The Center for Craniofacial Molecular Biology is looking for a talented Public Communications Coordinator to join the team!
Job Description
The Herman Ostrow School of Dentistry of USC’s Center for Craniofacial Molecular Biology is a unique facility that unites world-class researchers in a variety of disciplines centered around structures of the craniofacial region. Since its inception in 1991, CCMB has been home to several major discoveries and has attracted top researchers from around the world.
Position specific job summary:
This position will be responsible for editing scientific manuscripts in developmental biology and related biomedical fields. In addition, this position will manage the Center’s public communications programs to promote the Center and its research projects and programs.
Position specific job accountabilities:
Edits scientific manuscripts and presentations for content and style in preparation for submission and publication. Produces newsletters and other educational and promotional materials in printed and digital formats. Develops content for social media; develops and maintains website and database; coordinates and manages press and communication tasks such as contents, interviews, website news, etc.
Position specific job qualifications:
Must have a deep understanding of biomedical research and help to prepare research manuscripts and grant applications. Must have Master’s degree in biology or a related field; PhD preferred. Must be a confident communicator and presenter, excellent in verbal and written communication skills. Must possess excellent organizational and planning skills. Must be proactive, reliable, responsible and accurate with an attention to detail. Must possess the ability to keep information confidential. Must have a tactical understanding of social media platforms. Must be self-motivated with a positive and professional approach to management.
Post-doc in wing pattern formation and morphogenesis:
1.Job/ project description:
The research will involve using and refining an existing mathematical model of wing morphogenesis to explore whether it can be used to predict how wing morphology changes over generations in an artificial selection experiment. These predictions would be contrasted with predictions stemming from a quantitative genetics analysis of fly populations.
The research will take place in the Center of Excellence in Experimental and computational developmental biology of the Biotechnology Institute of the University of Helsinki, Finland.
Can we understand the processes by which complex organisms are build in each generation and how these evolved?
The process of embryonic development is now widely acknowledged to be crucial to understand evolution since any change in the phenotype in evolution (e.g. morphology) is first a change in the developmental process by which this phenotype is produced. Over the years we have come to learn that there is a set of developmental rules that determine which phenotypic variation can possibly arise in populations due to genetic mutation (the so called genotype-phenotype map). Since natural selection can act only on existing phenotypic variation, these rules of development have an effect on the direction of evolutionary change.
Our group is devoted to understand these developmental rules and how these can help to better understand the direction of evolutionary change. The ultimate goal is to modify evolutionary theory by considering not only natural selection in populations but also developmental biology in populations. For that aim we combine mathematical models of embryonic development that relate genetic variation to morphological variation with population models. The former models are based on what is currently known in developmental biology.
There are two traditional approaches to study phenotypic evolution. One is quantitative genetics and one is developmental evolutionary biology. The former is based in the statistics of the association between genetic relatedness and phenotypic variation between individuals in populations, the latter in the genetic and bio-mechanical manipulation of the development of lab individuals. While the former models trait variation with an statistical linear approach the latter models it by deterministic non-linear models of gene networks and tissue bio-mechanics. For the most, these two approaches are largely isolated from each other.
The current project aims to contrast and put together these two approaches in a specific easy to study system: the fly wing. In brief, we are growing fly populations and, in each generation, we select the founders of the next generation based on how close they resemble an arbitrary optimal morphology in their wings (based on the proportions between several of their traits). In each generation also, we estimate the G matrix and the selection gradient to see how well one can predict evolution in the next generation. The quantitative genetics predictions will be contrasted with the predictions stemming from a wing morphogenesis model that we built based on our current understanding of wing developmental biology (see Dev Cell. 2015 Aug 10;34(3):310-22 for the model and for slightly similar approaches: Nature. 2013 May 16;497(7449):361-4. and Nature. 2010 Mar 25;464(7288):583-6).
Our center of excellence includes groups working in tooth, wing, hair and mammary glands development. In addition to evolutionary and developmental biologists the center of excellence includes bioinformaticians, populational and quantitative geneticists, systems biologists and paleontologists. The group leaders of the center involved in this project are Jukka Jernvall, Salazar-Ciudad and Shimmi.
“The Academy of Finland’s Centres of Excellence are the flagships of Finnish research. They are close to or at the very cutting edge of science in their fields, carving out new avenues for research, developing creative research environments and training new talented researchers for the Finnish research system.”
3. Requirements:
The applicant must hold a PhD in either evolutionary biology, developmental biology or, preferably, in evolutionary developmental biology (evo-devo). Applicants with a PhD in theoretical or mathematical biology are also welcome.
Programming skills or a willingness to acquire them is required.
The most important requirement is a strong interest and motivation on science and evolution. A capacity for creative and critical thinking is also required.
4. Description of the position:
The fellowship will be for a period of up to 1,5 years (100% research work: no teaching involved).
Salary according to Finnish postdoc salaries.
5. The application must include:
-Motivation letter including a statement of interests
-CV (summarizing degrees obtained, subjects included in degree and grades, average grade).
-Summary of PhD project, its main conclusions and its underlying motivation.
Postdoctoral position in the Saunders laboratory, Mechanobiology Institute, Singapore
A postdoctoral research position in quantitative biology is available from March 2019 in Asst. Prof. Timothy Saunders’ group at the Mechanobiology Institute, Singapore. The Saunders lab has been active since 2013 and studies the fundamental processes shaping organs and tissues during development.
The Saunders lab extensively uses live imaging of developing Drosophila and zebrafish embryos to understand how complex tissue shape emerges. The position will involve developing image analysis tools to quantitatively analyse such datasets. We are particularly interested in utilising machine learning to improve data analysis. Further, there is the opportunity to develop theoretical tools for understanding tissue mechanics and signalling.
This position is partially funded by an HFSP Young Investigator Award and there are opportunities to work with collaborators in Austria, Spain and Portugal. In particular, the researcher will analyse ex vivo data from Drosophila embryonic extracts and develop biophysical models of this system.
The Saunders lab works at the interface between developmental biology and biophysics. As such, this position offers researchers with expertise in either image analysis or biophysics to work directly with developmental biologists. This offers an exciting opportunity for a dedicated researcher to be part of a genuinely interdisciplinary lab tackling fundamental problems in developmental biology.
Candidates should have strong experience in at least one of the following, and display a willingness to learn the other: (1) experience with image analysis and handling large datasets; (2) biophysical modelling of developing systems. Knowledge of microscopy methods is desired.
The Saunders’ lab is a young group at the Mechanobiology Institute. This provides an exciting prospect for a motivated post-doc to be involved in developing research directions. The post-doc will also be expected to guide and help the graduate students in the laboratory. More information can be found at: https://mbi.nus.edu.sg/timothy-saunders/saunders-lab/
Qualifications:
1) A Ph.D in Biophysics, Computational Biology, or related subject. Applicants with a background in biology but who can show proficiency in computational analysis are also encouraged to apply.
2) At least one first-author paper in English submitted to an international peer-reviewed journal
3) Experience in at least one of: (i) Image analysis and handling large datasets; and (ii) Biophysical modelling
Salary and benefits are commensurable to educational qualifications and working experience of the candidates. Benefits include annual leave, medical and flexi-benefits, etc.
If interested, please contact Asst. Prof. Saunders with curriculum vitae and a letter of research interest.
Asst. Prof. Timothy Saunders
Principal Investigator, Mechanobiology Institute, National University of Singapore, Singapore
Email: dbsste@nus.edu.sg
If that is not enough, check out my evaluation of my course experience.
Embryology 2018:
I evaluate experiences by this basic philosophy: Some things are a good experience, some are a good story.When I’m lucky, sometimes they are both.
My summer at #Embryo2018 had all three scenarios.
The story:
I applied to Embryology in January 2018 because I was eager to fall deeper in love with developmental biology. Unfortunately, I was waitlisted in March and bummed to not join the 2018 cohort. Fast-forward to the week before the course started in June, I received an email of an open spot. I accepted, booked flights, got over a hump of imposter syndrome, and in a whirlwind of a week ended up in Woods Hole, MA for a six-week experience that I will never forget.
The experience:
As a whole experience, this course changed how I approach science in three main ways:
I acknowledged that failure is evident, but less likely if you actually try the experiment. Thinking up imaginative experiments and trying them is not something to be scared of, but something to be celebrated. Yes, science is 95% failure, but the ride might as well be interesting and without fear.
Creativity and use of whatever tools are at hand can yield clever and important results. Scientists performed some of the most delicate, and important embryological experiments by simply attaching an eyelash to a glass pipet or wooden stick to use as a knife. Creativity is celebrated, and most embryologists could give MacGyver a run for his money.
Science is fun, it’s social, and the people at the top still genuinely enjoy it. This course was a good reminder that the popular “loner, anti-social scientist” stereotype is a work of fiction. I met incredible peers taking the course, enthusiastic TAs who worked tirelessly to give us embryos at all hours, and faculty who were willing to share their experiences with us and demonstrate their love for science. Experiments can be hard, but sharing the experience with other scientists going through the same paces make the long road in academia much more inviting.
99 % of the time, #Embryo18 was both a good story & a good experience:
When I describe my time at the MBL this summer, the version I give varies depending on the audience. To my colleagues, I explain how every day we listened and interacted with phenomenal seminars. TAs and faculty supplied embryos and all of the reagents to work with them. We had the rest of the day to try any experiment we could think of. I mention how we used several cutting-edge microscopes and had access to staff to help us use them. I talk about the privilege and freedom of having only to think about experiments, free of grants, meetings and other obligations. I end with a couple of my favorite stories about my scientific heroes I had the pleasure of meeting (https://www.youtube.com/watch?v=QZrrDDabEuo&feature=youtu.be).
When I tell my non-science friends about the course, I describe it as science summer camp where you make incredible new friends and stay up all night exploring organisms you would never think to study. I explain how in this course we learned history, we networked, and we grooved our way through town on the Fourth of July. We also swam at the beach, went whale watching, won the annual softball game, and even met the Prince of Monaco! For everyone, I end my#Embryo18 story the same by concluding the course was a magical six weeks I could have never imagined.
I can’t guarantee all of the same stories and experiences to the 2019 cohort, but I can guarantee both a good experience and a good story. Go apply now!
The Thompson lab, based at University College London, is currently seeking a Research Fellow working on understanding gene network heterogeneity in development.
Recently, we found that cell-cell variation in cell cycle position facilitates symmetry breaking during development, as it primes cells to respond to different differentiation cues (Gruenheit et al, Developmental Cell, 2018).
You will perform single cell gene expression analysis to understand the molecular mechanisms underlying this cell cycle control of cell fate choice you. For this, you will utilise our recently generated single cell RNA-seq dataset in which gene expression in 1000s of single cells was generated at different times after receiving differentiation cues.
Your aim will be to reconstruct gene network dynamics to follow their temporal changes in gene activity in individual cells from different cell cycle positions as they differentiate along different linages. You will develop novel computational and statistical methods (e.g. gene network identification, pseudotime, machine learning) to characterize the dynamics of gene network activity, and capture temporal changes in gene network activity in individual cells from different cell cycle stages as they differentiate. Live imaging of transcription and molecular genetic approaches to modify network activity in genetically modified cells will be used to validate your findings. You will also develop predictive models to understand the mechanism controlling cell fate choice. This will include computer simulation of the molecular basis of cell cycle control of differentiation. High throughput live cell imaging to quantify the differentiation behaviour of cells at different cell cycle phases will be used to test these models. This framework will be fundamental in generating new hypothesis guiding future experiments.
You will join a multidisciplinary team led by Professor Chris Thompson. The approaches used in the lab include transcriptomics, functional genomics, molecular genetics, live cell imaging and mathematical modelling.
Candidates with extensive experience of using either computational genomic approaches or wet lab approaches to understand the molecular basis of gene networks will be considered. You should currently hold or be about to obtain a PhD in Computational, Cell, Molecular or Developmental Biology.
The post is funded by Wellcome and is available for 24 months in the first instance (with a possibility of extension).
Appointment at Grade 7 is dependent upon having been awarded a PhD, if this is not the case, initially appointment will be at research assistant Grade 6B (Salary £30,922 – £32,607 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.
Position Summary: A postdoctoral position is available in Dr. Loïs Maignien’s laboratory and Dr. Hilary Morrison’s laboratory in the Josephine Bay Paul Center for Comparative Molecular Biology and Evolution to study rhizosphere microorganisms during plant development. This project uses Brassica rapaas a model organism and will seek to understand how temporal changes in microbial community structure at the taxonomic, genomic and transcriptomic level influence plant growth, physiology and gene expression in a controlled greenhouse system. This research is integrated with a larger collaborative and interdisciplinary project funded by NSF and will involve close interactions with plant science, modelling and bioinformatics partner labs. (https://www.nsf.gov/awardsearch/showAward?AWD_ID=1444571).
Dr Maignien, who will be the primary advisor, has a joint appointment at the University of Brest (France) and at MBL in Woods Hole (http://pagesperso.univ-brest.fr/~maignien/index.html). At the MBL, the Maignien Lab focuses on understanding plant microorganisms interactions in natural and controlled environments. The lab uses various ‘omics and bioinformatics approaches including genome-resolved metagenomics and metatranscriptomics to study microbial community structure and dynamics. For more information about the laboratory, please contact Dr. Maignien at lois.maignien@mbl.edu.
Dr Morrison is a MBL year-round resident scientist with research interests in parasite genomics, microbial ecology, and sequencing technology. You can read more about Morrison’s research at http://www.mbl.edu/jbpc/staff/morrison/and contact Dr. Morrison for more information at hmorrison1981@gmail.com.
The position is available immediately and is for one year, renewable for a second year depending upon progress. The position is based at MBL in Woods Hole, but the project will give opportunities to spend extended period of time at the University of Brest or in partner labs in Wyoming (Weinig lab) or the University of Chicago.
Basic Qualifications: To apply for this position, you should hold a Ph.D. degree in microbiology, preferentially focused on soil or plant-associated microorganisms, with a record of scientific rigor, productivity, and creativity. In addition, you should have a good background in bioinformatics, including knowledge of the Unix environment, bash and python scripting, and data analysis with R.
Excellent oral and written communication skills will be required to carry out research in a highly collaborative environment.
Preferred Qualifications: Applicants with experience in handling and analysis of complex environmental ‘omics datasets, including genome-resolved metagenomics, are particularly encouraged to apply.
Physical Requirements: Minimal exposure to biohazardous chemicals. Occasional lifting of heavy objects (<30 pounds).
A highly motivated postdoc is sought immediately to join the Lyons Lab at the Scripps Institution of Oceanography (www.lyonslab.org) in our investigation of the development and function of the nervous system in the nudibranch Berghia stephanieae. This project is part of a collaborative NIH BRAIN grant entitled “A 5-dimensional connectomic approach to the neural basis of behavior”: The goal of our part of the project is to generate transgenic lines of Berghia expressing fluorescent reporters in the brain to facilitate the study of behavior. We will establish high-resolution fate maps of the nervous system. The postdoc will generate genomic resources such as developmental transcriptomes, whole-genome sequences, and ATAC-seq data. The Lyons Lab offers a broad range of systems for comparative developmental studies among molluscs and echinoderms, and provides a highly interdisciplinary and collaborative environment within the lab and among other labs at the Scripps Institution of Oceanography and UC San Diego’s main campus.
To qualify, applicants must have a Ph.D. (or be close to earning one) and have experience in molecular biology and genetics. In addition, the ideal candidate will possess strong training in transgenesis, genome engineering technology (including CRISPR/Cas9 editing), gene delivery techniques (e.g. microinjection, electroporation), and cis-regulatory element analysis.
The Wennerberg Group is seeking a motivated postdoc to explore informatic and/or experimental approaches to discover new ways to target leukemic stem cells, differentiation and drug resistance in acute myeloid leukaemia.
Our research/The group
The Wennerberg group at BRIC focuses on identifying new effective precision cancer therapies. This is done with a systems-driven approach where we combine chemical biology, phenotypic profiling, molecular profiling and informatics to gain understanding of individual cancers, their drug resistance mechanisms and how they may be targeted. Our ultimate goal is that our results will lay the foundation for new types of cures for individual and subsequently larger groups of cancer patients.
Project/The research project(s)
We are seeking a postdoc for the Wennerberg group to study drug responses of leukemic stem and progenitor cells from patients with acute myeloid leukaemia using single cell approaches. The postdoc will combine the drug response information with other molecular profiling with the goal of discovering new approaches to treat individual or targeted groups of leukemic patients. The postdoc may use experimental and/or informatic approaches address questions in this area, depending on her/his expertise and interests. The postdoc will also become part of the greater Program in Translational Hematology that joins several research groups at BRIC and Rigshospitalet (https://danstem.ku.dk/research1/transstem/program-for-translational-hematology/), giving the postdoc a dynamic work environment that is an outstanding setting for making translational discoveries.
Qualifications We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:
A PhD in Life Sciences or equivalent.
An excellent research track record.
Expertise in leukemic biology and cancer drug response research.
Experience with multi-omics data research.
A team player.
Excellent English skills written and spoken.
Place of employment
The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD and our own Postdoc Career Programme. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/.
Terms of salary and employment
The employment as postdoc is fixed-term position, initially until December 2020 with the possibility to extend the contract later. Starting date is as soon as possible, exact date after agreement.
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 33,700 DKK/approx. 4,520 Euro plus an employer paid pension contribution. Depending on qualifications, a higher salary may be negotiated.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on https://www.bric.ku.dk/jobs/. The application must include the following documents/attachments – all in PDF format:
Motivation letter of application (max. one page).
CV incl. education, work/research experience, language skills and other skills relevant for the position.
A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
List of publications.
Names and contact information for 2-3 professional references.
Application deadline: 10 January 2019, 23.59 CET.
We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.
Welcome to our monthly trawl for developmental biology (and related) preprints.
December’s haul includes a succession of preprints on Drosophila patterning (embryos, wings, brains and intestines), single cell investigations into the neural crest, hair cells, spinal cord and retina, a comparison of primate brain organoids, and plant development covered from root to shoot.
The preprints were hosted on bioRxiv, PeerJ, andarXiv. Let us know if we missed anything, and use these links to get to the section you want:
Mitofusin 1 is required for the oocyte-granulosa cell communication that regulates oogenesis
Thiago S Machado, Karen F. Carvalho, Bruna M. Garcia, Amanda F. Zangirolamo, Carolina H. Macabelli, Fabricia H. C. Sugiyama, Mateus P. Grejo, Jose Djaci Augusto Neto, Fernanda K. S. Ribeiro, Fabiana D. Sarapiao, Flavio V. Meirelles, Francisco E. G. Guimaraes, Lena Pernas, Marcelo M. Seneda, Marcos R. Chiaratti
Liquid-crystal organization of liver tissue
Hernan Morales-Navarrete, Hidenori Nonaka, Andre Scholich, Fabian Segovia-Miranda, Walter de Back, Kirstin Meyer, Roman L Bogorad, Victor Koteliansky, Lutz Brusch, Yannis Kalaidzidis, Frank Julicher, Benjamin M. Friedrich, Marino Zerial
Sustained oscillations of epithelial cell sheets
Gregoire Peyret, Romain Mueller, Joseph d’Alessandro, Simon Begnaud, Philippe Marcq, Rene-Marc Mege, Julia Yeomans, Amin Doostmohammadi, Benoit Ladoux
Radial F-actin Organization During Early Neuronal Development
Durga Praveen Meka, Robin Scharrenberg, Bing Zhao, Theresa Koenig, Irina Schaefer, Birgit Schwanke, Oliver Kobler, Sergei Klykov, Melanie Richter, Dennis Eggert, Sabine Windhorst, Carlos G. Dotti, Michael R. Kreutz, Marina Mikhaylova, Froylan Calderon de Anda
| Genes & genomes
Assaying chick enhancers in Williams, et al.’s preprint
Dynamics of microRNA expression during mouse prenatal development
Rabi Murad, Sorena Rahmanian, Alessandra Breschi, Weihua Zeng, Brian A Williams, Mark Mackiewicz, Brian Roberts, Sarah Meadows, Dianne Moore, Carrie Davis, Diane Trout, Chris Zaleski, Alexander Dobin, Lei-Hoon Sei, Jorg Drenkow, Alex Scavelli, Thomas R Gingeras, Barbara Wold, Richard M. Myers, Roderic Guigo, Ali Mortazavi
Bioprinted kidney organoids from Higgins, et al.’s preprint
Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening.
J. William Higgins, Alison Chambon, Kristina Bishard, Anke Hartung, Derek Arndt, Jamie Brugnano, Pei Xuan Er, Kynan T Lawlor, Jessica M Vanslambrouck, Sean Wilson, Alexander N Combes, Sara E Howden, Ker Sin Tan, Santhosh V Kumar, Lorna J Hale, Benjamin Shepherd, Stephen Pentoney, Sharon C Presnell, Alice E Chen, Melissa H Little
A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart
Hessel Honkoop, Dennis de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong Nguyen, Cecilia de Heus, Laurence Garric, Mauro Muraro, Adam Shoffner, Federico Tessadori, Joshua Peterson, Wendy Noort, George Posthuma, Dominic Grun, Willem van der Laarse, Judith Klumperman, Richard Jaspers, Kenneth Poss, Alexander van Oudenaarden, Eldad Tzahor, Jeroen Bakkers
Light remote control of alternative splicing in roots through TOR kinase
Stefan Riegler, Lucas Servi, Armin Fuchs, Micaela A. Godoy Herz, Maria Guillermina Kubaczka, Peter Venhuizen, Alois Schweighofer, Craig Simpson, John W.S. Brown, Christian Meyer, Maria Kalyna, Andrea Barta, Ezequiel Petrillo
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
Alex A Pollen, Aparna Bhaduri, Madeline G Andrews, Tomasz J Nowakowski, Olivia S Meyerson, Mohammed A Mostajo-Radji, Elizabeth Di Lullo, Beatriz Alvarado, Melanie Bedolli, Max L Dougherty, Ian T Fiddes, Zev N Kronenberg, Joe Shuga, Anne A Leyrat, Jay A West, Marina Bershteyn, Craig B Lowe, Bryan J Pavolvic, Sofie R Salama, David Haussler, Evan Eichler, Arnold A Kriegstein
The mayfly embryonic nervous system, from Almudi, et al.’s preprint
Deep evolutionary origin of limb and fin regeneration
Sylvain Darnet, Aline Cutrim Dragalzew, Danielson Baia Amaral, Andrew W Thompson, Amanda N Cass, Jamily Lorena, Josane F Sousa, Carinne M Costa, Marcos P Sousa, Nadia B Froebisch, Patricia N Schneider, Marcus C Davis, Ingo Braasch, Igor Schneider
Silent crickets reveal the genomic footprint of recent adaptive trait loss
Sonia Pascoal, Judith E. Risse, Xiao Zhang, Mark Blaxter, Timothee Cezard, Richard J. Challis, Karim Gharbi, John Hunt, Sujai Kumar, Emma Langan, Xuan Liu, Jack G. Rayner, Michael G. Ritchie, Basten L. Snoek, Urmi Trivedi, Nathan Bailey
Sex chromosome evolution via two genes
Alex Harkess, Kun Huang, Ron van der Hulst, Bart Tissen, Jeffrey L Caplan, Aakash Koppula, Mona Batish, Blake C Meyers, Jim Leebens-Mack
Programmed DNA elimination of germline development genes in songbirds
Cormac M. Kinsella, Francisco J. Ruiz-Ruano, Anne-Marie Dion-Côté, Alexander J. Charles, Toni I. Gossmann, Josefa Cabrero, Dennis Kappei, Nicola Hemmings, Mirre J. P. Simons, Juan P. M. Camacho, Wolfgang Forstmeier, Alexander Suh
Recombination in a natural population of the bdelloid rotifer Adineta vaga
Olga A. Vakhrusheva, Elena A. Mnatsakanova, Yan R. Galimov, Tatiana V. Neretina, Evgeny S. Gerasimov, Svetlana G. Ozerova, Arthur O. Zalevsky, Irina A. Yushenova, Irina R. Arkhipova, Aleksey A. Penin, Maria D. Logacheva, Georgii A. Bazykin, Alexey S. Kondrashov
Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis
Merit Wildung, Tilman Uli Esser, Katie Baker Grausam, Cornelia Wiedwald, Larisa Volceanov-Hahn, Dietmar Riedel, Sabine Beuermann, Li Li, Jessica Lynn Simcox Zylla, Ann-Kathrin Guenther, Magdalena Wienken, Evrim Ercetin, Zhiyuan Han, Felix Bremmer, Orr Shomroni, Stefan Andreas, Haotian Zhao, Muriel Lizé
Xenopus axons from Shigeoka, et al.’s preprint
On-site ribosome remodeling by locally synthesized ribosomal proteins in axons
Toshiaki Shigeoka, Max Koppers, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Asha Dwivedy, Janaina de Freitas Nascimento, Roberta Cagnetta, Francesca van Tartwijk, Florian Strohl, Jean-Michel Cioni, Mark Carrington, Clemens F. Kaminski, William A. Harris, Hosung Jung, Christine E. Holt
Stone Age “chewing gum” yields 5,700 year-old human genome and oral microbiome
Theis ZT Jensen, Jonas Niemann, Katrine Hoejholt Iversen, Anna K Fotakis, Shyam Gopalakrishnan, Mikkel HS Sinding, Martin R Ellegaard, Morten E Allentoft, Liam T Lanigan, Alberto J Taurozzi, Sofie Holtsmark Nielsen, Michael W Dee, Martin N Mortensen, Mads C Christensen, Soeren A Soerensen, Matthew J Collins, Tom Gilbert, Martin Sikora, Simon Rasmussen, Hannes Schroeder
We are at the National Institute of Child Health and Human Development (NICHD) at NIH. Our lab is interested in understanding cell lineage differentiation, gene regulation and how non-coding DNA elements and the 3D architecture of chromosomes contribute to these processes during early mouse development.
Fully-funded postdoc positions up to five years including health benefits.
Opportunity to start your own research program or lead ongoing projects.
Who you are:
You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development.
You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, massively-parallel sequencing techniques or computational biology.
Advantages of postdoctoral training at NIH
Fully-funded positions up to five years.
Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. The NIH research community is unparalleled in its size, diversity and resources.
Possibility of living in a diverse, liberal and vibrant city: Washington DC
Or living in a calm residential area with great schools and good affordable housing, Bethesda and Rockville.
2 paragraph cover letter explaining your scientific trajectory and why you would like to join us.
CV and email contacts for 3 references.
The NIH is dedicated to building a diverse community in its training and employment programs.
We combine imaging techniques in both fixed and living cells with sequencing- based genomic techniques that assess DNA-DNA interactions. (A) Hi-C and CTCF ChIP- seq of GM1278 cells (B) dCAS9 MCP-EGFP and PCP-CHERRY live imaging of the Igh and Akap6 loci. The mouse embryo is an unparalleled system in mammalian biology for understanding how tissue- specific gene expression is achieved. (C) Whole mount in-situ hybridization for patterning markers in mid and late gastrulating embryos. (D) Tetraploid aggregation with GFP ES cells allows generation of fully ES-cell derived embryos.
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