The National Institute of Standards and Technology (N.I.S.T.) is recruiting recent PhD’s. The laboratory is located near Washington, DC. Our research program focuses on characterizing the dynamics of gene regulatory networks in human iPSCs and in developing quantitative models that describe the pluripotency landscape. Possible start dates: 6/2021 – 12/2021

We invite interested candidates to apply for Postdoctoral Research Fellowships available through the National Research Council (NRC). These research associateships are two-year appointments with an annual salary of $71,128 (U.S. citizenship is a requirement). These positions are highly competitive and attract outstanding candidates. Research challenges include:

• applying state-of-the-art live cell imaging and image analysis and deep learning models to follow gene expression dynamics in single cells
• gene editing (i.e. CRISPR-Cas9) to engineer iPSC lines with multiple fluorescent reporters
• statistical analysis of time series data to infer gene network interactions
• modeling pluripotency regulation

Experience with cell culture, quantitative imaging and image analysis, and/or mathematical modeling is a plus.  These postdoc appointments are excellent opportunities for recent Ph.D. graduates who are seeking additional experience prior to accepting a permanent academic or industrial position. Historically, a number of these awardees have also become permanent employees at NIST. Next application deadline is February 1.

Begin the application process by sending your CV and cover letter to Michael Halter (michael.halter@nist.gov).

Job requirements:

-US citizenship

-Within 5 years of obtaining PhD in bioengineering, cell biology, or physical sciences

-PhD is not required at time of application, but is required before beginning Fellowship

-Ability to work in a multidisciplinary team with biologists, bioengineers, computer scientists, physicists, and statisticians

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The Marín-Juez laboratory, at the CHU Sainte-Justine Research Center,is recruiting a PhD student and a postdoctoral fellow (4-year fully funded positions). Our laboratory is interested in the cellular and molecular mechanisms regulating cardiac regeneration. The successful applicant will join the Marín-Juez laboratory at the CHU Sainte-Justine Research Center, where he/she will have access to state-of-the-art facilities and technology platforms including Advance imaging platform (light-sheet, spinning-disc confocal, multiphoton, STED super-resolution, etc.), genomics (DropSeq, 10x, Illumina Novaseq) and bioinformatics platforms. CHU Sainte-Justine Research Center provides a thriving scientific environment where the successful applicant will have the opportunity to work with multidisciplinary scientific teams and to collaborate with talented clinicians and researchers.

Research project description

For this project, we are particularly interested in understanding how the cardiac endothelium regulates different aspects of cardiac regeneration and how alterations in the coronary network formation impact the ability of coronary vessels to support tissue replenishment. We have recently found early coronary regeneration as a key determinant of heart regeneration (Marín-Juez et al., PNAS 2016), and identified mechanisms regulating coronary network replenishment to form a vascular scaffold that supports cardiomyocyte regeneration (Marín-Juez et al., Dev Cell 2019). We now seek to define how the different components of the cardiac endothelium regulate tissue replenishment and identify the different mechanisms involved in their regulation of CM proliferation and migration.

Required training and profile

Ph.D. student position: Applicants should have training in vascular biology, molecular biology, cell biology, or related fields. Suitable candidates should be enthusiastic about regenerative and vascular biology. Previous research experience with zebrafish and/or heart regeneration is desired.

Postdoctoral position: We are looking for candidates with a Ph.D. in the biological sciences and laboratory experience in tissue repair/regeneration, cellular, molecular biology, or genetics. Previous experience working with zebrafish, imaging and histology are highly valued but not essential.

Both positions: Candidates with experience in confocal/light-sheet imaging and/or genome engineering are strongly encouraged to apply. Preference will be given to applicants with excellent collaborative and communication skills. The Marín-Juez lab and the CHU Sainte-Justine Research Center subscribe to the principle of equal access to opportunities and encourage women, members of visible and ethnic minorities, persons with disabilities and Indigenous people to apply.

Submit your application

Candidates must send the required documents before 02/2021 to Rubén Marín Juez at ruben.marin.juez.hsj@ssss.gouv.qc.ca

Please provide: Curriculum vitæ, Cover letter and References (2 or 3).

(2 votes)

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PhD or postdoc project at the Zaidel-Bar lab: A systematic analysis of C. elegans gastrulation in order to uncover molecular mechanisms of cell ingression.

Information about the lab: https://www.zaidelbarlab.com/

Application: Send CV, transcripts and cover letter to zaidelbar@tauex.tau.ac.il

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We are currently seeking an independent and motivated research associate to work on a research project led by Dr. Anestis Tsakiridis (https://www.tsakiridislab.com/) and Prof. Peter Andrews at the Centre for Stem Cell Biology, University of Sheffield, UK. The successful applicant will work on the characterisation of candidate human pluripotent stem cell (hPSC)-derived enteric nervous system (ENS) progenitor
populations for use in cell therapy approaches to treat Hirschsprung disease (HSCR), one of the most common congenital diseases affecting the ENS. This project is funded by the MRC and is a collaboration with the group of Conor McCann/Nikhil Thapar at the UCL Great Ormond Street Institute of Child Health in London.

You should have a PhD (or be close to completion/have equivalent experience) in Stem Cell/Developmental Biology and have experience in hPSC culture and neural differentiation as well as in one or more of the following: immunocytochemistry, qPCR, flow cytometry, and Crispr/Cas9 based genetic modification approaches. You must be self-motivated, well-organised, highly independent, and willing to work with other members of the existing research team. Excellent communication, written and interpersonal skills are essential.

We are keen to attract a diverse applicant pool, and we are aware that some under-represented groups are typically less confident about applying for jobs unless they are sure they comfortably meet all the criteria. With this in mind, we encourage
all potential candidates to reflect on their strengths and experience in the broadest sense, including transferable skills where appropriate, when considering their suitability for the position.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research,
teaching and student experience.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and
development courses to support your personal and professional development

Closing date: 9th December 2020. Please apply here (Job  reference: UOS026765). For informal enquiries email: a.tsakiridis@sheffield.ac.uk

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Development is excited to announce the completion of our Special Issue on The Origins and Mechanisms of Developmental Disorders, guest edited by Sally Dunwoodie (Victor Chang Cardiac Research Institute in Sydney) and John Wallingford (University of Texas in Austin).

The Special Issue features 4 Spotlights, 1 Primer, 1 Review, 20 research articles and, reprinted below, an introductory editorial by Sally and John. Check out the full issue here:

https://dev.biologists.org/content/147/21

Diseases of development:  leveraging developmental biology to understand human disease

Sally L. Dunwoodie and John B. Wallingford

Developmental disorders, often called ‘birth defects’, represent the number one cause of infant mortality in the USA and are nearly as lethal in the UK and Australia. The incidence of birth defects is highest in countries with the lowest income per capita. Owing to the highly heterogeneous nature of these conditions, they are commonly thought to be very rare. Collectively, however, they represent the leading biological cause of death for children of all ages. Indeed, in the USA, congenital anomalies are more than twice as lethal as pediatric cancers. These conditions all share an origin in embryonic development, so developmental biologists have a key role to play in addressing this important biomedical problem. In this Special Issue of Development, we highlight that role by presenting a collection of articles in diverse formats that are focused on developmental disorders.

The issue starts with a series of four Spotlight articles (Beames and Lipinski, 2020; Khokha et al., 2020; Leslie, 2020; Link and Bellen, 2020) designed to bridge the still-too-wide gaps that separate developmental biology, human genetics and epidemiology. The Special Issue also includes a short Primer article (Bruneau, 2020) on congenital heart disease, the most common form of congenital anomaly, and a longer Review (Bagnat and Gray, 2020) on the mechanisms controlling spine straightness, highlighting the often overlooked fact that developmental processes continue to play key roles in children and adolescents.

The core of this Special Issue is a series of 20 Research articles and reports that provide a broad view of the state of the field. Using mice, chickens, fish, frogs and human cells, the authors of the studies published here reveal new insights into conditions ranging from structural anomalies, to neurodevelopmental disorders, to pediatric cancers. As genetic causes are only one piece in the developmental disorder puzzle, the role of environmental factors and how these interact with genetic variation is also highlighted. Importantly, these papers also run the gamut from fundamental investigation of developmental mechanisms to direct modeling of genetic lesions known to underlie a human disease, further highlighting the ever-blurring lines between basic and clinical developmental biology.

We hope you enjoy reading this Special Issue and would like to thank everyone – authors and reviewers – who contributed to it. We also hope you will consider sending your next manuscript on this fundamental topic our way!

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Department/Location

Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, University of Cambridge

Reference: PS24718

Closing date: 7 January 2021

The University of Cambridge is exceptional in the depth and diversity of its research in Stem Cell Biology and has a dynamic and interactive research community that is ranked amongst the foremost in the world. Applications are now being accepted for places on the Wellcome Four-Year PhD Programme in Stem Cell Biology and Medicine, to commence in October 2021. Applicants are welcomed from any country, culture, socio-economic background or university and should demonstrate both a passion for scientific research and a desire to learn about Stem Cell Biology. By bringing together members of both the Schools of Biology and Medicine, this four-year PhD programme enables students on the programme to take advantage of the strength and breadth of stem cell research available in Cambridge, plus the opportunity to complete their research in one of the 25 host laboratories in Cambridge.

Course Outline

The first year MRes degree gives the students an opportunity to complete three different rotation projects in research laboratories, under the supervision of a dedicated Principal Investigator. In addition, students are required to attend weekly Stem Cell Discussion Courses, participate in both presentation sessions and an annual symposium and complete a Personal Researcher Development Training programme. New postgraduate students at the CSCI will become members of the Postgraduate School of the Life Sciences, which organise and promote many further training opportunities. Towards the end of the third rotation project, students are expected to choose a laboratory for their PhD thesis research. Students will prepare a PhD Research Proposal which will form part of the assessment towards the MRes in Stem Cell Biology. Successful completion of the MRes will then lead onto the fully-funded three-year PhD, in a host laboratory.

Further details can be found at: https://www.stemcells.cam.ac.uk/join-us/Students/MRes-PhD_Programme.

Funding

These fully-funded studentships commence in October 2021. The funding includes the University Composition Fee (at Home (UK) rate), a travel and consumables budget and a stipend at the Wellcome rate (see here). International students can apply for a Cambridge Trust Scholarship during the application process to cover the difference between the ‘Home’ and ‘Overseas’ Fee rate. Other funding opportunities are also available. Further information can be found here: https://www.postgraduate.study.cam.ac.uk/funding/university-funds

Application

Further details on the application process can be found here: https://www.postgraduate.study.cam.ac.uk/courses/directory/blscpdscb/apply

Fixed-term: 4 years.

Informal course-specific enquiries can be sent to: PhD@stemcells.cam.ac.uk

Postgraduate Admissions queries can be sent to: pg.admissions@admin.cam.ac.uk

The closing date for receipt of applications is: 7 January 2021. Short-listed applicants will be invited to interview the week commencing 25 January 2021. You will be interviewed by a panel from the Cambridge Stem Cell Institute.

To Apply, please visit: https://www.jobs.cam.ac.uk/job/27655/

Please quote reference PS24718 on your application and in any correspondence about this vacancy.

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Yesterday we held the second webinar in our new series, this time coinciding with the publication of our Special Issue on The Origins and Mechanisms of Developmental Disorders and featuring three fantastic talks on the theme.

Here you’ll find the three talks and their live Q&A sessions, moderated by John Wallingford, one of the guest editors of the issue. The talks will be taken down on Thursday 26 November.

Helen Rankin Willsey (postdoc in Matthew State’s lab at UCSF, working closely with Richard Harland’s lab at UC Berkeley)

‘The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos’

See Helen’s paper in the Special Issue here.

Eric Brooks (postdoc in Jennifer Zallen’s lab at the Sloan Kettering Institute, New York)

‘Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure’

See Eric’s new paper in eLife here.

Kyle Drake (PhD student in Rahul Kanadia’s lab at the University of Connecticut)

‘Loss of U11 small nuclear RNA in the developing mouse limb results in micromelia’

See Kyle’s paper in the Special Issue here.

(1 votes)

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Department/Location: Sainsbury Laboratory, University of Cambridge UK

Salary: £41,526-£52,559

Reference: PT24318

Closing date: 1st December 2020

Applications are invited for a David Sainsbury Career Development Fellowship in the Sainsbury Laboratory, Cambridge University. The Fellowships provide an opportunity for talented junior investigators to develop their own research programme and become creative leaders in the field of quantitative plant developmental biology. We are searching for a candidate who is developing an understanding of design principles that can be used to construct predictive models for complex behaviours in living systems. Applicants are likely to be using theoretical and/or quantitative experimental approaches. Examples include transcriptional modelling, computational morphodynamics, single molecule/cell imaging, systems or synthetic biology and biophysics. The position fits within the overarching goal of the Sainsbury Laboratory to develop a quantitative, dynamic and predictive understanding of plant development, but no previous experience of plant science is necessary. Rather, it is critical that the appointee is willing to engage in the Sainsbury Laboratory’s collaborative research environment.

The Sainsbury Laboratory, Cambridge University is a research institute located in central Cambridge, providing an outstanding scientific environment. It has excellent resources and core facilities, with state-of-the-art equipment including growth rooms, glasshouses, microscopy and computing facilities. It provides a collaborative research atmosphere where researchers can take risks in a supportive environment. We are seeking to appoint David Sainsbury Career Development Fellows who can both contribute to and benefit from this environment. In particular we are looking for scientists with imaginative research ideas that will contribute to our quantitative understanding of plant development by including theoretical and computational approaches.

Applicants from all nationalities are welcome to apply and will typically have postdoctoral experience in a field related to the overall scientific focus of the Laboratory. No prior experience with plants is required – researchers wishing to bring their current wet lab or modelling experience to open novel questions in quantitative plant developmental biology are welcome to apply. Applicants should be able to provide strong evidence of their potential to develop an independent research programme.

The maximum duration of the Fellowship is five years. Successful applicants will initially receive three years of funding, with an extension for a further two years contingent on a successful review and will hold an appointment with the University of Cambridge. Funds include full salary, ranging from £41,526 to £52,559, an additional 30% Gatsby distinction award, benefits and £50,000 p.a. of unrestricted research support. As they develop into independent researchers, Fellows will be encouraged to apply for external funding.

The Laboratory provides a welcoming and collaborative environment with a wide range of family-friendly benefits and development opportunities. More about the Sainsbury Laboratory and details of what the University offers to employees, can be found at https://www.slcu.cam.ac.uk/

Fixed-term: The funds for this post are available for up to 5 years.

Please ensure that you also upload your application as a single pdf file including a full CV, a research proposal for five years, and the names of at least three referees.

Further details about the post and guidance and on how to apply are available below.

All enquiries should be directed to enquiries@slcu.cam.ac.uk.

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/27222/

Please quote reference PT24318 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Talks now available here!

The second webinar in the Development presents… series coincides with the November release of our Special Issue: The Origins and Mechanisms of Developmental Disorders. The Special Issue showcases the role of developmental biologists in addressing developmental disorders – the leading biological cause of death for children of all ages – and the talks in our November webinar come from researchers at the forefront of this field. The webinar will be chaired by John Wallingford, Professor of Molecular Biosciences at the University of Texas at Austin, who is one of the guest editors of the Special Issue together with Sally Dunwoodie, Professor of Medicine at the Victor Chang Cardiac Research Institute.

Wednesday 11 November 2020 – 19:00 GMT

Helen Rankin Willsey (postdoc in Matthew State’s lab at UCSF, working closely with Richard Harland’s lab at UC Berkeley)

‘The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos’

Eric Brooks (postdoc in Jennifer Zallen’s lab at the Sloan Kettering Institute, New York)

‘Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure’

Kyle Drake (PhD student in Rahul Kanadia’s lab at the University of Connecticut)

‘Loss of U11 small nuclear RNA in the developing mouse limb results in micromelia’

To register for the event, go to

https://virtual.biologists.com/e/development-presents-1/register

The webinar will be held in Remo, our browser-based conferencing platform – after the talks you’ll have the chance to meet the speakers and other participants at virtual conference tables. If you can’t make it on the day, talks will be available to watch for a couple of weeks after the event (look out for details on the Node).

For more information about what to expect in Remo, go to

thenode.biologists.com/devpres/

Feel free to share the poster with your colleagues:

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