20 September 2017
Development often involves the asymmetric partitioning of cellular components to daughters, and this process is crucial for successful gametogenesis. Today’s paper, published in the current issue of Development, explores the cytoskeletal ...Posted by the Node Interviews, on 16 August 2017
Embryogenesis begins with fertilisation, and defective activation of the egg by the sperm is implicated in human infertility. Today’s paper, published in the most recent issue of Development, investigates the ...Posted by the Node Interviews, on 2 August 2017
Ion channels are famous for their roles in neurons and muscles, but the spectrum of phenotypes seen in ion channel mutants indicate a diversity of roles in development; the underlying ...