Calling All Regenerative Biologists! Please read this announcement!
Posted by Henry Roehl, on 1 March 2022
(No Ratings Yet)
Loading...
developmental and stem cell biologists
Posted by Henry Roehl, on 1 March 2022
(No Ratings Yet)Loading...
Posted by the Node, on 1 March 2022
Read on for our news roundup of the past month, with an emphasis on what has caught our eyes from our twitter feed.
#ScienceForUkraine – many labs are offering internships for scientists suffering in the conflict in Ukraine. For more information check out the tweet below:
#Single-CellSequencing – what would Darwin think of single-cell sequencing? And would his grant be funded?
#preLights turns 4!! And to help them celebrate we hosted a joint event on ‘Promoting yourself as an ECR’ on Wednesday 23 February. The recordings from the event and our panellists answers to the questions that we didn’t have time to address will be available soon. Thanks to everyone involved, especially our panellists, Maria Abou Chakra, Pablo Sáez and Sarvenaz Sarabipour.
#DiversityinScience – one of the landmarks we are celebrating at our ECR event, is the 2nd birthday of the Node Network. It was launched to help promote diversity in selection of reviewers, panellist and speakers for event in developmental and stem cell biology. Read the interesting twitter thread from Michelle Facette on why she thinks it is important.
#preprints – why do you preprint, or not? – Check out the thread started by Prachee Avasthi to find out the views from the twitterverse:
#WorkHabits
If you would like to contribute to our ‘Developing news’ blog, please get in touch at thenode@biologists.com. If you are interested in writing preLights, you can find more information here.
(No Ratings Yet)Loading...
Posted by Sharon Ahmad, on 28 February 2022
Journal of Cell Science and its publisher The Company of Biologists are seeking to appoint a new Community Manager to run our microscopy community website, FocalPlane.
Launched in 2020, FocalPlane is a curated and centralised platform for the microscopy community to share news and techniques, discuss issues relevant to the field and read about the latest research and events. We are now looking for an enthusiastic and motivated person with fresh ideas and a willingness to learn to join us to develop and maintain this site.
Core responsibilities of the position include:
• Creating and commissioning content for FocalPlane, including writing posts and soliciting
content from the academic community, societies, companies and other organisations
• Providing user support and ensuring site functionality on a day-to-day basis
• Providing creative and practical input into the development of the site
• Maintaining and developing the site’s presence on social networking sites such as Facebook, Twitter and Instagram
• Representing Journal of Cell Science and FocalPlane at relevant conferences
Essential skills:
• PhD in a relevant scientific field, ideally with experience of microscopy
• Familiar with current trends and hot topics in microscopy and image analysis
• Willingness to grow and develop knowledge of microscopy
• Demonstrable ability to write for an online audience and/or produce social media content
• Clear understanding of the online environment as it applies to scientists
• Excellent interpersonal and communication skills
• Strong networking abilities online and in person
Desirable:
• Experience with additional media (e.g. video or podcasting)
• Experience with WordPress
• Contacts within the microscopy community
This is an exciting opportunity to further develop this hub for the microscopy community – in a similar vein to the Company’s established community site for developmental biologists, the Node – and to engage with relevant people at all levels: academics, developers, facilities, institutes and companies. The Community Manager will work alongside an experienced in-house team, including the Executive Editor of Journal of Cell Science. Additional responsibilities may be provided for the right candidate.
The Company of Biologists exists to support biologists and inspire advances in biology. At the heart of what we do are our five specialist journals – Development, Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open. All are edited by expert researchers in the field, and all articles are subjected to rigorous peer review. We believe that the profits from publishing the hard work of biologists should support scientific discovery and help develop future scientists. Our grants help support societies, meetings and individuals. Our workshops and meetings give the opportunity to network and collaborate.
Applicants should send a CV along with a covering letter that summarises their relevant experience, and in particular any specific microscopy/image analysis skills. Please also include links to any online activities, salary expectations, and details about why you are enthusiastic about this opportunity.
Applications and informal queries should be sent by email to recruitment@biologists.com by 18 March 2022.
We may request written tests in advance of any interview.
Applicants should be eligible to work in the UK.
(No Ratings Yet)Loading...
Posted by Kat Arney, on 24 February 2022
If these dates are correct, it means people must have gotten into North America sometime before 25,000 years ago. And that opens up this whole new avenue of exploration and understanding in both the archaeological record and genetics.
It really makes for a whole new story.
Professor Jennifer Raff
In the latest episode of the Genetics Unzipped podcast, we’re looking at a genetic history of the Americas. We chat with Jennifer Raff about her new book, Origin: The Genetic History of the Americas, covering the controversies surrounding how humans first migrated to the continent. plus Krystal Tsosie tells us about some of the modern day issues about how Native American genomes are used in genetic research.
Genetics Unzipped is the podcast from The Genetics Society. Full transcript, links and references available online at GeneticsUnzipped.com.
Subscribe from Apple podcasts, Spotify, or wherever you get your podcasts.
Head over to GeneticsUnzipped.com to catch up on our extensive back catalogue.
If you enjoy the show, please do rate and review on Apple podcasts and help to spread the word on social media. And you can always send feedback and suggestions for future episodes and guests to podcast@geneticsunzipped.com Follow us on Twitter – @geneticsunzip
(No Ratings Yet)Loading...
Posted by Alex Eve, on 23 February 2022
As lockdowns ease and the prospect of attending a conference in person rises on the horizon, it might be time to take stock of what conferences offer that virtual meetings have fallen behind on: networking. Although networking is an important part of the conference experience, it can be daunting for some. I hope that these “Top ten tips” can help make networking a more enjoyable experience for those that aren’t feeling so confident. I don’t – by any means – consider myself an expert but I think that because I’ve actively had to work at my networking skills in my role as a Reviews Editor for Development, I’ve thought a lot about how to improve. I hope to share what I’ve learned through trial and error.
First, and most importantly, go easy on yourself! I can’t stress this enough. Big conferences can be overwhelming – even if you’re a natural communicator. It can be difficult to interact, especially when you are new to the field, jet-lagged, speaking a language that isn’t your mother tongue in a noisy room where other people might be speaking with unfamiliar accents. All these components can add up and it’s difficult! However, as with most things, the beginning is always the most challenging; it will get easier with time and better with practice.
If you’re interested in speaking to someone in particular you can email them in advance of the meeting to arrange a time and place to meet. This way, you don’t need to worry about bumping into them by chance or spending time hunting them down. You can also use the conference Twitter hashtag, or a meeting app, to let other people know you’ll be at the meeting.
When meeting new people, don’t feel like every interaction needs to be revolutionary. For example, don’t feel pressure to start a 40-minute conversation about the minutiae of your research project, ending with a collaboration or a job offer. Set small goals. Sometimes, it’s enough just to introduce yourself to someone and catch up with them again later. Once they know who you are, you begin to lay the groundwork for a longer-term relationship. It’s enough to say who you are and that you’re looking forward to/enjoyed their talk. You can then leave it there for the time being.
That being said, an introduction is quite important and it’s often the hardest thing to do. Personally, it’s something I still struggle with a lot and for many people with speech problems, such as stammers and stutters, saying your own name is often a trigger. Overall, my advice here is to practice and find something that works for you. If your introduction doesn’t go as planned, just carry on with the conversation; there’s no harm done, it just means you spend a bit of time correcting any misunderstanding. Don’t put pressure on yourself (remember Tip 1 above).
For me, one of the barriers to starting a conversation is a fear that I’ll be perceived as ignorant or stupid if I don’t know something or someone that I feel I should. This can be especially prevalent if you’re not confident about the scientific topic of the meeting. In these cases, make some small talk and find some common ground until you feel more comfortable. There are supposedly six degrees of separation between everyone in the world. I expect in scientific circles – developmental biology in particular – it’s probably half that. You’ll probably find it won’t take much time to find a colleague or institute in common.
| Some fail-safe questions, which are obvious to some, include: |
|
On the other hand, there are some questions I’d advise people to avoid, primarily about assuming someone’s academic position. I think it’s important to address our unconscious biases; even if you’re fairly confident of someone’s position (for example, if you’re attending a meeting for graduate students only), it’s still better to treat everyone equally.
| Instead of… | Why not try… |
| “Are you a student/postdoc?” | “What is your background?” |
| “What do you work on?” | “What are you interested in?” |
| “What’s your project?” | “What are your research questions?” |
| “Who’s lab are you in?” | “Where are you based?” |
| “Who is your supervisor?” | “How long have you been there?” |
I find developmental biology amazing and I can sometimes find myself getting a bit over excited. I used to worry that this would come across as being unprofessional but – as the cliché goes – be yourself. We are people first and scientists second. Commit to things that interest you and don’t feel apologetic for things you are (or aren’t) enthusiastic about.
Networking with a friend, colleague or even someone you met on the conference bus, can be a useful way of meeting new people without the pressure of trying to keep a conversation moving by yourself. You can ‘tag out’ and get some time to find your feet. Just make sure you don’t end up too reliant on support or only staying part of a group because you want to develop a unique identity and stay approachable (see Tip 8 below).
A reciprocal part of being a “good networker” is allowing others to network with you. Be conscious and aware of your surroundings; open the conversation circle when new people want to engage in your group discussion, or move aside if someone wants to listen in on a poster talk. Although travelling as a lab is great for bonding, and meeting old friends can be the personal highlight of a meeting, be careful not to come across as cliquey or exclusive. Talk to poster presenters and ask them questions – you never know what opportunities might arise out of a chance encounter.
Presenting a poster or a talk, or being a meeting organiser, is a great ice breaker and provides an opportunity for people to initiate a conversation with you.
At the first opportunity for networking, it could be that you’ve been travelling halfway around the world and been awake for more than 24 hours. Know when to stop and get some rest; the harder the push yourself the more exhausted you will be and the harder it will become to keep up a conversation. Sometimes, knowing your limits is a really useful skill and there’s no shame in leaving the welcome drinks a little early.
So, those are my suggestions! Do you have any other tips for networking? Share them in the comments below!
(7 votes)Loading...
Posted by Cédric Finet, on 23 February 2022
In this post I will discuss our recent paper entitled “Leg length and bristle density, both necessary for water surface locomotion, are genetically correlated in water striders” [1]. Probably all of you have ever encountered one of those elegant semi-aquatic bugs that, as their vernacular names reflect, glide, measure, scoot, skate, skim, skip, stride, tread over the surface of all water surfaces on the planet (ocean included).
Semi-aquatic bugs (or Gerromorpha) likely derived from a terrestrial ancestor that evolved the ability to stand and move on the water-air interface about 200 million years ago. Access to previously unexploited ecological opportunities is associated with phenotypic evolution and often results in significant lineage diversification [2]. Our favorite bugs are no exception to the rule. Early-diverging lineages of semi-aquatic bugs occupy transitional zones and walk both on land and water, whereas derived lineages evolved rowing as a novel mode of locomotion on open-water surface [3,4]. Water surface invasion is commonly viewed as a stepwise process that involved both the diversification of leg morphologies and the evolution of densely arranged water-repellent ‘hairs’ that allow the insects to exploit surface tension. However, the mechanisms by which species develop traits adapted to the new ecological niche are not well understood.
Previous studies having predominantly focused on leg morphologies, we decided to explore the other side of the coin — the leg ‘hairs’. We first shown that the leg ‘hairs’ are nothing else than bristles [5]. Then the central question remains still on the table: how do semi-aquatic bugs evolve such a high density of bristles on their legs? Here started our investigation to find out what makes a water strider so hairy. After several years of leg-focused research, the Khila lab was quite excited and well determined to enter the bristle world.
Candidate gene approach
We first compiled a list of more than 120 genes known to play a role in bristle development in Drosophila, and searched for gene duplication events in the Gerromorpha. We found that the gene Beadex has two copies in the Gerromorpha. Whereas the copie BxA plays a role in bristle development in Gerris buenoi (= species with high bristle density), BxA is not significantly expressed during embryogenesis in Mesovelia mulsanti (= species with low bristle density). This result suggests that differences in leg bristle density might be partly attributable to differential expression level of BxA. We also identified two copies of the gene taxi in the semi-aquatic bugs that result from a duplication in the lineage leading to the Gerromorpha. We found that the gene taxiB evolves faster than taxiA and we detected positive selection along the taxiB lineage, suggesting functional divergence of the two copies. We depleted taxiA or taxiB transcripts using RNAi, and we observed defects in the development of leg bristles. However, we found that only ds-taxiB knockdown individuals exhibited shorter legs. Again, we were here to focus on the bristles, so we did not linger on the leg phenotype.
Genes involved leg bristle development in Gerromorpha…
By combining comparative transcriptomics and RNA interference, we identified six genes whose role in bristle development had never been documented in model organisms. We unraveled the role of the GPN-loop GTPase 2, the c-Myc binding protein MYCBP, and a protein-glutamate O-methyltransferase in bristle patterning; the role of the bHLH transcription factor Net and the MAP kinase signal responder protein Dodo in bristle elongation; and the role of the actin binding protein Simiate in bristle orientation and size.
… played also a role in leg growth!
Looking for bristle genes, finding bristle genes! It sounded like a pretty straightforward research project. Well, the truth turned out to be much more complicated and exciting. We found that suppressing the expression of bristle-related genes resulted in a leg shortening. This time, the leg phenotype was so predominant that we could not overlook it. We spent a substantial number of hours with our pictures of legs and our ruler. The quantification was unequivocal: most of the legs in the knockdown individuals were shorter. In brief, shorter and barer, or barer and shorter!
Cell division as a shared molecular mechanism
This hypothesis remained to be verified. To this end, we stained all nuclei with DAPI, and M-phase nuclei with anti-PH3 antibodies in the developing embryonic legs. We then compared the cell division rate between control and ds-taxiB knockdown individuals. We found that the legs T2, which are shorter in ds-taxiB individuals, showed a reduced mitotic activity. By doing so, we noticed that the orientation of cell division might also be affected. Thus, we measured the angle of division relative to the proximo-distal (PD) axis of the leg. We found that epithelial cells bias their orientation perpendicular to the PD axis in knockdown individuals, whereas these cells predominantly orient their divisions parallel to the PD axis in the control embryos.
Pleiotropy as a facilitator of diversification
The key message of the project began to take shape: leg length and bristle density, both necessary for water surface locomotion, are genetically correlated in the semi-aquatic bugs. We had the feeling we could go even a bit further. We plotted the bristle density against the leg length for controls and knockdown individuals of G. buenoi: linear correlation, checked! Because bristle density and leg length vary a lot across the semi-aquatic bugs, we extended our correlation analysis to all the species we had in the laboratory. The correlation between our two favorite traits still stands at the infraorder level.
The classical view of the origin of the semi-aquatic bugs implies the stepwise evolution of longer legs and denser leg bristles. Our findings suggest that the invasion of water surface might have been more ‘straightforward’ because of genetic pleiotropy. However, even if leg length and bristle density are both necessary for water surface locomotion, it does not necessarily mean these two traits have been selected for. Indeed, we cannot exclude that only one trait was selected whereas the other trait was simply a spandrel or by-product [6]. Our study represents the first step towards the deciphering of the molecular mechanism of high bristle density in the Gerromorpha, and further investigation will be needed to build a better picture of this ecologically relevant trait. Nevertheless, one thing is certain: in Gerromorpha, it is all about leg length!
References
[1] Finet C, Decaras E, Rutkowska M, Roux P, Collaudin S, Joncour P, Viala S, Khila A. (2022). Leg length and bristle density, both necessary for water surface locomotion, are genetically correlated in water striders. PNAS 119: e2119210119.
[2] Schluter D. (2000). The ecology of adaptive radiation. Oxford University Press, Oxford.
[3] Andersen NM. (1976). A Comparative Study of Locomotion on the Water Surface in Semiaquatic Bugs (Insecta, Hemiptera, Gerromorpha). Vidensk. Meddel. Dansk Naturhist. Foren. Kjobenhavn 139: 337-396.
[4] Crumière AJJ, Santos ME, Sémon M, Armisen D, Moreira FFF, and Khila A. (2016). Diversity in Morphology and Locomotory Behavior Is Associated with Niche Expansion in the Semi-aquatic Bugs. Curr. Biol. 26: 3336-3342.
[5] Finet C, Decaras, Armisén D, Khila A. (2018). The achaete–scute complex contains a single gene that controls bristle development in the semi-aquatic bugs. Proc. R. Soc. B 285: 20182387.
[6] Gould SJ, Lewontin RC. (1979). The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme. Proc. R. Soc. B 205: 581-598.
(No Ratings Yet)Loading...
Posted by the Node, on 17 February 2022
Welcome to our monthly trawl for developmental biology (and related) preprints.
The preprints this month are hosted on bioRxiv, arXiv and preprints.org – use these links to get to the section you want.
mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
Kristin D. Dahl, Hannah A. Hathaway, Adam R. Almeida, Jennifer Bourne, Tanya L. Brown, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin
Sufu regulation of Hedgehog signaling is required for proper glial cell differentiation
Danielle M. Spice, Joshua Dierolf, Gregory M. Kelly
Characterization of alveolar epithelial lineage heterogeneity during the late pseudoglandular stage of mouse lung development
Matthew R. Jones, Lei Chong, Arun Reddy Limgapally, Jochen Wilhem, Meshal Ansari, Herbert B. Schiller, Gianni Carraro, Saverio Bellusci
Tiling mechanisms of the compound eye through geometrical tessellation
Takashi Hayashi, Takeshi Tomomizu, Takamichi Sushida, Masakazu Akiyama, Shin-Ichiro Ei, Makoto Sato
A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila
Alice C. Yuen, Anadika R. Prasad, Vilaiwan M. Fernandes, Marc Amoyel
Rnf149-related is an FGF/MAPK-independent regulator of pharyngeal muscle fate specification
Burcu Vitrinel, Christine Vogel, Lionel Christiaen
Cell Rearrangement Generates Pattern Emergence as a Function of Temporal Morphogen Exposure
Timothy Fulton, Kay Speiss, Lewis Thomson, Yuxuan Wang, Bethan Clark, Seongwon Hwang, Brooks Paige, Berta Verd, Benjamin Steventon
In vivo imaging of calcium dynamics in zebrafish hepatocytes
Macarena Pozo-Morales, Inés Garteizgogeascoa, Camille Perazzolo, Sumeet Pal Singh
cdon and boc affect trunk neural crest cell migration through a non-cell autonomous reduction of hedgehog signaling in zebrafish slow-twitch muscle
Ezra Lencer, Rytis Prekeris, Kristin Artinger
Complement facilitates developmental microglial pruning of astrocyte and vascular networks
Gopalan Gnanaguru, Steven J. Tabor, Kentaro Yuda, Ryo Mukai, Jörg Köhl, Kip M. Connor
An essential function for autocrine Hedgehog signaling in epithelial proliferation and differentiation in the trachea
Wenguang Yin, Andreas Liontos, Janine Koepke, Maroua Ghoul, Luciana Mazzocchi, Xinyuan Liu, Chunyan Lu, Haoyu Wu, Athanasios Fysikopoulos, Alexandros Sountoulidis, Werner Seeger, Clemens Ruppert, Andreas Günther, Didier Y.R. Stainier, Christos Samakovlis
Cell lineage specification during development of the anterior lateral plate mesoderm and forelimb field
Axel H Newton, Sarah M Williams, Andrew T Major, Craig A Smith
Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling
Douglas G. Brownfield, Alex Diaz de Arce, Elisa Ghelfi, Astrid Gillich, Tushar J. Desai, Mark A. Krasnow
Lysosomes are Required for Early Dorsal Signaling in the Xenopus Embryo
Nydia Tejeda-Muñoz, Edward M. De Robertis
High Hedgehog signaling is transduced by a multikinase-dependent switch controling the apico-basal distribution of the GPCR Smoothened
Marina Gonçalves-Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, et Isabelle Bécam
pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo
Jonathan D. Rumley, Elicia A. Preston, Dylan Cook, Felicia L. Peng, Amanda L. Zacharias, Lucy Wu, Ilona Jileaeva, John Isaac Murray
Prenatal murine skeletogenesis partially recovers from absent skeletal muscle as development progresses
V. Sotiriou, S. Ahmed, N. C. Nowlan
Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos
Hailey E. Edwards, Jaclyn P. Souder, Daniel A. Gorelick
Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers
Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana A. Gupta, Pierre-François Lenne, Bianca H. Habermann, Olivier Theodoly, Olivier Pourquie, Frank Schnorrer
Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin
Elizabeth S. Van Itallie, Christine M. Field, Timothy J. Mitchison, Marc W. Kirschnerm
Multifunctional role of GPCR signaling in epithelial tube formation
Vishakha Vishwakarma, Thao Phuong Le, SeYeon Chung
TrpA1 is a shear stress mechanosensing channel regulating intestinal homeostasis in Drosophila
Jiaxin Gong, Niraj K. Nirala, Jiazhang Chen, Fei Wang, Pengyu Gu, Qi Wen, Y. Tony Ip, Yang Xiang
Mechanics of human embryo compaction
Julie Firmin, Nicolas Ecker, Diane Rivet Danon, Virginie Barraud Lange, Hervé Turlier, Catherine Patrat, Jean-Léon Maître
SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation
Leyao Shen, Yilin Yu, Yunji Zhou, Shondra M. Pruett-Miller, Guo-Fang Zhang, Courtney M. Karner
Geometric control of Myosin-II orientation during axis elongation
M.F. Lefebvre, N.H. Claussen, N.P. Mitchell, H.J. Gustafson, S.J. Streichan
Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish
Josepha Godivier, Elizabeth A. Lawrence, Mengdi Wang, Chrissy L. Hammond, Niamh C. Nowlan
Syndecan Regulates Cellular Morphogenesis in Cooperation with the Netrin Guidance Pathway and Rho-family GTPases
Raphaël Dima, Marianne Bah Tahé, Yann A. Chabi, Lise Rivollet, Anthony F. Arena, Alexandra M. Socovich, Daniel Shaye, Claire Y. Bénard
Hedgehog regulation of epithelial cell state and morphogenesis in the larynx
Janani Ramachandran, Weiqiang Zhou, Anna E. Bardenhagen, Talia Nasr, Aaron M. Zorn, Hongkai Ji, Steven A. Vokes
Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium
Laura Bocanegra-Moreno, Amrita Singh, Edouard Hannezo, Marcin Zagorski, Anna Kicheva
Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to robust cell-cell adhesion
Noriyuki Kinoshita, Takamasa S. Yamamoto, Naoko Yasue, Chiyo Takagi, Toshihiko Fujimori, Naoto Ueno
Matrix viscoelasticity controls spatio-temporal tissue organization
Alberto Elosegui-Artola, Anupam Gupta, Alexander J. Najibi, Bo Ri Seo, Ryan Garry, Max Darnell, Wei Gu, Qiao Zhou, David A. Weitz, L. Mahadevan, David J. Mooney
A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID
Bénédicte M. Lefèvre, Marine Delvigne, Josué Vidal, Virginie Courtier-Orgogozo, Michael Lang
Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
Jaclyn Camuglia, Soline Chanet, Adam C Martin
High affinity enhancer-promoter interactions can bypass CTCF/cohesin-mediated insulation and contribute to phenotypic robustness
Shreeta Chakraborty, Nina Kopitchinski, Ariel Eraso, Parirokh Awasthi, Raj Chari, Pedro P Rocha
Oct1 recruits the histone lysine demethylase Utx to canalize lineage specification
Jelena Perovanovic, Yifan Wu, Zuolian Shen, Erik Hughes, Mahesh B. Chandrasekharan, Dean Tantin
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis
Dahai Wang, Mayuri Tanaka-Yano, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Stuart H. Orkin, Trista E. North, George Q. Daley, R. Grant Rowe
Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM sleep regulatory neurons
Anna Kirjavainen, Parul Singh, Laura Lahti, Patricia Seja, Zoltan Lelkes, Aki Makkonen, Sami Kilpinen, Yuichi Ono, Marjo Salminen, Teemu Aitta-Aho, Tarja Stenberg, Svetlana Molchanova, Kaia Achim, Juha Partanen
RETINOBLASTOMA RELATED (RBR) interaction with key factors of the RNA-directed DNA methylation (RdDM) pathway
León-Ruiz Jesús, Espinal-Centeno Annie, Blilou Ikram, Scheres Ben, Arteaga-Vázquez Mario, Cruz-Ramírez Alfredo
Distinct responses to rare codons in select Drosophila tissues
Scott R. Allen, Rebeccah K. Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M. Counter, Jessica K. Sawyer, Donald T. Fox
DNA methylation meta-analysis confirms the division of the genome into two functional groups
Lev Salnikov, Saveli Goldberg, Parvathy Sukumaran, Eugene Pinsky
Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons
Jennifer M. Lin, Tyler A. Mitchell, Megan Rothstein, Alison Pehl, Ed Zandro M. Taroc, Raghu R. Katreddi, Katherine E. Parra, Damian G. Zuloaga, Marcos Simoes-Costa, Paolo E. Forni
Identification and characterization of a dlx2b cis-regulatory element both sufficient and necessary for correct transcription during zebrafish tooth development
William R. Jackman, Yujin Moon, Drew R. Anderson, Audrey A. DeFusco, Vy M. Nguyen, Sarah Y. Liu, Elisabeth H. Carter, Hana E. Littleford, Elizabeth K. Richards, Andrea L. Jowdry
Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development
Christopher J. Playfoot, Shaoline Sheppard, Evarist Planet, Didier Trono
TEX13B is important for germ cell development and male fertility
Umesh Kumar, Digumarthi V S Sudhakar, Nithyapriya Kumar, Hanuman T Kale, Rajan Kumar Jha, Nalini J Gupta, B N Chakravarthy, Mamata Deenadayal, Aarti Deenadayal Tolani, Swasti Raychaudhuri, P Chandra Shekar, Kumarasamy Thangaraj
Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Samantha M. Barnada, Andrew Isopi, Daniela Tejada-Martinez, Clément Goubert, Sruti Patoori, Luca Pagliaroli, Mason Tracewell, Marco Trizzino
Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells
Stylianos Bakoulis, Robert Krautz, Nicolas Alcaraz, Marco Salvatore, Robin Andersson
Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster
Aaron T. Crain, Stephen Klusza, Robin L. Armstrong, Priscila Santa Rosa, Brenda R. S. Temple, Brian D. Strahl, Daniel J. McKay, A. Gregory Matera, Robert J. Duronio
DiSCs – Domains involving SETDB1 and Cohesin are critical regulators of genome topology and stem cell fate
Tushar Warrier, Chadi El Farran, Yingying Zeng, Benedict Shao Quan Ho, Don Loi Xu, Qiuye Bao, Zi Hao Zheng, Xuezhi Bi, Kelly Yu Sing Tan, Huck Hui Ng, Derrick Sek Tong Ong, Justin Jang Hann Chu, Amartya Sanyal, Melissa Jane Fullwood, James Collins, Hu Li, Jian Xu, Yuin-Han Loh
Distinct roles of core autophagy-related genes (ATGs) in zebrafish definitive hematopoiesis
Xiang-Ke Chen, Zhen-Ni Yi, Jack Jark-Yin Lau, Alvin Chun-Hang Ma
Effects of α-crystallin gene knockout on zebrafish lens development
Mason Posner, Kelly L. Murray, Brandon Andrew, Stuart Brdicka, Alexis Butterbaugh-Roberts, Kirstan Franklin, Adil Hussen, Taylor Kaye, Emmaline Kepp, Mathew S. McDonald, Tyler Snodgrass, Keith Zientek, Larry David
Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1
Yan Qin, Peiling Ni, Qingye Zhang, Xiao Wang, Xiaoling Du, Zixi Yin, Lingling Wang, Lihong Ye, Lingyi Chen
hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function
Homa Majd, Ryan M Samuel, Jonathan T Ramirez, Ali Kalantari, Kevin Barber, Zaniar Ghazizadeh, Angeline K Chemel, Andrius Cesiulis, Mikayla N Richter, Subhamoy Das, Matthew G Keefe, Jeffrey Wang, Rahul K Shiv, Conor J McCann, Samyukta Bhat, Matvei Khoroshkin, Johnny Yu, Tomasz J Nowakowski, Hani Goodarzi, Nikhil Thapar, Julia A Kaltschmidt, Faranak Fattahi
The onset of whole-body regeneration in Botryllus schlosseri: morphological and molecular characterization
Lorenzo Ricci, Bastien Salmon, Caroline Olivier, Rita Andreoni-Pham, Ankita Chaurasia, Alexandre Alie, Stefano Tiozzo
Macrophages break interneuromast cell quiescence by intervening the inhibition of Schwann cells in zebrafish lateral line
Meng-Ju Lin, Chia-Ming Lee, Wei-Lin Hsu, Bi-Chang Chen, Shyh-Jye Lee
Spatially unique Shh-Fgf8 distribution in regenerating limb guarantees consistent limb morphogenesis in different limb sizes and contributes to axolotl specific digit patterning
Saya Furukawa, Sakiya Yamamoto, Rena Kashimoto, Yoshihiro Morishita, Akira Satoh
Generation of rat lungs by blastocyst complementation in Fgfr2b-deficient mouse model
Shunsuke Yuri, Yuki Murase, Ayako Isotani
SOX17 Is Not Required for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines
Xudong Dong, Ailing Ding, Jiangwei Lin
Single-cell Transcriptomic Profiling Unveils Cardiac Cell-type Specific Response to Maternal Hyperglycemia Underlying the Risk of Congenital Heart Defects
Sathiyanarayanan Manivannan, Corrin Mansfield, Xinmin Zhang, Karthik. M. Kodigepalli, Uddalak Majumdar, Vidu Garg, Madhumita Basu
Hypertrophic Chondrocytes Serve as a Reservoir for Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development
Jason T. Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J. Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M. Karner, Matthew J. Hilton
Differential Requirement of DICER1 Activity during Development of Mitral and Tricuspid Valves
Shun Yan, Yin Peng, Jin Lu, Saima Shakil, Yang Shi, David K. Crossman, Walter H Johnson Jr., Shanrun Liu, Joy Lincoln, Qin Wang, Kai Jiao
Amniotic fluid stem cell extracellular vesicles promote fetal lung branching and cell differentiation in experimental congenital diaphragmatic hernia
Kasra Khalaj, Rebeca Lopes Figueira, Lina Antounians, Sree Gandhi, Matthew Wales, Louise Montalva, George Biouss, Augusto Zani
Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles
Kasra Khalaj, Lina Antounians, Rebeca Lopes Figueira, Martin Post, Augusto Zani
Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development
P Palmquist-Gomes, A Ruiz-Villalba, JA Guadix, JP Romero, B Bessiéres, D MacGrogan, L Conejo, A Ortiz, B Picazo, L Houyel, D Gómez-Cabrero, SM Meilhac, JL de la Pompa, JM Pérez-Pomares
Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells
Evelien Eenjes, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Dick Tibboel, Robbert J. Rottier
The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys
Keren Cheng, Yasunari Seita, Taku Moriwaki, Kiwamu Noshiro, Yuka Sakata, Young Sun Hwang, Toshihiko Torigoe, Mitinori Saitou, Hideaki Tsuchiya, Chizuru Iwatani, Masayoshi Hosaka, Toshihiro Ohkouchi, Hidemichi Watari, Takeshi Umazume, Kotaro Sasaki
Decoding the activated stem cell phenotype of the vividly maturing neonatal pituitary
Emma Laporte, Florian Hermans, Silke De Vriendt, Annelies Vennekens, Diether Lambrechts, Charlotte Nys, Benoit Cox, Hugo Vankelecom
Coupled myovascular expansion directs cardiac growth and regeneration
Paige DeBenedittis, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, Yoshihiko Kobayashi, Svati H. Shah, Christopher D. Kontos, Purushothama Rao Tata, R. Thomas Lumbers, Ravi Karra
Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
Saeideh Nakhaei-Rad, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Andrea Borchardt, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian
Central role of Prominin-1 in lipid rafts during liver regeneration
Myeong-Suk Bahn, Dong-Min Yu, Myoungwoo Lee, Sung-Je Jo, Ji-Won Lee, Hyun Lee, Arum Kim, Jeong-Ho Hong, Jun Seok Kim, Seung-Hoi Koo, Jae-Seon Lee, Young-Gyu Ko
Plasticity of body axis polarity in Hydra regeneration under constraints
Anton Livshits, Liora Garion, Yonit Maroudas-Sacks, Lital Shani-Zerbib, Kinneret Keren, Erez Braun
Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells
Stanislava Sladeček, Katarzyna Anna Radaszkiewicz, Martina Bőhmová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Jiří Pacherník
TRF2 rescues pathogenic phenotypes in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs
Asuka Eguchi, Sofía I. Torres-Bigio, Kassie Koleckar, Foster Birnbaum, Helen M. Blau
Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia
Jimmy Hom, Theodoros Karnavas, Emily Hartman, Julien Papoin, Yuefeng Tang, Brian M. Dulmovits, Mushran Khan, Hiren Patel, Jedediah Bondy, Morris Edelman, Renaud Touraine, Geneviève Chanoz-Poulard, Gregory Ottenberg, Robert Maynard, Douglas J. Adams, Raymond F. Robledo, Daniel A Grande, Philippe Marambaud, Betsy J Barnes, Sébastien Durand, Anupama Narla, Steven Ellis, Leonard I. Zon, Luanne L. Peters, Lydie Da Costa, Jeffrey M. Lipton, Cheryl L. Ackert-Bicknell, Lionel Blanc
Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence
Dorsa Toghani, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian Burns, David Gravano, Stefan Radtke, Hans-Peter Kiem, Sonia Rodriguez, Nadia Carlesso, Amogh Pradeep, Nicola K. Wilson, Sarah J. Kinston, Berthold Göttgens, Claus Nerlov, Eric Pietras, Marion Mesnieres, Christa Maes, Atsushi Kumanogoh, Thomas Worzfeld, Peter Kharchenko, David T. Scadden, Antonio Scialdone, Joel A Spencer, Lev Silberstein
Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration
Anthea Weng, Mariana Maciel-Herrerias, Satoshi Watanabe, Lynn Welch, Annette S. Flozak, Rogan Grant, Raul Piseaux Aillon, Laura Dada, Seung Hye Han, Monique Hinchcliff, Alexander Misharin, GR Scott Budinger, Cara J. Gottardi
A lymphatic-stem cell interactome regulates intestinal stem cell activity
Rachel E. Niec, Tinyi Chu, Shiri Gur-Cohen, Marina Schernthanner, Lynette Hidalgo, Hilda Amalia Pasolli, Raghu P. Kataru, Babak J. Mehrara, Dana Pe’er, Elaine Fuchs
Lymphatics constitute a novel component of the intestinal stem cell niche
Norihiro Goto, Shinya Imada, Vikram Deshpande, Ömer H. Yilmaz
Integrated cyto-physiological and proteomic analyses reveal new insight into CMS mechanism in a novel upland cotton CMS line LD6A
Zheng Jie, Aziz Khan, Zhou Bujin, Zhou Qiong, Najeeb Ullah, Kong Xiangjun, Liu Yiding, Liu Fang, Zhou Ruiyang
Microscopic and ultramicroscopic anatomical characteristics of root nodules in Podocarpus macrophyllus during development
Li-Qiong Zhu, Hui-Xin Chen, Li-Jun Zhao, Wei-Xin Jiang
Cell- and non-cell-autonomous ARF3 coordinates meristem proliferation and organ patterning in Arabidopsis
Ke Zhang, Hao Zhang, Yanyun Pan, Lin Guo, Shijun Tian, Jiarong Wei, Yunze Fu, Cong Wang, Ping Qu, Liantao Liu, Yongjiang Zhang, Hongchun Sun, Zhiying Bai, Jingao Dong, Cundong Li, Xigang Liu
Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis
Shashi Bhushan, Amit Kumar Singh, Yogendra Thakur, Ramamurthy Baskar
GhCO and GhCRY1 accelerate floral meristem initiation in response to increased blue light to shorten cotton breeding
Xiao Li, Yuanlong Wu, Zhenping Liu, Zhonghua Li, Huabin Chi, Pengcheng Wang, Feilin Yan, Yang Yang, Yuan Qin, Xuehan Tian, Hengling Wei, Aimin Wu, Hantao Wang, Xianlong Zhang, Shuxun Yu
The m6A writer FIONA1 methylates the 3’UTR of FLC and controls flowering in Arabidopsis
Bin Sun, Kaushal Kumar Bhati, Ashleigh Edwards, Louise Petri, Valdeko Kruusvee, Anko Blaakmeer, Ulla Dolde, Vandasue Rodrigues, Daniel Straub, Stephan Wenkel
ARF small GTPases in the developmental function mediated by ARF regulators GNOM and VAN3
Maciek Adamowski, Ivana Matijević, Jiří Friml
Actin isovariant ACT7 controls root meristem development in Arabidopsis through modulating auxin and ethylene responses
Takahiro Numata, Kenji Sugita, Arifa Ahamed Rahman, Abidur Rahman
Developmental patterning function of GNOM ARF-GEF mediated from the plasma membrane
Maciek Adamowski, Ivana Matijević, Jiří Friml
Apical and basal auxin sources pattern shoot branching in a moss
Mattias Thelander, Katarina Landberg, Arthur Muller, Gladys Cloarec, Nik Cunniffe, Stéphanie Huguet, Ludivine Soubigou-Taconnat, Véronique Brunaud, Yoan Coudert
Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana
Guangyu Liu, Jie Li, Ji-Ming Li, Zhiyong Chen, Peisi Yuan, Ruiying Chen, Ruilian Yin, Zhiting Liao, Xinyue Li, Ying Gu, Hai-Xi Sun, Keke Xia
Pectin cell wall remodeling through PLL12 and callose deposition through polar CALS7 are necessary for long-distance phloem transport
Lothar Kalmbach, Matthieu Bourdon, Jung-ok Heo, Sofia Otero, Bernhard Blob, Ykä Helariutta
Knockout of OsSWEET15 impaired rice embryo formation and seed-setting
Zhenjia Tang, Jing Yang, Shuhui Bao, Zhi Hu, Huihuang Xia, Lai Ma, Qingsong Zheng, Fang Yang, Dechun Zhang, Tai Wang, Shubin Sun, Yibing Hu
MISF2 Encodes an Essential Mitochondrial Splicing Co-factor Required for nad2 mRNA Processing and Embryo Development in Arabidopsis thaliana
Tan-Trung Nguyen , Corinne Best , Sofia Shevtsov , Michal Zmudjak , Martine Quadrado , Ron Mizrahi , Hagit Zer , Hakim Mireau , Oren Ostersetzer-Biran
Ontogenetic Color Switching in Lizards as a by-Product of Guanine Cell Development
Gan Zhang, Venkata Jayasurya Yallapragada, Michal Shemesh, Avital Wagner, Alexander Upcher, Iddo Pinkas, Harry L.O. McClelland, Dror Hawlena, Benjamin A. Palmer
Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos
Triin Tekko, Ana Nóvoa, Moisés Mallo
An ancient role for the Hippo pathway in axis formation and morphogenesis
Maria Brooun, Willi Salvenmoser, Catherine Dana, Marius Sudol, Robert Steele, Bert Hobmayer, Helen McNeill
Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
Márton Demeter, Imre Derényi, Gergely J. Szöllősi
Cardiomyocyte differentiation from iPS cells is delayed following knockout of Bcl-2
Tim Vervliet, Robin Duelen, H. Llewelyn Roderick, Maurilio Sampaolesi
Conserved meiotic mechanisms in the cnidarian Clytia hemisphaerica revealed by Spo11 knockout
Catriona Munro, Hugo Cadis, Evelyn Houliston, Jean-René Huynh
Acetyl-CoA mediated autoacetylation of fatty acid synthase in de novo lipogenesis
Ting Miao, Jinoh Kim, Ping Kang, Hua Bai
unc-37/Groucho and lsy-22/AES repress Wnt target genes in C. elegans asymmetric cell divisions
Kimberly N. Bekas, Bryan T. Phillips
Ccdc38 is required for sperm flagellum biogenesis and male fertility in mouse
Ruidan Zhang, Bingbing Wu, Chao Liu, Xiuge Wang, Liying Wang, Sai Xiao, Yinghong Chen, Huafang Wei, Fei Gao, Li Yuan, Wei Li
Germline-soma Supply Mitochondria for mtDNA Inheritance in Mouse Oogenesis
Hongying Sha, Zhao Ye, Zhen Ye, Sanbao Shi, Jianxin Pan, Xi Dong, Yao Zhao
Progenitor cell integration into a barrier epithelium during adult organ turnover
Paola Moreno-Roman, Yu-Han Su, Anthony Galenza, Lehi Acosta-Alvarez, Alain Debec, Antoine Guichet, Jon-Michael Knapp, Caroline Kizilyaprak, Bruno M. Humbel, Irina Kolotuev, Lucy Erin O’Brien
Rab35 Governs Apicobasal Polarity Through Regulation of Actin Dynamics During Sprouting Angiogenesis
Caitlin R. Francis, Hayle Kincross, Erich J. Kushner
Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration
Audrey M. Williams, Seth Donoughe, Edwin Munro, Sally Horne-Badovinac
A key role for p60-Katanin in axon navigation is conditioned by the tubulin polyglutamylase TTLL6
Daniel Ten Martin, Nicolas Jardin, François Giudicelli, Laïla Gasmi, Juliette Vougny, Cécile Haumaître, Xavier Nicol, Carsten Janke, Coralie Fassier, Jamilé Hazan
doi: https://doi.org/10.1101/2022.01.20.477127
PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos
Ida Calvi, Françoise Schwager, Monica Gotta
The biosynthetic-secretory pathway, supplemented by recycling routes, specifies epithelial membrane polarity
Nan Zhang, Hongjie Zhang, Liakot A. Khan, Gholamali Jafari, Yong Eun, Edward Membreno, Verena Gobel
ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis
Timothy J. Mullen, Gabriel Cavin-Meza, Ian D. Wolff, Emily R. Czajkowski, Nikita S. Divekar, Justin D. Finkle, Sarah M. Wignall
A flexible network of lipid droplet associated proteins support embryonic integrity of C. elegans
Zhe Cao, Chun Wing Fung, Ho Yi Mak
Cell Centred Finite Element Model for Intestinal Organoids Shape Analysis: From tissue architecture to mechanics
J. Laussu, D. Michel, S. Segonds, S. Marguet, F. Barreau, D. Hamel, E. Mas, A. Ferrand, F. Bugarin
The grapevine leaves that are (or were) not: constraints on leaf development and choosing to see what seemingly is not
Daniel H. Chitwood, Joey Mullins
Differential cellular stiffness contributes to tissue elongation on an expanding surface
Hiroshi Koyama, Makoto Suzuki, Naoko Yasue, Hiroshi Sasaki, Naoto Ueno, Toshihiko Fujimori
Contact-mediated signaling enables disorder-driven transitions in cellular assemblies
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
Spontaneous mechanical and energetic state transitions during Caenorhabditis elegans gastrulation
Jiao Miao, Guoye Guan, Chao Tang
Oscillations and Bifurcation Structure of Reaction-Diffusion Model for Cell Polarity Formation
Masataka Kuwamura, Hirofumi Izuhara, Shin-ichiro Ei
Retina organoids: Window into the biophysics of neuronal systems
Katja A. Salbaum, Elijah R. Shelton, Friedhelm Serwane
The two body problem: proprioception and motor control across the metamorphic divide
Sweta Agrawal, John C Tuthill
Tardigrades and Their Emergence as Model Organisms
Bob Goldstein
oca2 targeting using CRISPR/Cas9 in the Malawi cichlid Astatotilapia calliptera
Bethan Clark, Joel Elkin, Aleksandra Marconi, George F. Turner, Alan M. Smith, Domino Joyce, Eric A. Miska, Scott A. Juntti, M. Emília Santos
mBeRFP, a versatile fluorescent tool to enhance multichannel live imaging and its applications
Emmanuel Martin, Magali Suzanne
Sex-specific association between urinary kisspeptin and pubertal development
Rafaella Sales de Freitas, Thiago Fonseca Alves França, Sabine Pompeia
The generation of a Nutm1 knock-in reporter mouse line for imaging post-meiotic spermatogenesis
Maxwell Hakun, Janet Rossant, Bin Gu
Generation of Vascularized Brain Organoids to Study Neurovascular Interactions
Xin-Yao Sun, Xiang-Chun Ju, Yang Li, Peng-Ming Zeng, Jian Wu, Li-Bing Shen, Yue-Jun Chen, Zhen-Ge Luo
A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
Peng He, Kyungtae Lim, Dawei Sun, Jan Patrick Pett, Quitz Jeng, Krzysztof Polanski, Ziqi Dong, Liam Bolt, Laura Richardson, Lira Mamanova, Monika Dabrowska, Anna Wilbrey-Clark, Elo Madissoon, Zewen Kelvin Tuong, Emma Dann, Chenqu Suo, Isaac Goh Kai’En, Xiaoling He, Roger Barker, Sarah A Teichmann, John C. Marioni, Kerstin B Meyer, Emma L Rawlins
Developmental origins of cell heterogeneity in the human lung
Alexandros Sountoulidis, Sergio Marco Salas, Emelie Braun, Christophe Avenel, Joseph Bergenstråhle, Marco Vicari, Paulo Czarnewski, Jonas Theelke, Andreas Liontos, Xesus Abalo, Žaneta Andrusivová, Michaela Asp, Xiaofei Li, Lijuan Hu, Sanem Sariyar, Anna Martinez Casals, Burcu Ayoglu, Alexandra Firsova, Jakob Michaëlsson, Emma Lundberg, Carolina Wählby, Erik Sundström, Sten Linnarsson, Joakim Lundeberg, Mats Nilsson, Christos Samakovlis
EZ Clear for simple, rapid, and robust mouse whole organ clearing
Chih-Wei Hsu, Juan Cerda III, Jason M. Kirk, Williamson D. Turner, Tara L. Rasmussen, Carlos P. Flores Suarez, Mary E. Dickinson, Joshua D. Wythe
FRaeppli, a multispectral imaging toolbox for cell tracing and dense tissue analysis in zebrafish
Sara Caviglia, Iris A. Unterweger, Akvilė Gasiūnaitė, Alexandre E. Vanoosthuyse, Francesco Cutrale, Le A. Trinh, Scott E. Fraser, Stephan C. F. Neuhauss, Elke A. Ober
Mechanosensitive Osteogenesis on Native Cellulose Scaffolds for Bone Tissue Engineering
Maxime Leblanc Latour, Andrew E. Pelling
Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
Lewis Macdonald, Gillian Taylor, Jennifer Brisbane, Ersi Christodoulou, Lucy Scott, Alex Von Kriegsheim, Janet Rossant, Bin Gu, Andrew Wood
Highly efficient multiplex genome editing in dicots using improved CRISPR/Cas systems
Bingjie Li, Yun shang, Lixianqiu Wang, Jing Lv, Fengjiao Wang, Jiangtao Chao, Jingjing Mao, Anming Ding, Xinru Wu, Mengmeng Cui, Yuhe Sun, Changbo Dai
Light-driven biological actuators to probe the rheology of 3D microtissues
Adrien Méry, Artur Ruppel, Jean Révilloud, Martial Balland, Giovanni Cappello, Thomas Boudou
Becoming metrics literate: An analysis of brief videos that teach about the h-index
Lauren A. Maggio, Alyssa Jeffrey, Stefanie Haustein, Anita Samuel
Integrating Math Modeling, Coding, and Biology in a CURE Lab
Renee Dale, Stewart Craig
Re-use of labware reduces CO2 equivalent footprint and running costs in laboratories
Martin Farley, Benoit P. Nicolet
A remote lecture series roadmap to equity, diversity, and inclusion in STEM
Evan A. Boyle, Gabriela Goldberg, Jonathan C. Schmok, Jillybeth Burgado, Fabiana Izidro Layng, Hannah A. Grunwald, Kylie M. Balotin, Michael S. Cuoco, Keng-Chi Chang, Gertrude Ecklu-Mensah, Aleena K. S. Arakaki, Noorsher Ahmed, Ximena Garcia Arceo, Pratibha Jagannatha, Jonathan Pekar, Mallika Iyer, DASL Alliance, Gene W. Yeo
The role of collegiality in academic review, promotion, and tenure
Diane Dawson, Esteban Morales, Erin C. McKiernan, Lesley A. Schimanski, Meredith T. Niles, Juan Pablo Alperin
Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences
Riley A. Hess, Olivia A. Erickson, Rebecca B. Cole, Jared M. Isaacs, Silvia Alvarez-Clare, Jonathan Arnold, Allison Augustus-Wallace, Joseph C. Ayoob, Alan Berkowitz, Janet Branchaw, Kevin R. Burgio, Charles H. Cannon, Ruben Michael Ceballos, C. Sarah Cohen, Hilary Coller, Jane Disney, Van A. Doze, Margaret J. Eggers, Edwin L. Ferguson, Jeffrey J. Gray, Jean T. Greenberg, Alexander Hoffmann, Danielle Jensen-Ryan, Robert M. Kao, Alex C. Keene, Johanna E. Kowalko, Steven A. Lopez, Camille Mathis, Mona Minkara, Courtney J. Murren, Mary Jo Ondrechen, Patricia Ordoñez, Anne Osano, Elizabeth Padilla-Crespo, Soubantika Palchoudhury, Hong Qin, Juan Ramírez-Lugo, Jennifer Reithel, Colin A. Shaw, Amber Smith, Rosemary J. Smith, Fern Tsien, Erin L. Dolan
Correction of the scientific production: publisher performance evaluation using a dataset of 4844 PubMed retractions
Catalin Toma, Liliana Padureanu, Bogdan Toma
High School Science Fair: Ethnicity Trends in Student Participation and Experience
Frederick Grinnell, Simon Dalley, Joan Reisch
(No Ratings Yet)Loading...
Posted by Helen Zenner, on 11 February 2022
For more information and to register: https://www.organoidmedicinesymposium.org/
(No Ratings Yet)Loading...
Posted by the Node, on 10 February 2022
One of the key objectives of the Node Network is to allow scientists, especially early-career researchers (ECRs), to raise their profiles in the developmental and stem cell biology community. With this in mind, and as part of our second birthday celebrations, we are delighted to launch our discussion and networking event, ‘Promoting yourself as an ECR’ hosted with our sister community sites FocalPlane and preLights. The interactive event will begin with a panel discussion with our three invited panellists Maria Abou Chakra, Pablo Sáez and Sarvenaz Sarabipour and then continue with a networking event where you can meet the panellists, representatives from The Company of Biologists and other ECRs.
Dr Maria Abou Chakra is a research associate at the University of Toronto, where her research focuses on mathematical modelling of stem cell development. She is the organiser of the Modelling Cell Development & Regeneration Discussion Group, as well as having been involved in outreach, mentorship and EDI events.
Professor Pablo J. Sáez is a new PI at UKE, Hamburg, where his international team is studying the role of cell communication and migration, with a particular focus on immune cells. Pablo is a regular contributor to our preprint posts on FocalPlane, and is an advocate for better representation for ECRs in academic conferences.
Dr Sarvenaz Sarabipour is an assistant research scientist at Johns Hopkins University, where her research focuses on receptor signalling networks at the cell and tissue level. As well as her scientific interests, she is an active advocate for ECRs, open science, mentorship, and diversity in science.
(No Ratings Yet)Loading...
Posted by Kat Arney, on 10 February 2022
Whereas previously, most biologists felt that the living world had to be dealt with in a completely separate way from the non-living world, D’Arcy was saying, “Actually, no. We can look at a lot of basic forms in biology and explain their growth and shapes according to fundamental laws of physics and mathematics. A living thing may grow in exactly the same way as a non-living thing because it’s just obeying these fundamental laws.”
Matthew Jarron describing D’Arcy Thompson
In the latest episode of the Genetics Unzipped podcast, we’re exploring the life and work of D’Arcy Wentworth Thompson – one of the first scientists to bring together the worlds of mathematics and biology in the quest to understand how living things are built. Dr Kat Arney sat down with the curator of the University of Dundee’s D’Arcy Thompson Zoology Museum, Matthew Jarron, to find out more about this larger than life character…
Genetics Unzipped is the podcast from The Genetics Society. Full transcript, links and references available online at GeneticsUnzipped.com.
Subscribe from Apple podcasts, Spotify, or wherever you get your podcasts.
Head over to GeneticsUnzipped.com to catch up on our extensive back catalogue.
If you enjoy the show, please do rate and review on Apple podcasts and help to spread the word on social media. And you can always send feedback and suggestions for future episodes and guests to podcast@geneticsunzipped.com Follow us on Twitter – @geneticsunzip
(No Ratings Yet)Loading...