the community site for and by developmental biologists

In Development this week (Vol. 141, Issue 20)

Posted by on October 7th, 2014

Here are the highlights from the current issue of Development:   Small (molecule) steps to making bone The repair of cartilage and bone following damage remains a clinical challenge. Current cell-based therapies rely mostly on adult mesenchymal stromal cells, but the expansion of these into correctly differentiated and functionally competent chondrocytes, which give rise to[…]

Tough decisions for the developing brain

Posted by on October 3rd, 2014

To form complex organs, somatic stem cells proliferate and then differentiate during development. In this process, intrinsic factors, i.e. the sequential expression of transcriptional genes, and extrinsic factors, i.e. extracellular microenvironment, are intimately involved. Recent in vitro studies have revealed that the physical properties of the extracellular niche, possibly tissue stiffness, may play an important[…]

‘From Stem Cells to Human Development’ – A Company of Biologists’ Workshop

Posted by on October 3rd, 2014

Last week, several of the Company of Biologists’ team de-camped to Surrey for our latest Workshop ‘From Stem Cells to Human Development’. Unlike previous events, this was a larger meeting, with 112 participants from all over the world. Organised by the editors of Development, the theme of the meeting (as implied by the title!) was[…]

What do sperm have to do with brain tumors?

Posted by on October 2nd, 2014

  This post was originally published in the Knoepfler Lab Stem Cell Blog.      Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including[…]

This month on the Node- September 2014

Posted by on October 1st, 2014

Here are some of the highlights for September:   Research: – Sylvain discussed his recent Development paper on the tristable regulatory network behind cell fate decisions in the early embryo. – Aryeh wrote about his research on spontaneous patterning of human ES cells, recently published in Nature Methods (he is also hiring a postdoc!). – and Christelle highlighted a recent[…]

The Future of Research Symposium:

The Funding of Research

Posted by on October 1st, 2014

This is the last of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond[…]