The Department of Biological Sciences at Louisiana State University invites applications for a tenure-track Assistant Professor position in all areas of stem cell and regenerative biology, including neurobiology, developmental biology, and molecular-cell biology. Biological Sciences is a large and dynamic department, with research ranging across all levels of biological organization, and the successful candidate will complement these strengths. Researchers utilizing non-traditional model organisms and those who would appreciate joining diverse and interactive faculty are especially encouraged to apply. In addition to the Department of Biological Sciences, opportunities for collaboration research are available at the LSU School of Veterinary Medicine, the LSU College of the Coast & Environment, the LSU College of Agriculture, and the LSU Pennington Biomedical Research Center. Successful candidates will be expected to establish and maintain a vigorous, extramurally funded research program and to contribute to undergraduate and graduate teaching. Applicants should have a Ph.D. in Biological Sciences or related field, a successful track record of productive research and publication, and postdoctoral experience.
Our department is dedicated to the goal of building a culturally diverse and pluralistic faculty, and we strongly encourage applications from women, minorities, individuals with disabilities, veterans, and other members of groups underrepresented in science. We seek candidates whose research, teaching, or service has prepared them to contribute to diversity and inclusion in higher education. Candidates should include a statement describing how they will promote an inclusive learning environment, and how their scholarship and mentoring practices support a diverse academic community.
The Sumigray lab in the Department of Genetics at Yale School of Medicine invites applications for a postdoctoral scientist to work on an exciting project at the interface of cell biology, morphogenesis and stem cell biology. The successful applicant will have a strong background in cell and developmental biology, genetics and/or stem cell biology and a track-record of original and impactful research in biomedical science.
The Sumigray lab studies the molecular and cellular processes that drive intestinal crypt morphogenesis and the importance of crypt architecture on intestinal stem cell activity/function. We use a combination of in vivo and in vitro models combined with live imaging, confocal microscopy and next-generation sequencing. For more information about the lab’s research, please see sumigraylab.org.
Applicants should possess a Ph.D. in molecular biology, cell biology, biochemistry, genetics, or a related field. Experience in mammalian cell culture is preferred but not required.
Please submit i) a cover letter with a brief description of your research experience and motivations for joining the lab, ii) CV and iii) contact details for 2-3 references to Dr. Kaelyn Sumigray (kaelyn.sumigray@yale.edu).
The Giraldez laboratory at Yale University is seeking to recruit a highly qualified Associate Research Scientist as a long-term scientist in the laboratory (www.giraldezlab.org). Prerequisites for appointment on the research scientist track include a doctoral degree and relevant postdoctoral experience.
The successful candidate will be a highly-motived scientist with excellent organizational, mentoring and leadership skills. They will be responsible for coordinating the overall scientific operations of the Giraldez lab and will provide critical training and mentoring to individual lab members. In addition, the successful candidate will have the opportunity to participate in multiple research projects and drive a scientific project aligned with the major interests of the laboratory. The successful candidate will have the following attributes:
A doctoral degree and relevant postdoctoral experience
Excellent interpersonal and communication skills
Excellent organizational skills and attention to detail
Solid publication record and the ability to drive long-term, successful research projects
Expertise in one or more of the following: molecular biology, chromatin biology, developmental
biology, genomics, and/or imaging
This appointment can be renewed indefinitely provided the need for the position continues, the funding for the position is available.
Tenure-track position in the Division of Biological Sciences
The Center for Craniofacial Molecular Biology (CCMB) of the Herman Ostrow School of Dentistry of the University of Southern California is recruiting outstanding candidates for a tenure-track position at the rank of Assistant Professor in the Division of Biomedical Sciences to conduct cutting-edge research in the areas of cell and developmental biology, tissue regeneration, cell signaling, gene regulation, computational modeling and human diseases using genetic and genomic approaches. At the CCMB, these disciplines focus on craniofacial biology and there are significant resources to support all aspects of our research. The University of Southern California offers an exciting, and highly supportive environment to conduct collaborative basic, clinical, and translational research. At the health science campus, faculty members at CCMB have access to all research centers and graduate students in all programs.
Candidates must have a Ph.D. in developmental biology, stem cell biology, or molecular biology. Candidates with both a Ph.D. and either a D.D.S. or D.M.D. degree are encouraged to apply. Candidates must have a strong record of high-quality research with significant publications in their field. Candidates with K99/R00 or other independent support are strongly encouraged to apply. For more information: https://usccareers.usc.edu/job/los-angeles/assistant-professor-of-dentistry/1209/17867982
Consideration of applicants will begin immediately and will continue until the position is filled. USC is an equal-opportunity educator and employer, proudly pluralistic and firmly committed to providing equal opportunity for outstanding persons of every race, gender, creed, and background. The University particularly encourages women, members of underrepresented groups, veterans, and individuals with disabilities to apply. USC will make reasonable accommodations for qualified individuals with known disabilities unless doing so would result in an undue hardship. Further information is available by contacting uschr@usc.edu.
A postdoctoral position is available immediately in Yang Chai‘s laboratory at the Center for Craniofacial Molecular Biology, University of Southern California in Los Angeles, California. We are interested in the regulation of developmental patterning, organogenesis, and mesenchymal stem cells. Our studies will seek to define molecular mechanisms governing both normal and abnormal craniofacial development, providing scientific rationales for future therapeutic strategies to prevent and treat craniofacial birth defects, as well as stem cell based craniofacial tissue regeneration. The candidate must have a PhD and be experienced with molecular and developmental biology. Supported by the NIDCR, NIH. For details, please visit http://chailab.usc.edu/
Send application, resume, and three letters of recommendation to
Wen, Q., Jing, J., Han, X., Feng, J., Yuan, Y., Ma, Y., Chen, S., Ho, T.H., and Chai, Y. (2020) Runx2 regulates mouse tooth root development via activation of Wnt inhibitor Notum. JBMR,PMID 32569388.
Jing, J., Feng, J., Li, J., Han, X., He, J., Ho, T., Du, J., Zhou, X., Urata, M., and Chai, Y. (2019) Antagnistic interaction between Ezh2 and Arid1a coordinate dental root patterning via Cdkn2a. eLife, Jul 1;8. e46426.
Guo, Y., Yuan, Y., Wu, L., Ho, T., Jing, J., Sugii, H., Li, J., Han, X., Guo, C., and Chai, Y. (2018) BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Research. 6, 355-367. PMCID: PMC6193039
Li, J., Parada, C., and Chai, Y. (2017) Cellular and Molecular Regulatory Mechanism of Tooth Root Development. Development, 144, 374-384. PMCID: PMC5341797
Brinkley, J.F., Fisher, S., Harris, M., Holmes, G., Hooper, J.E., Wang Jabs, E., Jones, K.L., Kesselman, C., Klein, O.D., Maas, R.L., Marazita, M.L., Selleri, L., Spritz, R.A., van Bakel, H., Visel, A., Williams, T.J., Wysocka, J., the FaceBase Consortium, and Chai, Y. (2016) The FaceBase Consortium: A comprehensive resource for craniofacial researchers. Development, 143, 2677-2688.PMCID: PMC4958338.
Zhao, H., Feng, J., Ho, T. V., Grimes, W. C., Urata, M., and Chai, Y. (2015) The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nature Cell Biology, 17, 386-396. PMCID: PMC4380556
Zhao, H., Feng, J., Seidel, K., Shi, S., Klein, O., Sharpe, P., and Chai, Y. (2014) Secretion of Shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14, 160-173. PMCID:PMC3951379
In this episode we’re taking a look at the story and the characters behind one of the most transformative – and ubiquitous – techniques in modern molecular biology: the polymerase chain reaction.
Anyone who has worked with DNA in the laboratory is undoubtedly familiar with the polymerase chain reaction – PCR, as it’s usually known. Invented in 1985, PCR is an indispensable molecular biology tool that can replicate any stretch of DNA, copying it billions of times in a matter of hours, providing enough DNA to use in sequencing or further research, or for applications like forensics, genetic testing, ancient DNA analysis or medical diagnostics.
It’s hard to overstate the transformation that PCR brought to the world of molecular biology and biomedical research. Suddenly, researchers could amplify and study DNA in a way that had been simply impossible before, kickstarting the genetic revolution that’s still going strong today. But where did this revolutionary technology come from? Officially, PCR was invented in 1985 by a colourful character called Kary Mullis, who won a Nobel Prize for the discovery, but, as we’ll see, all the components of PCR were in place by the early 1980s – it just took a creative leap to assemble them into one blockbusting technique.
Image: Illustration depicting semi-conservative DNA replication. Three generations of DNA are shown. After separation of the DNA double helix, two new complementary DNA strands are synthesised (indicated by a new colour). Complementary base pairing and hydrogen bonding results in formation of a new double helix. Credit: Susan Lockhart. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
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A postdoctoral research position is available to study the cellular, genetic, and epigenetic mechanisms of maternal age effects on offspring health and lifespan. The project will focus on the role of mitochondrial dynamics and function in maternal age effects, using molecular, bioinformatic, biochemical, and imaging techniques.
This is an NIH-funded project in the laboratory of Dr. Kristin Gribble at the Marine Biological Laboratory, Woods Hole, MA. The lab researches the mechanisms and evolution of aging and maternal and transgenerational effects on offspring health. We use rotifers as a model system for our work. For more information about the lab’s research and publications, see mbl.edu/jbpc/gribble.
Applicants should possess a Ph.D. molecular biology, cell biology, biochemistry, genetics, bioinformatics, or a related field. The ideal candidate will have a record of scientific rigor, productivity, and creativity. Excellent oral and written communication skills are required. Knowledge of rotifer biology is not required; highly motivated individuals with experience in other model systems and with a background in bioinformatics, cell biology, biochemistry, epigenetics, and/or imaging are encouraged to apply. Salary commensurate with experience and qualifications.
Applicants must apply for this position via the Marine Biological Laboratory careers website. Please submit (1) a cover letter with a brief description of your research experience and how you will contribute to research on the mechanisms of maternal effects on offspring, (2) a CV, and (3) contact information for at least three references.
Development invites you to submit your latest research to our upcoming special issue: Imaging development, stem cells and regeneration.
Imaging-based approaches have long played a role in the field of developmental biology. However, recent technical advances now provide us with the ability to visualise cell and developmental processes at extraordinary resolution and in real-time. From progress in light sheet and super-resolution microscopy, to the development of tissue-clearing techniques and sophisticated image analysis platforms, we are now able to capture and quantitatively analyse the beauty and dynamics of development across different scales – from individual molecules and cells, to complete tissues and embryos. This Special Issue aims to showcase articles that, at their core, have applied such advanced techniques in innovative ways to further our understanding of developmental and regenerative processes. We also encourage the submission of articles that report the development or application of a novel imaging-based technique.
Prospective authors are welcome to send pre-submission enquiries to dev.specialissue@biologists.com. We also invite proposals for Review articles: if you are interested in contributing a Review, please send a summary of your proposed article to us by 15 December 2020.
The Special Issue will be published in mid-2021 (although note that, in our new continuous publication model, we will aim to publish your article as soon as it is accepted*). The issue will be widely promoted online and at key global conferences, guaranteeing maximum exposure for your work.
For information about article types and manuscript preparation, please refer to our author guidelines. To submit your article, visit our online submission system; please highlight in your cover letter that the submission is to be considered for this Special Issue.
The deadline for submitting articles is 30 March 2021.
Why choose Development?
Submissions handled by expert Academic Editors
Competitive decision speeds and rapid publication
Format-free submission
Strong commitment at first decision – over 95% of invited revisions accepted
Free to publish – no page or colour charges, no hidden fees
Easy one-click transfer option to Biology Open
Not-for-profit publisher
* Please note that not all articles accepted for publication will be included in the Special Issue; they may instead be published in earlier or later issues of the journal based on timing and editorial discretion.
Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1
Prasanna Kandel, Fatih Semerci, Aleksandar Bajic, Dodge Baluya, LiHua Ma, Kevin Chen, Austin Cao, Tipwarin Phongmekhin, Nick Matinyan, William Choi, Alba Jiménez-Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes-Prior, Kevin R. MacKenzie, Caroline L. Benn, Eva Estébanez-Perpiñá, Koen Venken, David D. Moore, Damian W. Young, Mirjana Maletic-Savatic
Cardiac Sex Differences are Established Prior to Gonad Formation
Wei Shi, Xinlei Sheng, Kerry M. Dorr, Josiah E. Hutton, Haley A. Davies, Tia D. Andrade, Todd M. Greco, Yutaka Hashimoto, Joel D. Federspiel, Zachary L. Robbe, Xuqi Chen, Arthur P. Arnold, Ileana M. Cristea, Frank L. Conlon
Olig3 acts as a master regulator of cerebellar development
Elijah D. Lowenstein, Aleksandra Rusanova, Jonas Stelzer, Marc Hernaiz-Llorens, Adrian E. Schroer, Ekaterina Epifanova, Francesca Bladt, Eser Göksu Isik, Shiqi Jia, Victor Tarabykin, Luis R. Hernandez-Miranda
Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential
Ge Guo, Giuliano Giuseppe Stirparo, Stanley Strawbridge, Daniel Spindlow, Jian Yang, James Clarke, Anish Dattani, Ayaka Yanagida, Meng Amy Li, Sam Myers, Buse Nurten Özel, Jennifer Nichols, Austin Smith
A Library of Induced Pluripotent Stem Cells from Clinically Well-Characterized, Diverse Healthy Human Individuals
Christoph Schaniel, Priyanka Dhanan, Bin Hu, Yuguang Xiong, Teeya Raghunandan, David M. Gonzalez, Sunita L. D’Souza, Arjun Yadaw, Jens Hansen, Gomathi Jayaraman, Bino Mathew, Moara Machado, Seth Berger, Joseph Tripodi, Vesna Najfeld, Jalaj Garg, Marc Miller, Colleen Lynch, Katherine Michelis, Neelima Tangirala, Himali Weerahandi, David C. Thomas, Robert Sebra, Milind Mahajan, Eric Schadt, Dusica Vidovic, Stephan C Schürer, Joseph Goldfarb, Evren U. Azeloglu, Marc R. Birtwistle, Eric A. Sobie, Jason C. Kovacic, Nicole C. Dubois, Ravi Iyengar
Cathepsin K maintains the number of lymphocytes in vivo
Renate Hausinger, Marianne Hackl, Ana Jardon-Alvarez, Miriam Kehr, Sandra Romero Marquez, Franziska Hettler, Christian Kehr, Sandra Grziwok, Christina Schreck, Christian Peschel, Rouzanna Istvanffy, Robert A.J. Oostendorp
Early Stem Cell Aging in the Mature Brain
Albina Ibrayeva, Maxwell Bay, Elbert Pu, David Jörg, Lei Peng, Heechul Jun, Naibo Zhang, Daniel Aaron, Congrui Lin, Galen Resler, Axel Hidalgo, Mi-Hyeon Jang, Benjamin D. Simons, Michael A. Bonaguidi
Cell size is a determinant of stem cell potential during aging
Jette Lengefeld, Chia-Wei Cheng, Pema Maretich, Melanie R. McReynolds, Marguerite Blair, Hannah Hagen, Emily J Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim Steiner, Teemu P Miettinen, Scott Manalis, Adam Antebi, Jacqueline Lees, Laurie Boyer, Omer H. Yilmaz, Angelika Amon
Endogenous Galectin-3 is Required for Skeletal Muscle Repair
Daniel Giuliano Cerri, Lilian Cataldi Rodrigues, Vani Maria Alves, Juliano Machado, Víctor Alexandre Félix Bastos, Isis do Carmo Kettelhut, Luciane Carla Alberici, Sean R. Stowell, Maria Cristina R. Costa, Richard D. Cummings, Marcelo Dias-Baruffi
A CRISPR-Cas9–engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions
Miguel Rodríguez de los Santos, Marion Rivalan, Friederike S. David, Alexander Stumpf, Julika Pitsch, Despina Tsortouktzidis, Laura Moreno Velasquez, Anne Voigt, Karl Schilling, Daniele Mattei, Melissa Long, Guido Vogt, Alexej Knaus, Björn Fischer-Zirnsak, Lars Wittler, Bernd Timmermann, Peter N. Robinson, Denise Horn, Stefan Mundlos, Uwe Kornak, Albert J. Becker, Dietmar Schmitz, York Winter, Peter M. Krawitz
Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia
Marja Koskuvi, Šárka Lehtonen, Kalevi Trontti, Meike Keuters, Ying Chieh Wu, Hennariikka Koivisto, Anastasia Ludwig, Lidiia Plotnikova, Pekka L. J. Virtanen, Noora Räsänen, Satu Kaipainen, Ida Hyötyläinen, Hiramani Dhungana, Raisa Giniatullina, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Markku Lähteenvuo, Jussi Tohka, Rashid Giniatullin, Claudio Rivera, Iiris Hovatta, Heikki Tanila, Jari Tiihonen, Jari Koistinaho
A comprehensive overview of computational tools for RNA-seq analysis
Dhrithi Deshpande, Karishma Chhugani, Yutong Chang, Aaron Karlsberg, Caitlin Loeffler, Jinyang Zhang, Agata Muszynska, Jeremy Rotman, Laura Tao, Lana S. Martin, Brunilda Balliu, Elizabeth Tseng, Eleazar Eskin, Fangqing Zhao, Pejman Mohammadi, Pawel P Labaj, Serghei Mangul
Comparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature
Clarissa F. D. Carneiro, Victor G. S. Queiroz, Thiago C. Moulin, Carlos A. M. Carvalho, Clarissa B. Haas, Danielle Rayêe, David E. Henshall, Evandro A. De-Souza, Felippe E. Amorim, Flávia Z. Boos, Gerson D. Guercio, Igor R. Costa, Karina L. Hajdu, Lieve van Egmond, Martin Modrák, Pedro B. Tan, Richard J. Abdill, Steven J. Burgess, Sylvia F. S. Guerra, Vanessa T. Bortoluzzi, Olavo B. Amaral
The study of regenerative biology aims to elucidate the innate ability of organisms to repair tissues or organs after they have been removed or damaged. During vertebrate regeneration, tissue damage causes the immediate release of signals that initiate wound closure and initiate regeneration. This project uses larval zebrafish to study how cells respond to when the epithelia is damaged. Zebrafish repair wounds quickly and efficiently, and their small size and transparency allow us to follow cell behaviour easily. Our previous research found that there are very surprising movements of cells over the first few hours after damage, and this current project aims to understand the forces involved in these movements and the signals that orchestrate the wound response. We plan to image fluorescently labelled cells over time to give positional data across the fish using a custom built lightsheet microscope. Data sets will be analysed using physical and computational modelling to calculate passive and active forces such as compression, stretching, shear and friction. Once a physical model of whole animal cell movement is established we will interrogate our predictions by manipulating known early wound signals.
Funding Notes
White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting October 2021:
• Research Council Stipend (estimated £15,600 per year)
• Tuition Fees at the UK fee rate (£4,473 per year)
• Research support and training grant (RTSG)
Please note: international tuition fees for 2021 entry are £23,750
To Apply:
Informal inquiries: h.roehl@sheffield.ac.uk
The deadline for applications will be the 10th January 2021 with selection of final candidates for interview shortly after.
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In this episode we’re taking a look at the story and the characters behind one of the most transformative – and ubiquitous – techniques in modern molecular biology: the polymerase chain reaction.
