Postdoctoral Fellowship: Studies of how niche-rearrangements control organ progenitor fate
Posted by Danstemjob, on 17 December 2019
Closing Date: 15 March 2021
Posted by Danstemjob, on 17 December 2019
Closing Date: 15 March 2021
Posted by Juan R Martinez-Morales, on 17 December 2019
Closing Date: 15 March 2021
Postdoctoral position.
Centro Andaluz de Biología del Desarrollo (CABD), Seville.
Juan R. Martinez-Morales Lab (jrmarmor@upo.es) is recruiting competitive
postdoctoral researchers to participate in an interdisciplinary project on comparative
tissue morphogenesis
Research project/ Research Group description:
The main focus of our laboratory is to study cellular and molecular mechanisms
involved in the morphogenesis of the vertebrate eye. Using the teleost models
zebrafish and medaka, we investigate the machinery driving the folding of the retinal
neuroepithelium.. Although it is generally accepted that optic cup formation follows a
tissue-intrinsic program in vertebrates, several mechanisms have been postulated
(basal constriction, rim involution) and some important differences in cell behaviour
have been reported among species. Many important questions still remain open. Which
is the relative contribution of each mechanism to the folding of the optic cup? Do they
act in a cooperative manner? Do they have the same regulatory weight in different
species? To answer these questions, we aim to integrate genetic information, imaging
analysis of cell shape changes, and tensional forces distribution into coherent
computational models able to predict the key morphogenetic rules that shape the entire
organ. We plan to extend our observations to mammalian tissue, by examining cell
shape changes and tensions in 3D retinal organoids developed in vitro. A key aspect of
the project is to understand how classical signalling events, which have proved to be
essential for the proper patterning of the organ, act in coordination with tensional
forces. This highly interdisciplinary approach, combining genetics, imaging, biophysics
and computational modelling should yield information relevant not only to understand
optic cup formation, but also to deduce general self-organization principles of the living
matter.
Relevant Publications:
Letelier et al. (2018a) Nat Genetics, Letelier et al (2018b) PNAS, Nicolás-Pérez et
al (2016). eLife; Gago-Rodrigues et al (2015). Nat Comm ; Tena et al (2014) Genome Research. 24(7):;
Bogdanovic et al (2012). Developmental Cell. 23 (4).
For a full list: https://www.ncbi.nlm.nih.gov/pubmed/?term=Martinez-morales+JR
Job position description:
Given the interdisciplinary character of the project above described, we are seeking
talented and highly motivated postdoctoral researchers with a background either in
Developmental Biology or in Biophysics. Previous experience with teleost models will
be well received. The candidates should have good communication skills, critical for
ensuring the success of the team effort. We offer full support to apply for external
funding in upcoming postdoctoral call “Juan de la Cierva” (deadline-21st January 2020).
Contact information:
Email: jrmarmor@upo.es
Phone: + 34 954977827
Web pages :
http://cellcollectives.com/dt_doctors/control-of-epithelial-morphogenesis-in-vertebrates/
Posted by Jiou Wang, on 15 December 2019
Closing Date: 15 March 2021
Highly motivated postdoctoral candidates are invited to lead several new projects to address fundamental questions in RNA homeostasis related to neurodegenerative diseases in the laboratory of Jiou Wang. Experimental approaches, including biochemistry, genetics, and cell biology, from invertebrate to mammalian systems are employed. Candidates with a strong background in biochemical, molecular, and/or cellular biology are encouraged to apply.
The Johns Hopkins Medical Institutions provide a stimulating and collaborative environment for biomedical research. Our lab is affiliated with the Department of Biochemistry and Molecular Biology at the Bloomberg School of Public Health and the Department of Neuroscience at the School of Medicine. The Baltimore/Washington D.C. area also offers rich professional and living opportunities.
Candidates should have a doctoral degree and strong research background. Please send a statement of research experience and career goals, a copy of Curriculum Vitae, and contact information of at least one reference to Dr. Jiou Wang at jiouw@jhmi.edu.
A complete listing of PubMed-accessible publications can be accessed at the following URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Jiou+Wang.
More information available at: http://www.jhu-bmb-phd.org/faculty/jiou-wang. The Johns Hopkins University is an Equal Opportunity Employer.
Posted by xiongfz, on 13 December 2019
Closing Date: 15 March 2021
https://www.jobs.cam.ac.uk/job/24058/
The Wellcome/Cancer Research UK Gurdon institute is a leading institution in basic research of development and cancer, embedded in the first-class interdisciplinary environment of the University.
Applications are invited for a 4-year PhD studentship in the group led by Dr Fengzhu Xiong, on a project titled Tissue mechanics in body axis symmetry. For further information about Dr Xiong’s group, please go to https://www.gurdon.cam.ac.uk/research/fengzhu-xiong
Xiong Lab is interested in the role and regulation of tissue mechanics in morphogenesis (shape change) during development. We integrate a variety of tools from imaging to soft matter physics with the long-term goal of quantitatively predicting morphogenesis. Early vertebrate embryos increase the length of the body significantly during somitogenesis while maintaining straightness. The cell dynamics and tissue forces that prevent axis curvature remain unknown. The project will involve: observing and analysing the dynamics and variability of tissue symmetry and cell behaviours in avian embryos; performing microsurgeries and quantitative tissue force measurements to understand the mechanical constraints on the body axis; developing computational models linking signalling, cell dynamics to tissue mechanics to assess robustness of symmetry. A variety of other projects on tissue mechanics are possible, depending on the student’s interest and background. The student is expected to complete the PhD thesis in the fourth year of study.
Applicants must have (or expect to obtain) a Bachelor’s or Master’s degree in developmental biology, genetics, physics and/or engineering disciplines relevant to the project. Motivation, creativity and intellectual independence are desirable as are excellent communication skills with the ability to work collaboratively. This project includes full funding for University and College fees and a stipend. Applicants are encouraged to seek external funding sources. For example, applicants eligible for various scholarships at Cambridge (https://www.cambridgetrust.org/scholarships/) should submit a copy of the application through the University portal and select Department of Physiology, Development and Neuroscience graduate course before the deadline.
To apply, please send the following as a combined PDF file to jobs@gurdon.cam.ac.uk, please indicate “Application – PR21447” in your email subject:
In addition, please arrange 3 recommendation letter to be sent to jobs@gurdon.cam.ac.uk directly from the referees with the reference number PR21447 and your name in the title.
The closing date for applications is 7 January 2020, with interviews expected to take place in February.
Fixed-term: The funds for this post are available for 4 years in the first instance.
The University values diversity and is committed to equality of opportunity. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family friendly schemes. The Gurdon Institute is committed to equality and diversity in the workplace, for more information go to https://www.gurdon.cam.ac.uk/wed/SWAN
Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any questions about this vacancy or the application process, please contact jobs@gurdon.cam.ac.uk
Please quote reference PR21447 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Posted by Noami Dayan, on 13 December 2019
The ISLET project is a multi-center collaboration of leading European researchers that has been awarded 8 million Euros in a 5-year period. The project will develop advanced stem cell products ready for use in clinical trials in Type 1 Diabetes. Professor Henrik Semb from DanStem is coordinating the project.
The ISLET project will develop a manufacturing pipeline for stem cell-based products to treat patients with Type 1 Diabetes. In Type 1 Diabetes a patient’s immune system destroys the beta cells within the islets of Langerhans in the pancreas making a patient dependent on life-long delivery of insulin. Based on in-house methods, ISLET will deliver a product composed of clusters of insulin-producing beta cells, derived from human pluripotent stem cells, ready to be used in phase 1 clinical trials.
ISLET also aims to advance this product by engineering clusters of hormone-producing cells that not only consist of the insulin-producing beta cells but also other hormone-producing islet cells, thereby engineering a product that is more alike the islets of Langerhans that are found in the pancreas.
Finally, ISLET researchers will develop innovative solutions to a common bottleneck in stem cell therapy, namely how to predict the therapeutic capacity of stem cell products.
With hubs at University of Copenhagen, Denmark, and the Helmholtz Diabetes Center, Munich, Germany, the European team of world-leading and complementary expertise has been carefully hand-picked to move the work smoothly from the lab bench to the clinic and to market the new products.
“I am very proud that prominent researchers from the University of Copenhagen will participate in taking a great leap forward in the field of diabetes research. The ISLET project, coordinated by Professor Henrik Semb, is a strong example of complementary collaboration between world-leading researchers. Furthermore, this demonstrates how long-term dedication to basic research can have transformative effect. Thus, I hope that future patients will benefit from the development of the clinical stem cell-based transplantation program, says Ulla Wewer, Dean at The Faculty of Health and Medical Sciences, University of Copenhagen”.
The funding is awarded through the Horizon 2020 EU Research and Innovation actions programme that also supported the discoveries that laid the foundations for ISLET, in previous funding rounds.
Type 1 Diabetes is a global health challenge, affecting more than one million children and adolescents worldwide, with close to 129,000 new cases diagnosed each year. Diabetes impacts on quality of life and is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation. The condition is a severe economic burden on healthcare and the labour force.
“We are extremely excited and honoured that the EU are continuing to support this vital work in driving forward a stem cell therapy for Diabetes. The immensely talented pan-European ISLET team highlights the strength in collaboration between institutions. It is only by working together transparently in this way that we can fulfill the promise that stem cell technology offers to human health globally.” – Professor Henrik Semb, scientific coordinator
“IDF Europe is hugely excited to be participating in ISLET, which we believe has the potential to pave the way for a Type 1 Diabetes cure in the future. The funding allocated to this project will have a huge effect on our ability to effectively represent the voice of, and improve the lives of people living with diabetes and connect all relevant stakeholders to ensure that knowledge is shared as broadly and rapidly as possible for maximum impact.” – Professor Dr Sehnaz Karadeniz, IDF Europe Chair
Professor Henrik Semb: E-mail: semb@sund.ku.dk, henrik.semb@helmholtz-muenchen.de
Posted by Christina James-Zorn, on 12 December 2019
Closing Date: 15 March 2021
Xenbase (www.xenbase.org) is the Xenopus bioinformatics and genomics knowledgebase funded by the NIH/NICHHD. We have has two performance sites: the curation team at Cincinnati Children’s, Cincinnati OH (PI: Dr. Aaron Zorn) and the database management team at the University of Calgary in Canada (PI Dr. Peter Vize).
Xenbase is seeking to fill 1 full time Genomic Analyst position to join the curation team at the Division of Developmental Biology, Cincinnati Children’s. This position offers a challenging job involving diverse tasks related to genomic data management and the integration of genotype and phenotype data. As part of the Xenbase team the Genomic Analyst will function at the interface between biocurators, database administrators and software developers to improve data curation; test and help optimize website functionality; develop programming scripts; interact with our user community at research conferences and contribute to Xenbase publications.
Job Description:
• Management and “wrangling” of genomic data.
• Help manage Xenopus genomes and participate in genome annotation and gene nomenclature.
• Help test newly developed code features and provide feedback for developers.
• Work with biocurators, developers and database administrators to promote data integrity, develop he technical specification of new features for the site.
• Participate in data analysis and development of new ways to visualize data.
• Help manage data exports for public use and data exchange with other databases.
• Co-author reports and publications and give presentations at national and international meetings and workshops.
Qualifications:
• MSc or PhD degree in bioinformatics and/or genomics.
• Experience working with genomic data
• Experience with a programming language such as Perl or Python
• Experience with standard bioinformatic tools, analyses, file formats (BLAST, BLAT, multi-seq. alignments, GFF, GTF, etc).
• Demonstrated writing skills (scientific papers, reports and presentations).
• Demonstrated ability to work in a team as well as independently, quickly and accurately and be self-motivated
• Strong interpersonal and communication skills, including excellent written and spoken English.
Preference will be given to an applicant with:
• 2 or more years’ experience with a bioinformatics, genomics or work with another model organism database
• Experience in relational databases, data annotation/biocuration, knowledge of and familiarity with ontologies.
• Experience in analyzing genomics data, using GRN software, genome browsers and common bioinformatics tools.
• Experience with SVN or Git based version control, particularly GitLab, and continuous integration.
• Experience in constructing and maintaining bioinformatic pipelines.
How to Apply:
Please submit your application here: https://jobs.cincinnatichildrens.org/search/jobdetails/analyst-bioinformatics-genomics/ac4265c1-9a1e-4a3e-9880-35de3f5a6398 Due date: January 31st 2020. Please include:
• A cover letter, including a statement of interest in the position.
• CV/Resume, with 3 references whom we may contact: please include their postal address, email and phone number
• Copy of your degree(s), and undergraduate transcripts.
Salary and Start Date:
Salary will be commensurate with qualifications and experience.
Start date is negotiable, expected to be in early 2020.
Cincinnati Children’s employees undergo background checks, orientation and a 6-month probationary period. All employees are required to receive an annual flu vaccination. More information about working at Cincinnati Children’s, and living in Cincinnati, can be found here: http://www.cincinnatichildrens.org/careers/working/default/
Posted by Jenna Galloway, on 12 December 2019
Closing Date: 15 March 2021
The Galloway lab is for a highly motivated individual to join a research program focused on musculoskeletal development and regenerative biology. The lab uses genomic approaches combined with zebrafish, mouse, and stem cell models to understand the pathways involved in musculoskeletal development, regeneration, and repair. The position provides an exciting opportunity to work at the interface of basic and translational research in a collaborative and stimulating environment at the Center for Regenerative Medicine and the Department of Orthopaedic Surgery at MGH, Harvard Stem Cell Institute, and the Harvard Medical School.
Minimum degree and field of knowledge: B.S./B.A. in Biology or related field.
Research experience: Candidates with a strong background in molecular biology and cell culture are preferred. The position requires excellent organizational and record keeping skills.
Duties:
The candidate is expected to independently carry out the daily activities of the laboratory, which include:
Required Skills:
For more information, visit our lab website (http://gallowaylab.mgh.harvard.edu/).
Interested candidates should submit a CV, a brief cover letter stating current and future career goals, and contact information for three references by email to Dr. Jenna Galloway (jenna_galloway@hms.harvard.edu).
Posted by Jenna Galloway, on 12 December 2019
Closing Date: 15 March 2021
Full-time postdoctoral positions are available in the Galloway lab in the field of stem cells and regenerative biology with a focus on musculoskeletal biology. The Galloway laboratory aims to understand the genetic pathways regulating tendon development and repair with the goal of designing therapies for age-related degeneration and injury. Our current projects use genomic approaches combined with zebrafish, mouse, and stem cell models to understand the pathways involved in tendon development, regeneration, and repair.
The position provides an exciting opportunity to work at the interface of basic and translational research in a collaborative and stimulating environment at the Center for Regenerative Medicine and the Department of Orthopaedic Surgery at MGH, Harvard Stem Cell Institute, and the Harvard Medical School community.
Applicants with a strong background in genetics, developmental biology, and molecular biology are encouraged to apply. Bioinformatics experience is preferred.
For more information, visit our lab website (http://gallowaylab.mgh.harvard.edu/). Interested candidates should submit a CV, brief description of research experience, and names and contact information for three references to Dr. Jenna Galloway at jenna_galloway@hms.harvard.edu.
Posted by BSDB, on 12 December 2019
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Posted by Noami Dayan, on 11 December 2019
Closing Date: 15 March 2021
The Semb group is looking for a postdoctoral candidate with a strong developmental biology/cellular mechanobiology and/or a biological image processing background to identify and study novel cell and molecular mechanisms predicting the differentiation of bi-potent progenitors in the developing pancreas.
During organogenesis fate-determining cues are generated by dynamic interactions between stem cells/progenitors, their progenies and the cellular environment. We are looking for a postdoctoral candidate with a strong developmental biology/ cellular mechanobiology background and/or a biological image processing background to identify cellular fate determining cues and their mechanism of action in the developing pancreas. This exciting project will use a combination of high-resolution confocal live imaging and machine learning to identify potential regulators of pancreatic fate. The successful candidate will work closely with a biophysicist and a live imaging specialist already in the lab. The research project will also involve collaboration with a team of computer scientist and a team of researchers developing novel spatial transcriptomic techniques. The employment is planned to start 1 April 2020 or upon agreement with the chosen candidate.
Background:
The Novo Nordisk Foundation Center for Stem Cell Biology – DanStem has been established as a result of a series of international recruitments coupled with internationally recognized research groups focused on insulin producing beta cells and cancer research already located at the University of Copenhagen. DanStem addresses basic research questions in stem cell and developmental biology and has activities focused on the translation of promising basic research results into new strategies and targets for the development of new therapies for cancer and chronic diseases such as diabetes and liver failure. Find more information about the Center at http://danstem.ku.dk/.
Job Description:
We are looking for a postdoctoral candidate with a strong developmental biology/cellular mechanobiology and/or a biological image processing background to identify and study novel cell and molecular mechanisms predicting the differentiation of bi-potent progenitors in the developing pancreas. The candidate is expected to use both in vivo (mouse) and in vitro (human pluripotent stem cells) experimental models to address hypothesis lead research questions. Whilst the aim of the project is to identify regulators of cell fate in an unbiased manner, the researcher will also pursue ‘candidate’ regulators identified from the labs recent publications. The position is for 2 years with possible extension.
Qualifications:
Terms of employment:
The employment is planned to start 1 April 2020 or upon agreement with the chosen candidate.
The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. The position will be at the level of postdoctoral fellow and the basic salary according to seniority. Currently, the salary starts at 34.360 DKK/approx. 4,.590 Euro (October 2019-level). A supplement could be negotiated, dependent on the candidate´s experiences and qualifications. In addition a monthly contribution of 17.1% of the salary is paid into a pension fund.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.
Questions:
For further information contact Professor Henrik Semb, henrik.semb@sund.ku.dk.
Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk.
Application Instruction:
The application must be submitted in English, by clicking on “Apply online” below. Only online applications will be accepted.
The application must include:
Deadline for applications is 15 February 2020, 23.59pm.
The further process:
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on his/her assessment. You may read about the recruitment process at http://employment.ku.dk.
Link for general info on the recruitment process: http://employment.ku.dk/faculty/recruitment-process.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.