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EMBO Workshop. Frontiers in Sensory Development, Barcelona, Spain

Posted by , on 2 February 2011

by MorBCN Flickr creative commons

Barcelona is the setting for the EMBO Workshop, Frontiers in Sensory Development from 3rd-6th May, 2011. The meeting will focus on different aspects of sensory development, function and evolution in both vertebrate and invertebrate systems. We hope this workshop will allow a better understanding of common themes in sensory function and will encourage colleagues working in different systems to exchange and discuss ideas and techniques. The schedule will feature invited talks, selected oral talks, poster sessions, and many opportunities to socialize in Barcelona.

The meeting will take place in at the PRBB Institute, located on the seafront of the Mediterranean Sea.

To register visit here (abstract submission is soon)

The flyer can be downloaded here

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The (re)birth of the DSDB

Posted by , on 1 February 2011

As the world of research into developmental biology becomes larger, and the arrival of online communities such as The Node allows us to bring that world a little closer to hand, the importance of using scientific communities to share expertise and experience only grows.   Therefore, here in the Netherlands we are pleased to announce that a little over a week ago the Hubrecht Institute in Utrecht hosted the inaugural meeting of the recently reformed Dutch Society for Developmental Biology (DSDB).

Upon coming to the Netherlands as a postdoc over a year ago, I was a little surprised there was no active developmental biology society or community in place, particularly considering that research which was being conducted in the Netherlands in the early 1900’s was one of the early initiatives for the founding of the first Society for Developmental biology (more about the new society later, first it’s time for a brief trip through history…).

Born in 1853, Ambrosius Hubrecht (for whom the modern Hubrecht Institute is named) was Professor of Zoology at Utrecht University.  He amassed a vast collection of embryological material, and his fascination for Darwin’s evolutionary theory led him into correspondence with Darwin himself.  In 1911, Hubrecht founded the ‘Institut Internationale d’Embryologie’ (IIE), a selective society of embryologists who would meet and discuss aspects of comparative embryology.  The home of the IIE, where meetings would take place, was Hubrecht’s private home in the centre of Utrecht.

A year after Hubrecht’s death in 1915, it was decided to establish the first Hubrecht Laboratory at Hubrecht’s house in Utrecht, and Daniel de Lange became the first director, leading the IIE, and  continuing to organise small international meetings between 1930 and 1938.  At this time, the IIE existed to serve the scientific needs of others, in the field of descriptive comparative embryology.
Concurrently, the field of experimental embryology was making great strides, and in 1968 the IIE renamed itself as the International Society of Developmental Biologists (ISDB), retaining its function as a discussion forum, and keeping its headquarters at the Hubrecht Laboratory

In Europe, and for some time, the functions of the ISDB were assumed in parallel by the European Developmental Biology Organisation (EDBO), grouping together the European national societies of Developmental Biology. At the time this included the Dutch NVOB (Netherlands Society for Developmental Biology). In 1997 the ISDB took over all EDBO functions, and became the world umbrella of national societies of developmental biology.  At this point, the NVOB lost its momentum (but was never officially dissolved), while the ISDB has continued to increase its affiliated members, as the international development community continues to grow.

Therefore, the large community of developmental biologists we belong to came about in part through the activities of a similar society formed here in the Netherlands 100 years ago.  It seemed a shame that a country with a rich history in developmental biology research and with much exciting research still taking place here, had lost its roots somewhat.  After an initial meeting of interested scientists in the summer last year, the DSDB/NVOB has been reborn.

The first meeting was a 1 day event, with 15 speakers (mostly PI’s from within the Netherlands) covering topics including axis patterning, developmental clocks, cell migration, organogenesis, hematopoiesis, plant growth and flowering and small RNAs .  The full program can be found on the DSDB website.  Discussion afterwards yielded the conclusion that the day had been a great success, and that there is definitely the need and enthusiasm for the resurrection of such a community in the Netherlands.

This initial meeting served to familiarise all developmental groups in the Netherlands with the research topics that are the main point of focus in different labs. In future years I would like to see the expansion of the meeting, hopefully so that it can also provide a forum for younger scientists to showcase their own work.  The mission statement of the society is to serve as a forum for developmental biologists in the Netherlands and, through the ISDB, throughout the world.  It should facilitate the sharing of conceptual and technical expertise within our field, and allow us to share research output and stimulate discussions through yearly meetings.  And of course, it will function as a national training network for young scientists. Certainly, as a young postdoc coming from a very interactive developmental biology community in England, my hope is that this society will grow and will once more flourish as a resource for developmental biologists in the Netherlands.  There is a website (it’s running but still rather under construction) for the new society, which can be found at www.nedvob.nl

The committee members for the new DSDB are:

Secretary: Dies Meijer (ErasmusMC, Rotterdam)

Treasurer: Rik Korswagen, (Hubrecht Institute, Utrecht)

President: Jacqueline Deschamps (Hubrecht Institute and UMC, Utrecht)

(Meeting co-organisers – Ben Scheres, Jeroen Bakkers, Susana Lopes and Derk ten Berge)

Membership to the society is now open, and membership enquiries can be directed to Rik Korswagen.

Many thanks to the organisers for getting the society up and running again, and to the NWO for financial support in organising the first meeting.  Also many thanks also to Jacqueline for a digested history of Dutch Dev Bio.



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How to stay in contact with the French Community of Developmental Biologists?

Posted by , on 1 February 2011

I remember when I was a post doc abroad. Science was great, life in a foreign country was very nice, but there was one huge drawback for a French in exile: how to stay in contact with research in France (or any country…), especially when you are a newcomer in the developmental biology field?

One answer is to be a (active) member of the society for developmental biology of your country. In France, the SFBD exists for many years now (see Margaret Buckingham’s interview on the Node…).  We diffuse to our members, informations concerning the community of the French developmental biologists (see our website and our monthly newsletter in french and in english). We also organize an annual meeting (september this year, in Nice with the BSDB). This meeting is a great opportunity for post docs or post doc candidates wishing to reach the community of developmental biologists in France. Another good reason to be a SFBD member is that there is a discount registration fee for members…

It is time to register to the SFBD or to renew your SFBD membership (sorry, we are still working on the online payment…).

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Conference Announcement: Chick meeting

Posted by , on 1 February 2011

A pensive chick

The 4th international chick meeting will be held in Sendai, Northern Japan, from August 29th to September 2nd, 2011. The meeting aims to build on previous meetings consolidating the links between the different disciplines within the bird community, exploring new frontiers in avian research and developing key community resources. The program is still being finalized, but session topics are listed on the website, and we are really happy that the plenary lecturers have all accepted. Despite the packed schedule, there will be plenty of chances for informal interactions, and break-out meeting. You can download the poster here.

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News roundup

Posted by , on 31 January 2011

Just a quick roundup of some interesting bits of news.

Embryo research in France
This one’s rather interesting to read together with the interview with Margaret Buckingham we posted last week. France has very strict regulations in place for research on embryos or ESCs. Now, Nature reports that researchers in France are urging their government to authorize ESC/embryo research.
(This will be an interesting story to follow. If you’re in France, are you affected by this regulation? If so, would you like to write about it on the Node? Get in touch if you’d like to keep your colleagues around the world in the loop.)

EMBO installation grants
In December, EMBO announced that they’ve awarded Installation Grants to six researchers, allowing them to set up research groups in the Czech Republic, Poland, Portugal and Turkey. Many of the recipients are working, or have worked, in areas related to developmental biology: Szymon Świeżewski and Tomasz Wilanowski set up labs in Poland to study ncRNA-based gene regulation and Grainyhead-like transcription factors respectively. Alena Krejčí is starting a group in the Czech Republic to study Notch signalling in cellular metabolism, after a postdoc with Sarah Bray in Cambridge, and Cory Dunn moved to Turkey to work on mitochondrial DNA damage after a postdoc with Iva Greenwald at Columbia.

Research Blogging
We found a nice blog post about a Development paper on the Sanford-Burnham blog, with interviews with the authors. It’s also listed on Research Blogging – a site that indexes blog posts about peer reviewed research.
If you search for “developmental biology” on Research Blogging, you’ll find a few familiar posts, as we use this on the Node as well. We love to hear your stories behind papers (in any journal), and if you don’t have your own (or institutional) blog, you’re more than welcome to use the Node to show off your work.

Heard any other news that the Node should cover? Please sign up and post it yourself, to prevent delays

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Blogging the Flood at the University of Queensland

Posted by , on 30 January 2011

On January 12th, about three quarters of the Australian State of Queensland was flooded as local rivers and creeks overflowed from rainfall. Needless to say, it’s been an extremely wet summer. One victim was the University of Queensland, which still stands next to the Brisbane River, the cause of the city of Brisbane’s troubles. Flood waters receded on January 14th.

To clarify, I’m not in Brisbane’s University of Queensland, but many other students are.  A few thousand in fact.To keep everyone in the loop, UQ students have a blog on the University’s website. the latest post from January 13th comes just after the flood reached record highs on their St. Lucia campus (they have several other campuses in other areas). It’s aim was to be informative to students on and off campus. Details include which buildings were affected, university closure dates, who to call if you need counselling etc. Rest assured, no biological buildings were harmed in the flooding.

In a quote from the chancellor, water levels reached those of recording breaking 1974. In the university news website, Brisbane has only experienced massive flooding 2x in its history, once in 1893, the other in 1974. It can now add 2011 to the short list.

(Tad jealous, if only the ANU had a student run blog too. On the other hand, happy to be missing out on the excitement up at UQ.)

UQ also keeps a Flickr photostream, with images of the recent flooding and clean-up. Click here

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An interview with Margaret Buckingham: President of the French Society of Developmental Biology

Posted by , on 27 January 2011

(This interview originally appeared in Development)

Margaret Buckingham is Professor in the Department of Developmental Biology at the Pasteur Institute in Paris and she is also the current President of the French Society of Developmental Biology (Société Française de Biologie du Développement, SFBD). We spoke with her about the role of the SFBD and about ongoing changes in the French research system.

What is your laboratory currently working on?

We work on skeletal myogenesis and cardiogenesis. The skeletal myogenesis research involves studying gene regulatory networks that govern cell fate choices and the entry into the myogenic programme in the embryo, as well as satellite cell behaviour during muscle regeneration in the adult. For cardiogenesis, work involves examining the second heart field and lineages that contribute to different parts of the heart. We’re also interested in cardiac morphogenesis, and how the chambers of the heart are shaped as development proceeds.

How long have you been President of the SFBD?

I’ve been President since 2006; the term is for 3 years, renewable once, so that after 6 years somebody else should take over.

How old is the society?

There was originally a much older society in France called the Société de Biologie, that was founded in the 19th century and still continues today. The actual French developmental biology society was set up in the 1980s.

What does the SFBD do for its members?

One of our main activities is the annual meeting, which is very important and which brings together all of the developmental biology community in France. We very often hold that annual meeting as a joint meeting with another developmental biology society. For example, next year our annual meeting will be in Nice with the British Society for Developmental Biology, this year it was in Paris with the Japanese society, last year it was in Toulouse with the Spanish society. So this is tradition.

We also have smaller meetings like one with the French Genetics Society on microRNAs in plant and animal development in December 2010.

(more…)

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Ernest McCulloch 1926-2011

Posted by , on 27 January 2011

Last week (January 19), stem cell pioneer Ernest McCulloch died at the age of 84. Together with James Till, McCulloch discovered stem cells in the 1960s. For their work, the pair won the Gairdner Award in 1969 and the Lasker Award in 2005. McCulloch was professor emeritus of the University of Toronto and former Director at the Ontario Cancer Institute at the Princess Margaret Hospital in Toronto. See the news article on UofT’s website for more information.

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In Development this week (Vol. 138, Issue 4)

Posted by , on 26 January 2011

Here are the research highlights from the current issue of Development:

New moves in haematopoiesis: rumba and samba

Vertebrate haematopoiesis relies on a pool of haemetopoietic stem/progenitor cells (HSPCs) that can self-renew and differentiate into all haematopoietic lineages. But what are the molecular mechanisms that regulate this process? Here, Zilong Wen and co-workers (p. 619) identify two novel factors that regulate zebrafish HSPC maintenance. During zebrafish development, HSPCs originate from the ventral wall of the dorsal aorta (VDA), migrate to the caudal haematopoietic tissue (CHT) and finally colonise the kidney. The researchers isolated and characterised two haematopoiesis-deficient mutants, rumbahkz1 and sambahkz2. In these mutants, HSPC specification in the VDA and subsequent homing to the CHT are normal, but further HSPC development within the CHT is compromised. Using positional cloning, they show that Rumba is a novel nuclear C2H2 zinc-finger protein and that samba encodes a protein that is homologous to human augmin complex subunit 3 (Haus3). Both factors, they report, act independently and cell-autonomously to regulate cell cycle progression in HSPCs, and thus are essential regulators of zebrafish haematopoiesis.

Pancreatic Hh signalling: a play in two acts

In amniotes, inhibition of hedgehog (Hh) signalling in the early embryonic endoderm is a prerequisite for pancreatic specification. By contrast, loss of Hh signalling in zebrafish severely disrupts pancreas development, suggesting opposite roles for Hh signalling in fish versus mammalian pancreas organogenesis. Zahra Tehrani and Shuo Lin (p. 631) now reconcile these contrasting functions by showing that the Hh pathway plays distinct roles during various stages of zebrafish pancreas development. Using genetic and pharmacological approaches to temporally modulate Hh activity, they show that Hh activity during early gastrulation is essential for the subsequent migration and differentiation of pancreatic precursors. This positive role of Hh acts to restrict Bmp signalling and to promote β-cell differentiation. By the end of gastrulation, they report, Hh signalling adopts a negative role by antagonizing retinoic acid (RA)-mediated induction of endocrine pancreatic precursors. These findings highlight sequential roles for Hh signalling in pancreas development and uncover antagonistic relationships between the Hh, Bmp and RA pathways during pancreas organogenesis.

Sox9+ progenitors make β-cells in embryo but not in adult

All pancreatic cell types, including insulin-producing β-cells, arise from pancreatic progenitors during embryonic development, but whether the adult pancreas contains β-cell progenitors remains a controversial issue. Using fate-mapping studies in mice, Maike Sander and colleagues (p. 653) now demonstrate that cells positive for Sox9 give rise to β-cells during embryogenesis, but not in the normal or injured adult pancreas. They generated Sox9CreERT2 mice in which Sox9-expressing cells can be accurately and temporally labelled. Lineage tracing shows that these cells can generate all pancreatic lineages during embryogenesis. By contrast, they report, endocrine and acinar cell neogenesis from Sox9-positive cells does not occur in the adult pancreas. Using partial duct ligation (PDL) to induce pancreatic injury, they also show that Sox9-positive cells do not generate β-cells following injury; PDL initiates pre-endocrine programs but not complete β-cell differentiation. Given the increasing use of PDL as a model to study β-cell regeneration, these studies provide important insights into the specification and regeneration of β-cells.

The first author of this paper has also written a post about these exciting discoveries.

engrailed links Hh and Bmp muscle development signals

Myotome morphogenesis requires the specification of distinct muscle cell types. In zebrafish, the specification of medial fast-twitch fibres (MFFs) and slow-twitch muscle pioneers (MPs), both of which express engrailed (eng) genes, is regulated by hedgehog (Hh) signalling but the mechanistic basis of this regulation is unclear. On p. 755, Philip Ingham and co-workers demonstrate that the eng2a promoter integrates repressive and activating signals from the Bmp and Hh pathways, respectively, to limit its expression to MFFs and MPs during zebrafish myotome development. The researchers identified a minimal element in the eng2a promoter that can drive reporter gene expression specifically in MFFs and MPs. This element binds both Gli2, a mediator of Hh signalling, and activated Smads, mediators of Bmp signalling. They demonstrate that Hh activity antagonises Smad activation in myotomal cells and, conversely, that aberrant Smad activation suppresses eng2a expression. Their studies identify novel crosstalk between the Hh and Bmp pathways that may be mediated by direct interactions between Gli and Smad proteins.

Non-embryonic Nodals orchestrate early development

Vertebrate development and patterning require Nodal signalling. However, the upstream inducers of Nodal expression and the relative contributions of Nodal ligands from embryonic, extraembryonic and maternal sources to embryogenesis are unclear. Now, Benjamin Feldman and co-workers show that non-embryonic sources of Nodal-related ligands, activated in part by the transcription factor Mxtx2, account for the spectrum of zebrafish early Nodal signalling events (p. 787). They report that Mxtx2 activates and is required for the expression of nodal-related 2 (ndr2) in the yolk syncytial layer, an extraembryonic tissue, thus identifying a novel upstream component of Nodal signalling. They further demonstrate that the co-disruption of extraembryonic ndr2, extraembryonic nodal-related 1 (ndr1) and maternal ndr1 recapitulates Nodal mutant phenotypes: embryos show a loss of endoderm and anterior mesoderm specification. Based on their findings, the authors propose that endoderm and anterior mesoderm specification during zebrafish development is executed by a failsafe mechanism involving the combined action of non-embryonic Nodal-related ligands, and that this mechanism may be relevant to higher vertebrates.

Plus…

Technical advances, together with increasing collaborations between experimentalists and theorists, have highlighted the importance of stochasticity in cell and developmental biology. As reviewed by Andy Oates, this was explored in detail at the Company of Biologists’ recent workshop in Windsor, UK. See the Meeting Review on p. 601

Also see the earlier post by Fernando Casares about this meeting

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A career in publishing: a developing story

Posted by , on 25 January 2011

In a follow up to Eva’s first post in our alternative careers series about how a research background in developmental biology can lead to a career path that lies outside of research, I hope that my description here of how I made the move from a PhD in developmental genetics to a career in publishing will be of use to anyone else out there in the community who is considering making a similar move.

My journey in science began with an undergraduate degree, not in genetics, but in pharmacology at King’s College, London, where the most important thing I learned was that I was much more interested in genetics and development than I was in pharmacology, interests that led me to a PhD with Ian Jackson and Cathy Abbott at the MRC Human Genetics Unit in Edinburgh. From there, I became a post doc in Val Wilson’s lab.

At the time of my PhD, Ian was a regular contributor to the journal club section of Trends in Genetics, and when short on time, he would ask me to write these brief pieces on a paper of interest in his place. I came to enjoy this writing exercise and, as a result of it, was offered other writing opportunities, such as summarizing new mouse knockout phenotypes for a knock out database then under development at BioMedCentral. (In fact, one of the journals I had to check every month for new knock out papers was Development.)

As my fondness for writing grew, another opportunity arose towards the end of my PhD that helped me to choose between the different career paths I was starting to consider: research, science journalism, or a job in science publishing. This opportunity took the form of a Media Fellowship from the British Science Association. These fellowships place British scientists with a media organisation for a couple of months, where they learn to work within the constraints of the media to produce interesting stories about science. I was placed with the Guardian, a national daily newspaper in the UK, where I spent several weeks under the tutelage of Tim Radford,  who was its science editor at the time. Under the guidance of Tim’s red pen, I wrote science-related stories covering a wide range of topics, from archaeological discoveries (see picture), to cancer, and even about why Mozart had such a foul tongue (he had Tourette’s, so the story went). I also had many a story ‘spiked’ by the news desk editor, when it failed to pass the “so what?’ barrier that most science-related stories have to pass. This experience taught me several important things: how to write concisely and engagingly about science; about the constraints that journalists work under; and about the importance of scientists learning to communicate clearly and succinctly with the media about their work. But it also left me a little disheartened about the difficulties of getting good science stories covered, even by a reputable newspaper such as the Guardian, when they have to compete for space with stories about politics, crime and celebrity gossip, all of which have a more tangible ‘human interest’ angle for most news desk editors.

As a BSA media fellow, you write about whatever story is sent your way

As a result, I returned to the lab knowing that a career in science journalism was probably not for me while suspecting that my scientific interests were too broad to remain in research. But first I needed to give research a proper chance because to leave it felt like an irreversible decision not to be taken lightly. I have never regretted my time as a post doc; I learned much about embryology from Val, which has stood me in good stead to this day. My postdoc also broadened my scientific horizons and contacts, while giving me time to learn more about career options in publishing.

In time, I successfully applied for the job of assistant editor at Trends in Molecular Medicine (TMM), having heard good things about the Trends journals while writing for them as a student. I joined the office in Cambridge, which became a training ground for a generation of British editors, many of whom still work in publishing today. From feedback on my application, it became clear that I was offered this post because my CV showed that I was demonstrably interested in writing and in science communication; skills that complemented my role on TMM, where I assisted with developmentally editing reviews and was responsible for copyediting the content of the journal, while occasionally writing news stories for its front section and being dispatched to do live conference reporting for BioMedNet. It was a great first job in publishing, but not, as I subsequently discovered, what I really wanted to be, which was a commissioning editor. And so within a year of being recruited to TMM, I successfully applied for the role of Editor of Trends in Genetics, where I began to learn properly, for the first time, the job of a commissioning editor.

I have at heart been a commissioning editor ever since. In science publishing, a commissioning editor’s job is to determine the content of a journal, book or journal section and then to invite people – such as scientists, science writers and commentators, to write for their publication. The commissioning part of the job requires an editor to travel widely to conferences and to keep in close contact with their field, so that they can identify the topics that are the hottest and most interesting to commission articles on. The editorial part of the job comes in developmentally editing articles to improve their focus, structure, scientific content and accessibility and in making editorial decisions about whether a manuscript should be revised, accepted or rejected in response to the reviewers’ and your own editorial assessment of it.

My own experience as a commissioning reviews editor was further strengthened when I moved from Trends in Genetics to Nature Reviews Genetics,where I joined Mark Patterson and Tanita Casci to launch NRG as one of the first Nature Reviews journals. Launching NRG was a hugely exciting project that taught me not only a fantastic amount about genetics from working with Mark and Tanita and our many great authors, but also how to launch a journal from scratch. When Mark stood down as Editor in Chief of NRG, I successfully applied for this role and from this position moved to Development: my first experience at managing a primary research (and not-for-profit) journal.

My signed copy of the launch issue of NRG

As Executive Editor of Development, I wear many hats: I manage the in house journal team, and commission and handle reviews and other front section articles, together with Seema Grewal, the journal’s associate reviews editor. I also work closely with Development’s Editor in Chief, first Jim Smith and now Olivier Pourquie, and our team of dedicated scientific editors in handling papers and author queries, and in developing the journal editorially. I am also responsible for the journal’s online presence. And in response to a Development readers’ survey in 2009, I kick started another new and exciting launch project that, once we had Eva on board, came to fruition as this: the Node, which I had the honour of naming.

Being a managing and commissioning editor is a highly interesting and rewarding role. As an editor, you learn about new scientific findings every day and have to assimilate a lot of new information quickly, and you work within a wider community, building sometimes long-standing relationships with researchers, authors and reviewers. I’m particularly fortunate in having the developmental community to work with, a community I’ve found to be tremendously collegial. And, occasionally, I’m asked to do other fun things, such as speaking at meetings about publishing and interviewing speakers at the CSHL symposia.

Getting that first foothold in publishing is by far the hardest, most competitive step of all. I was successful in making this initial move by being able to demonstrate my enthusiasm for writing about and communicating science, and by having gained experience while still in research that significantly strengthened my application for my first editorial job. Other Editors, particularly primary manuscript editors who mainly handle research papers, may  have taken different paths from research to publishing, and it’s our hope that they will also share those different career paths and their experience with you here on the Node.

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