Kamberov lab at the University of Pennsylvania Perelman School of Medicine, Philadelphia PA.
About the lab: The primary research focus of the Kamberov lab is to define the developmental programs controlling the formation and patterning of skin organs like sweat glands and hair follicles and to discover how these programs have been modified during to generate diversity in skin traits among modern humans as well as to give rise to human-specific skin traits . To this end, the lab leverages powerful genetic and genome editing tools for discovery and functional testing in the mouse coupled with in vitro study in mouse and human cell culture, comparative evolutionary genomics and high-throughput single transcriptomics.
About the position: A post-doctoral position is available leading a project on mechanisms underlying developmental specificity and evolutionary variation of enhancers controlling the formation and patterning of skin appendages. The position is supported by NIH funding.
To apply: Interested applicants should send a CV, contact information of three references and a letter detailing your interest in the position to Yana Kamberov. Applicants should hold a Ph.D. in biology or related field. Applicants with a background in developmental biology, enhancer biology, mouse genetics, regenerative biology or evolutionary genetics are especially encouraged to apply.
There are two open positions in my lab. We are the Neural circuits and Evolution lab at The Francis Crick Institute in London (https://prietogodinolab.org/). The lab employs a multidisciplinary approach to understand how neural circuits function and evolve, combining techniques that range from in vivo calcium imaging, electrophysiology, electron microscopy circuit tracing, molecular biology, single-cell RNA sequencing, genome editing, behavioural analysis and field work. The two open positions are:
Senior Lab Research Scientist. This position is best suited for a motivated postdoctoral researcher that wishes to continue doing amazing science in a collaborative environment with a permanent contract, rather than following the PI route. The role will be a mix of a permanent advanced postdoctoral researcher and lab manager supporting other people’s projects in the lab. The link to the official application and job description can be found here: https://my.corehr.com/pls/frckrecruit/erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=014727&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y
Postdoctoral researcher. This position is best suited for a motivated finishing PhD student or a postdoc that wishes to continue their academic path in a supportive environment, it is a four year contract with possibility of extension to a total of 6 years. In addition to a supportive lab environment, the Crick provides an excellent postdoctoral training programme, and we have regular meetings as well as formal and informal collaborations with other neuroscience groups at the crick. The link to the official application can be found here:https://my.corehr.com/pls/frckrecruit/erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=014747&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y
Both positions require independence and a strong interest in either cellular and molecular neuroscience or circuit/systems neuroscience and evolution.
Informal enquires can be made to lucia.prietogodino@crick.ac.uk
I would be thankful if you could distribute this adds widely.
PhD offers: modelling the effect of noise in gene regulatory network governing early mammalian development, starting from 1 October 2020 or later – (1 +3 years )
We are seeking two PhD students to work in the Unit of Theoretical Chronobiology (Brussels, Belgium) on a project related to the modelling of cell differentiation. This interdisciplinary project will focus on the relation between the structure of the gene regulatory network (GRN) governing cell differentiation and its sensitivity to noise.
For more information, see: https://www2.ulb.ac.be/sciences/utc/home.html
The Tissue Regeneration Laboratory within the Biology Department at Wake Forest University is seeking a qualified and highly motivated individual for the position of Lab Manager / Research Assistant to support our work uncovering mechanisms of tissue regeneration in axolotl salamanders. The primary tasks will include managing lab resources, caring for the lab’s axolotl colony, and undertaking research. The candidate will be involved in setting up our lab as it launches at Wake Downtown. Wake Downtown is located in Winston-Salem’s Innovation Quarter, adjacent to the Wake Forest School of Medicine and the Wake Forest Institute for Regenerative Medicine (WFIRM). Winston-Salem boasts a phenomenal cost of living, a thriving arts scene as the home to the North Carolina School of the Arts, and is only a few hours’ drive to either the Outer Banks or the Blue Ridge Parkway/Smoky Mountains.
The candidate will be responsible for managing lab inventories, implementing safety protocols, maintaining and caring for axolotls and their facility, and conducting lab work such as PCR genotyping, RNA and DNA extractions, molecular cloning, creating transgenic axolotls, and fluorescence microscopy. The candidate should be motivated to gain proficiency at troubleshooting experiments, analyzing data, and communicating results. Opportunities exist for independent research and mentorship toward next professional steps (e.g. postbac to grad/med school). The candidate should minimally have a Bachelor’s degree and a fundamental understanding of molecular biology, including hands-on research experience in cell and molecular biology or a related field. Experience working with animals, especially aquatic organisms, is appreciated but not required. Excellent organizational, record-keeping and collaborative interpersonal skills are essential.
This position has full benefits and is funded for two years, with the possibility of extension dependent upon lab funding. Salary will be commensurate with prior experience. We are intentional about building a diverse, inclusive, and supportive team of colleagues. More information about our lab values can be found here.
To apply, please send a CV, a cover letter expressing interest and highlighting relevant experience, and contact information for 3 references to Dr. Josh Currie (currie.regenerationlab@gmail.com). Please reference “Tissue Regeneration Lab Manager / Research Assistant” in the subject line. Starting dates are flexible beginning from September 1st, 2020.
The N-Glycome regulates the endothelial-to-hematopoietic transition
Dionna M. Kasper, Jared Hintzen, Yinyu Wu, Joey J. Ghersi, Hanna K. Mandl, Kevin E. Salinas, William Armero, Zhiheng He, Ying Sheng, Yixuan Xie, Daniel W. Heindel, Eon Joo Park, William C. Sessa, Lara K. Mahal, Carlito Lebrilla, Karen K. Hirschi, Stefania Nicoli
Maternal iron deficiency perturbs embryonic cardiovascular development
Jacinta I. Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E. Harris, Aimée Jacquemot, Jack J. Miller, Eleanor M. Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Timothy J. Mohun, Samira Lakhal-Littleton, Eleni Giannoulatou, Duncan B. Sparrow
Cell surface fluctuations regulate early embryonic lineage sorting
Ayaka Yanagida, Christopher Revell, Giuliano G. Stirparo, Elena Corujo-Simon, Irene M. Aspalter, Ruby Peters, Henry De Belly, Davide A. D. Cassani, Sarra Achouri, Raphael Blumenfeld, Kristian Franze, Ewa K. Paluch, Jennifer Nichols, Kevin J. Chalut
Epithelial layer unjamming shifts energy metabolism toward glycolysis
Stephen J. DeCamp, Victor M.K. Tsuda, Jacopo Ferruzzi, Stephan A. Koehler, John T. Giblin, Darren Roblyer, Muhammad H. Zaman, Scott T. Weiss, Margherita DeMarzio, Chan Young Park, Nicolas Chiu Ogassavara, Jennifer Mitchel, James P. Butler, Jeffrey J. Fredberg
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Olga Gewartowska, Goretti Aranaz Novaliches, Paweł S Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski
Paranode stability requires UNC5B expression by oligodendrocytes
Omar de Faria Jr., Diane S. Nakamura, Samuel Clemot, Doyeun Kim, Mihai Victor Mocanu, Roland Pilgram, Jenea M. Bin, Edwin W. Wong, Amir Shmuel, Abbas Sadikot, Susan L. Ackerman, Timothy E. Kennedy
Cell-type, single-cell, and spatial signatures of brain-region specific splicing in postnatal development
Anoushka Joglekar, Andrey Prjibelski, Ahmed Mahfouz, Paul Collier, Susan Lin, Anna Katharina Schlusche, Jordan Marrocco, Stephen R. Williams, Bettina Haase, Ashley Hayes, Jennifer G. Chew, Neil I Weisenfeld, Man Ying Wong, Alexander N. Stein, Simon Hardwick, Toby Hunt, Zachary Bent, Olivier Fedrigo, Steven A. Sloan, Davide Risso, Erich D. Jarvis, Paul Flicek, Wenjie Luo, Geoffrey S. Pitt, Adam Frankish, August B. Smit, M. Elizabeth Ross, Hagen U. Tilgner
Wnt/PCP-primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells
Anika Böttcher, Maren Büttner, Sophie Tritschler, Michael Sterr, Alexandra Aliluev, Lena Oppenländer, Ingo Burtscher, Steffen Sass, Martin Irmler, Johannes Beckers, Christoph Ziegenhain, Wolfgang Enard, Andrea C. Schamberger, Fien M. Verhamme, Oliver Eickelberg, Fabian J. Theis, Heiko Lickert
Human muscle stem cells are refractory to aging
James S. Novak, Davi A.G. Mázala, Marie Nearing, Nayab F. Habib, Tessa Dickson, Olga B. Ioffe, Brent T. Harris, Marie N. Fidelia-Lambert, Christopher T. Rossi, D. Ashely Hill, Kathryn R. Wagner, Eric P. Hoffman, Terence A. Partridge
Macrophages provide a transient muscle stem cell niche via NAMPT secretion
Dhanushika Ratnayake, Phong D. Nguyen, Fernando J. Rossello, Verena C. Wimmer, Abdulsalam I. Isiaku, Laura A. Galvis, Alasdair J. Wood, Ziad Julier, Thomas Boudier, Viola Oorschot, Kelly L. Rogers, Mikaël M. Martino, Christophe Marcelle, Graham J. Lieschke, Jeroen Bakkers, Peter D. Currie
Hematopoietic stem cells fail to regenerate following inflammatory challenge
Ruzhica Bogeska, Paul Kaschutnig, Malak Fawaz, Ana-Matea Mikecin, Marleen Büchler-Schäff, Stella Paffenholz, Noboru Asada, Felix Frauhammer, Florian Buettner, Melanie Ball, Julia Knoch, Sina Stäble, Dagmar Walter, Amelie Petri, Martha J. Carreño-Gonzalez, Vinona Wagner, Benedikt Brors, Simon Haas, Daniel B. Lipka, Marieke A.G. Essers, Tim Holland-Letz, Jan-Philipp Mallm, Karsten Rippe, Paul S. Frenette, Michael A. Rieger, Michael D. Milsom
A Wnt-specific astacin proteinase controls head formation in Hydra
Berenice Ziegler, Irene Yiallouros, Benjamin Trageser, Sumit Kumar, Moritz Mercker, Svenja Kling, Maike Fath, Uwe Warnken, Martina Schnölzer, Thomas W. Holstein, Markus Hartl, Anna Marciniak-Czochra, Jörg Stetefeld, Walter Stöcker, Suat Özbek
The Echeverri lab at the MBL seeks a highly motivated individual to join the Eugene Bell Center for Regenerative Biology and Tissue Engineering as a Postdoctoral Researcher. The successful candidate will work on the molecular mechanisms of scar free skin regeneration in axolotls.
The specific goal of the project is to examine the role of different cell types in responding to the injury cues and in later remodeling collagen. The position will initially be offered for two years with the possibility of extension.
Basic Qualifications:
Applicants should have a Ph.D. in a biology related field. Must have prior experience working in the field of cell and developmental biology, as well as experience with molecular biology, cell culture and research animals. Must be independent, enthusiastic, self-motivated, productive, and enjoy working in a collaborative environment.
Preferred Qualifications:
The ideal candidate will have direct experience with working in vivo in an animal model. Previous experience with cell culture, molecular biology and imaging would be a plus.
Required documents:
1. Cover letter explaining specifically why you are interested in joining our lab to work on this project and what positive qualities you would bring to our team.
2. Curriculum vitae.
3. Apply online : https://recruiting.ultipro.com/MAR1033MBL/JobBoard/4c3007c3-6354-41de-a13f-d95be60d91e9/?q=&o=postedDateDesc
4.
A Postdoctoral Fellow position is immediately available (08/21/20) in the NSF-Simons Center for Quantitative Biology and in the Department of Molecular Biosciences at Northwestern University.
The successful candidate will employ high throughput genomics (e.g. CRISPR and next-generation sequencing) and computational tools to study dynamic gene regulatory networks in mammalian stem cells.
Examples of our representative publications include: https://biorxiv.org/cgi/content/short/2020.04.20.050559v1, Cell 167 (1555-1570), Journal of American Statistical Association 109 (48-62), Molecular Cell 55 (758-770), Nature 486 (496–501).
Applicants should have a Ph.D. or equivalent in relevant fields. The background in genomics or computational biology or stem cell biology is a plus. The candidate will work with a group of developmental and computational biologists in a highly interdisciplinary environment.
Interested applicants should email their curriculum vitae and contact information for three references to Professor Alec Wang awang@northwestern.edu.
In the latest episode of Genetics Unzipped, Dr Kat Arney takes a look at the progress that’s been made in tackling rare genetic disorders (and the challenges that remain) and we hear from a prenatal genetic counsellor about how new tests are helping people carrying genetic variations make decisions about starting a family.
With Dr Ron Jortner (founder and CEO of Masthead Biosciences and trustee of the Cambridge Rare Disease Network) and Genetic counsellor Kira Dineen.
A postdoctoral Research Associate position is currently available for an individual to work in the laboratory of Prof. Anna Philpott within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/research/pis/philpott). The Philpott lab has broad interests in understanding the fundamental mechanisms that determine cell fate choice and differentiation during embryonic development and in cancers, as well as how these processes are co-ordinated with cell cycle progression.
The successful candidate will undertake a project focused around transcriptional regulation of lineage fidelity during fate specification and differentiation of mouse embryonic stem cells, focusing on uncovering epigenetic and co-factor-dependent mechanisms underlying these processes. There is also an opportunity to work on parallel mechanisms of fate specification and differentiation in Xenopus frog embryos.
The successful candidate will have a PhD, considerable experience in stem cell biology, epigenetics, molecular biology, developmental biology, or a similar field, and a proven track record in scientific publication. Prior experience in mammalian cell culture is essential. Experience of epigenetics and/or transcriptional regulation are essential, while experience of genome-wide transcriptional analysis, and in particular analysis at the single cell level, and/or CRISPR technology would also be an advantage. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have good presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers.
The Wellcome – MRC Cambridge Stem Cell Institute (CSCI) is a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/ .
Apply online at http://www.jobs.cam.ac.uk/job/26715/
Fixed-term: The funds for this post are available for 3 years in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
Closing date for applications is 21/09/2020 with interviews date to be confirmed.
Informal enquiries should be directed to Prof. Anna Philpott, ap113@cam.ac.uk
Please quote reference PS23867 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Transitions between cellular identities are fundamental to metazoan biology, from development to disease. Yet how cells navigate accurately between distinct identities remains poorly understood. A primary challenge is that transition is intrinsically dynamic, an outcome of time and stimulation. The methodology and the theory necessary to capture and decode these molecular and cellular dynamics are underdeveloped.
This Workshop aims to highlight innovative interdisciplinary approaches to the question of how biological transitions occur. We bring together practitioners in stem cell and developmental biology with theorists and experimentalists from physics, mathematics and engineering. The goal is to explore avenues for examining cell state transitions across multiple scales. We will consider concepts, tools and technologies, and model systems.
The Workshop will be run in virtual format using bespoke software to facilitate break out discussions. Early-career researchers will be offered a 1 to 1 mentoring opportunity with a senior investigator. The Workshop will be free for those selected to attend.
We offer 10 places for early-career researchers (PhD, postdocs and PIs in the first 3 years of their first appointment) to attend our virtual Workshops along with the our invited speakers.
The deadline date for applications is 28 August 2020.
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In the latest episode of Genetics Unzipped, Dr Kat Arney takes a look at the progress that’s been made in tackling rare genetic disorders (and the challenges that remain) and we hear from a prenatal genetic counsellor about how new tests are helping people carrying genetic variations make decisions about starting a family.