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Displaying posts with the tag: mouse [Clear Filter]

New phenotype screen examines causes of neonatal death

Posted by on October 4th, 2016

This post first appeared on Annotations, the DMDD blog ( Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a significant number of gene knockouts result in death at or shortly after the time of birth. Mice from these knockout lines provide a valuable animal[…]

New data reveals gene expression during mouse embryo development

Posted by on September 29th, 2016

This article was originally posted on the DMDD website Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes for developing embryos from knockout mouse lines, DMDD has now released a gene expression[…]

Postdoctoral Opportunities at the National Institutes of Health

Posted by on September 28th, 2016

ROLE of THYROID HORMONE in MOUSE INTESTINAL DEVELOPMENT and REGENERATION. Thyroid hormone (T3) is known to be critical for postembryonic development in mammals (around birth). This laboratory has been taking a multi-faceted approach to investigate the function of T3 and T3 receptors (TRs) in vivo by using Xenopus and mouse as models. A major recent focus is on how[…]

A Tale of Trunks or Zen and the art of doing a PhD

Posted by on September 1st, 2016

The story of this paper is also the story of my PhD. It begins as most papers and PhDs do: with a distinct and often unrelated starting project or plan. It is great to have a plan. But time and luck and data bend and twist the plan; until it finally breaks and you end[…]

FaceBase: An online resource for craniofacial research

Posted by on August 16th, 2016

In 2009, FaceBase was launched in response to the need for more comprehensive analysis of craniofacial development: with so much craniofacial data being generated, there is a danger of relevant datasets being buried in the avalanche of genomic and other data. FaceBase is a curated, one-stop shop for facial development and research offering the community input and[…]

New DMDD embryonic-lethal mouse data now available

Posted by on August 15th, 2016

  This post was originally posted on the DMDD blog.   New embryonic-lethal knockout mouse lines are now available on the DMDD database. If you haven’t previously taken a look at our data (or even if you have) now would be a good time to explore our website.  We’ve added new embryo phenotype data and[…]

The Zika Virus and Systematic Screens of Mouse Mutations

Posted by on July 14th, 2016

  This post was originally published on the DMDD blog.     The Zika virus has raised global awareness of birth defects more than at any time in the last 50 years [1]. A recent Nature Editorial explores the opportunities this presents to increase support for vaccination programmes, compulsory fortification of food staples and investment[…]

Replicating spinal cord development with microfluidics

Posted by on July 5th, 2016

Unraveling Development Embryonic development is a complex and regulated spatiotemporal ensemble of signaling cues that control cell differentiation. Most of what we now know comes from experimenting directly on embryos. This provides biological realism, but involves a sea of uncontrolled/unobserved variables that sometimes obscures the basic underlying mechanisms. More recently, in vitro models, based on[…]

Forgotten classics- Regulating the size of the mouse embryo

Posted by on April 6th, 2016

  Snow, M. H. L., Tam, P. P. L. (1979) Is compensatory growth a complicating factor in mouse teratology? Nature 279, 555-557 Lewis, N. E., Rossant, J. (1982) Mechanism of size regulation in mouse embryo aggregates J. Embryol. exp. Morph 72, 169-181 Recommended by James Briscoe (Francis Crick Institute)     As our previous forgotten[…]

Mouse-human neural crest chimeras: Not only a matter of black and white

Posted by on February 25th, 2016

The neural crest arises between neural and non-neural ectoderm and represents a somatic cell type with unique properties of multipotency. The neural crest cells (NCCs) migrate throughout the body and differentiate into a diverse array of cell types and tissues including the peripheral nervous system, enteric and sensory nervous system, Schwann cells, skin melanocytes, as[…]