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Development presents… a Special Issue on The Immune System in Development and Regeneration

Posted by , on 22 April 2022

Twitter card with details of the Development presents... webinar.

Wednesday 4 May 2022 – 15:00 BST

Our next Development presents… webinar celebrates the Special Issue on The Immune System in Development and Regeneration. Guest editors, Paul Martin (University of Bristol) and Florent Ginhoux (A*STAR Singapore) have invited three authors from the issue to present their work.

Ana Zenclussen (Professor for Environmental Pediatric Immunology at the Leipzig University and Head of the Department of Helmholtz Centre for Environmental Research)
‘Relevance of maternal B cell signaling for fetal development and well-being’

Elena Melendez (Postdoctoral researcher in Manuel Serrano‘s lab at the IRB, Barcelona)
‘Natural killer cells act as an extrinsic barrier for in vivo reprogramming’

Franziska Knopf (Junior Professor at the Centre for Regenerative Therapies, Dresden)
‘Laser mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish’

The webinar will be held in Remo, our browser-based conferencing platform. After the talks you’ll have the chance to meet the speakers and other participants at virtual conference tables. If you can’t make it on the day, talks will be available to watch after the event on the Node. You can also sign up to our mailing list for email alerts.

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Genetics Unzipped: Have a heart – the science of xenotransplantation

Posted by , on 21 April 2022

A heart

“This really is a historical first, because it’s potentially the start of a new era where nobody has to die waiting for an organ transplant”

Dr Rohin Francis, cardiologist

In the latest episode of the Genetics Unzipped podcast, we’re delving into the seemingly science fiction world of xenotransplantation, that is, taking organs from animals and using them as organ transplants for humans. We chat with cardiologist Dr Rohin Francis about the groundbreaking operation this year transplanting a genetically modified pig heart into a human, and we chat with Professor Angelika Schnieke about how we can avoid getting more than we bargained for from pigs.

Genetics Unzipped is the podcast from The Genetics Society. Full transcript, links and references available online at GeneticsUnzipped.com.

Subscribe from Apple podcasts, Spotify, or wherever you get your podcasts.

Head over to GeneticsUnzipped.com to catch up on our extensive back catalogue.

If you enjoy the show, please do rate and review on Apple podcasts and help to spread the word on social media. And you can always send feedback and suggestions for future episodes and guests to podcast@geneticsunzipped.com Follow us on Twitter – @geneticsunzip

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EMBO Workshop: Timing mechanisms linking development and evolution

Posted by , on 20 April 2022

Only a few days left to register for the EMBO workshop on time in development and evolution.

Barcelona, 29 Jun – 1 Jul 2022.

/www.embl.org/about/info/course-and-conference-office/events/tmd22-01/

Time is inherent to biological processes. It determines the order of events and the speed at which they take place. This is particularly obvious during embryonic development where the sequence and rate of events ensures that structures develop in the right place, at the right time. Modifying the developmental tempo can affect the final size and composition of tissues, as well as their plasticity and function. Comparisons between species reveals that although the order and underlying molecular mechanisms are often indistinguishable, the pace at which they advance can differ substantially. Hence comparison of biological processes between species is likely to provide insight into time-keeping mechanisms and how they change. Despite the centrality of these questions to embryo development, and evolution, it has remained an understudied topic. The workshop will foster dialogue between researchers from different fields to stimulate new ideas and catalyse the study of the genetic, molecular and cellular mechanisms controlling the tempo of embryonic development.

/www.embl.org/about/info/course-and-conference-office/events/tmd22-01/

Conference poster

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Young Embryologist Network Conference 2022

Posted by , on 15 April 2022

Registration for attendance now extended until the 29th of April!

The Young Embryologist Network conference 2022 (YEN 22) is the 14th iteration of the network’s hugely successful yearly developmental biology meeting. This will be a hybrid conference hosted at the Francis Crick Institute and streamed over Zoom on Monday the 16th of May 2022.

Our meetings provide an opportunity for early-career-stage developmental biologists to share their own research, network and engage with peers and pioneers in the field, with delegates attending from across the globe

We have a varied and exciting programme for YEN 22: Dr. Andrew Gillis (University of Cambridge) and Dr. Kate McDole (MRC LMB) will be delivering talks as two of our invited speakers. Furthermore, we have the pleasure of welcoming Prof. Elly Tanaka (Institute of Molecular Pathology, Vienna) to give the Sammy Lee memorial keynote address. Plus, PhD students and postdocs may submit abstracts for the chance to give a short talk or present a poster.

Moreover, we are immensely proud to be hosting our first “Scientific Perspectives: Working in Science with a Disability” talks at YEN 22. Disability is a tremendous barrier not only to entry, but also to the progression of a scientific career, and researchers with disabilities remain immensely underrepresented at every career stage. Our community could be much better equipped in helping ensure inclusion and equal opportunities for disabled scientists, and so we have invited Dr. Elisabeth Kugler (UCL), Prof. John Hutchinson (RVC) and Dr. Oscar Cazares (UCSF) to share their perspectives and experiences of working in science with a disability. We also have the pleasure of welcoming Dr. Cynthia Andoniadou (King’s College London), who will be delivering the summary address for these sessions.

Abstract submission is now closed but, due to ongoing demand, we have extended the attendance registration deadline to 11:59pm on the 29th of April. 

You can register for this free event, and learn a little more about our organisation, via the link below:

http://www.youngembryologists.org/yen-2022/ 

You can also follow us on Twitter here:

Thanks again and we hope to see you all there! 

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SciArt profile: Cirenia Arias Baldrich

Posted by , on 14 April 2022

In our latest SciArt profile, we hear from Cirenia Arias Baldrich. Cirenia is a freelance illustrator, who has a background in plant physiology and stem cell bioinformatics.

Where are you originally from and what do you work on now?

I am from La Línea de La Concepción (Cádiz), but I lived in Seville for 16 years, where I studied biology and completed my PhD on Molecular Biology and Genetics. After that I moved on in my scientific career to Portugal and then to the UK, where I was rocking bioinformatics as a postdoctoral researcher in the Stem Cell Biology and Evolution Group (Dr Jordi Solana – Oxford Brookes University). Nowadays, I am based in Cádiz, Spain, working as a full time freelance illustrator, helping organisations and other scientists to communicate their work using the power of images.

There’s a friend in me, how we domesticate our pets. This is one of the 15 illustrations introducing the 15 chapters of ‘GENES: Escribiendo el guion de la vida’ book (Guadalmazán, Almuzara Libros). With these illustrations, my goal was to introduce the chapters to the reader, to make them curious about what they are about to be immersed in, and at the same time trigger them to rethink what they had already read.
Birdwatching. Illustration featured in the paper ‘No Bird Database is Perfect: Citizen Science and Professional Datasets Contain Different and Complementary Biodiversity Information’, Sofía Galván, Rafael Barrientos, Sara Varela (Ardeola, 2022).

Were you always going to be a scientist?

Not really, at least it was not clear in my mind. Though since I learned how to talk, I started asking questions, and replying with ‘but how/why?’ or ‘are you sure of that?’ to every answer. I also loved to decipher how things worked; opening electronic stuff to see its components, making tests, playing with computers – I was pretty curious! I also had other interests like arts, design, informatics, marketing, but I always loved to read the biology notes of my older sister, who is also a biologist. Like her, I decided to study biology. It was amazing to learn about genetics, cell biology, zoology, plant physiology, biochemistry, ecology, to better understand both the world around us and ourselves.

Visual Identity of the BalkanDetoxLIFE project: Strengthening national capacities to fight wildlife poisoning and raise awareness about the problem across seven Balkan countries. The #BalkanDetoxLIFE’s project logotype illustrates the severity of illegal wildlife poisoning, while also signifying hope through the project’s goal to detox the Balkans from this threat.
Cover published in GENETICS, Genetics GSA.‘DNA Repair Kit’ highlights the essential role of a chromatin remodelling complex in the DNA repair process. This cover is linked to Morillo-Huesca et al., 2019.

And what about art – have you always enjoyed it? 

Definitely. I can’t even remember when I started drawing, what I know is that I never stopped. Since I was a child, I never had enough colours, watercolours, crayons or markers (I still cannot go into an art supply store without going mad)! I loved trying new materials, trying to draw everything I saw, such as everyday objects, or the room where I was. I was always doodling, even in meetings, (I still do) and, funny fact, that is actually how my adventure as a professional illustrator started, taking graphic notes at scientific talks. I discovered that I could  join my three passions: science, art and communication, using illustration as a science communication service.

Las Que Cuentan La Ciencia 2022. Animated Poster for Scicomm Event ‘Las Que Cuentan La Ciencia’ (The Women who Explain Science). The 2022 theme was ‘Amor, Amor, Amor’ (Love, Love, Love). In this poster, love is illustrated in diverse forms, while the theatre represents the return to on-site events. This event is organised by the Unit of Scientific Culture and Innovation (UCC+i) of Cordoba (Spain), (University of Córdoba, Maldita.es, The Conversation ES)

What or who are your most important artistic influences?

This is probably one of the toughest questions to answer, since I try to consume as much art/design as I can. From literally everywhere. I’m inspired by movie posters, records covers (I love vinyls), restaurant menus, street signs, street art, graphic novels, etc. However, there are some creators that had made a big impact on the way I see the profession of an illustrator. I really admire the work of many diverse artists like Cristopher Niemann, Malika Favre, Rachel Ignotofsky, Adolfo Arranz, the Etherington Brothers, Andy Riley, Agustina Guerrero, Andry Rasoahaingo (Dedouze), Tom Gauld, Raquel Córcoles (ModernaDePueblo) and many others (I could go on with a never-ending list).

The Depths of the Amundsen Sea. Illustration featured in the article ‘From the depths of the Amundsen Sea’ (Courtillat, M). The image is one of the series of graphic summaries and illustrations created for Horizons Magazine (PAGES- Past Global Changes Project). Horizons highlights paleoscience topics that are of interest for the next generation, and is written in an easy to understand, visual format.

How do you make your art?

Digital tools help me to deliver the work efficiently. It makes the reviewing process easier, and the final artwork can be directly shared in social media, websites, or used for printing or publication. Also, I love the infinite possibilities digital tools provide and learning new resources. Despite all this, I start every project sketching in paper. For my ideas to run wild, I like the feeling of a notebook and a pen, and once I have a plan, I move on to digital fun using both a digital tablet and the computer (depending on the project), hand-drawing apps, vector graphics software, or animation programmes.

The effects of deleterious mutations on ageing. Cover for Martin Iinatti Brengdahl’s doctoral thesis on evolutionary genetics of ageing and sex differences (Friberg Lab), Linköping University. This illustration reflects Martin’s work investigating the age-specificity of deleterious mutations and their contribution to sex differences in ageing and lifespan in Drosophila melanogaster.

Does your art influence your science at all, or are they separate worlds?

Art has always influenced my science: the way I communicate with my colleagues, planning lab strategies, preparing presentations, posters, figures, giving a chalk-talk, or even thinking about a project. I think creativity and science are completely inseparable. Nowadays, being a freelance illustrator,  science is my everyday ingredient in my art, since my job is helping to communicate science efficiently, to both expert and non-expert audiences, and my scientific background plays a key role in allowing me to do so. I also feel very motivated and enthusiastic about having an influence on the way other scientists approach the creation of visuals in their work. In this sense, I really enjoy training other researchers, and give them tips and tools so that they can make better illustrations and have fun instead of struggling!

Graphic Summary Poster for Methods and Models in Biomedical Sciences: Building Bridges Meeting, a Champalimaud Foundation workshop co-organised with the European Commission’s Joint Research Centre (JRC), CONGENTO, QuantOCancer and FRESCI. This poster gathers all the ideas and key messages on scientific methods and models used in biomedical research discussed in the session ‘Breakout World Group Exercise’ of the meeting

What are you thinking of working on next?

One of the things I love the most of my job is how exciting it is to work on so many different things, thanks to the diversity of collaborators. In the next few months, I will be working on very cool projects ranging from awareness about vulture conservation, rare diseases,  digital gender gap, palaeoecology editorial illustration and producing several infographics, covering topics such as microbiology or climate change, among others. I would like to take advantage of this awesome spot to thank all the amazing people trusting me to help showcase their amazing work. Last but not least, big thanks to The Node for creating the SciArt profile series, it’s great to get to know other colleagues and I am very honoured to be part of it.

The Sticky Floor. This illustration showcases the ‘sticky floor’ keeping women in the lower ranks of the job scale. Done in collaboration with MAPAS LAB and The Equality Commission of the Spanish Association of Terrestrial Ecology (AEET).

You can find Cirenia Arias Baldrich (aka CireniaSketches) on: Twitter @CireniaSketches Instagram @CireniaSketches Linkedin Cirenia Arias Baldrich

Thanks to Cirenia and all the other SciArtists we have featured so far. You can find the full list here. We’re always on the lookout for new people to feature in this series – whatever kind of art you do, from sculpture to embroidery to music to drawing, if you want to share it with the community just email thenode@biologists.com (nominations are also welcome!)

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Developing news

Posted by , on 12 April 2022

Read on for our news roundup of the past two weeks, with an emphasis on what has caught our eyes on twitter. We have also include a list of meetings with upcoming deadline, a selection of preLights and finish with our favourite April fools jokes .

Doing better as a community

There have been a few tweets in the last fortnight discussing some of the negative aspects of our research culture with a call to do better in the future. Lets make that happen!

Reviewing papers

Behaviour at meetings

Support for early-career researchers

https://twitter.com/evolscientist/status/1510783424117702656

Funding news

The impact of Brexit on British science continues with notification from the ERC that awardees will need to move to the EU to take up their grants. The UK government is guaranteeing the grants in the UK but details remain sketchy.

Upcoming registration and meeting deadline

It’s been exciting to see the return of in-person meetings including the joint BSCB and BSDB meeting in the UK (we’ll post our meeting report soon) and #Dros22 in the US. Check out the list below for meetings with upcoming deadline and check our events page for our full listing.

MeetingAbstract deadlineRegistration deadlineMeeting start date
The ISRB Regeneration Around the World Meetingpassed17.04.2219.04.22
EMBO | EMBL Symposium Cellular mechanisms driven by phase separation02.05.22 (virtual only)09.05.22
Weinstein Cardiovascular Development and Regeneration ConferencepassedOpen12.05.22
Fusion Conference – Probing Human Disease Using Single-Cell Technologies Conferencepassed15.04.2213.05.22
EMBO | EMBL Symposium Mechanobiology in development and diseasepassed08.05.2022 (virtual only)15.05.22
GRC: Cell Polarity Signaling01.05.2201.05.2229.05.22
Euro Evo Devo31.05.22
55th Annual Meeting of the Japanese Society of Developmental Biologistspassed22.04.2231.05.22
GRC: Epithelial Stem Cells and Niches08.05.2208.05.2205.06.22
EMBO | EMBL Symposium Microtubules: from atoms to complex systems01.06.22 (virtual)08.06.22
EMBL-IBEC Conference on Engineering Multicellular Systems15.05.2208.06.22
GRC: Plant Molecular Biology15.05.2215.05.2212.06.22
ISSCR 2022 Annual Meeting13.04.22 (advance deadline)15.06.22
Stem Cells for Disease Modeling and Regeneration29.04.2229.04.2227.06.22
Summer school in transcriptomics during development and cancer15.04.22 (early) 01.06.2227.06.22
EMBO Workshop: Timing Mechanisms in Linking Development and Evolution20.04.2209.05.2229.06.22
Joint SDB and PASEDB Meeting11.04.2209.05.22 (early deadline)17.07.22
European Worm Meeting 202201.05.22 (for talks)27.07.22
Advanced approaches to neuro evo-devo18.04.2205.09.22
The Company of Biologists Workshop – Developmental Metabolism and the Origins of Health and Disease22.04.22 (ECRs only)24.10.22
Please note that some meetings may be full before their application deadline.

preLights in #devbio

In the spotlight: How human neural progenitors were caught red-handed

Will you be pun-ished for a funny title?

Quantifying the absolute RNA content of single cells is possible for existing data sets and biologically relevant.


If you are interested in science communication, would like to improve your writing skills and become part of the preLights community, don’t miss the open call for new preLighters.

Just for fun – our favourite April fools

If you would like to write for the Node, check out our recent list of writing ideas. If you would like to contribute to our ‘Developing news’ blog, please get in touch at thenode@biologists.com

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Summer School in TRANSCRIPTOMICS in Development and Cancer – Join us in Sweden 27-30 June 2022

Posted by , on 9 April 2022

Join us in a Swedish enchanting scenario at the end of June (27-30) when it’s always light in Sweden!

If you are a Student (bachelor/Master’s/PhD), a Postdoc, or a young PI, and are using transcriptomics technologies, or you wish to approach them, this is the right event for you!

A line-up of Famous Scientists (see: http://nmmpschool2022.se) will teach you:

1) How the #3Dgenome works

2) When to use bulk vs scRNA-seq

3) How to combine WET and DRY tools

4) How to Write and #publish high quality and #impact

We have limited places – make sure you reserve one by sending a short abstract and REGISTER before the deadline at http://nmmpschool2022.se

This event is co-organized by Claudio Cantù at Linköping University, Sweden; Silvia Remeseiro at Umeå University, Sweden; and Andreas Moor at ETH-Zurich, Switzerland.

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Categories: Careers, Discussion, Education, Events, Research

March in preprints

Posted by , on 8 April 2022

Welcome to our monthly trawl for developmental biology (and related) preprints.

The preprints this month are hosted on bioRxiv, arXiv and preprints.org – use these links to get to the section you want.

Developmental biology

Cell Biology

Modelling

Reviews

Tools & Resources

Research practice & education

Developmental biology

| Patterning & signalling

Cytoneme contacts in Drosophila from Du, et al.

GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion
Lijuan Du, Alex Sohr, Yujia Li, Sougata Roy

Modelling global mRNA dynamics during Drosophila embryogenesis reveals a relationship between mRNA degradation and P-bodies
Lauren Forbes Beadle, Jennifer C. Love, Yuliya Shapovalova, Artem Artemev, Magnus Rattray, Hilary L. Ashe

Canonical Wnt Signaling and the Regulation of Divergent Mesenchymal Fgf8 expression in Axolotl Limb Development and Regeneration
Giacomo L. Glotzer, Pietro Tardivo, Elly M. Tanaka

Bone Morphogenetic Protein (BMP) signaling regulates germline stem cell self-renewal in the newly formed Drosophila testis stem cell niche
Merci N Best, Ashley Fidler, Marieke K Jones, Matthew Wawersik

High-resolution Ribosome Profiling Reveals Translational Selectivity for Transcripts in Bovine Preimplantation Embryo Development
Linkai Zhu, Tong Zhou, Rajan Iyyappan, Hao Ming, Yinjuan Wang, Michal Dvoran, Qi Chen, R. Michael Roberts, Andrej Susor, Zongliang Jiang

Combinatorial interactions of Hox genes establish appendage diversity of the amphipod crustacean Parhyale hawaiensis
Erin Jarvis Alberstat, Kevin Chung, Dennis A Sun, Shagnik Ray, Nipam H. Patel

Complement facilitates developmental microglial pruning of astrocyte and vascular networks
Gopalan Gnanaguru, Steven J. Tabor, Gracia M. Bonilla, Ruslan Sadreyev, Kentaro Yuda, Jörg Köhl, Kip M. Connor

Unmyelinated neurons use Neuregulin signals to promote myelination of neighboring neurons in the CNS
Daniel E. Lysko, William S. Talbot

Nr6a1 controls axially-restricted body elongation, segmentation, patterning and lineage allocation
Yi-Cheng Chang, Siew Fen Lisa Wong, Jan Schroeder, Gabriel M. Hauswirth, Natalia A Shylo, Emma L Moore, Annita Achilleos, Victoria Garside, Jose M. Polo, Jan Manent, Paul Trainor, Edwina McGlinn

Innexin function dictates the spatial relationship between distal somatic cells in the Caenorhabditis elegans gonad without impacting the germline stem cell pool
Theadora Tolkin, Ariz Mohammad, Todd Starich, Ken C. Q. Nguyen, David H. Hall, Tim Schedl, E. Jane Albert Hubbard, David Greenstein

Butterfly eyespots from Banerjee, et al.

Reuse of a wing venation gene-regulatory network in patterning the eyespot rings of butterflies
Tirtha Das Banerjee, Seah Kwi-Shan, Antónia Monteiro

Wnt and BMP signaling enhance melanocyte regeneration and suppress melanoma cell migration
Esra Katkat, Yeliz Demirci, Guillaume Heger, Irene Papatheodorou, Alvis Brazma, Gunes Ozhan

Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling
M. Micaela Sartoretti, Carla A. Campetella, Guillermo M. Lanuza

Ecdysone signaling controls early embryogenesis in the short-germ hemimetabolous insect Blattella germanica
Josefa Cruz, Oscar Maestro, Xavier Franch-Marro, David Martín

Lrig1 and Wnt dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis
Susanne C. Baess, Ann-Kathrin Burkhart, Sabrina Cappello, Annika Graband, Kristin Seré, Martin Zenke, Catherin Niemann, Sandra Iden

Distinct phospho-variants of STAT3 regulate naïve pluripotency and developmental pace in vivo
Takuya Azami, Sophie Kraunsoe, Graziano Martello, Yihan Pei, Thorsten Boroviak, Jennifer Nichols

Integrated analysis of Wnt signalling system component gene expression
Paula Murphy, Chris Armit, Bill Hill, S. Venkataraman, Patrick Frankel, Richard Baldock, Duncan Davidson

Hippo Signaling Cofactor, WWTR1, at the Crossroads of Human Trophoblast Progenitor Self-Renewal and Differentiation
Soma Ray, Abhik Saha, Ananya Ghosh, Namrata Roy, Ram P Kumar, Gudrun Meinhardt, Abhirup Mukerjee, Sumedha Gunewardena, Rajnish Kumar, Martin Knöfler, Soumen Paul

Cell size asymmetries in the sea star embryo
Barone Vanessa, Maria Byrne, Deirdre C. Lyons

Follicle cell contact maintains main body axis polarity in the Drosophila melanogaster oocyte
Ana Milas, Jorge de-Carvalho, Ivo A. Telley

The role of TGFβ signaling in Gli1+ tendon and enthesis cells
Lee Song, Mikhail Golman, Adam C. Abraham, Elazar Zelzer, Stavros Thomopoulos

Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells
Kaitlin E. Murtha, Yang Yang, Federico Ceriani, Jing-Yi Jeng, Leslie K. Climer, Forrest Jones, Jack Charles, Sai K. Devana, Aubrey J. Hornak, Walter Marcotti, Dwayne D. Simmons

A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage
Gautam Chandra Sarkar, Umanshi Rautela, Anita Goyala, Sudeshna Datta, Nikhita Anand, Anupama Singh, Prachi Singh, Manish Chamoli, Arnab Mukhopadhyay

IFT20 governs mesenchymal stem cell fate through positively regulating TGF-β-Smad2/3-Glut1 signaling mediated glucose metabolism
Yang Li, Shuting Yang, Yang Liu, Ling Qin, Shuying Yang

Levels of p53 expression determine the competitive ability of embryonic stem cells during the onset of differentiation
Salvador Perez Montero, Sarah Bowling, Rubén Pérez-Carrasco, Tristan A. Rodriguez

| Morphogenesis & mechanics

Dynamic de novo adipose tissue development during metamorphosis in Drosophila melanogaster
Taiichi Tsuyama, Hanae Komai, Yusaku Hayashi, Kohei Shimono, Tadashi Uemura

Zebrafish cornea formation and homeostasis reflect robustness in camera-type eye biology, regardless of its environment
Kaisa Ikkala, Sini Raatikainen, Frederic Michon

Cardioblasts in Drosophila embryos from Balaghi, et al.

Myosin waves and a mechanical asymmetry guide the oscillatory migration of Drosophila cardiac progenitors
Negar Balaghi, Gonca Erdemci-Tandogan, Christopher McFaul, Rodrigo Fernandez-Gonzalez

Paf1C denoises transcription and growth patterns to achieve organ shape reproducibility
Duy-Chi Trinh, Marjolaine Martin, Lotte Bald, Alexis Maizel, Christophe Trehin, Olivier Hamant

Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole
Kaichi Watanabe, Yuhei Yasui, Yuta Kurose, Masashi Fujii, Takashi Yamamoto, Naoaki Sakamoto, Akinori Awazu

Plakoglobin is a mechanoresponsive regulator of naïve pluripotency
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellerman, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder

Patterned apoptosis modulates local growth and tissue shape in a fast-growing epithelium
Alexis Matamoro-Vidal, Tom Cumming, Anđela Davidović, Romain Levayer

Thymus formation in uncharted embryonic territories
Isabel Alcobia, Margarida Gama-Carvalho, Leonor Magalhães, Vitor Proa, Domingos Henrique, Hélia Neves

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation
Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V. Anderson

The multi-level regulation of clownfish metamorphosis by thyroid hormones
Natacha Roux, Saori Miura, Mélanie Dussene, Yuki Tara, Fiona Lee, Simon de Bernard, Mathieu Reynaud, Pauline Salis, Agneesh Barua, Abdelhay Boulahtouf, Patrick Balaguer, Karine Gauthier, David Lecchini, Yann Gibert, Laurence Besseau, Vincent Laudet

A tissue boundary orchestrates the segregation of inner ear sensory organs
Ziqi Chen, Shuting Xu, Magdalena Żak, Nicolas Daudet

Drosophila egg chambers from Osswald, et al.

Apical constriction induces tissue rupture in a proliferative epithelium
Mariana Osswald, André Barros-Carvalho, Ana M Carmo, Nicolas Loyer, Patricia C Gracio, Claudio Sunkel, Catarina C Homem, Jens Januschke, Eurico Morais-de-Sá

Retinal neuroblast migration and laminar organization requires the cytoskeletal-interacting protein Mllt11
Marley Blommers, Danielle Stanton-Turcotte, Angelo Iulianella

Rac1 controls cell turnover and mammary gland reversibility in post-partum involution
Aleksander Mironov, Matthew Fisher, Randa Elsayed, Melis Karabulutoglu, Nasreen Akhtar

A Morphogenetic Wave that Generates Mesenchymal-to-Epithelial Transition in the Lateral Plate Mesoderm
Manar Abboud Asleh, Mira Zaher, Julian Jadon, Lihi Shaulov, Ronit Yelin, Thomas M. Schultheiss

Mechanical stress driven by rigidity sensing governs epithelial stability
Surabhi Sonam, Lakshmi Balasubramaniam, Shao-Zhen Lin, Ying Ming Yow Ivan, Irina Pi Jaumà, Cecile Jebane, Marc Karnat, Yusuke Toyama, Philippe Marcq, Jacques Prost, René-Marc Mège, Jean-François Rupprecht, Benoît Ladoux

| Genes & genomes

Transcriptomics, Regulatory Syntax, and Enhancer Identification in Heterogenous Populations of Mesoderm-Induced ESCs at Single-Cell Resolution
Mamduh Khateb, Jelena Perovanovic, Kyung Dae Ko, Kan Jiang, Xuesong Feng, Natalia Acevedo-Luna, Jérome Chal, Veronica Ciuffoli, Pavol Genzor, James Simone, Astrid D. Haase, Olivier Pourquié, Stefania Dell’Orso, Vittorio Sartorelli

Molecular Signatures and Cellular Diversity During Mouse Habenula Development
Lieke L. van de Haar, Danai Riga, Juliska E. Boer, Youri Adolfs, Thomas E. Sieburgh, Roland E. van Dijk, Kyoko Watanabe, Nicky C.H. van Kronenburg, Mark H. Broekhoven, Danielle Posthuma, Frank J. Meye, Onur Basak, R. Jeroen Pasterkamp

The addition of antibiotics to embryo culture media caused altered expression of genes in pathways governing DNA integrity in mouse blastocysts
Qianqian Han, Yan Li, Xu Ji, Lu Chang, Wenjuan Li, Jianfeng Shi, Jing Liu, Wuhua Ni, Xuefeng Huang, Chris O’Neill, Xingliang Jin

GLOBAL HOST RESPONSES TO THE MICROBIOTA AT SINGLE CELL RESOLUTION IN GNOTOBIOTIC ZEBRAFISH
Michelle S. Massaquoi, Garth Kong, Daisy Chilin, Mary K. Hamilton, Ellie Melancon, Judith S. Eisen, Karen Guillemin

Genome-wide enrichment of histone marks in medaka embryos from Fukushima, et al.

Histone marks retained during epigenetic reprogramming and their roles essential for fish early development
Hiroto S. Fukushima, Hiroyuki Takeda, Ryohei Nakamura

Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation
Megan M. Colonnetta, Paul Schedl, Girish Deshpande

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation genes but inhibit expression of cell-cell adhesion genes independently of MITF
Colin Kenny, Ramile Dilshat, Hannah Seberg, Eric Van Otterloo, Gregory Bonde, Annika Helverson, Christopher M. Franke, Eiríkur Steingrímsson, Robert A. Cornell

Premature translation of the zygotic genome activator Zelda is not sufficient to precociously activate gene expression
Elizabeth D. Larson, Hideyuki Komori, Zoe A. Fitzpatrick, Samuel D. Krabbenhoft, Cheng-Yu Lee, Melissa Harrison

Fate and state transitions during human blood vessel organoid development
Marina T. Nikolova, Zhisong He, Reiner A. Wimmer, Makiko Seimiya, Jonas M. Nikoloff, Josef M. Penninger, J. Gray Camp, Barbara Treutlein

Simultaneously spatiotemporal gene expression and chromatin accessibility for mouse brain development
Fuqing Jiang, Xin Zhou, Yingying Qian, Li Wang, Qingmei Shen, Fangfang Qu, Guizhong Cui, Kai Chen, Guangdun Peng

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta
Bryan Marsh, Yan Zhou, Mirhan Kapzidic, Susan Fisher, Robert Blelloch

Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals
Victorya Richardson, Kai Zhang, Nora Engel, Rob J Kulathinal

Maternal H3K36 and H3K27 HMTs protect germline immortality via regulation of the transcription factor LIN-15B
Chad Cockrum, Susan Strome

Arginine 65 methylation of Neurogenin 3 by PRMT1 is a prerequisite for development of hESCs into pancreatic endocrine cells
Gahyang Cho, Kwangbeom Hyun, Jieun Choi, Eunji Shin, Bumsoo Kim, Jaehoon Kim, Hail Kim, Yong-Mahn Han

Developmental phenomics suggests that H3K4 monomethylation catalyzed by Trr functions as a phenotypic capacitor
Lautaro Gandara, Albert Tsai, Mans Ekelöf, Rafael Galupa, Ella Preger-Ben Noon, Theodore Alexandrov, Justin Crocker

Targeted deletion of uterine glandular Foxa2 induces embryonic diapause in mice
Mitsunori Matsuo, Jia Yuan, Yeon Sun Kim, Amanda Dewar, Hidetoshi Fujita, Sudhansu K. Dey, Xiaofei Sun

TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway
Moïra Rossitto, Stephanie Déjardin, Chris M Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat

Quantitative Analysis of Transcriptome Dynamics Provides Novel Insights into Developmental State Transitions
Kristin Johnson, Simon Freedman, Rosemary Braun, Carole LaBonne

microCT scans of mouse embryos from Wilderman, et al.

A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development
Andrea Wilderman, Eva D’haene, Machteld Baetens, Tara N. Yankee, Emma Wentworth Winchester, Nicole Glidden, Ellen Roets, Jo Van Dorpe, Sarah Vergult, Timothy C. Cox, Justin Cotney

ID1 and CEBPA Coordinate Epidermal Progenitor Cell Differentiation
Christina Geraldine Kantzer, Wei Yang, David Grommisch, Kim Vikhe Patil, Kylie Hin-Man Mak, Maria Genander

A cell cycle-dependent GARP-like transcriptional repressor regulates the initiation of differentiation in Giardia lamblia
Han-Wei Shih, Germain C.M. Alas, Alexander R. Paredez

Sox8 remodels the cranial ectoderm to generate the ear
Ailin Leticia Buzzi, Jingchen Chen, Alexandre Thiery, Julien Delile, Andrea Streit

DNA Double Strand Breaks cause chromosome loss through sister chromatid tethering in human embryos
Jenna Turocy, Diego Marin, Shuangyi Xu, Jia Xu, Alex Robles, Nathan Treff, Dieter Egli

A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2
Marta Losa, Iros Barozzi, Marco Osterwalder, Peyman Zarrineh, Jean Denis Benazet, Brandon Chacon, Ausra Girdziusaite, Angela Morabito, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Nicoletta Bobola, Diane Dickel, Aimee Zuniga, Axel Visel, Rolf Zeller, Licia Selleri

Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary
Neha Singh, Domdatt Singh, Anshul Bhide, Richa Sharma, Sarthak Sahoo, Mohit Kumar Jolly, Deepak Modi

Timing of neurogenesis through sequential accumulation of miR-9 due to additive expression of multiple alleles
X. Soto, J. Burton, C. Manning, T. Minchington, R. Lea, J. Lee, J. Kursawe, M. Rattray, N. Papalopulu

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
Wenbo Liu, Xukun Lu, Zheng-Hui Zhao, Qian-Nan Li, Yue Xue, Zheng Gao, Si-Min Sun, Wen-Long Lei, Lei Li, Geng An, Hanyan Liu, Zhiming Han, Ying-Chun Ouyang, Yi Hou, Zhen-Bo Wang, Qing-Yuan Sun, Jianqiao Liu

The shifting epigenetic landscape and roles of key transcription factors during early retinal cell differentiation
Yichen Ge, Xushen Chen, Nan Nan, Jonathan Bard, Fuguo Wu, Donald Yergeau, Tao Liu, Jie Wang, Xiuqian Mu

Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
Chenfei Wang, Chuan Chen, Xiaoyu Liu, Chong Li, Qiu Wu, Xiaolan Chen, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yawei Gao, Yong Zhang, Shaorong Gao

The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting
Milou W.M. Meeuse, Smita Nahar, Kathrin Braun, Helge Großhans

Histone H3 in C.elegans embryos from Gleason, et al.

Developmentally programmed epigenome regulates cellular plasticity at the parental-to-zygote transition
Ryan J. Gleason, Christopher S. Semancik, Gitanjali Lakshminarayanan, Xin Chen

A promoter-proximal silencer modifies the activity of a shared enhancer to mediate divergent expression of nub and pdm2 paralogs in wing development
Ryan Loker, Richard S. Mann

Nrf2 promotes thyroid development and hormone synthesis
Gillotay Pierre, Romitti Mirian, Dassy Benjamin, Haerlingen Benoit, Parakkal Shankar Meghna, Faria Fonseca Barbara, Ziros G. Panos, Pal Singh Sumeet, Sykiotis P. Gerasimos, Costagliola Sabine

microRNA-1 represses signaling pathway components to impact embryonic structures derived from all three germ layers
Nina Faye Sampilo, Jia L. Song

Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex
Richard P. Meisel, Danial Asgari, Florencia Schlamp, Robert L. Unckless

Sperm mosaicism predicts transmission of de novo mutations to human blastocysts
Martin W. Breuss, Xiaoxu Yang, Valentina Stanley, Jennifer McEvoy-Venneri, Xin Xu, Arlene J. Morales, Joseph G. Gleeson

Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Samantha M. Barnada, Andrew Isopi, Daniela Tejada-Martinez, Clément Goubert, Sruti Patoori, Luca Pagliaroli, Mason Tracewell, Marco Trizzino

Physoxia influences global and gene-specific methylation in pluripotent stem cells
Fatma Dogan, Rakad M Kh Aljumaily, Mark Kitchen, Nicholas R. Forsyth

LINE-1 retrotransposon activation intrinsic to interneuron development
Gabriela O. Bodea, Maria E. Ferreiro, Francisco J. Sanchez-Luque, Juan M. Botto, Jay Rasmussen, Muhammed A. Rahman, Laura R. Fenlon, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H.C. Kempen, Chloe J. Love, Lucy M. Palmer, Adam D. Ewing, Dhanisha J. Jhaveri, Sandra R. Richardson, Anthony J. Hannan, Geoffrey J. Faulkner

Genome-wide binding of Drosophila Mask reveals its role in maintenance of gene activation by Trithorax group
Ammad Shaukat, Muhammad Haider Farooq Khan, Jawad Akhtar, Muhammad Abdul Haseeb, Khalida Mazhar, Zain Umer, Muhammad Tariq

Effects of somatic mutations on cellular differentiation in iPSC models of neurodevelopment
Pau Puigdevall, Julie Jerber, Petr Danecek, Sergi Castellano, Helena Kilpinen

TATTOO-seq delineates spatial and cell type-specific regulatory programs during limb patterning
Sébastien Bastide, Elad Chomsky, Baptiste Saudemont, Yann Loe-Mie, Sandrine Schmutz, Sophie Novault, Heather Marlow, Amos Tanay, François Spitz

| Stem cells, regeneration & disease modelling

Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure Closure
Elangovan Boobalan, Amy H. Thompson, Ramakrishna P. Alur, David McGaughey, Lijin Dong, Grace Shih, Emile R. Vieta-Ferrer, Ighovie F. Onojafe, Vijay K. Kalaskar, Gavin Arno, Andrew J. Lotery, Bin Guan, Chelsea Bender, Omar Memon, Lauren Brinster, Clement Soleilhavoup, Lia Panman, Tudor C. Badea, Andrea Minella, Antonio Jacobo Lopez, Sara Thomasy, Ala Moshiri, Genomics England Research Consortium, Delphine Blain, Robert B. Hufnagel, Tiziana Cogliati, Kapil Bharti, Brian P. Brooks

Embryonic mouse hearts stained with hematoxylin and eosin from Chang, et al.

Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse models
Suhee Chang, Diana Fulmer, Stella K. Hur, Joanne L. Thorvaldsen, Li Li, Yemin Lan, Eric A. Rhon-Calderon, Xiaowen Chen, Jonathan A. Epstein, Marisa S. Bartolomei

Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition
Cansu Koyunlar, Emanuele Gioacchino, Disha Vadgama, Hans de Looper, Joke Zink, Remco Hoogenboezem, Marije Havermans, Eric Bindels, Elaine Dzierzak, Ivo P Touw, Emma de Pater

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes
Haiting Ma, Esmée de Zwaan, Yang Eric Guo, Paloma Cejas, Prathapan Thiru, Martijn van de Bunt, Jacob F. Jeppesen, Sudeepa Syamala, Alessandra Dall’Agnese, Brian J. Abraham, Dongdong Fu, Carrie Garrett-Engele, Tony Lee, Henry W Long, Linda G. Griffith, Richard A. Young, Rudolf Jaenisch

A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development
Javier Solivan-Rivera, Zinger Yang Loureiro, Tiffany DeSouza, Anand Desai, Qin Yang, Raziel Rojas-Rodriguez, Pantos Skritakis, Shannon Joyce, Denise Zhong, Tammy Nguyen, Silvia Corvera

Stem cells partner with matrix remodeling cells during regeneration
Blair W. Benham-Pyle, Frederick G. Mann Jr., Carolyn E. Brewster, Enya R. Dewars, Stephanie H. Nowotarski, Carlos Guerrero-Hernández, Seth Malloy, Kate E. Hall, Lucinda E. Maddera, Shiyuan Chen, Jason A. Morrison, Brian D. Slaughter, Anoja Perera, Alejandro Sánchez Alvarado

Stem cell homeostasis regulated by hierarchy and neutral competition
Asahi Nakamuta, Kana Yoshido, Honda Naoki

Single-cell analyses of axolotl forebrain organization, neurogenesis, and regeneration
Katharina Lust, Ashley Maynard, Tomás Gomes, Jonas Simon Fleck, J. Gray Camp, Elly M. Tanaka, Barbara Treutlein

Cfdp1 is Essential for Cardiac Development and Function
Giardoglou Panagiota, Deloukas Panos, Dedoussis George, Beis Dimitris

Altered patterning of trisomy 21 interneuron progenitors
Yathindar Giffin-Rao, Jie Sheng, Bennett Strand, Ke Xu, Leslie Huang, Margaret Medo, Kirstin A. Risgaard, Samuel Dantinne, Sruti Mohan, Aratrika Keshan, Roger A. Daley Jr., Bradley Levesque, Lindsey Amundson, Rebecca Reese, André M.M. Sousa, Yunlong Tao, Daifeng Wang, Su-Chun Zhang, Anita Bhattacharyya

Impact of Maternal Protein Restriction on Hypoxia-Inducible Factor (HIF) Expression in Male Fetal Kidney Development
Júlia Sevá Gomes, Letícia de Barros Sene, Gabriela Leme Lamana, Patricia Aline Boer, José Antônio Rocha Gontijo

VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
Sara Cioffi, Gemma Flore, Stefania Martucciello, Marchesa Bilio, Maria Giuseppina Turturo, Elizabeth Illingworth

SARS-CoV-2 Can Infect Human Embryos
Mauricio Montano, Andrea R. Victor, Darren K. Griffin, Tommy Duong, Nathalie Bolduc, Andrew Farmer, Vidur Garg, Anna-Katerina Hadjantonakis, Alison Coates, Frank L. Barnes, Christo G. Zouves, Warner C. Greene, Manuel Viotti

Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships
Nathaniel Zbasnik, Katie Dolan, Stephanie A. Buczkowski, Rebecca Green, Benedikt Hallgrimsson, Ralph S. Marcucio, Anne M. Moon, Jennifer L. Fish

En1 and Lmx1b do not recapitulate embryonic dorsal-ventral limb patterning functions during mouse digit tip regeneration
Gemma L. Johnson, Morgan B. Glasser, Julia F. Charles, Jeffrey Duryea, Jessica A. Lehoczky

Mouse and human blastocyts from Yang, et al.

Differential expression of Nanog 3UTR and coding region mRNA components defines an embryonic stem cell niche
Ze Yang, Shaoyi Ji, Leonardi Gozali, Mujib Ullah, Sophie Parsa, Barry Behr, Mary A. Hynes

Uterine injury during diestrus leads to embryo spacing defects and perturbations in the COX pathway in subsequent pregnancies
Elisa T. Zhang, Kristen L. Wells, Lars Steinmetz, Julie C. Baker

“Integration of multimodal data in the developing tooth reveals candidate dental disease genes”
Emma Wentworth Winchester, Alexis Hardy, Justin Cotney

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions
Damien Detraux, Marino Caruso, Louise Feller, Maude Fransolet, Sébastien Meurant, Julie Mathieu, Thierry Arnould, Patricia Renard

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality
Samuel J. Wattrus, Mackenzie L. Smith, Cecilia Pessoa Rodrigues, Elliott J. Hagedorn, Bogdan Budnik, Leonard I. Zon

Ependymal cell maturation is heterogeneous and ongoing in the mouse spinal cord and dynamically regulated in response to injury
Aida Rodrigo Albors, Gail A. Singer, Andrew P. May, Chris P. Ponting, Kate G. Storey

Elevated p21 (CDKN1a) mediates β-thalassemia erythroid apoptosis but its loss does not improve β-thalassemic erythropoiesis
Vijay Menon, Miao Lin, Raymond Liang, Tasleem Arif, Anagha Menon, Laura Breda, Stefano Rivella, Saghi Ghaffari

Proteomic Profiling of Hypoplastic Lungs Suggests an Underlying Inflammatory Response in the Pathogenesis of Abnormal Lung Development in Congenital Diaphragmatic Hernia
Richard Wagner, Paula Lieckfeldt, Hadeesha Piyadasa, Moritz Markel, Jan Riedel, Camelia Stefanovici, Nicole Peukert, Daywin Patel, Gabrielle Derraugh, Suyin Lum Min, Jan-Hendrik Gosemann, Jan Deprest, Christopher D. Pascoe, Andrew Tse, Martin Lacher, Neeloffer Mookherjee, Richard Keijzer

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects
Maja Solman, Sasja Blokzijl-Franke, Florian Piques, Chuan Yan, Qiqi Yang, Marion Strullu, Sarah M. Kamel, Pakize Ak, Jeroen Bakkers, David M. Langenau, Hélène Cavé, Jeroen den Hertog

Planarians and their heterotrimeric G proteins from Jenkins and Roberts-Galbraith

Heterotrimeric G proteins regulate planarian regeneration and behavior
Jennifer E. Jenkins, Rachel H. Roberts-Galbraith

FAM172A controls the nuclear import and alternative splicing function of AGO2
Sephora Sallis, Félix-Antoine Bérubé-Simard, Benoit Grondin, Elizabeth Leduc, Fatiha Azouz, Catherine Bélanger, Nicolas Pilon

Snrpb, the CCMS gene, is required in neural crest cells for proper splicing of genes essential for craniofacial morphogenesis
Sabrina Shameen Alam, Shruti Kumar, Marie-Claude Beauchamp, Eric Bareke, Alexia Boucher, Nadine Nzirorera, Reinnier Padilla, Si Jing Zhang, Jacek Majewski, Loydie A. Jerome-Majewska

Neovascularization and the recruitment of CD31+ cells from the bone marrow are unique under regenerative but not wound repair conditions
Kamila Bedelbaeva, Young Zhang, Azamat Azlanukov, Dmitri Gourevitch, Iossif Strehin, Phillip Messersmith, Ellen Heber-Katz

Alcam-a and Pdgfr-α are essential for the development of sclerotome derived stromal cells that support hematopoiesis in vivo
Emi Murayama, Catherine Vivier, Anne Schmidt, Anne-Lou Touret, Philippe Herbomel

The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
Erna Raja, Gopakumar Changarathil, Lalhaba Oinam, Yen Xuan Ngo, Jun Tsunezumi, Ryutaro Ishii, Takako Sasaki, Kyoko Imanaka-Yoshida, Hiromi Yanagisawa, Aiko Sada

Integrative analysis of transcriptomics in human craniofacial development reveals novel candidate disease genes
Tara N. Yankee, Andrea Wilderman, Emma Wentworth Winchester, Jennifer VanOudenhove, Justin Cotney

A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate
Michael Xiao, Chia-Hua Wu, Graham Meek, Brian Kelly, Lyndsay E.A. Young, Sara Martire, Dara Buendia Castillo, Purbita Saha, Altair L. Dube, Matthew S. Gentry, Laura A. Banaszynski, Ramon C. Sun, Chintan K. Kikani

Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells
Stanislava Sladeček, Katarzyna Anna Radaszkiewicz, Martina Bőhmová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Jiří Pacherník

| Plant development

Cell-based model shows complex rearrangement of tissue mechanical properties are needed for roots to grow in hard soil
Matthias Mimault, Mariya Ptashnyk, Lionel Dupuy

Transcriptome profiling of barley and tomato shoot and root meristems unravels physiological variations underlying photoperiodic sensitivity
Michael Schneider, Lucia Vedder, Benedict Chijioke Oyiga, Boby Mathew, Heiko Schoof, Jens Léon, Ali Ahmad Naz

Dopamine pathway characterization during the reproductive mode switch in the pea aphid
Gaël Le Trionnaire, Sylvie Hudaverdian, Gautier Richard, Sylvie Tanguy, Florence Gleonnec, Nathalie Prunier-Leterme, Jean-Pierre Gauthier, Denis Tagu

Redundant PLETHORA activity promotes development of early embryonic cell lineages in Arabidopsis
Merijn Kerstens, Carla Galinha, Hugo Hofhuis, Michael Nodine, Ben Scheres, Viola Willemsen

14 day old Arabidopsis seedlings from Stitz, et al.

TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana
Michael Stitz, David Kuster, Maximilian Reinert, Mikhail Schepetilnikov, Béatrice Berthet, Denis Janocha, Anthony Artins, Marc Boix, Rossana Henriques, Anne Pfeiffer, Jan Lohmann, Emmanuel Gaquerel, Alexis Maizel

Complex developmental and transcriptional dynamics underlie pollinator-driven evolutionary transitions in nectar spur morphology in Aquilegia (columbine)
Molly B. Edwards, Evangeline S. Ballerini, Elena M. Kramer

Liguleless narrow and narrow odd dwarf act in overlapping pathways to regulate maize development & physiology
María Jazmín Abraham-Juárez, Michael Busche, Alyssa A. Anderson, China Lunde, Jeremy Winders, Shawn A. Christensen, Charles T. Hunter, Sarah Hake, Jacob O. Brunkard

The DC1 domain protein BINUCLEATE POLLEN is required for pollen development in Arabidopsis
Leonardo Agustín Arias, Sebastián D’Ippolito, Jésica Frik, Natalia Loreley Amigo, Claudia Anahí Casalongué, Gabriela Carolina Pagnussat, Diego Fernando Fiol

Phyllochron duration and changes through rice development shape the vertical leaf size profile
Janet P. Pablo, Benoit Clerget, Crisanta Bueno, Jacqueline Dionora, Abigail J. Domingo, Constancio C. De Guzman, Edna A. Aguilar, Nina M. Cadiz, Pompe C. Sta Cruz

The NIN-LIKE PROTEIN 7 (NLP7) transcription factor modulates auxin pathways to regulate root cap development
Narender Kumar, Chloe Caldwell, Anjali S. Iyer-Pascuzzi

MYB12 spatiotemporally represses TMO5/LHW-mediated transcription in the Arabidopsis root meristem
Brecht Wybouw, Helena E. Arents, Baojun Yang, Jonah Nolf, Wouter Smet, Michael Vandorpe, Daniël Van Damme, Matouš Glanc, Bert De Rybel

Stem cell regulators control a G1 duration gradient in the plant root meristem
Clara Echevarria, Bénédicte Desvoyes, Marco Marconi, José Manuel Franco-Zorrila, Laura Lee, Masaaki Umeda, Robert Sablowski, Kenneth D. Birnbaum, Krzysztof Wabnik, Crisanto Gutierrez

An environmentally-responsive transcriptional state modulates cell identities during root development
Marina Oliva, Tim Stuart, Dave Tang, Jahnvi Pflueger, Daniel Poppe, Jafar S. Jabbari, Scott Gigante, Jonathan Michael Dragwidge, James Whelan, Mathew G. Lewsey, Ryan Lister

| Evo-devo

Developmental timing of Drosophila pachea pupae is robust to temperature changes
Bénédicte M. Lefèvre, Stecy Mienanzambi, Michael Lang

Wildtype Parhyale hatchling from Sun, et al.

Distinct regulation of Hox genes by Polycomb Group genes in a crustacean
Dennis A Sun, Yuri Takahashi, Rebecca J Chang, Nipam H Patel

Gill developmental program in the teleost mandibular arch
Mathi Thiruppathy, J. Andrew Gillis, J. Gage Crump

Sea anemone Frizzled receptors play partially redundant roles in the oral-aboral axis patterning
Isabell Niedermoser, Tatiana Lebedeva, Grigory Genikhovich

Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins
Phillip L Davidson, Haobing Guo, Jane S Swart, Abdull J Massri, Allison Edgar, Lingyu Wang, Alejandro Berrio, Hannah R Devens, Demian Koop, Paula Cisternas, He Zhang, Yaolei Zhang, Maria Byrne, Guangyi Fan, Gregory A Wray

The conserved transcriptional program of metazoan male germ cells uncovers ancient origins of human infertility
Rion Brattig Correia, Joana M. Almeida, Margot J. Wyrwoll, Irene Julca, Daniel Sobral, Chandra Shekhar Misra, Leonardo G. Guilgur, Hans-Christian Schuppe, Neide Silva, Pedro Prudêncio, Ana Nóvoa, Ana S. Leocádio, Joana Bom, Moisés Mallo, Sabine Kliesch, Marek Mutwil, Luis M. Rocha, Frank Tüttelmann, Jörg D. Becker, Paulo Navarro-Costa

Ultrabithorax modifies a regulatory network of genes essential for butterfly eyespot development in a wing sector-specific manner
Yuji Matsuoka, Antónia Monteiro

Distal-less and spalt are distal organisers of pierid wing patterns
Jocelyn Liang Qi Wee, Tirtha Das Banerjee, Anupama Prakash, Kwi Shan Seah, Antónia Monteiro

Cell Biology

Ubiquitin ligases and a processive proteasome facilitate protein clearance during the oocyte-to-embryo transition in Caenorhabditis elegans
Caroline A. Spike, Tatsuya Tsukamoto, David Greenstein

SPACA6 structure reveals a conserved superfamily of gamete fusion-associated proteins
Tyler D.R. Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E. Lee

Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis
Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E. Wheelock, Sasha A. Singh, Masanori Aikawa, Lois E. Smith, Richard L. Proia, Timothy Hla

Simultaneous suppression of ribosome biogenesis and Tor activation by TRIM-NHL proteins promotes terminal differentiation
Jinghua Gui, Tamsin J Samuels, Katarina ZA Grobicki, Felipe Karam Teixeira

Proteasomal subunit depletions differentially affect germline integrity in C. elegans
Lourds Michelle Fernando, Cristina Quesada-Candela, Makaelah Murray, Caroline Ugoaru, Judith L. Yanowitz, Anna K. Allen

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
Alberto Dinarello, Riccardo Massimiliano Betto, Linda Diamante, Chiara Cioccarelli, Giacomo Meneghetti, Margherita Peron, Annachiara Tesoriere, Claudio Laquatra, Natascia Tiso, Graziano Martello, Francesco Argenton

The X chromosome is a potential polarising signal for asymmetric cell divisions in meiotic cells of a nematode
Talal Alyazeedi, Emily Xu, Jasmin Kaur, Diane Shakes, Andre Pires-daSilva

Crumbs complex-directed apical membrane dynamics in epithelial cell ingression
Sérgio Simões, Gerald Lerchbaumer, Milena Pellikka, Paraskevi Giannatou, Thomas Lam, Dohyun Kim, Jessica Yu, David ter Stal, Kenana Al Kakouni, Rodrigo Fernandez-Gonzalez, Ulrich Tepass

Microtubules control Buc Phase separation and Balbiani body condensation in zebrafish oocyte polarity
Rachael Deis, Yaniv M. Elkouby

Cilia regulate meiotic recombination in zebrafish
Haibo Xie, Xiaosi Wang, Minjun Jin, Lanqin Li, Junwen Zhu, Yunsi Kang, Zhe Chen, Yonghua Sun, Chengtian Zhao

Kymographs of migrating cells in Drosophila egg chambers from Williams, et al.

Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration
Audrey M. Williams, Seth Donoughe, Edwin Munro, Sally Horne-Badovinac

A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation
Chenhui Deng, Amanda Ya, Duane A. Compton, Kristina M. Godek

Cell-intrinsic differences between human airway epithelial cells from children and adults
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N. J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes

“Two-story building” of a ctenophore comb plate provides structural and functional integrity for motility of giant multicilia
Kei Jokura, Yu Sato, Kogiku Shiba, Kazuo Inaba

Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations
Guizela Huelsz-Prince, Rutger N.U. Kok, Yvonne J. Goos, Lotte Bruens, Xuan Zheng, Saskia I. Ellenbroek, Jacco van Rheenen, Sander J. Tans, Jeroen S. van Zon

Induction of cortical Par complex polarity by designed proteins causes cytoskeletal symmetry breaking in unpolarized mammalian cells
Joseph L. Watson, Ariel J. Ben-Sasson, Alice Bittleston, James D. Manton, David Baker, Emmanuel Derivery

Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis
Weidao Zhang, Min Tang, Lin Wang, Hu Zhou, Jing Gao, Zhongliang Chen, Bo Zhao, Ping Zheng

Lrig3 restricts the size of the colon stem cell compartment
Janelle G. Stevenson, Ryan Sayegh, Natalie Pedicino, Natalie A. Pellitier, Tim Wheeler, Matthew E. Bechard, Won Jae Huh, Robert J. Coffey, Anne E. Zemper

Modelling

Modelling embryogenesis in Arabidopsis thaliana from Laruelle, et al.

Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis
Elise Laruelle, Katia Belcram, Alain Trubuil, Jean-Christophe Palauqui, Philippe Andrey

A constraints-based theory of the primary cause of senescence: imbalance of epigenetic and non-epigenetic information in histone crosstalk
Felipe A. Veloso

Universal dynamics of biological pattern formation in spatio-temporal morphogen variations
Mohit P. Dalwadi, Philip Pearce

Stability of asymmetric cell division under confinement: A deformable cell model of cytokinesis applied to C. elegans development
Maxim Cuvelier, Wim Thiels, Rob Jelier, Bart Smeets

Minimizing cell number fluctuations in self-renewing tissues with a stem cell niche
Rutger N.U. Kok, Sander J. Tans, Jeroen S. van Zon

Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis
Krishnan S Iyer, Madan Rao, Chaitra Prabhakara, Satyajit Mayor

Modelling mechanically dominated vasculature development
Benjamin J. Walker, Adriana T. Dawes

A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis
Claudiu V. Giuraniuc, Shabana Zain, Shahmama Ghafoor, Stefan Hoppler

Reviews

Genetic Regulation of Central Synapse Formation and Organization in Drosophila melanogaster
Juan Carlos Duhart and Timothy J. Mosca

Pluripotent Core in Bovine Embryos: A Review
Luis Aguila, Claudia Osycka-Salut, Favian Treulen , Ricardo Felmer

Tools & Resources

SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo
Mattias Malaguti, Rosa Portero Migueles, Jennifer Annoh, Daina Sadurska, Guillaume Blin, Sally Lowell

Recently hatched Loligo vulgaris from Duruz, et al.

Molecular characterization of cell types in the squid Loligo vulgaris
Jules Duruz, Marta Sprecher, Jenifer C. Kaldun, Alsayed Alsoudy, Heidi Tschanz-Lischer, Geert van Geest, Pamela Nicholson, Rémy Bruggmann, Simon G. Sprecher

siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos
Tokiha Masuda-Ozawa, Sosuke Fujita, Ryotaro Nakamura, Hiroshi Watanabe, Erina Kuranaga, Yu-ichiro Nakajima

Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells
Tao Deng, Carlos A. Tristan, Claire Weber, Pei-Hsuan Chu, Seungmi Ryu, Vukasin M. Jovanovic, Pinar Ormanoglu, Prisca Twumasi, Jaehoon Shim, Selwyn Jayakar, Han-Xiong Bear Zhang, Sooyeon Jo, Ty C. Voss, Anton Simeonov, Bruce P. Bean, Clifford J. Woolf, Ilyas Singeç

A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian
Eleni Chrysostomou, Hakima Flici, Sebastian G Gornik, Miguel Salinas-Saavedra, James M Gahan, Emma T McMahon, Kerry Thompson, Shirley Hanley, Michelle Kilcoyne, Christine E. Schnitzler, Paul Gonzalez, Andreas D Baxevanis, Uri Frank

Enhancing the Fitness of Embryoid Bodies and Organoids by Chemical Cytoprotection
Seungmi Ryu, Claire Weber, Pei-Hsuan Chu, Carlos A. Tristan, Ben Ernest, Vukasin M. Jovanovic, Tao Deng, Jaroslav Slamecka, Hyenjong Hong, John Braisted, Marissa Hirst, Anton Simeonov, Ty C. Voss, Ilyas Singeç

From neural border to migratory stage: A comprehensive single cell roadmap of the timing and regulatory logic driving cranial and vagal neural crest emergence
Aleksandr Kotov, Mansour Alkobtawi, Subham Seal, Vincent Kappès, Sofia Medina Ruiz, Hugo Arbès, Richard Harland, Leonid Peshkin, Anne H. Monsoro-Burq

Mechanisms underlying the reprogramming of mouse embryonic fibroblasts to thymic epithelial cells
Zhongyao Ma, Seung Woo Kang, Brian G. Condie, Nancy R. Manley

Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico
Elizabeth M. Duncan, Stephanie H. Nowotarski, Carlos Guerrero-Hernández, Eric J. Ross, Julia A. D’Orazio, Clubes de Ciencia México Workshop for Developmental Biology, Sean McKinney, Mark C. McHargue, Longhua Guo, Melainia McClain, Alejandro Sánchez Alvarado

Organoids from Rahman, et al.

Local actuation of organoids by magnetic nanoparticles
Abdel Rahman Abdel Fattah, Niko Kolaitis, Katrien Van Daele, Andika Gregorius Rustandi, Adrian Ranga

Identification of fetal liver stroma in spectral cytometry using the parameter autofluorescence
Marcia Mesquita Peixoto, Francisca Soares-da-Silva, Sandrine Schmutz, Marie-Pierre Mailhe, Sophie Novault, Ana Cumano, Cedric Ait-Mansour

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
Brandon T. Wesley, Alexander D. B. Ross, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier

A guide to examining intramuscular fat formation and its cellular origin in skeletal muscle
Connor D. Johnson, Lylybell Y. Zhou, Daniel Kopinke

Temporal and spatial dynamics mapping reveals follicle development regulated by different stromal cell populations
Xiaoqiang Sheng, Jidong Zhou, Nannan Kang, Wenwen Liu, Lina Yu, Zhe Zhang, Yang Zhang, Qiuling Yue, Qiwen Yang, Xinke Zhang, Chaojun Li, Guijun Yan, Haixiang Sun

In vivo assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy
Camilo Riquelme-Guzmán, Timon Beck, Sandra Edwards-Jorquera, Raimund Schlüßler, Paul Müller, Jochen Guck, Stephanie Möllmert, Tatiana Sandoval-Guzmán

Highly efficient generation of blastocyst-like structures from mouse totipotent blastomere-like cells
Pengfei Zhang, Xuzhao Zhai, Boyan Huang, Shu Sun, WenJing Wang, Man Zhang

Antiviral and Neuroprotective Abilities of Influenza Virus Infection in Tractable Brain Organoids
Xiaodong Zhang, Haishuang Lin, Liangzhen Dong, Qing Xia

Major transcriptomic, epigenetic and metabolic changes underly the pluripotency continuum in rabbit preimplantation embryos
Wilhelm Bouchereau, Luc Jouneau, Catherine Archilla, Irène Aksoy, Anais Moulin, Nathalie Daniel, Nathalie Peynot, Sophie Calderari, Thierry Joly, Murielle Godet, Yan Jaszczyszyn, Marine Pratlong, Dany Severac, Pierre Savatier, Véronique Duranthon, Marielle Afanassieff, Nathalie Beaujean

The Digital 3D-Atlas MAKER (DAMAKER): a dynamic and expandable digital 3D-tool for monitoring the temporal changes in tissue growth during hindbrain morphogenesis
Matthias Blanc, Frederic Udina, Cristina Pujades

An Open-source, Cost-Efficient Excitation Module for Single-molecule Microscopy
Dylan R. George, Benjamin Ambrose, Ashley J. Cadby, Timothy D. Craggs

SCExecute: cell barcode-stratified analyses of scRNA-seq data
Nathan Edwards, Christian Dillard, NM Prashant, Hongyu Liu, Mia Yang, Evgenia Ulianova, Anelia Horvath

SpyChIP identifies cell type-specific transcription factor occupancy from complex tissues
Siqian Feng, Richard S. Mann

Development of a Novel Microfluidic Co-culture model to study Organoid Vascularization
Lydia S. Schulla, E. Diana Alupoaie, Leanne De Silva, Debby Gawlitta, Sabine Middendorp, Paul J. Coffer, M. Guy Roukens

Endometriotic Organoids: A Novel In Vitro Model of Endometriotic Lesion Development
Yong Song, Gregory W. Burns, Niraj R. Joshi, Ripla Arora, J. Julie Kim, Asgerally T. Fazleabas

A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells
Hans Jiro Becker, Reiko Ishida, Adam C. Wilkinson, Takaharu Kimura, Michelle Sue Jann Lee, Cevayir Coban, Yasunori Ota, Arinobu Tojo, David Kent, Satoshi Yamazaki

Mouse intestine from Battistella, et al.

Light-sheet mesoscopy with the Mesolens provides fast sub-cellular resolution imaging throughout large tissue volumes
Eliana Battistella, Jan Schniete, Katrina Wesencraft, Juan Quintana, Gail McConnell

A microfluidic platform to investigate the role of mechanical constraints on tissue reorganization
Sham Tlili, François Graner, Hélène Delanoë-Ayari

Multimodal spatiotemporal phenotyping of human organoid development
Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Aline Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, Maximilian Hess, Gregor Schmidt, Tom Lummen, Yanyan Hou, Patricia Galliker, Magdalena Renner, Lucas Pelkmans, Barbara Treutlein, J. Gray Camp

Comparison of CRISPR/Cas9-mediated megabase-scale genome deletion methods in mouse embryonic stem cells
Masayuki Miyata, Junko Yoshida, Itsuki Takagishi, Kyoji Horie

An integrated cell atlas of the human lung in health and disease
L Sikkema, D Strobl, L Zappia, E Madissoon, NS Markov, L Zaragosi, M Ansari, M Arguel, L Apperloo, C Bécavin, M Berg, E Chichelnitskiy, M Chung, A Collin, ACA Gay, B Hooshiar Kashani, M Jain, T Kapellos, TM Kole, C Mayr, M von Papen, L Peter, C Ramírez-Suástegui, J Schniering, C Taylor, T Walzthoeni, C Xu, LT Bui, C de Donno, L Dony, M Guo, AJ Gutierrez, L Heumos, N Huang, I Ibarra, N Jackson, P Kadur Lakshminarasimha Murthy, M Lotfollahi, T Tabib, C Talavera-Lopez, K Travaglini, A Wilbrey-Clark, KB Worlock, M Yoshida, Lung Biological Network Consortium, T Desai, O Eickelberg, C Falk, N Kaminski, M Krasnow, R Lafyatis, M Nikolíc, J Powell, J Rajagopal, O Rozenblatt-Rosen, MA Seibold, D Sheppard, D Shepherd, SA Teichmann, A Tsankov, J Whitsett, Y Xu, NE Banovich, P Barbry, TE Duong, KB Meyer, JA Kropski, D Pe’er, HB Schiller, PR Tata, JL Schultze, AV Misharin, MC Nawijn, MD Luecken, F Theis

Epithelial monolayer development and tight junction assembly on nanopillar arrays
Jose Yeste, Xavi Illa, Nitesh Shashikanth, Anton Guimerà-Brunet, Rosa Villa, Jerrold R Turner

Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture
Ece Ergir, Jorge Oliver-De La Cruz, Soraia Fernandes, Marco Cassani, Francesco Niro, Daniel Sousa, Jan Vrbský, Vladimír Vinarský, Ana Rubina Perestrelo, Doriana Debellis, Francesca Cavalieri, Stefania Pagliari, Heinz Redl, Peter Ertl, Giancarlo Forte

The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans
The Tabula Sapiens Consortium, Stephen R Quake

Research practice & education

PhD and postdoc training outcomes at EMBL: changing career paths for life scientists in Europe
Junyan Lu, Britta Velten, Bernd Klaus, Mauricio Ramm, Wolfgang Huber, Rachel Coulthard-Graf

Animal-reliance bias in publishing is a potential barrier to scientific progress
Catharine E. Krebs, Ann Lam, Janine McCarthy, Helder Constantino, Kristie Sullivan

The gender gap in academic career achievements and the mediation effect of work-family conflict and partner support
Xiang Zheng, Haimiao Yuan, Chaoqun Ni

Hybrid conferences: opportunities, challenges and ways forward
Eleonora Puccinelli, Daniela Zeppilli, Paris Stefanoudis, Annaïg Wittische-Helou, Marjorie Kermorgant, Sandra Fuchs, Jozée Sarrazin, Erin E. Easton, Alexandra Anh-Thu Weber

Analysis of science journalism reveals gender and regional disparities in coverage
Natalie R. Davidson, Casey S. Greene

If this title is funny, will you cite me? Citation impacts of humour and other features of article titles in ecology and evolution
Stephen B. Heard, Chloe A. Cull, Easton R. White

An approachable, flexible, and practical machine learning workshop for biologists
Chris S Magnano, Fangzhou Mu, Rosemary S Russ, Milica Cvetkovic, Debora Treu, Anthony Gitter

Replacing bar graphs of continuous data with more informative graphics: Are we making progress?
Nico Riedel, Robert Schulz, Vartan Kazezian, Tracey Weissgerber

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Categories: Highlights, Research

Genetics Unzipped: Face to face – the viruses that made us human

Posted by , on 7 April 2022

Image licensed from Envato

In the latest episode of the Genetics Unzipped podcast, we’re looking at the monkey in the mirror, investigating how flipped genetic switches and long-dead viruses make all the difference between our human faces and those of our closest primate relatives.

“The bits in our genome that encode functional elements like proteins are pretty much identical to a chimp’s. But straight away you can see that a chimp’s face is very different from our own, even though it’s made using the same biological ingredients.”

Dr Kat Arney, presenter

Genetics Unzipped is the podcast from The Genetics Society. Full transcript, links and references available online at GeneticsUnzipped.com.

Subscribe from Apple podcasts, Spotify, or wherever you get your podcasts.

Head over to GeneticsUnzipped.com to catch up on our extensive back catalogue.

If you enjoy the show, please do rate and review on Apple podcasts and help to spread the word on social media. And you can always send feedback and suggestions for future episodes and guests to podcast@geneticsunzipped.com Follow us on Twitter – @geneticsunzip

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Cell Bio 2022-An ASCB|EMBO Meeting

Posted by , on 6 April 2022

December 3-7, 2022 | Walter E. Washington Convention Center | Washington, DC

Returning in person in 2022—this mid-sized unique joint meeting of the American Society for Cell Biology (ASCB) and the European Molecular Biology Organisation (EMBO) focuses on cell biology as the fundamental basis of biology, while also offering sessions on emerging interdisciplinary topics.

Besides offering attendees opportunities to present their research, the meeting provides an unparalleled forum for attendees to network and initiate collaborations across disciplines. Cell Bio 2022 offers eight different tracks—seven scientific and one covering educational, professional development, diversity, and inclusion.

Website: ascb.org/cellbio2022

Abstract Talk Deadline: August 2, 2022

Early Registration Deadline: September 30, 2022

Final Abstract Deadline (Poster only): October 12, 2022

For More info contact ascbinfo@ascb.org.

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Categories: Events, Societies