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Soapbox Science on London’s South Bank – Using Flies to Fight Cancer

Posted by , on 14 March 2014

Courtesy of Silvana Goberdhan-VigleSoapbox Science follows the format of using historical areas for public debate, such as London Hyde Park’s Speakers Corner, providing a way of bringing scientists and their work to the public.  It strips away props such as powerpoint slides and encourages a dynamic dialogue between the scientist standing on a soapbox and the general public, all within a bustling city environment.

I was delighted when out of the blue I received an invitation from the dynamic organisers, Dr Nathalie Pettorelli and Dr Seirian Sumner, to speak at Soapbox Science in July 2012.  Soapbox Science was then in its third year and hosted by the Zoological Society of London (ZSL) and L’Oréal-UNESCO for Women in Science Programme.  The aim was to increase the visibility of UK women in science by giving them the opportunity to present their science in an accessible, engaging way to the general public.

This particular Soapbox science event took place on London’s South Bank, and was focused on inspiring a new generation of female scientists, by showing them how accessible a career in science is.  Indeed a special effort had been made to encourage 14-18 year old school children to attend.

Courtesy of Silvana Goberdhan-VigleCourtesy of Silvana Goberdhan-Vigle

I was one of thirteen speakers, selected to speak about their science and to field questions from the school children and members of the public.  Dr Seirian Sumner commented, “This year we showcase how women in science can and do reach the top: these women are some of the UK’s top real women in science, and from their Soapboxes they will share their passion, motivation and scientific excellence with the public.”  Co-organiser Dr Nathalie Pettorelli, said “We hope this event will inspire a new generation of scientists, giving them the confidence to push through existing barriers, and help change the societal norms that currently hold women scientists back.”

Soapbox Science is not restricted exclusively to speakers from academic backgrounds.  For example, the Soapbox Science event I was involved with also featured entrepreneur Ruth Amos, Young Engineer for Britain in 2006.  Ruth invented the StairSteady, an aid to enable people with limited mobility to use their stairs confidently and safely.

I run a research group in the Department of Physiology, Anatomy and Genetics (DPAG) at Oxford.  We are interested in understanding how cell and animal growth is controlled, and study these processes both in fruit flies and in human cell culture .  Of course, I am much more accustomed to dealing with, for example, an audience of fellow scientists at a conference or students in a lecture.  However, the Soapbox presentation did not involve a ‘captive audience’ of that kind, but a transient flow of people along the South Bank who had not necessarily been expecting to have to get their heads around scientific concepts that day.  It was our job to grab their attention and to try to get them to engage with us in a dialogue.  With the aid of a trusty assistant, who was teamed up with me for the day, I chose to illustrate my talk with laminated pictures, some of which my daughters, Silvana (aged 21) and Tara (aged 14), who accompanied me, had helped to draw the day before.  I’ve always enjoyed engaging with the public and Soapbox Science turned out to be a really fun way to do this.

 

Image courtesy of Graham Flack/L’OréalCourtesy of Graham Flack/L’Oréal

Before the event had started, I had wondered whether members of the general public would be interested in my work.  As it turned out, they clearly were.  As always in Outreach events, a key challenge was to be able to communicate the specialist ideas that we focus on from day-to-day in the lab in an engaging and accessible manner to people from a broad range of backgrounds.

My story had a number of key ideas to get across, many of which could be posed as questions: How can focusing on flies help us to understand human biology?  Why aren’t we three metres tall?  What does developmental biology tell us about cancer?  It was interesting to see the reactions when unsuspecting people found out how similar to flies they were!  Children and adults are often fascinated by animal development, but they frequently don’t connect it to the human diseases they know of.  It was a real opportunity to engage with the public and to convey how our most recent work, which probes the mechanisms by which cells sense nutrient levels around them, is suggesting new ways of blocking human cancer growth and monitoring cancer progression.  Some of this is discussed on a blog I wrote around that time.  Soapcox Science is expanding nationally this year, to provide more opportunities for women scientists around the UK to engage with the public in this way. This year (2014), Soapbox events are being held in London (29th June), Bristol (14th June), Dublin (26th April) and Swansea (5th July). The venues and speaker line ups can be found on the Soapbox website . If you would like to have a go at discussing your science from a Soapbox, you can put yourself forward for the events next year, via the annual call for speakers at www.soapboxscience.org.  This call for is advertised around December to January, for a February deadline. Throughout the year, Soapbox is active in other ways. For example, its website hosts blogs from women in science, sharing their personal stories, experiences and opinions. If you would like to contribute to this, you can contact the Soapbox Science team via soapboxscience@gmail.com, or via twitter @SoapboxScience.

My involvement in Soapbox Science in June 2012 was an important step for me in taking a much more active role in Outreach activities.  Soon after this, I was invited to become a member of the Department’s Athena SWAN Self-Assessment Team, focusing on developing Outreach activities within my Department. Following on from the Department’s successful Athena SWAN Bronze Award application in September 2013, I now have the lead role in promoting and publicising Outreach activities in my Department.  We are currently developing an Outreach section to our Departmental website, which will highlight Outreach activities and also act as a resource section.  There are a lot people in our Department who are already involved in Outreach activities and are keen to do more, and I am really pleased to be in a position to help this to happen.

For my part I am keen to be involved in more events like Soapbox Science, which involve communicating science to the public.  I would also like to encourage further participation in University Programmes designed to inspire school children from more challenging backgrounds, and those from schools without a tradition of sending students to Oxford, to consider a career in science and perhaps to study at Oxford or work in a lab like mine.

 

Prof Sunetra Gupta Dept of Zoology, University of Oxford), Dr Deborah Goberdhan (Dept of Physiology, Anatomy and Genetics, University of Oxford), Prof Giovanna Tinetti (University College London, University of London), Ruth Amos (StairSteady Ltd, Sheffield). Courtesy of Graham Flack/L’Oréal

 

 

Image 1 courtesy of Silvana Goberdhan-Vigle

 

 

Outreach logo new squareThis post is part of a series on science outreach. You can read the introduction to the series here and read other posts in this series here.

 

 

 

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When the mind is given wings…

Posted by , on 14 March 2014

In the beginning of 2014 (January 5-17th) we enjoyed one of the most fascinating experiences professionally and personally. Under the guidance of Dr. Roberto Mayor and a teaching staff that enlightened and motivated us at all times, a wonderful group of 21 students accomplished the 2014-International Course on Developmental Biology at the CIMARQ in Quintay-Chile. Students, mostly from Latin-American countries and some from Europe and the United States, participated in a unique and rewarding experience.

We could dedicate more than a hundred pages talking about the unbelievably high quality of lectures and discussions, the laboratory practices, and the professors themselves and that still wouldn’t be enough to describe the positive impact of this course on our careers. While we enjoyed the beauty and peace of that place during those long and exciting days a prerequisite for every top international course, we were blown away by the warmth of our hosts – and idols – in developmental biology, listening to them impart their expertise and sharing their personal experiences; how they became what they are, the hard decisions and sacrifices they made in order to follow their passion for this vocation.

We had the unique chance to interact with internationally renowned developmental biologists as they shared with us their insights on a wide range of topics. Everyone in their own manner taught us valuable lessons which will be helpful for our own research projects now and in the future. We were also encouraged to look beyond model animals and to go out and think about the fundamental questions in the field of developmental biology from a new perspective, to consider the depth of diversity in the developmental process and the forms it generates, to appreciate the interaction of an organism’s development with its natural habit and to integrate ideas not classically thought to be part of the field. These different views gave us the opportunity to understand development in a broad, holistic manner.

Moreover, we were given the gift of motivation. Motivation to follow our ideas, our instincts, to go into battle with our thoughts and try to give new insights to our projects. As young scientists, we spend our days in the lab trying to fulfill our desires and expectations, giving our absolute best for our projects, trying to push ourselves to be the best researchers we can; and it is not a minor fact that as Latin American students most of us have to deal with great challenges to ensure that our work is up to the right standards. For that reason, the encouragement that we received during the course from all the faculty members was a turning point in our careers. It made us realise that with hard work and enthusiasm, there is no goal that we cannot accomplish.

Another keystone of the course was the opportunity to formally present our own work to classmates and teaching staff. We received essential feedback not only about our projects but also on how to deliver and present science to a diverse scientific community, an art that is demanded of all scientists. This was certainly a rewarding experience for everyone, no doubt about it. Furthermore, we now have a better idea of the research that young Latin-American developmental biologists are doing and how we can network with other researchers and classmates around the world.

An addition to this outstanding experience was the mini-symposium about Developmental Biology which gave us the opportunity to take part in the life of the scientific community in Chile. High-quality lectures gave shape to this event as Chilean and international experts shared their research and thoughts in a delightful atmosphere. The symposium truly completed our experience.

We strongly believe that one of the most powerful tools we have in science is our desire to progress together as a community because we certainly know that the whole is greater than the sum of its parts and we choose that principle as a way of doing science. This course is tangible proof of that, bringing state-of-the-art technology and first class teaching to Latin American students and allowing us to take advantage of this every single day so that we all develop as a group and as researchers. We generated strong bonds and a great sense of community. This course gave to Latin America (and other parts of the world) a network of young developmental biologists that share each other’s interests, aspirations and passions.

We have learned the most fascinating strategies, pathways, and molecular principles for patterning of current and potential model organisms in developmental biology, and during our lab practices we actually heard some of the beautiful chords of their melodic development. However, even more interesting was to personally experience one of the most amazing biological processes; the development of wings in our mind, allowing us to see and think further and wider than we could have ever imagined.

Finally, we want to share a beautiful gift from our inspirational teacher Scott Gilbert, who sent to us this quote that he rescued from Pablo Neruda’s home in Isla Negra: “There is nothing more beautiful than something that comes into being, takes shape right in front of us. There is a rigor in the materials that prevents excess folly…” This is a good epigram for developmental biology.

 

Post by all the Students – class 2014.
International Course on Developmental Biology
Quintay – Chile

 

 

The authors of the post!
Picture by Emilio Lanna. From left to right: Jaime Espina Hidalgo , Gabriela Edwards, Maria Kotini, Kevin Leclerc, Francis Hervas, Santiago Cerrizuela, Gonzalo Aparicio, Daniel Smith, Elías Barriga, Ailin Buzzi, Emilio Lanna, Marcela Arenas G., Gloria Slattum, Gabriel Cavalheiro, Roberto Sanchez, Diego Rojas, Carla Grade, Angie Serrano, Dalmiro Blanco Obregón, Lucimara Sensiate, Guadalupe Barrionuevo, Paul Andrew.

 

Picture by Emilio Lanna. From left to right: Jaime Espina Hidalgo , Gabriela Edwards, Maria Kotini, Kevin Leclerc, Francis Hervas, Santiago Cerrizuela, Gonzalo Aparicio, Daniel Smith, Elías Barriga, Ailin Buzzi, Emilio Lanna, Marcela Arenas G., Gloria Slattum, Gabriel Cavalheiro, Roberto Sanchez, Diego Rojas, Carla Grade, Angie Serrano, Dalmiro Blanco Obregón, Lucimara Sensiate, Guadalupe Barrionuevo, Paul Andrew.

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Join us at the (alternative) careers in science session, BSCB/BSDB meeting 2014

Posted by , on 12 March 2014

The joint Spring meeting of the British Society for Cell Biology and British Society for Developmental Biology is coming up soon, and the Node will be there! Not only will we be there listening to the talks and meeting the community, but we will also be organising the (alternative) careers session. The session will take place on the first day of the conference (Sunday the 16th of March) at 3 p.m. (main lecture theatre). We have a great panel of science professionals who will tell us a little bit about their careers, but who will mostly answer any questions that you may have:

 

Woolner

 

 

 

 

 

 

 

 

Sean photo 2

 

 

 

 

 

 

 

 
Katherine profile pic

 

 

 

 

 

 

 

 
Dr Shum Prakash

 

 

 

 

 

 

 

 

 

Paul Turner Ph.D cropped

 

 

 

 

 

 

 

 

cat profile pic.jpg

 

 

 

 

Dr Sarah Woolner, Group Leader at the University of Manchester
Sarah obtained her degree in Biological Sciences from the University of Edinburgh in 2000. She did her PhD at UCL, studying on the MRC LMCB four-year PhD programme and carrying out her thesis work with Paul Martin. Sarah did a first postdoc in Bill Bement’s lab (University of Wisconsin-Madison) and a second in Nancy Papalopulu’s lab (University of Manchester). In July 2012, Sarah was awarded a Wellcome Trust/Royal Society Sir Henry Dale Fellowship to establish her own lab in the Wellcome Trust Centre for Cell Matrix Research at the University of Manchester. The major research goal of her lab is to understand how cell division orientation is coordinated across tissues in the developing embryo.

 

Dr Seán Mac Fhearraigh, Online marketing manager and sales representative at Molecutools Seán received his Bachelor’s in Genetics from Trinity College Dublin and his PhD from University College Dublin. From there Seán, carried onto to do a short post-doc at the University of Cambridge. After some thought, Seán began his career in industry by taking a job a Abcam as their cancer and stem cell marketer. He is currently online marketing manager and sales representative at molecutools.com and founder of the PhD and Post-Doctoral advice website PostPostDoc.com, you can find Seán on twitter with @PostPostDoc1

 

 

Dr Katherine Brown, Executive editor of Development

Katherine gained her PhD from the MRC-LMB in Cambridge, and carried out her postdoctoral work at EMBL Heidelberg. Her research expertise is in the field of morphogenesis, using both Drosophila and teleost fish as model systems. In 2008, she moved into a career in scientific publishing – spending three years as a Scientific Editor at The EMBO Journal before taking up her current position as Executive Editor of Development in late 2011.

 

 

 

Dr Shum Prakash, Business Development Manager at Warwick Ventures

Shum received a PhD in Biochemistry and conducted a postdoc in cancer therapy and brain diagnosis. She worked in policy at the European Parliament, Technopolis Ltd and SQW Ltd. Shum joined Warwick Ventures in 2001 and is an MBA qualified business development manager in technology transfer, taking a broad range of technologies from concept to royalty generating commercial licences and to trading spin off companies.

 

 

 

 
 
Dr Paul R Turner, Field Application Specialist for Affymetrix

Paul did a PhD in Cell Biology and Biophysics at the University of Connecticut and a postdoc at the University of California Berkeley. He was a group leader in academia between 1991 and 1999, and has worked in industry (Oxford Glycosciences and GRI) since. Paul has worked as a Field Application Specialist for Affymetrix (Panomics) since 2006.

 

 

 

 
Moderator- Dr Catarina Vicente, the Node community manager
Cat completed her PhD in Cell Biology at the University of Oxford, researching centrosomes in Drosophila with Prof Jordan Raff. She is now the community manager of the Node, a community blog for developmental biologists and related fields launched by the journal Development.

 

 

 

 
Please come along and join us! Even if you didn’t sign up for this session when you registered, you are still very welcome to join! And if you are interested in alternative careers in science, you may also want to read some of the posts in the alternative career series that featured on the Node last year. If you are not attending the conference, do follow the official Twitter hashtag: #cbdb14

 

 

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PhD position available to study regulation of macrophage migration in Drosophila

Posted by , on 11 March 2014

Closing Date: 15 March 2021

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PhD position available to study regulation of macrophage migration in vivo using Drosophila

Organisation: Department of Infection and Immunity, The Medical School, University of Sheffield

Supervisor: Dr Iwan Evans

Studentship starting: 1st October 2014

Application Deadline: 18th April 2014

Project:

Inappropriate immune cell responses cause or exacerbate a wide range of human diseases including autoimmunity, atherosclerosis, cancer and chronic inflammatory conditions. An important function of the white blood cells known as macrophages is to remove and degrade cells undergoing programmed cell death (apoptosis). This process can suppress pro-inflammatory responses of macrophages and is linked to the resolution of inflammation.

Fruit flies (Drosophila melanogaster) contain a population of highly migratory macrophages, called hemocytes. The genetic tractability and unparalleled live imaging possibilities of this system enables us to study the cell biology of apoptotic cell clearance by macrophages in vivo. This project will study how clearance of apoptotic cells affects the subsequent behaviour of macrophages, with a strong focus on regulation of their motility and inflammatory responses. We will also characterise how interactions between apoptotic cells and macrophages influences signalling and phenotype within the latter in order to understand how apoptotic cells can dampen inflammatory responses in vivo. Tissue culture approaches will also be used to test the relevance of mechanistic findings to mammalian macrophages.

This project is ideal for a candidate with strong interests in cell biology and the use of model organisms to study human disease-relevant questions in vivo. Knowledge of cell migration is desirable, but an enthusiasm for science and an enquiring mind is far more important. No prior knowledge of Drosophila is required, since the successful candidate will be given intensive training in the use of Drosophila as a genetic platform to study cell biology in vivo. This will involve a significant amount of dynamic imaging of macrophage behaviour in vivo using confocal microscopy, alongside standard cell biological techniques such as whole mount immunostaining and in situ hybridisation.

 

For further information see:

I. Evans, P. Ghai, V. Urbancic, K.-L. Tan and W. Wood (2013). SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in Drosophila. Cell Death and Differentiation. 20(5):709-20.

I. Evans and W. Wood (2011). Drosophila embryonic hemocytes. Curr Biol. 21(5):R173-4.

 

Evans lab website

 

Entry Requirements

Candidates must have a first or upper second class honours degree or significant research experience.

 

To apply

Interested candidates should in the first instance contact Iwan Evans (i.r.evans@sheffield.ac.uk).

For formal applications, visit: http://www.sheffield.ac.uk/faculty/medicine-dentistry-health/graduateschool/prospectivepg/vacancies/ii

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Free online Life Fantastic CHRISTMAS LECTURES teaching resources

Posted by , on 11 March 2014

Alison Woollard presenting the CHRISTMAS LECTURES.
Alison Woollard presenting the CHRISTMAS LECTURES.

The 2013 Life Fantastic CHRISTMAS LECTURES® presented by Alison Woollard from the University of Oxford, explored the frontiers of developmental biology and uncovered the remarkable transformation of a single cell into a complex organism.

The three hour long lectures investigated questions such as what do these mechanisms tell us about the relationships between all creatures on Earth? And can we harness this knowledge to improve or even extend our own lives?

The Royal Institution (Ri) has developed a series of online CHRISTMAS LECTURES teaching resources comprised of video clips, facts and questions to help primary and secondary school teachers explore the developmental biology covered by Life Fantastic with their students.

On the Ri’s website teachers will find an overview of each of the eight topics including DNA replication and mutation, proteins, cells and organs, and mitosis and meiosis covered by the clips, a brief summary of each clip, related questions and how the topics link to the curriculum. The pages are intended for use as a prompt to explore these topics further in lessons.
The resources are also available on the Ted-ED and TES websites.

All three Life Fantastic lectures, and a range of previous CHRISTMAS LECTURES from our archives, are available to watch in full and for free on the Ri’s critically acclaimed science video platform, the Ri Channel.

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From maps to circuits: Models and Mechanisms for Generating Neural Connections

Posted by , on 11 March 2014

We have an upcoming workshop that I hope will be of interest to members on this node.

From Maps to Circuits: Models and Mechanisms for Generating Neural Connections

28/29 July 2014, Edinburgh UK

http://maps2014.org

Organisers: Stephen Eglen, Matthias Hennig, Andrew Huberman, David Sterratt, Ian Thompson, David Willshaw

Aim of the meeting

Understanding the development of the nervous system is a key challenge that has been approached by both experimental and theoretical neuroscientists. In recent years there has been a gradual move towards the two groups working more with each other. The idea of this workshop is to bring key people together who have shown an interest at combining theoretical and experimental techniques to discuss current problems in neuronal development, and plan future collaborative efforts.

Time at the end of each day of the workshop will be devoted to a group discussion about questions that have been raised during the day to identify possible research directions and people willing to pursue them.

Speakers: Tom Clandinin (Stanford), Michael Crair (Yale), Irina Erchova (Cardiff), David Feldheim (UC Santa Cruz), Geoffrey Goodhill (U Queensland), Robert Hindges (Kings College London), Sonja Hofer (Basel), Hitoshi Sakano (U Tokyo), David Wilkinson (NIMR, London), David Willshaw (Edinburgh), Fred Wolf (Gottingen).

This meeting is supported by Cambridge University Press, Company of Biologists, Gatsby Charitable Foundation, Institute for Adaptive and Neural Computation, Wellcome Trust.

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Growing older gracefully – a review of the 10th edition of Developmental Biology

Posted by , on 9 March 2014

This article was first published in Development, and was written by Timothy T. Weil, Department of Zoology, University of Cambridge.

 

Gilbert Cover.6In the age of Google and Wikipedia, what is the role of the textbook? When revising lecture notes, what motivates a student to pull a clunky book off the shelf, rather than hitting the keyboard and accessing millions of search results in tenths of a second? The question for today’s educator might actually be how to steer undergraduates to the best-suited, most applicable source. When teaching developmental biology, the 10th edition of Developmental Biology by Scott F. Gilbert provides an elegant solution to this conundrum.

Any text in its 10th edition is likely to have had a great deal of success, and Gilbert is no different. The work is comprehensive, with all the expert detail and beautiful data that have become synonymous with his book. While online searches and primary articles can be very intimidating to students and often compound pre-existing confusion, Gilbert works well as an entry point into the vast literature on all the topics covered. The text can function both as a general tool that can be read chapter by chapter, and as a reference for specific questions. This dependable and friendly text enables students to acquire quality basic information, and subsequently directs them smoothly to the primary literature for further exploration.

Like a prologue to a play, the first pages of the text set the scene and introduce the main characters, relationships and drama that motivate the action to follow. Gilbert’s 10th edition is presented in four parts: Questions, Specification, The Stem Cell Concept and Systems Biology. This structure remains mostly unchanged from the previous version; a pragmatic reorganisation that was introduced between the 8th and 9th editions. Each part opens with an introduction in review-like style and standard. These prefaces work well, placing the information to be presented in context, as well as informing and exciting the reader as to why it is important.

The book is further divided into 20 chapters that are well organised, easy to navigate, comprehensive and enriched with primary images and effective diagrams (an impressive 694 illustrations in 719 pages). Within the four parts, the chapters are linked with short, concept-driven openings and end with concluding remarks in the ‘coda’ section, creating a cohesive quality to the book. Also included at the end of each chapter is a ‘snapshot summary’, suggestions for further reading and directions to the online resources that are provided as part of the book package. Although these are expected components of any top textbook, Gilbert executes them extremely well. Throughout the chapters, there are stand-alone sections entitled ‘Sidelights & Speculations’, such as ‘The Nonequivalence of Mammalian Pronuclei’, ‘BMP4 and Geoffroy’s Lobster’ and ‘Transposable DNA Elements and the Origins of Pregnancy’. These vignettes have a mini-review quality to them and are good launch points for small group discussions.

Notably, the 10th edition has considerable new content and references, helping to maintain its position at the leading edge of available textbooks. This includes, but is by no means limited to, content on microRNA-mediated gene silencing, a new Crepidula (sea snail) fate map, epigenetic mechanisms of X inactivation, new ideas of neural tube closure, epithelial-to-mesenchymal transitions in cancer and developmental plasticity due to climate change.

For undergraduate course designers and lecturers, it is useful that the text is question driven, and includes many techniques ranging from classical transplantation and genetic screens to modern molecular networks and super-resolution microscopy. This provides the reader with the necessary information to think about the data as the original researcher did – an essential component in the education of young scientists.

Inherently, however, a textbook is out of date as soon as ink hits paper. It is therefore unfair to criticise the book on failing to include recent advancements, such as the CRISPR/Cas technology for genome engineering in Drosophila and other species. However, these limitations must be noted when considering the place of textbooks, as education inexorably moves towards a paperless existence.

The book ‘extras’ are an attempt to bridge the gap between paper and screen. These include the companion website www.devbio.com – self-described as a ‘museum’ with different ‘exhibits’ that ‘enrich courses in developmental biology’ – and vade macum3, a ‘laboratory manual’ that ‘helps students to understand the organisms discussed and prepare for the laboratory’. Both supplement the text, but are not essential to the book experience. They seek to provide an interactive avenue for students to explore, but when competing against the web are unlikely to become the first point of call for a student. However, they do offer an additional resource for instructors to enhance their lecture material with some available images and short videos. Moreover, by contacting the publisher, lecturers who confirm adoption of the text as part of their course may be granted access to ‘The Instructor’s Resource Library’. This includes images and presentation documents of all figures, tables and videos found in the text. This is a windfall for new lecturers and established educators looking to refresh their material.

Beyond the scientific realm, the text displays Gilbert’s ability to wear other literary hats, keeping the reader interested and engaged. He acts as historian as he brings alive the rich tapestry of developmental biology research; as columnist when relating the science to cultural quotes from the likes of T. S. Eliot, Steve Jobs, Emily Dickinson and Frank Lloyd Wright to name but a few; and finally as comedian with a lighthearted section on the website including ditties such as ‘The Histone Song’, links to YouTube videos and amusing articles.

Altogether, Developmental Biology by Gilbert is a classic and fundamental text. At £52.99 (RRP €63.58, $139.95), it is worth considering whether the 10th edition is a necessary upgrade. For general biology students, older editions will likely suffice. For lecturers or aficionados, the new content is nice, but not essential, especially for anyone owning the 9th edition. However, if you want an excellent text for teaching and learning developmental biology, the 10th edition is an ideal resource.

In the social media-dominated world of today, the future of the traditional course textbook is uncertain. The prospect of a continuously updated, interactive online ‘book’, complete with embedded links to primary sources, live movies and interactive images, is appealing. Still, at present there is no substitute for the well-written, accurate and engaging reference book exemplified by the 10th edition of Developmental Biology by Gilbert.

 

 

Developmental Biology, 10th edition by Scott F. Gilbert. Sinauer Associates (2013), 750 pages. ISBN: 9780878939787. $139.95 (hardback).

International Edition: Palgrave Macmillan. ISBN: 9781605351735. £52.99, €63.58.

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Categories: Book Reviews

Best of both – balancing research and outreach

Posted by , on 7 March 2014

I have been trying to pin-point when exactly I became interested in science outreach. The earliest I can think back is when we had to dissect Helix aspersa, the garden snail, in our undergraduate zoology practical. It was a slimy business. Our lecturer had asked us to remove the specimen’s body from its shell. It popped out in a spiral, covered in mucus. I took it apart carefully, holding my breath and trying to keep a steady hand whilst unravelling its insides with my shiny new dissecting instruments. As I uncovered its digestive system, its muscles and its ‘love dart’, incision by incision my initial feeling of disgust turned into deep fascination.

A few weeks later I was looking for a present for my little cousin. The book “Die Schnecke” (“The Snail”) seemed like the perfect choice. We read it together, sitting on the ground and admiring the illustrations. I guess that a passion for science communication has always been a big part of my love for science.

Thanks to my supervisors and my University I have been able to develop this passion into an official part of my job. My last post-doc position included a day per week dedicated to outreach, funded by my Faculty. In 2012 I became the University’s first Research and Science Communication Fellow. Now my time is split between plant cell biology and science communication, with a bit of teaching sprinkled on top.

The split is not mathematically accurate and I do not work exactly 2.5 days per week on each. Rather, things come in phases. March is extremely busy with the Oxfordshire Science Festival, and our Brookes Science Bazaar of which I am now the lead organiser. Last year Dr Niall Munro, a lecturer in American Literature, and I developed a training programme for early career science and humanities researchers. With input from a science journalist and poet, our participants paired up to explore interdisciplinary ‘Visions of the Future’, and presented their work on a theatre stage.

Our stall at the Oxfordshire Science Festival 2013 launch event in Oxford City Centre.
Our stall at the Oxfordshire Science Festival 2013 launch event in Oxford City Centre.

I always have several smaller, long-term projects running on the side, such as our DNA gel electrophoresis loan kit scheme or our partnership with the Oxford Academy. Between busy periods I focus on research and restrict my activities to ‘one-offs’ like SciBar or Science Showoff, and social media. I also run internal and external training sessions for researchers and mentor students and scientists who want to dip their toe into science communication.

Sometimes people ask me if I prefer science or science communication. I reply that both have their upsides and downsides. I love the excitement of coming up with hypotheses and designing experiments to test them. But in science, progress tends to be slow. Plants need to grow. Experiments need to be repeated or suddenly stop working for no obvious reasons. This can be very frustrating. When I put hard work and long hours into science communication projects, I know that I will (usually!) get a good outcome. Without exception, all of my projects have been extremely rewarding. I often joke that outreach keeps me sane because it is a positive balance to the constant stream of failures and rejections in science. Sometimes however things happen too fast or sudden and I need to react quickly, for example when two kids are starting to fight in our workshop or volunteers drop out at the last minute.

Juggling research, science communication and teaching is difficult, but not unique to my position. Like many other early career researchers, I am still learning how to squeeze productive bursts into an increasingly fragmented work day. Being able to say ‘no’ is as much an important skill as knowing how to perform a scientific method, and I am getting better at it. I also try to regularly pause and assess – in all areas of my job – whether I am working too much in the ‘urgent, but not important’ quadrant, and not enough in the ‘important, but not urgent’ one.

So how do you get started with outreach? My main advice would be to start small. Engage in existing initiatives: Become a STEM Ambassador, volunteer at your local Science Festival, the British Science Festival or the Big Bang Fair. Try out different communication channels (hands-on activities, comedy gigs, science songs or blog posts, just to name a few!), locations (university, pub, theatre, museum, city centre…) and audiences (children or adults). But at the same time, be realistic about your time and your resources. Always keep in mind your audience and what you want to achieve. Read up on evaluation. Collaborate with others. Volunteer as a research group to run a stall at an event. Write an article with a fellow PhD student, or find like-minded people on Twitter. Work as a team to bounce ideas around and split tasks between you. Once you have tested the water, don’t be afraid to think bigger – who knows where it might lead!

Further reading:
National Co-ordinating Centre for Public Engagement – How to do it.
So you want to do a science communication project?

 

 

Outreach logo new squareThis post is part of a series on science outreach. You can read the introduction to the series here and read other posts in this series here.

 

 

 

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Outreach activity – The Animal Pairs Game

Posted by , on 6 March 2014

Everyone loves a game. So here’s a game that flexes that brain muscle, which can be adapted for all audiences, topics and required level of cuteness.

Presenting: the Animal Pairs Game.

I first produced this for a demonstration event at ThinkTank Museum in Birmingham, a Meet the Scientist day themed around evolution and adaptation. The idea was simple: pair up the most similar animals. So, among the laminated cards, each with striking images and brief descriptions, were two birds, two mammals, two insects and many other animal groups. Among them were animals from similar ecological niches with strikingly similar appearances, yet differing classification, such as the European hedgehog and the echidna; and similar animals with big differences in appearance, such as the hedgehog and a polar bear — one small, one big, both from very different habitats, yet both mammals. Among them, also, were a number of wildcards to provoke critical thinking: should the archaeopteryx, for example, pair with a bird or a reptile?

The full list of creatures was a veritable menagerie intended to provoke wonder and to broaden horizons about the natural world, and linked as much as possible with the museum’s taxidermy collection. Here, pre-paired, are what I presented:

Echidna – Platypus (Monotremes)
Hedgehog – Polar bear (Mammals)
Nautilus – Snail (Molluscs)
Turtle – Icthyosaur (Reptiles)
Fish – Shark (Fish)
Kakapo – Blue-footed booby (Birds)
Crab – Mite (Arthropods)
Bryozoa – Worm (Spiralia)
Butterfly – Beetle (Insects)
Coral – Sea anemone (Cnidaria, with a silent c if you please)
And the wildcards: the Archaeopteryx, Hagfish and Horeshoe crab

As you can see, many of them were pretty difficult, but the beauty of the activity was that cards could be removed for different audiences, and others reclassified (you could use a wider deuterostome/protostome classification, for example, or the lophotrochozoa/ecdysozoa split). You could make a big deal about living fossils, if you fancied, or just tell tales about your favourite animals. All in all, it had many children captivated, and kept their attention for a lot longer than other activities I have demonstrated in the past.

The activity could be tailored for any subject. For developmental biology, for example, you could stick with the protostome/deuterostome divide and ask which develop with a dorsal (like our spines) or ventral (like the Drosophila ventral nerve cord) nervous system, or which form mouth first… or alternative openings? Maybe you could use pictures to signify how similar the earliest stages of vertebrate embryology are? Plenty of developmental biology concepts could be introduced with weird and wacky pictures and a game to pair them, particularly for audiences who would never have seen anything on this topic before.

Here’s the downside: the game requires a lot of ongoing explanation, even for older children. I retired the bryozoa card early, for example, and found myself constantly explaining the differences between — on the surface, rather similar — creatures. But the reward for doing so was undivided attention, and evident fascination. To avoid this downside, consider carefully the details written on the cards below the pictures, and have clear examples on show. Alongside the activity I presented a poster of the tree of life, which I would recommend.

 

 

Also read Simon’s outreach post on his internship with the Naked Scientists, bringing developmental biology to the radio.

 

 

Outreach logo new squareThis post is part of a series on science outreach. You can read the introduction to the series here and read other posts in this series here.

 

 

 

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Generation of Embryoid Bodies: a great tool to study vascular development

Posted by , on 4 March 2014

Hello, my name is Helena and I am a PhD student within the Vascular Signalling Laboratory led by Mariona Graupera in the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona. It has been 4 years since I started my project in the lab, and before finishing my thesis research, we thought it was a good moment to explore another vascular signalling laboratory and learn from their knowledge and techniques. I just returned from a stage in Dr. Holger Gerhardt’s laboratory in London, funded by the Development Travelling Fellowship from the Company of Biologists.

During my visit at Dr. Gerhardt’s lab I have learned one of the most useful and interesting techniques in the vascular biology field: the generation of embryoid bodies. The embryoid bodies are three-dimensional aggregates of pluripotent stem cells that after stimulation with the vascular endothelial growth factor A (VEGF-A) can be differentiated into endothelial cells and generate vascular sprouts that will grow in between two collagen layers (figure 1).

Dr. Gerhardt’s team has helped me to create embryoid bodies generated from stem cells deficient of my protein of interest. This technique has offered me an excellent ex vivo approach to study in greater detail the role of my protein of interest in sprouting angiogenesis. The experiments that I have carried out during my stage in London will very nicely complement the in vivo work that I have been doing for the last years with the study of the retinal mouse vasculature. Besides the exciting experiments that I have done in London, I have also had the opportunity to meet and interact with different professionals involved in the vascular signalling field that have shared with me their knowledge.

Apart from the academic experience, my personal experience in London has also been fantastic. London has been a great city to spend these 3 months. It is a huge city with so many places, parks, markets and experiences to discover. Of course, compared to Barcelona, the weather was not the best thing to remember but I was lucky that I could enjoy quite a few sunny days!

This experience has been a very nice way to finish my PhD period and I sincerely thank to the Company of Biologists their support.

figure 6 EB

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