Are you interested in understanding how cooperative behaviour develops a cellular society?

Are you interested in live imaging at single-cell resolution?

Then, we have a fully funded PhD position for you!

Zebrafish Thyroid Gland

The group of Dr. Sumeet Pal Singh at the Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire (IRIBHM), an Institute of the Université libre de Bruxelles (ULB), is offering a PhD position starting 01 November, 2019.

The major aim of the group’s research is to understand the development of cellular communities using endocrine organs, specifically thyroid gland and pancreatic beta-cells, as a model system. The research is focussed on using zebrafish as a model system. The junior group uses a broad range of molecular, genetic, next-generation transcriptomic and imaging techniques to investigate developmental processes (https://sumeetpalsingh.github.io/).

The PhD student will be involved in live-imaging intercellular signalling pathways in the thyroid gland (https://sumeetpalsingh.github.io/project/live-imaging), and for developing tools modulating cAMP signalling in thyroid follicular cells. The tool development would additional lead to new models of hypo- and hyperthyroid disease models.

The PhD student is expected to:

1. Read literature and keep up-to-date with the current knowledge in the field.
2. Gain independence in planning, conduction and analysis of experiments.
3. Generate publication quality figures for presentations, manuscripts and grant applications.
4. Draft manuscripts for publication.
5. She/he will be required to attend institute seminars, encouraged to participate in after-hours social events and take part in retreats.
6. She/he will be encouraged to undertake skill-development courses (particularly bioinformatics skills) in the university or online (such as Coursera)

Requirements:

1. Diplomas and degrees equivalent to a European Union Master’s degree, which includes project work summarized in a written “small thesis”
2. Three referees willing to provide letter of recommendations
3. Excellent knowledge of English
4. Excellent interpersonal and organisational skills

Kindly submit your CV with the contact information for three referees and a letter of motivation by email to sumeetpalsingh@gmail.com.

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Interested in cell therapy?

Excited about discovering regulators of a differentiation program?

Then, this could be an exciting post-doc opportunity for you while ‘Investigating the cell fate decisions during differentiation of ES-cells to thyroid gland using single-cell technologies’.

At the Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire (IRIBHM), an Institute of the Université libre de Bruxelles (ULB), the research group of Dr Sabine Costagliola and Dr Sumeet Pal Singh are jointly offering support for Marie Curie Post-Doc application on using single-cell technologies to understand the directed differentiation of ES-cells into thyroid organoid.

The lab of Dr. Costagliola was the first to generate functional thyroid gland from mouse ES cells (Antonica et al., Nature, 2012). Together with Dr. Singh, an expert in single-cell transcriptome analysis (Singh et al., Scientific Reports, 2018), the project will aim to define the trajectory from naïve ES cells to functional thyroid gland using single-cell genomics. We hope to understand the bottlenecks and hurdles in the differentiation process so as to overcome them and generate a more efficient differentiation process.

The call for Marie Curie Post-Doc Fellowships opened on 15 June, 2019 and ends on 01 October, 2019. The Fellowship requires:

1. Applicants of any age and of any nationality are eligible.
2. Eligible applicants are Experienced Researchers, i.e.
   • Holders of a PhD degree obtained max. 7 years before the call deadline.
   • Applicants without a PhD, provided they have documented full-time equivalent research experience of minimum 4 and maximum 11 years.
     An eligibility extension of 15 weeks per child is granted in case of maternity
3. Eligible applicants must not have resided or carried out their main activity (work, studies, etc.) in Belgium for more than 12 months during the 3 years preceding the call deadline.

For further information, please refer to this website: https://if-at-ulb.ulb.be/call-information

Please contact us at the earliest with your CV and a letter of motivation via e-mail to scostag@ulb.ac.be and sumeetpalsingh@gmail.com.

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We are looking for highly motivated individuals who share our passion for science and would like to work in a friendly and collaborative environment.

Fully funded PhD student positions are available in the laboratory of Dr. Peng Huang in the Department of Biochemistry and Molecular Biology
at the University of Calgary, Canada.
 We use zebrafish as a model system to understand how tissue patterning is achieved and how tissue integrity is maintained. We study the spinal cord patterning to understand how different cell signaling pathways (Hedgehog and Notch signaling) interact during cell fate specification. We also study how non-muscle cells (e.g., tendon cells and muscle progenitor cells) contribute to muscle development, degeneration and regeneration. For more information about the lab and our recent publications, please visit: https://people.ucalgary.ca/~huangp/index.html

PhD student candidates should have a BS or MSc in Molecular Biology, Genetics, Developmental Biology or a related discipline, a strong academic background, good English skills and an enthusiasm for research. Previous lab experience with genetic model organisms is preferred but not required. Excellent written and verbal communication skills are critical.

To apply, please send a cover letter summarizing previous research experiences and future goals, the transcript and the CV with names of 2-3 references to Peng Huang, peng.huang@gmail.com with the subject line “PhD Student Position”. Application deadline: May 1, 2020.

Calgary, Canada’s fastest growing major city, is vibrant and multicultural with a population of more than 1.2 million. Situated near the Rocky Mountains, Banff National Park and Lake Louise, Calgary offers great quality of life and outstanding recreational activities.

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We have previously characterized processes underlying diversity in leaf form between and within species and have identified genetic pathways influencing this trait. Here, we propose to investigate the possible physiological and metabolic significance of this variation, as well as possible feedbacks between metabolism and leaf form. The project will involve comparative studies of Cardamine hirsuta and Arabidopsis thaliana. References: Kierzkowski, D, Runions, A, et al., (2019) Cell 177, 1405-1418. Vuolo F, et al., (2016) Genes Dev. 30, 2370-75. 2. Gan X, et al., (2016) Nat Plants 2, 16167.  3. Rast-Somssich, M.I et al.,  (2015). Genes Dev 29, 2391-2404  Cartolano, M., et al.,  4. 2015 PNAS 112, 10539-44. 5. Vlad D, et al., (2014) Science 343, 780-3.

Qualifications needed: Plant Molecular/Developmental Genetics (especially in Arabidopsis), Metabolic Physiology, NGS data analysis

Part of a bigger application call, please apply as described: https://www.ceplas.eu/en/training-careers/ceplas-postdoc-programme/call-2019/

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A cinematographer, shadowed scientists in their everyday work provides us with a glimpse into the incredible beauty of science.

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The Kamberov lab is seeking a post-doc to lead a project on the developmental and evolutionary significance of positively selected human variants affecting gene expression in mammary tissues.  Experimental approaches to be used include analysis and validation of large-scale transcriptomic data from the skin, and the generation and analysis of genetically modified mice.

Interested applicants should send a CV, contact information of three references and a letter detailing your interest in the position  to Yana Kamberov (yana2@pennmedicine.upenn.edu).  Applicants should hold a Ph.D. in biology or related field.  Applicants with a background in mouse genetics, developmental and evolutionary genetics are especially encouraged to apply.

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The Kamberov lab is seeking a creative and exceptionally motivated candidate to fill a post-doctoral position in the field of skin development and regeneration. The relevant project will investigate genetic networks controlling the development, patterning, and evolutionary variation of eccrine sweat glands, which are essential for thermoregulation in humans. A long-term goal of this project is to apply these findings to the regeneration of sweat glands in vitro.  Experimental approaches to be used include analysis and validation of large-scale transcriptomic data from the skin, functional testing and modeling in mice and in vitro organoid culture.

A doctorate in biology or related field is required. Applicants with a strong background in developmental biology, vertebrate genetics and molecular biology, and familiarity with large-scale data analysis are especially encouraged to apply.

Interested candidates should provide: 1) a CV 2) a brief letter detailing your interest in the lab and relevant past research experience 3) contact information for three references who can comment on your research. Application materials and any questions regarding the position should be addressed to Yana Kamberov: yana2@pennmedicine.upenn.edu

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A two year postdoc position is available in the group of Fabian Rentzsch at the Sars Centre in Bergen, Norway. 

The group studies neurogenesis in the cnidarian Nematostella vectensis with the aim to understand cellular, molecular and evolutionary aspects of nervous system development (https://www.uib.no/en/sarssenteret/114765/rentzsch-group). In this project we aim to characterize the function of transcription factors expressed in neural progenitor cells by analyzing existing mutants for these genes. In addition, CRISPR/Cas9 will be used to generate additional mutants for further analyses. The successful candidate has the opportunity to contribute to the development of the project in line with his/her interests.

Deadline for applications is 2nd August 2019. For additional information and submitting your application please follow this link:

https://www.jobbnorge.no/en/available-jobs/job/171983/postdoctoral-fellow-position-at-the-sars-centre-neural-development-in-nematostella

For more details, you can contact me by e-mail or phone: +4755584304, fabian.rentzsch@uib.no

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Research Scientist Position

German Centre for Diabetes Research

Dresden

A research scientist position is available in the research group of Dr Anthony Gavalas. The group investigates the role of signaling pathways and metabolism in the late stages of endocrine pancreas development, the application of novel signals for the conversion of human pluripotent stem cells into functional beta cells and the function of adult pancreas stem cells. A combination of directed pluripotent stem cell differentiation, genomics, in vivo genetic analyses and ex vivo experiments including organoids is being used (https://www.digs-bb.de/research/research-groups/anthony-gavalas/).

The successful candidate will have either a M.Sc. or Ph.D. degree in Biology and related disciplines, extensive experience in cell culture, preferably with embryonic and pluripotent stem cells, very good organizational skills and strong molecular biology background. Experience with mouse handling and genetics will be considered as an asset.

The lab is located in the Center for Regenerative Therapies Dresden (CRTD) with full access to state of the art core facilities for Deep Sequencing, including single cell RNA Seq, Genome Engineering, Imaging and FACS analysis.

The salary will be according to the TV-L scale commensurate with experience and qualifications. The contract will be initially for two years with the possibility for renewal. Applicants are requested to send their CVs along with names and emails of at least two referees to Dr Anthony Gavalas (Anthony.Gavalas@tu-dresden.de), before August 15^th, 2019.

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