The Section of Developmental Biology at the University of Colorado School of Medicine, with support from the Gates Frontiers Fund, is inviting applications for our Postdoctoral Training Program. Member labs in the program use diverse model systems to address a broad range of questions in the areas of Developmental Biology, Disease Modeling and Regenerative Medicine:

Bruce Appel, PhD, Professor and Diane G. Wallach Chair of Pediatric Stem Cell Biology; website: https://www.appellab.com

We investigate genetic, cellular and molecular mechanisms of neural development using zebrafish as a model system. In particular, we investigate how neural progenitor cells are specified for neuronal and glial cell fates and mechanisms that regulate myelin plasticity in response to brain activity.

• Ravanelli AM, and Appel, B. Genes & Development 29:2504-2515. PMCID: PMC4691953.
• Hughes, A. N. and Appel, B.bioRxiv 410969; doi: https://doi.org/10.1101/410969. Nature Communications (in press)

Emily Bates, PhD, Assistant Professor

The Bates lab uses human, mouse, and fly genetics to understand how cells coordinate to develop into complex structures like the human brain and face or a fly wing. Specifically, we are trying to understand how ion channels contribute to developmental signaling and how the cytoskeleton is regulated to build a brain.

• Dahal, GR, S. Pradhan, EA Bates. Development 2017 144:2771-2783. Doi:10.1242/dev146647. PMID: 28684627
• Belus, Matthew, Madison Rogers, Alladdin Elzubier, Josey, Megan, Rose, Steven, Bates, EA. Developmental BiologyDOI:10.1016/j.ydbio. PMID: 29571612
• Aiken, Jayne, Moore, J, Bates, EA. Human Molecular Genetics2018 doi:10.1093/hmg/ddy416. PMID: 30517687

Alexa Burger, PhD, Research Associate Professor

We use the zebrafish as our main model to understand the causes of congenital diseases affecting mesodermal organs. Our work combines gene-regulatory element discovery, genotype-phenotype association studies, and novel zebrafish-based models for pediatric diseases. We further develop new approaches for genome editing in zebrafish and beyond.

• D’Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A; Dis Model Mech. 2019 Jul 16;12(7). PMID: 31221659
• Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C. Development. 2016 Jun 1;143(11):2025-37. PMID: 27130213
• Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C, Robinson MD. Nat Biotechnol. 2016 Jul 12;34(7):701-2. PMID: 27404876

Peter Dempsey, PhD, Associate Professor

The Dempsey lab studies the development and function of epithelial cells in gastrointestinal tract during normal physiology and disease. In particular, we are interested in how extracellular signals regulate intestinal homeostasis and the role of cellular plasticity during intestinal regeneration and in colitis-associated cancer. We use genetically engineered mouse models and both adult and iPS-derived intestinal stem cell enteroid cultures to study these events.

• Jones JC, Brindley CD, Elder NH, Myers MG Jr, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ. Cell Mol Gastroenterol Hepatol. 2019;7(3):533-554
• Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ. Mol Cell Biol. 2015 Nov;35(21):3604-21.
• Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. Gastroenterology. 2014 Oct;147(4):822-834.

Caleb Doll, PhD, Research Assistant Professor

We study developmental myelination in zebrafish larvae, with focus on the mechanisms underlying local production of proteins in nascent myelin sheaths. We use cell type specific methods to visualize and manipulate RNA binding proteins and associated mRNA targets during oligodendrocyte development.

• Doll, C, Yergert, K, Appel, B. bioRxiv; doi: 10.1101/669895
• Doll, C,Vita, D, Broadie, K. Current Biology 27, 1–13;2017 Aug 7; https://doi.org/10.1016/j.cub.2017.06.046

Santos Franco, PhD, Assistant Professor and Boettcher Investigator; website:www.francolabcu.org

The Franco Lab uses mouse models to study several aspects of brain development. We are particularly interested in understanding early brain patterning, cell fate specification of neural stem cells, neuronal migration, dendrite formation and synaptogenesis.

• Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ. (2018) J Neurosci. Jun 6;38(23):5237-5250. PMID: 29739868
  • Fregoso SP, Dwyer BE, Franco SJ. (2019) Development. Mar 7;146(5). PMID: 30770393
  • Gutierrez MA, Dwyer BE, Franco SJ. (2019) eNeuro. May 7;6(2). PMID: 31073541

Christian Mosimann, PhD, Associate Professor and Johnson Endowed Chair in Heart Development Research

Our lab studies the mechanisms of cell fate determination during development and congenital disease, with particular focus on the origins of mesodermal cell types and of the cardiovascular system. We combine transgenic, genome editing, single-cell, and live-imaging approaches using the zebrafish as our principal model and engage in several cross-species collaborations.

• Felker A, Prummel KD, Merks AM, Mickoleit M, Brombacher EC, Huisken J, Panáková D, Mosimann C.; Nat Commun.2018 May 21;9(1):2001. PMID: 29784942
• Cantù C, Felker A, Zimmerli D, et al.; Genes Dev. 2018 Nov 1;32(21-22):1443-1458. PMID: 30366904
• Prummel KD, Hess C, et al.; bioRxiv261115; doi: https://doi.org/10.1101/261115(accepted/in print)

Charles Sagerström, PhD, Professor

Our group uses zebrafish to study transcriptional and epigenetic control of key transitions during embryogenesis. We are particularly interested in understanding the onset of zygotic gene expression at the maternal-to-zygotic transition and in the initiation of neural gene expression in the embryonic ectoderm.

• S.-K. Choe, F. Ladam and C. G. Sagerström. Developmental Cell 28:203-211. PMID:24480644
• F. Ladam, W. Stanney III, I. J. Donaldson, N. Bobola and C. G. Sagerström. eLife2018;7:e36144. PMID: 29911973

Julie Siegenthaler, PhD, Associate Professor; website: www.siegenthalerlabcu.org

The Siegenthaler lab is focused on identifying cellular and molecular mechanisms regulating development and adult function of the CNS vasculature and the meninges. In pursuit of this goal, we utilize mouse genetics to specifically target meningeal and vascular cell populations and perturb signaling pathways of interest (retinoic acid, Wnt-beta-catenin), advanced imaging modalities, cell culture and transcriptional profiling. We have recently completed a first ever single cell transcriptome analysis of the developing meninges; this valuable tool will aid in studying the development of meningeal fibroblast populations and exploring interactions of fibroblasts with meninges-located vasculature and immune populations as well as the developing and adult CNS.

• Bonney, S, Dennison, BJC, Wendlandt, M, Siegenthaler, JA. Frontiers in Cellular Neuroscience,
• Mishra, S, Kelly, KK, Rumian NL, Siegenthaler, JA. Stem Cell Reports.
• DeSisto, J, O’Rourke, R, Bonney, S, Jones, HE, Guimiot, F, Jones, KL, Siegenthaler, JA. bioRxiv.

Kelly Sullivan, PhD, Assistant Professor and Boettcher Investigator

Our lab is interested in how an extra copy of chromosome 21 gives rise to the condition known as Down syndrome. We use a combination of primary samples, cell culture, and mouse models, to understand how aberrant interferon signaling affects development and contributes to pathophysiology in Down syndrome.

• Sullivan KD*, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM*. Elife. PMID:27472900, PMCID: PMC5012864 *Co-corresponding Author
• Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle, KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lleo A, Blesa R, Fortea J, D’Alessandro A, Costello JC, Sullivan KD*, Espinosa JM*. Biorxiv 403642 *Co-corresponding Author

The Training Program provides a mechanism for postdoctoral trainees to mature into successful independent researchers in Developmental Biology and Regenerative Medicine. Trainees are provided salary support in accordance with the NIH pay scale and the University of Colorado offers a full benefits package. Successful applicants will be appointed as Gates Fellows with initial appointments made for one year and continued support contingent on satisfactory progress. The Program also provides each trainee with a mentoring committee, funds to attend conferences/courses and networking opportunities in the form of interactions with visiting scientists, national/international collaborations, journal clubs, research interest groups and annual retreats. Interested trainees will also be given opportunities to teach and mentor students as well as to improve writing skills.

Applicants must have a PhD degree and less than two years of postdoctoral experience as of September 1, 2019. Interested candidates should submit 1) a statement explaining their interest in the Program and indicating their preferred host lab (2-page maximum), 2) a CV and 3) arrange to have three reference letters sent. Review of applications will begin immediately and finalists will be invited for on-campus interviews. We anticipate filling four positions and interviews will continue until the positions are filled.

Questions and applications should be submitted by email to Dr. Charles Sagerström, Director of the Postdoctoral Training Program, at charles.sagerstrom@cuanschutz.edu

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The Radice laboratory in the Cardiovascular Research Center (CVRC) (http://cvrc.brownmedicine.org) at Rhode Island Hospital/Brown University is seeking a creative and exceptionally motivated postdoctoral researcher to investigate the mechanistic basis for how heart muscle cells sense and respond to mechanical force. Our current research emphasis is to identify how N-cadherin together with the underlying cytoskeleton transmits force into the cell and activates signaling events that control myocyte proliferation (Li et al., Circ. Res. 2015; Vite et al., Development 2018).  The position provides an exciting opportunity to work at the interface of basic and translational research in a highly collaborative, friendly and stimulating environment, and gain experience in a diverse set of technical approaches at the cutting edge of developmental and regenerative biology.

Candidates should hold a Ph.D. and/or M.D. with research training in the fields of cellular and molecular biology. The project utilizes genetically altered mouse models and primary cell culture. Experience in small animal surgery is highly preferred. Background in mechanobiology is desirable. Qualified candidates should possess strong communication and interpersonal skills, attention to detail, self-motivation, and the ability to work independently. This position provides an excellent opportunity to grow scientifically and work with a dynamic group of investigators studying important and exciting aspects of cardiac biology. Brown University offers a world-class research environment, very attractive benefits, and an appealing location in historic Providence, RI.

https://www.brown.edu/about/administration/biomed/graduate-postdoctoral-studies/

Interested applicants should send a single PDF file including:

1) Cover letter (please state how you heard about the position)

2) CV demonstrating publication of impactful work

3) One-page statement of research interests

4) Contact information for three references

Please email your application to Glenn Radice (glenn_radice@brown.edu) using the subject heading “Postdoctoral Fellow position”.

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Grade 8: £40,792 – £48,677 p.a. with a discretionary range to £53,174 p.a.
This is a new position that would suit someone who wants to help drive the success of a globally famous biomedical research department. The successful applicant will work with the head of department and other academics to initiate, develop and manage strategic projects in the areas of scientific planning, funding, recruitment, as well as external engagement with academic, commercial and other partners.

The successful applicant will have demonstrated experience and skill in writing for diverse audiences, as well as a biomedical PhD and good understanding of the research done at the Dunn School. A senior position, the expectation is that the postholder will be able to develop their own initiatives and work independently, while also forming collaborative relationships with academic and administrative staff at all levels.

Informal enquires can be made to the head of department, Matthew Freeman (matthew.freeman@pathology.ox.ac.uk).

This position is fixed-term for 3 years in the first instance.

If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statements as part of your online application.

The closing date for applications is 12.00 noon on Wednesday 2 October 2019, and interviews will be held as soon as possible thereafter.

For more information go to

https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form

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Anne Grapin-Botton has a background in developmental biology and initially studied nervous system and endoderm development. Her laboratory is currently focusing on pancreas development with the overall goals of understanding how pancreatic cells differentiate during embryogenesis, and determining what limits the pancreatic cells’ regeneration in adults.

Anne Grapin-Botton is a Director and a Group Leader at Max Planck Institute in Dresden and a Group Leader at The Novo Nordisk Foundation Center for Stem Cell Biology, DanStem.

(6 votes)

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As a first-year graduate student, I had the good fortune of accompanying Dr. Pierre Rasmont (U. Mons, Belgium) and his lab group on an expedition to collect bumble bees in Turkey. At our first stop onto the dry but flower-rich volcanic lands, we each dispersed to collect bees. At the time I was working to reconstruct a phylogeny of world bumble bees and one of each of the endemic species from this region was needed. When we reconvened to share what we found, I, not wanting to sacrifice unnecessary lives, came back with a limited catch. Pierre frowned, so I commented, “I only need one of each” and to that he commented, “They all look the same!”  It was then I learned the extremes to which bumble bees can mimic each other. While in the Eastern United States bumble bees are yellow and black, in Turkey nearly every species is white with black bands and a red tail…only in the details of color and morphology can they be told apart. Across the world there are several dozen bumble bee mimicry patterns each differing by geographic region. These locally shared warning signals enable enhanced predator learning, reducing predation for all – a process known as Mullerian mimicry.

I became interested in deciphering the phylogenetic patterns of this color diversity, noting that color is highly labile, exhibiting so much intraspecific and interspecific diversity that little phylogenetic signal can be recovered. The ~260 species of bumble bees globally can exhibit nearly every combination of red/orange, white, yellow, and black color in their fluffy pile across their segmental sclerites, with some species exhibiting dramatic color variation by geographic region [1].   My PhD advisor, Dr. Sydney Cameron (U. Illinois, U-C), and I were excited about the potential of this system to inform Evo-Devo. How is it that these bumble bees are capable of attaining such color diversity? What mechanisms may be driving the modular coloration we see in these bees? She set out to determine the diversity in patterns and how patterns vary across the bee body, revealing that some segments of the body are more prone to change relative to others [2]. The places on the body where color transitions were most likely to take place appeared to me to be locations where segment fate-determining Hox genes shift.

Examples of typical bumble bee mimicry patterns from different geographic regions. Upper left: Color patterns and their distribution among bumble bee species in subgenus Pyrobombus, demonstrating mimetic convergence (Image credit: H. Hines). Lower left: Bombus melanopygus red and black form (Photo credit: Li Tian, H. Hines), Upper middle: Bombus bimaculatus (Photo credit: H. Hines), Upper right: Bombus haemorrhoidalis (Photo credit: H. Hines), Lower right: Bombus incertus (Photo credit: Pierre Rasmont, available on http://www.atlashymenoptera.net) 

The evolutionary genetics literature however, would not predict that these patterns were driven by direct changes to Hox genes. Hox genes are highly pleiotropic, driving extensive body region-specific morphologies. Thus changes in the amount and locations of these genes should have large scale, often deleterious effects (e.g., antennapedia and bithorax). In Drosophila, nearly every case of color variation involves changes to a cis-regulatory module of a pigment gene in the melanin pathway.  Many pigment enzymes can be altered, but it is nearly always a pigment gene in cis [3]. The upstream regulators, as predicted in evolutionary genetics, stay unchanged.

To understand the genetic basis of color variation in bumble bees, I first set out to determine the pigments of their colored hairs, which yielded its own surprises. We discovered black is eumelanin, yellow is most likely a novel pterin (although melanin likely contributes) and that the red is a pheomelanin, the type of melanin that makes mammal hair and bird feathers red, but which was not thought until recently to be present in insects [4]. Thus color switches such as from black to red melanins lacked a clear enzyme candidate, as phaeomelanins are not part of known insect pigment pathways.  Building on technological advances, I decided to pursue whole genome approaches to discover genes driving color variation, and, the bumble bee Bombus melanopygus was an ideal choice. Bombus melanopygus has two color forms, one with a red abdominal stripe in the Rocky Mountain mimicry complex and another with a black abdominal stripe belonging to the Pacific Coastal mimicry group [5]. Previous work [6] revealed that this phenotype was under simple single-gene Mendelian inheritance, with red dominant to black, and that these color forms meet in a narrow hybrid zone, where they are genetically admixed [7].  These were perfect conditions for obtaining resolution in genome wide association analysis (GWAS).

With a NSF CAREER grant secured to pursue this project [8], graduate student Sarthok Rahman applied GWAS to determine the genetic basis of the color variation in B. melanopygus, identifying a single locus with just a few individuals.  We were excited to discover this locus fell in the cis-regulatory region between the abdominal fate determining Hox genes, abd-A and Abd-B. Is it possible that the pleiotropic Hox genes were changing their expression, counter to evolutionary genetics theory?

Discovering the expression patterns of these Hox genes was much harder than finding the locus. As a non-model system, the development of bumble bee pupae, the stage when coloration is established, had to be worked out. This was especially needed as bumble bees are highly labile in size, so time-based staging is unreliable. Li Tian, a postdoc at the time, developed a morphological staging system for bumble bee pupae that he used to perform comparative gene expression work [9; see time-lapse of pupal development below or download here]. 

This too took us longer than we would have liked as we originally focused on stages prior to the pigmentation process. Only later did we include the stages where color was being deposited, and discovered that Abd-B was differentially expressed concordant with this stage [10]. By comparing across segments of the body we discovered that Abd-B is upregulated only in the anterior abdominal segments bearing the color differences, a location it normally has little to no expression in, but only in the stages immediately prior to adult emergence. At this stage most abdominal Hox genes have low expression, concordant with the near completion of morphological change aside from color. This late-stage homeotic shift in Hox gene expression enabled segment-specific effects with little pleiotropic consequences, highlighting how upstream selector genes like Hox genes can be excellent evolutionary targets for promoting diversity as long as their shifting expression is compartmentalized.

Going forward we plan to dissect how Hox gene cis-regulatory regions enable these changes with transgenic approaches.  With this hyperdiverse system, our larger goal is to determine the role Hox genes might play in enabling the diversification across more bee species. Perhaps this story is unique to B. melanopygus (our analyses suggests the same variants are not involved in comimics) or perhaps Hox genes are commonly implicated across species but different regulatory targets are involved. With such diversity, our ability to study these mechanisms and fill out this story seems endless.

[1] Hines, H. M., & Williams, P. H. (2012). Mimetic colour pattern evolution in the highly polymorphic Bombus trifasciatus (Hymenoptera: Apidae) species complex and its comimics. Zoological Journal of the Linnean Society, 166(4), 805-826.

[2] Rapti, Z., Duennes, M. A., & Cameron, S. A. (2014). Defining the colour pattern phenotype in bumble bees (Bombus): a new model for evo devo. Biological Journal of the Linnean Society, 113(2), 384-404.

[3] Kronforst, M. R., Barsh, G. S., Kopp, A., Mallet, J., Monteiro, A., Mullen, S. P., … & Hoekstra, H. E. (2012). Unraveling the thread of nature’s tapestry: the genetics of diversity and convergence in animal pigmentation. Pigment cell & melanoma research, 25(4), 411-433.

[4] Hines, H. M., Witkowski, P., Wilson, J. S., & Wakamatsu, K. (2017). Melanic variation underlies aposematic color variation in two hymenopteran mimicry systems. PloS one, 12(7), e0182135.

[5] Ezray, B. D., Wham, D. C., Hill, C., & Hines, H. M. (2019). Müllerian mimicry in bumble bees is a transient continuum. bioRxiv, 513275.

[6] Owen, R. E., & Plowright, R. C. (1980). Abdominal pile color dimorphism in the bumble bee, Bombus melanopygus. Journal of Heredity, 71(4), 241-247.

[7] Owen, R. E., Whidden, T. L., & Plowright, R. C. (2010). Genetic and morphometric evidence for the conspecific status of the bumble bees, Bombus melanopygus and Bombus edwardsii. Journal of Insect Science, 10(1).

[8] National Science Foundation: Division of Environmental Biology: Evolutionary Processes, #1453473. CAREER: The genetics underlying adaptive diversification patterns in bumble bees. H.M. Hines.

[9] Tian, L., & Hines, H. M. (2018). Morphological characterization and staging of bumble bee pupae. PeerJ, 6, e6089.

[10] Tian, L., Rahman, S. R., Ezray, B. D., Franzini, L., Strange, J. P., Lhomme, P., & Hines, H. M. (2019). A homeotic shift late in development drives mimetic color variation in a bumble bee. Proceedings of the National Academy of Sciences, 116(24), 11857-11865.

(2 votes)

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We offer one fully-funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the National Institutes of Health (NHI/NCI, Bethesda, MD).

Our laboratory uses human and mouse embryonic stem cells (ESCs) as well as mouse embryos to understand the molecular mechanisms underlying the maintenance/exit of pluripotency and self-renewal. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are our scientific interests.

The applicant should have or about to have a PhD in Developmental Biology, Genetics or similar, and should have demonstrated expertise on molecular biology/mammalian tissue culture. Knowledge in mouse embryology, computational biology and next generation sequencing technologies will be considered as an advantage.

We seek a highly motivated, creative individual, eager to learn and develop new technologies and complex cell systems based on live cell/embryo imaging, single-cell technologies, 3D modelling and CRISPR-based editing interested in understanding how a single cell can develop into a complex multicellular organism in vitro and in vivo.

Please send a brief cover letter, CV and three reference letters via e-mail to:

sergio.ruizmacias@nih.gov

https://ccr.cancer.gov/Laboratory-of-Genome-Integrity/sergio-ruiz-macias

• Mayor-Ruiz C, et al. ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes & Dev. 32: 568-576, 2018.
• Olbrich T, et al. A p53-dependent response limits the viability of mammalian haploid cells. Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.

• Ruiz S, et al. A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors. Mol Cell. 62: 307-13, 2016.
• Ruiz S, et al. Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nature Commun. 6: 8036, 2015.
• Ruiz S, et al. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 109: 17196-201, 2012

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The Musculoskeletal Extracellular Matrix Laboratory (MEML) in the Department of Mechanical Engineering at the University of Colorado – Boulder is seeking an exceptionally creative postdoctoral researcher to investigate the mechanistic basis for how extracellular matrix (ECM) remodeling directs regeneration in mammals.  The project is a collaborative effort using spiny mice, an emerging model for mammalian musculoskeletal regeneration developed in the Seifert Lab in the Department of Biology at the University of Kentucky.  As such, the selected candidate will work with both groups, but will based at CU-Boulder.  The selected candidate will be trained to leverage cutting edge imaging and proteomic tools employed in the MEML to label, isolate and visualize newly generated ECM.  Using this methodology, in combination with in vitro and in vivo approaches in spiny mice and lab mice, the selected candidate will investigate how ECM production, composition and force generation regulate regenerative healing.

Ideal candidates will have a strong background in at least two of the following areas (and a drive to learn and master the others): biomechanics of soft tissues, developmental biology, 3D/4D visualization of biological tissues, protein engineering and quantitative bioinformatics.  Successful applicants will initially join an NIH funded project.  While this is a funded position, postdocs in the MEML are strongly encouraged to develop their own projects and external funding portfolios as a pathway toward independence.  Salary follows NIH guidelines for postdoctoral researchers.  Informal inquiries by email are strongly encouraged.  For additional information visit: https://www.colorado.edu/mechanical/sarah-calve.

Review of applications will begin on a rolling basis and will continue until the position has been filled.  Ideal start date is Fall 2019/Winter 2020.  Candidates will have completed their Ph.D. prior to starting the position but need not have defended their dissertation prior to applying.  Applicants should send a single pdf document to Sarah Calve (sarah.calve@colorado.edu) that includes their CV, names of three references, and a 1-2-page synopsis of their current research interests and how these complement our overall research program.

The Department of Mechanical Engineering at CU-Boulder houses a strong group of research labs interested in biomedical engineering, materials science, imaging, robotics and micro/nanoscale engineering.  Together, these labs create a vibrant atmosphere to leverage engineering principles and tools to clarify unanswered questions in biology.

The University of Colorado is an equal opportunity and affirmative action employer committed to assembling a diverse, broadly trained faculty and staff. In compliance with applicable laws and in furtherance of its commitment to fostering an environment that welcomes and embraces diversity, the University of Colorado does not discriminate on the basis of race, color, creed, religion, national origin, sex (including pregnancy), disability, age, veteran status, sexual orientation, gender identity or expression, genetic information, political affiliation or political philosophy in its programs or activities, including employment, admissions, and educational programs. Inquiries may be directed to the Boulder Campus Title IX Coordinator by calling 303-492-2127.

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In this episode from our centenary series exploring 100 ideas in genetics, we’re telling tales of sex and death, and exploring the very darkest side of genetics. We discover how Francis Galton’s eugenic ideas led to some of the worst atrocities of the 20th century, and ask how his legacy should be honoured today – if at all? Plus, the evolution of sex, and the total eradication of mosquitoes.

Please fill in our short listener survey, and you’ll be entered into a prize draw to win a signed copy of Kat Arney’s book, Herding Hemingway’s Cats.

Listen and download now from GeneticsUnzipped.com, plus full show notes and transcripts.

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A Research Fellow position is available at the Australian Regenerative Medicine Institute to study how body proportions are regulated during normal development and after perturbation of  growth of the long bones. The focus of research is on the communication mechanisms that operate between organs to maintain body proportions during development, especially those involving the circulatory and nervous systems. The main animal model utilised in the research group is the mouse (embryos and pups) with the future goal of starting a zebrafish colony. The expected duration of the project is at least 2 years.

If you want to join a vibrant group and institute, and live in Melbourne, one of the most liveable cities in the world, follow the link!:

http://careers.pageuppeople.com/513/cw/en/job/597100/research-fellow-interorgan-communication

Key selection criteria

Education/Qualifications

1. The appointee will have:

• a doctoral qualification and/or progress towards a doctorate in the relevant discipline or a closely related field

Knowledge and Skills

2. Management of a complex mouse colony with multiple genetically modified strains.
3. Previous experience working with mouse placenta: structure, staining, histological techniques.
4. Proficiency with routine laboratory techniques including DNA cloning, histology, western blot, immunohistochemistry, tissue culture; use/maintenance of common laboratory apparatus, storage and handling of hazardous materials
5. Proficiency with 3D imaging and image analysis software (Imaris/ImageJ/CellProfiler).
6. Demonstrated outstanding work ethics and quality standards.
7. Ability to work and think independently, solve complex problems by using discretion, innovation and the exercise diagnostic skills and/or expertise.
8. Well-developed planning and organisational skills, with the ability to prioritise multiple tasks and set and meet deadlines. Excellent record keeping skills are a must.
9. Excellent written communication and verbal communication skills with proven ability to produce clear, succinct reports and documents
10. A demonstrated capacity to work in a collegial manner with other staff in the workplace
11. Demonstrated computer literacy and proficiency in the production of high level work using software such as Microsoft Office applications and specified University software programs, with the capability and willingness to learn new packages as appropriate
12. Experience in the following categories will be considered a plus: dissection of mouse limb/bones, maintenance of zebrafish colony, CRISPR-based functional screens, ex vivo tissue culture and management of (under)graduate students.

For more information, feel free to contact Alberto Rosello-Diez (alberto.rosellodiez@monash.edu).

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Research technician position available for a project focused on functional technique development in annelid worms, with a conceptual focus on evo-devo and regeneration biology. This position is part of an NSF-funded project focused on developing approaches to test gene function in post-embryonic (juvenile and adult) stages of several annelid species. The project is a collaboration between Alexa Bely (U Maryland), Duygu Ozpolat (Marine Biological Laboratory, Woods Hole), and Elaine Seaver (U Florida, Whitney Marine Lab) and there are substantial interactions among the three lab groups.

​This position is in the lab of Elaine Seaver, with primary focus on the annelid Capitella teleta. Position is for 1 year, with possibility of renewal for a second year, and with a start in Fall 2019.

Required qualifications: bachelor’s degree in biological sciences or related field, at least 1 year research experience in molecular or developmental biology, good fine-motor skills, ability to troubleshoot and persevere, effective time management and organizational skills, and team-oriented outlook. Preferred but not required: experience with microinjection, electroporation, and approaches to disrupt gene function.

Through this position, the successful candidate will gain valuable experience in the development of novel methods, will gain experience in both molecular and organismal research, and will be part of a highly interactive and supportive team.

More information about this project and this position is available at: https://wormsontheedge.weebly.com

To apply: send a cover letter, CV, and name and contact information for three references to Elaine Seaver at seaver@whitney.ufl.edu.

Note: There is a similar position at Univ. Maryland – see separate posting at: https://thenode.biologists.com/research-technic…univ-of-maryland/jobs/

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