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Applying tandem timers to measure signalling and gene expression dynamics in developing embryos

Posted by on January 11th, 2016

The signalling systems that conduct the orchestra of embryonic development are fantastically complex and dynamic. We owe much of our knowledge of in vivo signalling dynamics to advances in microscopy and protein tagging with fluorescent reporters that have allowed visualization of signalling proteins. Looking forward, however, it is clear that simply analyzing the localization patterns[…]

AI tackles variability of metastatic conversion triggered by bioelectric disregulation

Posted by on November 7th, 2015

  One of the most important problems in experimental biology has to do with variability / heterogeneity (Rubin, 1990): why do different organisms react differently to the same perturbation or reagent? This is observed even among clonal populations (e.g., cohorts of planarian flatworms descended from the fission of 1 animal and living in the same[…]

Computing the worm: artificial intelligence approaches to planarian regeneration and beyond

Posted by on October 30th, 2015

Pattern formation and regulation emerges from cellular activity determined by specific biophysical and genetic rules. A major challenge for developmental biology, biomedicine, and synthetic bioengineering is this highly indirect (Lobo et al., 2014b) relationship between the rules that govern processes at the lower scales, and the anatomical outcomes observed at the macroscopic scale. It is[…]

2016 Workshop – Tissue mechanics in morphogenesis: Focus on theoretical modeling – May 9-13, 2016, Paris

Posted by on October 9th, 2015

We are happy to announce the forthcoming workshop on « Tissue mechanics in morphogenesis: Focus on theoretical modeling ». This is an informal workshop open to anyone, theorist or experimentalist, who is developing or is using theoretical models to understand tissue mechanics during morphogenesis. How tissues acquire and maintain their shape is a crucial question[…]

EmbryoMaker: a general modeling framework to simulate developing systems and perform experiments in silico.

Posted by on October 4th, 2015

One of the main challenges of Developmental Biology is to understand the complex developmental mechanisms giving rise to different organs or whole organisms. In most cases, these involve the interplay between cell-cell signalling and cell and tissue movements driven by one or several cell behaviours (such as cell proliferation, cell migration, etc.). Cell signalling will[…]

“Eppur (non) si muove”: why cellular movements may not be essential to the formation of Turing patterns in biology.

Posted by on September 23rd, 2015

D. Bullara* and Y. De Decker *domenico.bullara@mail.com   When Catarina Vicente (Community Manager of “The Node”) proposed us to write a post about our recent paper on pattern formation in zebrafish [Bullara2015] we were very glad for the opportunity she was giving us to tell the background story about our work in this blog. We[…]

An interview with Lewis Wolpert

Posted by on August 4th, 2015

This interview first featured in Development.   Lewis Wolpert is a retired developmental biologist who, over his long career, has made many important contributions to the field, from his French Flag model and the concept of positional information to the famous quote that it is “not birth, marriage or death, but gastrulation which is truly the[…]

Question of the month- interdisciplinary research

Posted by on July 29th, 2015

Developmental biology is becoming increasingly interdisciplinary, as biologists team up with physicists and mathematicians to address new and classical problems in the field from a new perspective. But should we all be pursuing such an approach or is there still room for ‘pure’ developmental biology approaches? Should we incorporate more physics/mathematics modules in the training of[…]

Group Leader Positions in Quantitative Biology and Modeling at Institut Pasteur

Posted by on November 13th, 2014

The Institut Pasteur (Paris, France) announces an international call for group leader positions in the field of quantitative biology and modeling in developmental systems. Successful applicants will be integrated into the cutting edge interdisciplinary environment offered by an internationally renowned institute combining fundamental and translational research, in an attractive location in central Paris, in close[…]

Crossing fields- EMBO conference on interdisciplinary plant development

Posted by on October 8th, 2014

There is something exciting about biologists joining forces with physicists and/or mathematicians, and finding a common language to solve biological problems that are just too complex to understand without stepping outside the realm of ‘traditional’ biology. At the recent EMBO conference on plant development, interdisciplinary studies were the main focus. And as the organiser of[…]