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Metabolic Origins: Steering of early developmental fate #MetabolismMondays

Posted by , on 7 July 2025

All the world’s a metabolic dance, early career scientists are leading the way!

Emerging perspectives in metabolism

Dr Kristina Stapornwongkul
X: @KStapornwongkul
Bluesky: ‪@kstapornwongkul.bsky.social‬

This week we’ll meet Dr Kristina Stapornwongkul, a new incoming faculty at IMBA, Vienna where her lab will focus on how metabolism influences the dynamic process of embryonic development. Kristina’s journey into the world of biology began with a simple school experiment involving potatoes, iodine, and saliva—an early lesson in the unseen chemical choreography that drives life. Today, she is at the forefront of a rapidly evolving field that explores how metabolism shapes embryonic development. With a background in developmental biology and a growing toolkit of synthetic and molecular approaches, Kristina investigates how cellular metabolism influences stem cell fate decisions during the earliest stages of life. Her recent work using gastruloids – a stem cell-based model of early embryos, reveals how metabolic pathways like glycolysis do more than supply energy; they act as key regulators of signaling and pattern formation. She often refers to metabolites and metabolic enzymes as “moonlighting” agents, highlighting their unexpected and influential roles in directing cellular behaviour. As she prepares to launch her own lab at IMBA in Vienna, Kristina is driven by a deep curiosity about how cells make decisions under changing nutritional conditions, and how robust development is maintained despite metabolic challenges. Through her interdisciplinary lens, she brings fresh insights into how environmental and cellular metabolism shape the blueprint of life. Check out her Lab page here and give her a follow over Twitter and Bluesky. She will be hiring soon at all levels so please reach out to her if you’re interested !

It was actually the first experiment I ever did in school: an iodine starch test with potatoes. We took a potato slice and applied saliva to one half before adding the iodine solution, which normally turns black in the presence of starch. The half without saliva turned black as expected, while the other half didn’t—showing that something in the saliva had already broken down the starch into simpler sugars. That clear, visual result was such a striking demonstration of how our bodies are built to break down food, and I think that’s why it made such a lasting impression on me.

I did my Master thesis in the Aulehla lab which did some pioneering work in the field of developmental metabolism at that time. It was a completely new and fascinating concept for me. So even though I didn’t work on a metabolism-related project myself at that time, it really got me interested in that topic.

To understand how metabolism shapes development, I believe we need to uncover molecular mechanisms at the cellular level and understand how they influence tissue-level behaviour and function. So far, my work has been mainly based on developmental and synthetic biology approaches. Looking ahead, I would like to incorporate mass spec-based readouts and develop new tools to manipulate metabolism in a targeted manner.

In the last decade, it has become increasingly clear that metabolic pathways do more than meet the bioenergetic needs of cells—they also play an active role in regulating differentiation. The underlying mechanisms include metabolite-driven post-translational modifications, metabolite-protein interactions, and moonlighting functions of metabolic enzymes, which can influence the epigenetic and signalling state of cells. Based on this, I set out to investigate whether the metabolic state can significantly impact cell fate decisions during the exit from pluripotency.

Using an in vitro model for gastrulation based on mouse embryonic stem cells (gastruloids), we found that inhibiting glycolysis promotes ectodermal differentiation at the expense of mesoderm and endoderm lineages. This effect is dose-dependent, indicating that germ layer proportions can be modulated by adjusting exogenous glucose levels. We further showed that glycolysis acts upstream of key developmental signalling pathways, including Nodal and Wnt, and that its influence on cell fate can be separated from its effects on growth. DOI: 10.1016/j.stem.2025.03.011.

The inhibition of glycolysis resulted in the clear downregulation of Nodal and Wnt signalling targets, which are absolutely required for mesoderm and endoderm specification. This suggested that glycolytic activity might be upstream of morphogen signalling. To test this we tried to rescue the phenotype by activating Nodal or Wnt signalling while inhibiting glycolysis. To my surprise, this restored normal germ layer patterning, even though glycolytic activity and overall growth were not recovered. That indicates that glycolysis is not merely fueling signalling but rather functions as an upstream activator!

The original work establishing gastruloids as a model is here – https://doi.org/10.1242/dev.113001. For me, stem cell-based model systems are an exciting and versatile tool for studying specific processes during development. Pluripotent stem cells are easy to genetically engineer, which opens the door to powerful synthetic and (opto)genetic tools for controlling metabolism in space and time. Their accessibility makes it possible to observe metabolic and signalling dynamics in real time, and the controlled culture conditions allow us to explore how different nutritional environments influence cell behaviour.

I am currently trying to put together an enthusiastic team and tackle some of the questions I am really excited about: How does metabolism influence cell fate decisions? What is the energetic cost of morphogenesis, and do cells adapt their metabolism to overcome energetic constraints? How robust are developmental processes, such as patterning and morphogenesis, to changes in the nutritional environment? We’ll definitely keep an eye on glycolysis, but I’m also really keen to explore other metabolic pathways and see what else we can discover.

I would say that being curious is one of my most important character trait, and I really cherish it. It’s what drives me to explore new people, cultures, places, and ideas. When it comes to basic science questions, I think curiosity is absolutely essential, since you can’t always rely on other motivations, such as direct applications to human health. For me, basic science questions are usually the most exciting ones, and I wouldn’t want to work on anything that doesn’t truly fascinate me. I guess it comes from the longing to understand how life works. How can that not be exciting J?

I think understanding basic science aspects of early development is absolutely crucial to understand the impact of the nutritional environment on embryonic development on a molecular level. We know since a long time that the maternal nutrition impacts even early stages of embryonic development. What we often don’t understand are the phenotypes and their underlying mechanisms. So, it’s important to support basic science on early development to better understand what goes wrong in suboptimal nutritional environments or during metabolic disorders.

Development happens in time and space, so I believe that visualizing metabolic dynamics is essential for better understanding the role of metabolism during development. Techniques like spatial metabolomics and the use of biosensors will be incredibly valuable for this purpose.

I’m also really excited about the development of new tools that allow us to manipulate metabolic pathways in a spatiotemporal manner. In my recent work, I developed a genetic tool to restrict glucose availability by leveraging a sucrose-cleaving enzyme from yeast, and I’m eager to further refine and expand this approach in the future.

One pivotal moment was seeing a zebrafish embryo develop during an undergraduate course (thank you, @Gerrit Begemann!). It was so beautiful and fascinating that I immediately wanted to understand how something like that works.

Not sure, whether there is an unexpected place but I like to think about things I don’t understand (including science) when I am moving between places, especially while cycling. Maybe it’s something about being in motion.

For students early-career scientists and actually everyone interested in the intersection of metabolism and cell fate regulation, my advice is to seek as much feedback as possible on your ideas and work. This is a complex and rapidly evolving field, and most of us were trained primarily in either developmental biology or metabolism, but rarely both. Engaging with experts from different backgrounds can really broaden your perspective and strengthen your research.

I really like to do outdoor sports, such as rock climbing and beach volleyball. It helps me to clear my head. 

That’s a tough question—I really love what I do! But if I hadn’t gone into biological research, I think I’d still want a career where I’m surrounded by smart, creative people and constantly learning new things. Whether it was in education, technology, or even the arts, the most important thing for me would be working in an environment that challenges me intellectually and encourages curiosity.

Yes, I actually will be starting my lab at IMBA Vienna in September! We’ll be looking at environmental and metabolic regulators of embryonic development. There is more info on our website (https://www.oeaw.ac.at/imba/groups/kristina-stapornwongkul). So please reach out if you feel enthusiastic to join the team!

Check out the article All the world’s a metabolic dance, and how early career scientists are leading the way !!

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June in preprints

Posted by , on 7 July 2025

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv and arXiv – use these links below to get to the section you want:

Developmental biology

Cell Biology

Modelling

Tools & Resources

Spotted a preprint in this list that you love? If you’re keen to gain some science writing experience and be part of a friendly, diverse and international community, consider joining preLights and writing a preprint highlight article.

Developmental biology

| Patterning & signalling

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation

Ilya Chuykin,Sergei Y. Sokol

Retinal Calcium Waves Coordinate Uniform Tissue Patterning of the Drosophila Eye

Ben Jiwon Choi, Yen-Chung Chen,Claude Desplan

Wnt11 Positively Regulates Neonatal Cardiomyocyte Maturation at the Interphase of Life via Frizzled 4 Receptor

Xuedong Kang, Joan Moci, Charlotte Wolf,Marlin Touma

Lifelong development of zebrafish gills: Asymmetries in early vascular patterning predict adult gill architecture

Mathieu Preußner, Anna Mertens, Marion Basoglu,Virginie Lecaudey

Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

Ravindra B. Chalamalasetty, Haley Tran, Ryan Kelly, Samuel Kuo,Mark W. Kennedy,Moonsup Lee, Sara Thomas,Nikolaos Mandalos,Vishal Koparde,Francisco Pereira Lobo,Terry P. Yamaguchi

A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics

Camilla Autorino,Diana Khoromskaia,Louise Harari, Elisa Floris, Harry Booth,Cristina Pallares-Cartes, Vesta Petrasiunaite,Michael Dorrity,Bernat Corominas-Murtra,Zena Hadjivasiliou,Nicoletta I. Petridou

Direct cell-to-cell transport of Hedgehog morphogen is aided by the diffusible carrier Shifted/DmWif1

Carlos Jiménez-Jiménez,Gustavo Aguilar,Clara Fernández-Pardo,Markus Affolter,Isabel Guerrero

The anti-neural role of BMP signaling is a side effect of its global function in dorsoventral patterning

Paul Knabl, June F. Ordoñez,Juan Daniel Montenegro Cabrera,Tim Wollesen,Grigory Genikhovich

A novel self-organizing embryonic stem cell system reveals the role of Wnt signaling parameters in anterior-posterior patterning of the nervous system

Siqi Du,Aryeh Warmflash

Rapid transcriptional response to a dynamic morphogen by time integration

Susanna E. Brantley, Jacqueline Janssen, Anna Chao, Massimo Vergassola, Shelby A. Blythe,Stefano Di Talia

Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis

Changle Zhao, Yongxun Chen, Lei Liu, Xiang Liu, Hesheng Xiao, Feilong Wang, Qin Huang, Xiangyan Dai, Wenjing Tao, Deshou Wang,Jing Wei

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling

Miriam Gordillo, Rebecca Wu, Kelly M. Banks, Neranjan de Silva,Todd Evans

TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm

Auriana Arabpour, Jonathan Adam DiRusso, Qiu Ya Wu, Mark Larsen, Young Sun Hwang, Elsie Jacobson, Thi Xuan Ai Pham, Nicole Agranonik, Megan Sparrow, Vernon Leander Monteiro, Zenya Rebecca Bian, Nicolas Pelaez-Restrepo, Antuca Callejas-Marin,Vincent Pasque,Kathrin Plath, Amander T. Clark

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning

Anastasios Balaskas,Isabelle Kraus, Hatice Ö. Özgüldez,Persia Akbari Omgba,René Buschow,Adriano Bolondi,Idan Berlad,Jacob H. Hanna,Helene Kretzmer,Aydan Bulut-Karslioğlu

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast

Elizabeth Abraham, Thomas Roule, Aidan Douglas, Emily Megill, Olivia M. Pericak, Jordan E. Howe, Carmen Choya-Foces, Joanne F. Garbincius, Henry M. Cohen, Paula Roig-Flórez, Mikel Zubillaga, Mark D. Andrake, Seonhee Kim, John W. Elrod, Naiara Akizu, Conchi Estaras

| Morphogenesis & mechanics

In vivo nuclear envelope adaptation during cell migration across confining embryonic tissue environments

Hanna-Maria Häkkinen,Soraya Villaseca, Zain Alhashem, Szymon Chomiczewski, Maxime Desevedavy, Solene Leleux, Atrin Hamidzadeh, Filomena Gallo, Dina El-Zohiry, Victor Petre,Elena Scarpa

Embryonic development of C. elegans sense organs

Leland R. Wexler,Irina Kolotuev,Maxwell G. Heiman

Transient epithelial mimicry reconciles stemness and regional specification in neural crest cells of avian beaks

Carmen Sánchez Moreno,Alexander V. Badyaev

A method for analysing tissue motion and deformation during mammalian organogenesis

Morena Raiola, Isaac Esteban,Kenzo Ivanovitch, Miquel Sendra,Miguel Torres

Mechanosensitive localization of Diversin highlights its function in vertebrate morphogenesis and planar cell polarity

Satheeja Santhi Velayudhan, Chih-Wen Chu, Keiji Itoh,Sergei Y. Sokol

Stiffness sensing fuels matrix-driven metabolic reboot for kidney repair and regeneration

Yuan Gui, Yuanyuan Wang, Wenxue Li, Jia-Jun Liu, Kelly Zheng, Jianzhong Li, Henry Wells Schaffer, Cameron Jones, Samantha Mae Mallari,Yanbao Yu, Silvia Liu,Yansheng Liu,Dong Zhou

Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity

Jian Xiong Wang,Yanina D. Alvarez,Siew Zhuan Tan,Samara N. Ranie,Samantha J. Stehbens,Melanie D. White

Resilience in zebrafish embryoids

Svetlana Jovanic, Julia Eckert, Thierry Savy,Nadine Peyrieras

Maternal exercise rescues fetal akinesia-impaired joint and bone development

Christopher J. Panebianco, Yuming Huang,Nidal Khatib,Devin C. Gottlieb,Maha Essaidi,Saima Ahmed,Nathaniel A. Dyment,Rebecca A. Simmons,Joel D. Boerckel,Niamh C. Nowlan

| Genes & genomes

piRNAs are abundant in the early embryo of the crustacean Parhyale hawaiensis

Llilians Calvo,Tom Pettini,Guillem Ylla,Matthew Ronshaugen,Sam Griffiths-Jones

Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK

Rose M. Doss, Sara A. Wirth, Jonathan W. Pitsch, Caroline M. Dias, Andrea L. Gropman, Martin W. Breuss

WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis

Acadia L. DiNardo, Nicole A. Kurhanewicz, Hannah R. Wilson, Veronica Berg,Diana E. Libuda

prdm1a drives a fate switch between hair cells of different mechanosensory organs

Jeremy E Sandler, Ya-Yin Tsai, Shiyuan Chen, Logan Sabin, Mark E. Lush, Abhinav Sur, Elizabeth Ellis, Nhung TT Tran, Malcolm Cook, Allison R Scott, Jonathan S. Kniss,Jeffrey A. Farrell, Tatjana Piotrowski

Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea

Junichi Tasaki,Labib Rouhana

Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity

Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Amber Elitz, Kathleen Cook, Sarah Trovillion,Natalia Bottasso-Arias, Simon J. Y. Han, Samantha Goodwin, Nicholas X. Russell,Amanda L. Zacharias, Samantha A. Brugmann,Jeffrey A. Whitsett,Debora Sinner, Xin Sun, Daniel T. Swarr,William J. Zacharias

Molecular profiling of bovine primordial germ cell specification and migration onset reveals a conserved program in bilaminar disc embryos

Carly Guiltinan,Ramon C. Botigelli,Rachel B. Arcanjo,Juliana I. Candelaria, Lawrence F. Lanzon, Justin M. Smith, Gloria Becerra-Cortes,Anna C. Denicol

Neuronal migration induces DNA damage in developing brain

Zhejing Zhang, Andres Canela, Peilin Zou, Takahiro Furuta, Noriko Takeda, Takumi Kawaue,Naotaka Nakazawa, Mai Saeki, Masaki Utsunomiya, Junko Kurisu, Fumiyoshi Ishidate, Hiroyuki Sasanuma,Yusuke Kishi, Mineko Kengaku

Loss of Meiotic Double Strand Breaks Triggers Recruitment of Recombination-independent Pro-crossover Factors in C. elegans Spermatogenesis

JoAnne Engebrecht,Aashna Calidas,Qianyan Li,Angel Ruiz, Pranav Padture, Consuelo Barroso, Enrique Martinez-Perez,Nicola Silva

Single-cell omics reveal distinct gene regulatory dynamics underpinning embryonic and extraembryonic lineage functions during pig blastocyst development

Adrien Dufour,Marie-Noëlle Rossignol, Patrick Manceau, Yoann Bailly,Stéphane Ferchaud,Marie-José Mercat,Ali G Turhan,Sarah Djebali,Sylvain Foissac,Jérôme Artus,Hervé Acloque

Major waves of H2A.Z incorporation during mouse oogenesis

Madeleine Fosslie, Erkut Ilaslan, Trine Skuland, Adeel Manaf, Mirra Louise Cicilie Soegaard, Marie Indahl, Maria Vera-Rodriguez, Rajikala Suganthan, Ingunn Jermstad, Shaista Khanam, Knut Tomas Dalen,Ragnhild Eskeland, Michel Choudalakis, Magnar Bjoras, Peter Zoltan Fedorcsak, Gareth David Greggains, Mika Zagrobelny,John Arne Dahl,Mads Lerdrup

Somatic gene repression ensures physical segregation of germline and soma in Drosophila embryos

Miho Asaoka, Mizuki Kayama, Tomoki Kawagoe,Makoto Hayashi, Shumpei Morita,Satoru Kobayashi

Core microRNAs regulate neural crest delamination and condensation in the developing trigeminal ganglion

Rocío B. Marquez,Estefanía Sánchez Vázquez,Andrés M. Alonso, Yanel E Bernardi,Emilio M. Santillan,Peter Lwigale,Luisa Cochella,Marianne E. Bronner,Pablo H. Strobl-Mazzulla

A porcine germ cell depletion model to investigate the role of germ cells in gonadal development

Chi-Hun Park, Young-Hee Jeoung, Sai Goutham Reddy Yeddula, JiTao Wang, Bhanu P. Telugu

Transgenerational effects induced by thiacloprid in Anterior prostate tissue are associated with alterations in DNA methylation at developmental genes

Ouzna Dali, Chaima Diba Lahmidi, Tayeb Mohammed Belkhir, Theo De Gestas, Christine Kervarrec, Pierre-Yves Kernanec,Fatima Smagulova

The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness

Pavel A. Komarov, Philipp Bammer,Ching-Yeu Liang,Hans-Rudolf Hotz,Grigorios Fanourgakis,Sunwoo Chun,Hubertus Kohler,Tim-Oliver Buchholz,Jean-Francois Spetz,Antoine H.F.M Peters

Slit1 -a MET target gene in the embryonic limbs, prevents premature differentiation during mammalian myogenesis

Masum Saini,Jyoti Jadhav,Giulio Cossu,Sam J. Mathew

A short conserved sequence in the HOT region of the C. elegans dlg-1 gene largely recapitulates its transcriptional behavior during embryogenesis

Cristina Tocchini, Palmer Bassett,Susan E. Mango

Single oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability during oocyte maturation

Yuqian Wang, Wei Wang, Yujun Liu, Yiming He, Hongyu Song, Ming Yang, Nan Wang, Xiaomeng Wang, Ling Ding, Ying Kuo, Yuwen Xiu, Zhengrong Du, Lu Chen, Ying Lian, Qiang Liu, Liying Yan, Jie Qiao, Peng Yuan

Due-B Is dispensable for early development and genome duplication in vertebrates

Courtney G. Sansam,Emily A. Masser,Duane Goins,Christopher L. Sansam

| Stem cells, regeneration & disease modelling

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

Joyce Esposito,Felipe de Souza Leite,Igor Neves Barbosa,Thaís Maria da Mata Martins, Giovanna Gonçalves de Oliveira Olberg,Ziad Al Tanoury,Kayque Alves Telles-Silva,Mayana Cristina da Silva Pardo,Tatiana Jazedje,Raul Hernandes Bortolin,Mario Hiroyuki Hirata,Olivier Pourquié,Mayana Zatz

A window of cell cycle plasticity enables imperfect regeneration of an adult postmitotic organ in Drosophila

Navyashree A Ramesh,Laura Buttitta

TGF-beta coordinates changes in Keratin gene expression during complex tissue regeneration

Dipak D Meshram, Yuchang Liu, Molly Worth, Changqing Zhang,Tom J. Carney, Henry H. Roehl

Heterogeneity of Sox2-expressing cells in mouse pituitary and their roles in postnatal gonadotroph differentiation

Kosara Smiljanic,Stephanie Constantin,Naseratun Nessa,Stanko S. Stojilkovic

WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm

Bao Q. Thai, Stephanie A. Luff, Jared M. Churko, Jonathan N. Young, Christopher M. Sturgeon,Deepta Bhattacharya

SWI/SNF ATPase Brahma and Notch signaling collaborate with CBP/p300 to regulate neural stem cell apoptosis in Drosophila larval central nervous system

Punam Bala,Viswadica Prakki,Rohit Joshi

Modeling Post-Gastrula Development via Bidirectional Pluripotent Stem Cells

Kuisheng Liu, Zihui Yan, Dandan Bai, Rui Jiang, Yan Bi, Xiangjun Ma, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi, Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, Yalin Zhang, Yanhe Li, Chenxiang Xi, Shanyao Liu, Shuyi Liu, Jiayu Chen, Jiqing Yin, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yixuan Wang, Ke Wei, Wenqiang Liu,Shaorong Gao

Primitive Hepatoblasts Driving Early Liver Development

Kentaro Iwasawa, Hiroyuki Koike, Hasan Al Reza, Yuka Milton, Keishi Kishimoto, Konrad Thorner, Marissa Granitto, Norikazu Saiki, Connie Santangelo, Kathryn Glaser, Masaki Kimura, Alexander Bondoc, Hee-Wong Lim, Mitsuru Morimoto, Makiko Iwafuchi, James M. Wells, Aaron M. Zorn,Takanori Takebe

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

Martina Demurtas, Samantha M. Barnada, Emma van Domselaar, Zoe H. Mitchell, Laura Deelen,Marco Trizzino

Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members

Allara K. Zylberberg,Emma I. Scully,Pei Xuan Er, Hannah Baric, Michelle Scurr,Mian Xie,Thanushi Peiris,Sara E. Howden,Kynan T. Lawlor,Melissa H. Little

ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity

Angelica Varesi, Murtaza S. Nagree, Isabella Di Biasio, Andy G.X. Zeng, Sayyam Shah, Hyerin Kim, Michael Zhang, Alex Murison, John E. Dick,Stephanie Z. Xie

ankrd1a consistently marks cardiomyocytes bordering the injury or scar area and affects their dedifferentiation during zebrafish heart regeneration after cryoinjury

Srdjan Boskovic,Mirjana Novkovic,

Asperous coordinates regenerative timing by regulating damage-induced WNT Signaling

Si Cave,Manashi Sonowal,Chloe Van Hazel,Petra Fromme,Robin E. Harris

The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation

Hideyuki Sato,Ayaka Yanagida, Mariko Kasai,Naoaki Mizuno,Eiji Mizutani, Hiromi Yamamoto,Satoko Ishii, Taro Hihara,Kazuto Yamazaki, Ayuko Uchikura, Kazuaki Nakano, Masashi Ito,Hiroshi Nagashima,Hideki Masaki,Hiromitsu Nakauchi

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Daniel P. Moore, Heather B. Steele-Stallard, Luca Pinton, Valentina Maria Lionello, Lucia Rossi, Artadokht Aghaeipour, Salma Jalal, Cherry Tsz Yan Wong, Angela Clara-Hwang, Gisèle Bonne, Peter S. Zammit,Francesco Saverio Tedesco

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug Screening

Ashis Kumar, Vignesh Kumar, Agnes Selina, Vrisha Madhuri, Vasanth Thamodaran

| Plant development

Maternal control of RNA decay safeguards embryo development

Gerardo Del Toro-De León, Maria Sofia Trenti, Varsha Vasudevan, Ursula Krause,Claudia Köhler

Redesigning petal shape, size, and color in soybean reveals unexpected phenotypes for floral organ development

Nicole Szeluga, Noor AlBader, Samantha Pelletier, Kylie Weis, Arielle Johnson, Noah Fahlgren,Mikhaela Neequaye, Gus Vogt, Ryan DelPercio,Patricia Baldrich, Kelsey J.R.P. Byers,Blake C. Meyers,Margaret H. Frank

FLOE1 maintains cellular viscosity in rehydrating Arabidopsis embryos

Sterling Field, John F. Ramirez, Yanniv Dorone, Jack A. Cox, Thomas C. Boothby,Seung Y. Rhee

Analysis of Wheat Spike Morphological Traits Using 2D Imaging

Fujun Sun, Shusong Zheng, Zongyang Li, Qi Gao, Ni Jiang

Cytokinin overcomes spikelet-driven inhibition of tillering in wheat and barley by delaying meristem development

Alex Wakeman,Tom Bennett

FERONIA defines intact tissue boundaries through cuticle development

Gayeon Kim, Jeongho Choi, Ryeo Jin Kim, Eunkyoo Oh, Seung Yong Shin, Hyun-Soon Kim, Hye Sun Cho, Mi Chung Suh, Hyo-Jun Lee

Urbanization drives genetic and plastic responses of the spotted jewelweed flower morphology

Jerome Burkiewicz, Julie Carvalho, Sophie Caporgno,Joelle Lafond, Celine Devaux, Etienne Normandin, Simon Joly

Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis

Yanru Li,Danli Fei, Jasmin Schubert,Kinga Rutowicz,Zuzanna Kaczmarska, Alberto Linares,Alejandro Giraldo Fonseca,Sylvain Bischof,Ueli Grossniklaus,Célia Baroux

Gene regulatory network analysis of somatic embryogenesis identifies morphogenic genes that increase maize transformation frequency

Jim Renema,Svitlana Lukicheva, Isabelle Verwaerde,Stijn Aesaert,Griet Coussens,Jolien De Block,Carolin Grones,Thomas Eekhout,Bert De Rybel,Rhoda A.T. Brew-Appiah, Christopher A. Bagley,Lennart Hoengenaert,Klaas Vandepoele,Laurens Pauwels

Arabidopsis RabGDIs are essential for the asymmetric division of zygotes and embryonic patterning

Gui-Min Yin, Ya-Nan Wu, Weiqi Wang, Shan-Shan Dun, Sha Li, Liwen Jiang, Zi-zhen Liang,Yan Zhang,Feng Xiong

Antagonistic and Synergistic Roles of Tomato AFP3 Isoforms in Hormonal Regulation and Development

Ylenia Vittozzi,Louise Petri, Maurizio J. Chiurazzi, Purificación Lisón,Carmen Grech Hernández, Adity Majee, Naveen Shankar, Meike Burow,Stephan Wenkel

Lf2 is a knotted homeobox regulator that modulates leaflet number in soybean

Chancelor B. Clark,Denise Caldwell, Qiang Zhu, Dominic Provancal, Austin C. Edwards, Qijian Song, Charles V. Quigley,Anjali S. Iyer-Pascuzzi, Jianxin Ma

| Environment, evolution and development

Projected warming disrupts embryonic development and hatch timing in Antarctic fish

Margaret Streeter,Nathalie R. Le François,Thomas Desvignes, Jacob Grondin,John H. Postlethwait,H. William Detrich III,Jacob M. Daane

Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida

Allan M. Carrillo-Baltodano,Emmanuel Haillot,Steffanie Mutiara Meha, Imran Luqman, Artenis Pashaj, Yun-Ju Lee,Tsai-Ming Lu,David E. K. Ferrier,Stephan Q. Schneider,José M. Martín-Durán

A tardigrade cytochrome P450 perturbs Drosophila melanogaster development

Caitlyn L Perry, Charles Robin

Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis

Flora Plessier,Heather Marlow

Differential fates of vertebrate Kazald gene quartet, from ancestral roles in skeletogenesis and regeneration to putative innovations in fish and birds

Sean D. Keeley,Rita Aires,Belfran Alcides Carbonell Medina,Claudia Marcela Arenas-Gómez,Alejandra Cristina López-Delgado,Jean Paul Delgado,Franziska Knopf,Shigehiro Kuraku,Tatiana Sandoval-Guzmán

Wound-induced eyespots on butterfly wings at the intersection of immune response and pigmentation development

Maria Adelina Jerónimo,Ana Rita Garizo,Guilherme W Atencio,David Duneau,Patrícia Beldade

Developmental plasticity of hermaphrodite sperm production across environments in Caenorhabditis elegans

Clotilde Gimond,Nausicaa Poullet,Anne Vielle, Emilie Demoinet,Christian Braendle

The evolution of gene regulatory programs controlling gonadal development in primates

Nils Trost,Amir Fallahshahroudi,Ioannis Sarropoulos,Céline Schneider,Julia Schmidt,Noe Mbengue, Eva Wolff, Charis Drummer,Robert Frömel,Steven Lisgo,Florent Murat,Mari Sepp,Margarida Cardoso-Moreira,Rüdiger Behr,Henrik Kaessmann

On wing pattern and wing shape evolution in Giant Silk Moths: Lessons from wing development in Luna and Polyphemus Moths

Andrei Sourakov

From Sourakov et al. This image is made available under a CC-BY-NC-ND 4.0 International license.

Cell Biology

Biological characteristics of rabbit KLF12 and its regulation of proliferation and apoptosis of ovarian granulosa cells

Jiawei Cai, Bohao Zhao, Zhiyuan Bao, Yunpeng Li, Xiaoman Han, Yang Chen,Xinsheng Wu

Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum

Zaili Luo, Mingyang Xia, Feng Zhang, Dazhuan Xin, Rohit Rao, Karrie M. Kiang, Kalen Berry, Yu Xiong, Hongqi Liu, Yifeng Lin, Ming Hu, Mei Xin, Jie Ma, Hao Li, Michael D. Taylor, Wenhao Zhou, Q. Richard Lu

Post-replicative initial expression of the cell fate regulator PAX6 during neuroectoderm differentiation

Song Hu, Rongao Kou, Zhuojie Su, Guanchen Li, Shutao Qi, Yanxiao Zhang, Haifeng Wang, Ling-Ling Chen, Hongtao Yu

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function

Chenhao Tong, Tao Lin, Han Wang, Carolina De La Torre, Hui Liu, Chen Shao, Seddik Hammad, Roman Liebe, Matthias P Ebert, Huiguo Ding, Steven Dooley, Hong-Lei Weng

The Sphingosine-1-phosphate pathway is differentially activated in human gestational tissuesv

Magdaleena Naemi Mbadhi, Hideji Fujiwara, Ruth Gill, Kaci T. Mitchum, Cici Lin,Nandini Raghuraman,Antonina I. Frolova

Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

Haruna Gekko, Ruri Nomura, Daiki Kuzuhara, Masato Kaneyasu, Genpei Koseki, Deepak Adhikari, Yasuyuki Mio, John Carroll, Tomohiro Kono, Hiroaki Funahashi,Takuya Wakai

“PDGFRα is required for postnatal cerebral perivascular fibroblast development”

Hannah E. Jones, Kelsey A. Abrams,Katherine A. Fantauzzo,Julie A. Siegenthaler

Aberrant placental structure is corrected with repeated nanoparticle-mediated IGF1 treatments in a guinea pig model of fetal growth restriction

Baylea N. Davenport,Rebecca L. Wilson, Alyssa A. Williams, Jaimi A. Gray, Edward L. Stanley, Helen N. Jones

Pcbp1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition

E. I. Bakhmet,E. V. Potapenko,O. Y. Shuvalov,A. A. Lobov,E. A. Repkin,N. E. Vorobyeva, A. N. Korablev,A. S. Zinovyeva, A. A. Kuzmin,N. D. Aksenov,A. T. Kopylov,G. Wu,H. R. Schöler,A. N. Tomilin

Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta

Siddharth Acharya,Eric Hanssen,Veronica B. Botha, Tia M. Smith,Sahan Jayatissa, Zlatan Trifunovic,Lucy A. Bartho,John E. Schjenken,Tu’uhevaha J. Kaitu’u-Lino,Anthony V. Perkins,Joanna L. James,Kirsty G. Pringle,James C. Bouwer,Roger Smith,Joshua J. Fisher

Developmental coordination of mitochondrial dynamics and membrane remodeling drives organelle morphogenesis

H Aravind, Vivek Kumar, Manish Jaiswal

Patched regulates cell cycle and tissue architecture in C. elegans gonad

Johanna Farley, Madeleine Schwalbe, Fredrik Forsberg, Aqilah Amran,Sandeep Gopal

Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle

Suma Garibova, Eva Stickler, Fatima Al Ali, Maha A Abdulla, Abbirami Sathappan,Sahar Da’as, Lilian Ghanem, M Nadhir Djekidel, Rick Portman,Matteo A Avella

Juvenile hormone degradation enzymes have shared and unique requirements in Drosophila development

Harry Siegel,Creehan Healy,Krystal Goyins,Amina Jumamyradova, Jie Ying,Alexey A Soshnev,Rebecca F Spokony,Lacy J Barton

MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis

Esther G. Ushuhuda, Jenniluyn T. Nguyen, Natalie G. Pfaltzgraff, Matthew Kofron,Maria M. Mikedis

Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations

Anna Frey,Laurin Ernst,Friedericke Fischer,Lale Alpar, Yohanns Bellaïche,Anne-Kathrin Classen

Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells

Abhrajit Ganguly, Cynthia M Carter, Aristides Rivera Negron, Hua Zhong, Alvaro Moreira, Matthew S. Walters, Lynette K Rogers, Y S Prakash, Trent E Tipple, Arlan Richardson

Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung

Melinda E. Snitow, Sylvia N. Michki, Fatima N. Chaudhry, Rachna Dherwani, Jeremy B. Katzen, David B. Frank, Jarod A. Zepp

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development

Shalini Chakraborty, Jack Govaerts, Abigail Hawke, Matthew Werbelow,Todd Schoborg

Taurine Transporter SLC6A6 Expression Promotes Mesenchymal Stromal Cell Function

Christina M. Kaszuba, Sonali Sharma, Benjamin J. Rodems, Cameron D. Baker, Palomi Schacht, Takashi Ito, Kyle P. Jerreld, Chen Yu, Edgardo I. Franco, Emily R. Quarato, Francisco A. Chaves, Jane L. Liesveld, Laura M. Calvi, Hani A. Awad, Roman A. Eliseev,Jeevisha Bajaj

Protein kinase C inhibitor suppresses 2-cell stage development and perinuclear vesicle formation in mouse zygotes

Toru Suzuki, Yuriko Sakamaki

Dolutegravir Developmental Toxicity is Mitigated by Magnesium and Folate in Zebrafish Embryos

Robert M Cabrera, Ahmed Mohamed, Ryoko Minowa, Katheryn A Neugebauer,Daniel A Gorelick

Stay or Stray: Lpar1 regulates neutrophil retention and epidermal homeostasis in early zebrafish development

Shih-Chi Li, Yu-Chi Lin,Chung-Der Hsiao,Shyh-Jye Lee

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages

Eloïse Bertiaux, Vincent Louvel, Caitlyn L. McCafferty, Hugo van den Hoek, Umut Batman, Souradip Mukherjee,Lorène Bournonville, Olivier Mercey, Isabelle Mean, Adrian Müller, Philippe Van der Stappen, Garrison Buss, Jean Daraspe,Christel Genoud, Tim Stearns,Benjamin D. Engel,Virginie Hamel,Paul Guichard

Modelling

BlastDiffusion: A Latent Diffusion Model for Generating Synthetic Embryo Images to Address Data Scarcity in In Vitro Fertilization

Alejandro Golfe, Natalia P. García-de-la-puente, Adrián Colomer, Valery Naranjo

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos

Xin Li, Robert J. Huebner, Margot L.K. Williams, Jessica Sawyer, Mark Peifer, John B. Wallingford, D. Thirumalai

Generative epigenetic landscapes map the topology and topography of cell fates

Victoria Mochulska,Paul François

From Mochulska et al. This image is made available under a CC-BY-NC 4.0 International license.

Tools & Resources

A cell atlas of the developing human outflow tract of the heart and its adult derivatives

Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A Hanley, Magnus Rattray, Simon D Bamforth, Nicoletta Bobola

A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability

Stanley E. Strawbridge,Lawrence E. Bates, Connor Ross, Kenneth A. Jones,Takuya Azami,Tim Lohoff,Maike Paramor, Vicki Murray,Ana Luíza Cidral, James Clarke,Maria Rostovskaya, Ge Guo,Jennifer Nichols

Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids

Keevon Flohr, Michael Janecek, Lingyun Wang, Vicente Valle, Shaohua Pi, Rui T. Peixoto, Susana da Silva

Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells

Shinichiro Ogawa, Mina Ogawa, Jeff C Liu, Abolfazl Dadvar, Britney Tian, Xinyuan Zhao, Ian Fernandes, Kentaro Minegishi, Kenichiro Takase, Yuichiro Higuchi,Hiroshi Suemizu,Ian McGilvray,Sonya MacParland,Gary Bader

Long-term ex ovo culture of Caenorhabditis elegans embryos

Clover Ann Stubbert, Cherry Soe,Pavak Kirit Shah

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Ittetsu Nakajima, Mitsuyoshi Shimane, Grace Holmstrom, Yuichiro Miyaoka

FOXM1 Inhibition Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway

Kayque Alves Telles-Silva, Lara Pacheco, Sabrina Komatsu, Fernanda Chianca, Gustavo Chagas, Gabrielly Cristine Martins, Maria Gridina, Daria Panchenko, Valdemir Melechco Carvalho, Elia G. Caldini, Veniamin S. Fishman,Michelle Arkin, Ernesto Goulart, Mayana Zatz

Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora

Ramona Brunner, Mila Grinblat, Aurelie Moya, Sylvain Foret, David C Hayward, Bruno Lapeyre, Eldon E Ball,Ira Cooke,David J Miller

A method for creating custom 3D-printed molds to facilitate zebrafish imaging studies, including of cardiac development

James Christian Miller, Prashanna Koirala, Maria Fernanda Argote de la Torre, Marjan Farsi, Jaret Lieberth, Rabina Shrestha,Joshua Bloomekatz

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Categories: Highlights

Event carbon calculator

Posted by , on 30 June 2025

I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your event’s carbon footprint in five minute or less. Our event carbon calculator provides insights into the main drivers of your meeting’s greenhouse gas emissions, offers reduction scenarios to test and provides resources to help you build a sustainable strategy for your event. 

Our calculator is still in its beta stage, so please explore our tool and send us feedback on how to make it better suited for your needs. We hope you will enjoy using our event carbon calculator and that it will help to inspire more sustainable actions in your academic meetings.  

Our calculator is part of The Company of Biologists Sustainable Initiative, read more about how we can support you. 

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Categories: Education, Events, Uncategorized

The Node Time Machine – June 2013

Posted by , on 27 June 2025

At the end of each month, I pick the same month from a random year from the past 15 years of the Node, and take a look at what people were talking about back then.

Previously, I’ve been busy travelling back to February 2011, March 2013, April 2014 and May 2016 to have a look around the Node. It’s been really fun peeking around the archives. This June, let’s jump back to 2013…

Career stories

This post from Kara Cerveny inspired our recent ‘No such thing as a standard career path‘ interview series.

Live meeting reporting

Remember back in the days when live tweeting from a conference is a thing, but the internet in conference venues could be a bit patchy?

Woods Hole image competition

We used to partner with the Woods Hole embryology course to run an image competition, with the winning image being featured on Development’s cover. We’re hoping to revive this tradition – watch this space!

Research Highlights

Read about the highlights and challenges that people encounter in their research in our ‘Behind the paper’ stories.

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FlyCROSS 2025–26: Mentor-mentee matching program

Posted by , on 25 June 2025

Call for Mentors from the Drosophila community.

The Fly Board is excited to announce the second cycle of FlyCROSS (2025–2026), following a successful launch in 2024. The goal of FlyCROSS is to empower early career Drosophila researchers by connecting them with mentors who can help them fly in their careers – whether in academia or beyond.

Through FlyCROSS, early career scientists in the Drosophila community will be paired with an experienced mentor who will help them navigate the world of fly research with ease. Designed to prioritize the needs of mentees by matching them with mentors of their preferences, the program offers seasoned researchers an opportunity to share their knowledge and pay it forward by supporting scientists who are seeking guidance and fresh perspectives. The program consists of three parts: the mentor survey, the mentee survey, and matching.

We are currently seeking mentors. Scientists with experience in Drosophila research, including postdoctoral researchers, faculty members, and those in equivalent roles across diverse scientific career paths are eligible to serve as mentors and invited to complete the Mentor survey by July 14. The mentor survey will gather important details about your areas of expertise and personal career journey. We’re looking for mentors from all career paths—academia, industry, biotech, science communication, policy, and more—who have experience with Drosophila research and are eager to support the next generation of fly scientists. (If you have earned a PhD and are currently involved in any scientific career path and have experience working with fruit flies as a model system at any stage of your career, we encourage you to volunteer to support the next generation scientists)

The prospective mentee survey will be open July 21 through September 1 and will collect in-depth information about the type of mentorship each mentee is seeking. Early-career scientists including graduate students, postdoctoral researchers working in fly labs or equivalent settings, and pre-tenure faculty leading Drosophila research groups are eligible to participate as mentees.

Mentees will review the list of available mentors and their responses, with the option to indicate their preferred mentors. After receiving mentee submissions, the FlyCROSS Committee will carefully review the preferences and finalize pairings, ensuring an optimal match between mentors and mentees. Matches will be announced by October. Incase of any queries reach out to dmelcross@gmail.com. FlyCROSS was adapted from a similar mentoring program running in the worm community, and we sincerely appreciate their support of our endeavor.

Thankyou
Shefali
FlyCROSS Co-chair
Grad student rep, Fly Board
PhD candidate, Tennessen Lab
IU Bloomington
Bluesky : ‪@iamshef.bsky.social‬
X : @iam_shef

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Categories: Careers, Education, News, Outreach, Resources, Societies

From Posters to Parades: Inside Woodstock.Bio² & Night Science Conference

Posted by , on 25 June 2025

A fever dream of science and spirit wrapped in the forests of Bohemia. Here’s an escalating list — starting with the standard (though nothing was standard about this) — and spiraling toward the legendary. This was what made Woodstock.Bio² & Night Science the most unforgettable conference of its kind (there is no such kind).

What We Had:

·       Scientists across all career stages — from undergrads to full professors (yes, there was one undergrad! He’s ahead of his time).

·       6 stunning venues

·       Cross-discipline scientific talks, showcasing cutting-edge (and sometimes delightfully mediocre) science.

·       Scientific debates over coffee and drinks.

·       A second screen showing live comments to the talk on bluesky.

·       Poster session in the forest — because… why not?

·      Walk-up songs (and often dances) for every talk, pre-chosen by the speaker.

·      random schedule (you don’t know when you’re talking) 

·      The “Stunningly Naïve” session (thanks Maya Bar!) — for asking the “dumbest” questions we’ve been too scared to say aloud.

·      A train chartered entirely for participants, from Prague to the woods of Bohemia.

·      Canoeing

·     Theology or Biology game by Yuval Ebstein.

·     Confessions booth (yes, to the editor)

·      The Barkley Marathons (Google it)

·      Meditation sessions — finding peace beyond Reviewer #2

·      Science debates turned boxing matches

·      Round-the-fire singing and late-night conversations

·      A wedding (!!) — congrats Lea and Daniel!

·      A Disney-style parade, as a thank-you to the Bohemian fixers, instigators, organizers, and every single participant.

·      Live Gypsy band party

·      Dance floor ruled by DJ-scientists Jesse Veenvliet & Oded Rechavi

What Made It Epic?

The people. Each and every participant of this meeting. 

In retrospect, being forced to choose a walk-up song might have been one of the most brilliant conference design decisions. It pushed us out of default mode, pipetted creativity and humor into the air, and made each session feel more like a show than a slot.

And because everyone was “performing” just a little — rethinking how to present their science in a more human, fun, or offbeat way — we found ourselves better able to stay tuned to ALL talks, even when they spanned wildly different disciplines. There was something about the levity and variety that made us listen more deeply.

Even the hashtag had a story. We used #TCTeAC on BlueSky – a compact string chosen as shorthand for #TheConferenceToEndAllConferences. It’s an acronym of the full phrase, but we also loved how it resembled a DNA sequence or binding motif. In a way, it was a motif — one you had to chant silently each time you typed it out.

TCTeAC… The Conference To end All Conferences…

TCTeAC… The Conference To end All Conferences…

But maybe it wasn’t just the events. It was the environment. Once a space was created where it felt safe — and common — to laugh, to question, to try weird things, to fail publicly, to be human — everything else followed. For all of us, as a collective.

People stepped out of their academic armor. Speakers forgot their next line, slides froze, and the crowd cheered. Honest dialogue blossomed. Ideas were born not just during talks, but on trains, under canopies, beside the fire.

“This project? It started with a chat on the train to the woods during Woodstock.Bio².”

Already thinking about the next one? The only spoiler I would give is that less than 24 hours after the ending of the meeting, the instigators and bohemian fixers were already conspiring on ideas for the next meeting. Needless to say the ideas are beyond imagination and bigger than life.

See you next time! 

Location: TBD.

Instigators:

Bohemian Fixers:

Website: https://woodstock.img.cas.cz/

Bits of the magic

Walk up songs:

My talk in the first session was accompanied by a local bass guitarist:

* Thank you Patric! You rock! (and roll…)

We had a huge amount of exciting talk across a broad range of scientific fields:

The final location was a YMCA campsite at Southeast Central Bohemia:

But most importantly, we were strict with time, if a speaker went overtime and would not leave the stage – we took care of that, to keep the tight schedule of the meeting:

* This act was coordinated with the speaker ahead of time (in other words… just a joke).

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Lab meeting with the Silveira Lab

Posted by , on 24 June 2025

This is part of the ‘Lab meeting’ series featuring developmental and stem cell biology labs around the world.

Lab introduction

Mariana S. Silveira: I am the head of LINDes, my current laboratory established in 2023. Prior to that, I shared another research space, the Neurogenesis Lab, with colleagues and my former advisor, Dr. Rafael Linden. I held the position of Associate Professor at the Institute of Biophysics Carlos Chagas Filho, part of the Center for Health Sciences at the Federal University of Rio de Janeiro, Brazil. Notably, this institution is the first university founded in our country, previously known as the University of Brazil, and our Institute is now approaching its 80th anniversary. In Brazil, this represents an esteemed and traditional institution, as our country is relatively young. Our Institute’s Program of Biological Sciences–Biophysics, one of the first doctoral programs in Brazil, has a history spanning 62 years.

The lab is in Rio de Janeiro and our city boasts unparalleled natural beauty and a vibrant cultural scene.

Research summary

Our current research focuses on leveraging advancements in retinal development and cell reprogramming to explore potential therapeutic strategies for vision loss. Specifically, we focus on retinal ganglion cells, the projection neurons of the retina, working in collaboration with both Brazilian and international research groups. Additionally, we are investigating the retinal microglia in a collaborative project aiming to design innovative tools employing machine learning for morphological categorization.

Lab roll call

José Nilson dos Santos – He’s been the go-to technician ready to help anyone in the lab ever since the lab head was a PhD student in the Neurogenesis Lab. Always there to tackle any kind of problem, it’s awesome to have him around!

Mariana S. Silveira – Associate professor and lab head. Honestly, leading this fresh and young team is both a challenge and a joy. My goal is to put all my energy into making sure they have a productive and happy experience in the lab.

Viviane Oliveira Valença – Postdoctoral researcher, Viviane serves as my right hand. Having recently completed her PhD; she is currently assisting in training the group and moving forward some new collaborations while finalizing manuscripts. Her presence is truly invaluable to the lab.

Daianne Torres – A combination of lab manager and technician, Daianne is consistently available to address both administrative and technical challenges.

Isabel Guedes Ferreira – A highly skilled Master’s student currently focusing on the study of retinal microglial morphology and the development of computational tools to enhance and optimize these analyses.

Bernardo Benincá – He has recently started his Master’s program, where his research project focuses on stimulating the reprogramming of Müller glial cells in vitro through the overexpression of transcription factors.

Kauã Mourão – An undergraduate student in Biological Sciences who joined the lab as a trainee in 2024. He is currently exploring various techniques to evaluate the potential for reopening the window of retinal ganglion cell generation and the synaptic integration of newly formed neurons.

Victoria Mattos – An undergraduate student in Biomedical Sciences who joined the lab in 2024. She is currently acquiring the essential foundational techniques needed to initiate her own project. Presently, she assists other students with their work and participates in routine laboratory activities.

Camila Barbosa – An undergraduate student in Microbiology and Immunology who joined the lab in 2024 and is currently enhancing her technical skills.

Loreena Klein – A PhD candidate who has recently joined the laboratory after completing her Master’s in the field of pain regulation, is currently investigating the regenerative potential of Müller glial cells for the generation of retinal ganglion cells in vivo.

Roberto Matias – An undergraduate student specializing in Biophysics, Roberto contributes to Isabel’s research by assisting in the morphological analysis of microglial cells across various functional states and investigating their correlation with neurodegenerative processes.

Talia Pontes – An undergraduate student in Biomedical Sciences, has recently joined the laboratory with the intention of pursuing a graduate program in the future.

Favourite technique, and why?

Mariana: In my opinion, microscopy remains an invaluable tool, particularly with advancements in resolution and the ability to detect multiple antigens simultaneously. This approach provides precise in situ information when combined with cell morphology, defining in a remarkably accurate way, cell identity within tissue. Nevertheless, employing a combination of various methodologies is always the optimal strategy. Recently, I have also become fascinated by scRNA-seq as a very relevant tool.

Mariana, apart from your own research, what are you most excited about in developmental and stem cell biology?

Mariana: The emerging field of organoids and assembloids, particularly for investigating early stages of brain development and the underlying mechanisms of diseases, is truly captivating.

Mariana, how do you approach managing your group and all the different tasks required in your job?

Mariana: I must admit it’s not an easy task. My approach involves holding regular meetings with the team, where we not only discuss relevant literature related to our projects and related fields but also hold individual and group follow-ups to review the goals set for each member. Despite time being limited, I always keep my office door open for them.

What is the best thing about where you work?

Mariana S. Silveira – Although science funding in Brazil remains quite limited, which makes competing for international grants an essential challenge, I truly appreciate working at such a prestigious institution. Here, we are often supported and encouraged to strive for quality and excellence, especially in training the next generation of researchers. While the number of young individuals pursuing this demanding career is gradually declining, it’s rewarding to discover talented individuals and witness their scientific growth and development. Celebrating small achievements serves as a motivation to keep moving forward.

Viviane Oliveira Valença– We are at one of Brazil’s top universities, which is definitely the highlight for me, as numerous scientific contributions are made here. Even though we lack good infrastructure, safety, and other resources, being inside the university and surrounded by students from different fields fosters interaction and knowledge exchange.

Daianne Torres – The best thing about our workplace is the people who make up our lab. Even when we’re stressed about failed experiments, having supportive and caring teammates always makes the effort worthwhile.

Isabel Guedes – The best thing about our lab is the camaraderie and sense of community. We genuinely look out for each other, and that support makes even the hardest days a lot easier to get through.  

Bernardo Benincá – It is the people. The scientific environment is challenging and can often be frustrating, but we take great pride in the quality of the work we produce despite numerous hardships and limited funding. Another important factor is how we always support each other, creating a welcoming and inclusive space. It’s an honor to be part of our lab.

Kauã Mourão – The people. They are not only my lab group with whom I talk about research and papers, but also my friends whom I know I can count on in this crazy work routine. It is really great to share my workspace with them because I learn more every day. They are truly skilled at what they do.

Victoria Mattos – It’s all about the connections we build with people and what we learn. Joining the lab helped me grow, both as a student and as a person. Being part of this environment and contributing to our research is very rewarding.

Camila Barbosa – The great thing about working in this lab is the constant exchange with the whole team, which always helps me learn something new, whether during experiments or in our meetings. Outside the lab, we have the privilege of being close to renowned professionals, and we get to attend various lectures and conferences, which also helps broaden our scientific perspectives.

Loreena Klein – The best thing about where I work is the strong sense of community. Everyone is very supportive and willing to help, which has made a big difference for me as a new PhD student adjusting to the environment.

Roberto Matias – I can say for sure that the best thing about where I work is the patient, dedicated and fun people who guide me in everything I need to learn, whether they are colleagues or teachers. The Institute is a peaceful and friendly place capable of comforting anyone in difficult times.

Talia Pontes – Honestly, the best thing about working here is getting to learn hands-on lab techniques from experienced researchers right at my own university. Plus, it feels great to know I’m helping push the boundaries of retinal studies.

What’s there to do outside of the lab?

Mariana S. Silveira – Besides enjoying the quiet pleasure of reading a captivating romance, I’m a big fan of Brazilian music. I enjoy attending live shows and participating in groups that use samba school instruments to explore the diverse rhythms of our rich musical culture.

Viviane Oliveira Valença – Here in Rio de Janeiro, there are plenty of things to do outside the lab, such as hiking in various places where you can enjoy breathtaking views of the city. Besides that, you can go to the beach, soak up the sun, and spend quality time with friends.

Daianne Torres – During my free time, I enjoy curling up on the couch with a good TV series to unwind or diving into the pages of a new book to escape into a world of fantasy.

Isabel Guedes Ferreira – Outside of the lab, I like to unwind by reading, playing games, and spending time with my friends. It helps me recharge and keep a healthy balance.

Bernardo Benincá – Sometimes it is important to take a break from the routine and do things to relax. Hobbies like watching movies, reading, playing video games, going out with friends, or simply going to the garden and looking at the trees.

Kauã Mourão – We are talking about Rio, so I must mention the beaches! They are amazing! There is nothing better than heading to the sea and unwinding from everything.

Victoria Mattos – Outside of the lab, I enjoy spending my time with my family and friends, it’s always a lot of fun to be surrounded by good people in a nice place. I like to go to the beach, enjoy samba and visit new restaurants.

Camila Barbosa – In my free time, I enjoy spending time with friends, going hiking, connecting with nature, watching series, and reading.

Loreena Klein – Outside of the lab, I love spending time with my friends, whether we’re going out or just hanging out together. I also enjoy staying home and watching some TV shows, which help me relax and recharge.

Roberto Matias – Rio de Janeiro offers many interesting activities, such as modern museums, restaurants with unique and exotic cuisine, and adrenaline-pumping amusement parks. With such a beautiful city full of activities and people, it is impossible to decide what to do.

Talia Pontes – Outside of the lab, I enjoy watching movies, reading, and spending quality time with my family. I also dedicate time to studying extracurricular subjects and learning new languages—currently, I am studying Spanish.

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MITOtalks and FocalPlane features… webinar on the cell biology of mitochondria

Posted by , on 23 June 2025

The recent Special Issue from Journal of Cell Science focussed on the cell biology of mitochondria. To showcase some of the research in this issue, FocalPlane and MITOtalks have teamed up to host a webinar on Thursday 3 July at 16:00 BST (17:00 CEST, 11:00 EDT, 08:00 PDT). MITOtalks organisers Nuno Raimundo and Sjoerd Wanrooij have invited Yuli Buckley, Mireia Nager and Dikaia Tsagkari to present their research.

Thursday 3 July at 17:00 CEST, 16:00 BST, 11:00 EDT, 08:00 PDT

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Categories: Events, News, Research

#DanioDigest (May 2025)

Posted by , on 21 June 2025


An easily-consumable recap of the latest happenings in the #zebrafish community and beyond!

Use these links below to get to the section you want:

Community news

Zebrafish careers

Publications

Preprints

Reviews

Protocols and tools

Link to Bluesky post: https://bsky.app/profile/zebrafishrock.bsky.social/post/3ls4uwx4pkv23

Community News:

Prof. Caren Norden (@nordenlab.bsky.social‬) appointed Darwin Professor of Animal Embryology in the Department of Physiology, Development, and Neuroscience at the University of Cambridge.

Image of Prof. Caren Norden.

Prof. Elizabeth Chen (@echenlab.bsky.social) elected as President of American Society of Cell Biology (@ascbiology.bsky.social‬) for 2027.

Image of Prof. Elizabeth Chen.

Prof. Iain Couzin (@icouzin.bsky.social ) elected as a Fellow to the Royal Society.

Image of Prof. Iain Couzin

Prof. Ken Poss (@kenposs.bsky.social) becomes a Full Editor at the Journal Development (@dev-journal.bsky.social‬).

Dr. Margarida C. Gomes (@cgmargarida.bsky.social) joins University of Warwick (@warwicklifesci.bsky.social) as an Assistant Professor.

Dr. Júlia Peloggia de Castro (@jupeloggia.bsky.social)  awarded the Behrensen – Guzmán Palma Award for the most outstanding research paper by a predoctoral student at Stowers Institute for Medical Research.

Drs. Leanne Iannucci (@leanneiannucci.bsky.social) & Katie Martin selected as 2025 Leading Edge Fellows (@leadingedgeprogram.bsky.social‬).

PhDs awarded to:

Dr. Kaushik Chowdhury (@kcinc.bsky.social) of ‪Lai Lab (@benlai-taiwan.bsky.social‬) at Academia Sinica.

Dr. Laura Childers of Bagnat Lab (@bagnatlab.bsky.social) at Duke University.


#ZebrafishCareers posted by: 

‪@zfinmod.bsky.social 🇺🇸 (Software Developer)

https://zfin.atlassian.net/wiki/spaces/jobs/blog/2025/05/14/6335332365/Software+Developer+Zebrafish+International+Resource+Center+University+of+Oregon+Eugene+OR

@simoesfilipa.bsky.social‬ 🇬🇧 (Researcher)

https://www.heartdevelopment.org

@zfinmod.bsky.social 🇺🇸 (Postdoc)

https://zfin.atlassian.net/wiki/spaces/jobs/blog/2025/05/29/6365380620/Zebrafish+Post-Doctoral+Scientist+in+Pediatric+Oncology+Cleveland+Clinic+Cleveland+Oh

Joanna Thomas via online submission 🇺🇸 (Postdoc) https://zfin.atlassian.net/wiki/spaces/jobs/blog/2025/06/09/6383075333/Postdoc+Fellow+Overcoming+the+Blood-Brain+Barrier+to+Treat+Brain+Cancer+Gottesman+Lab+National+Cancer+Institute+NIH+Bethesda+MD

@bertaverd.bsky.social‬ (Cichlid) 🇬🇧 (Postdoc)– Contact Directly

https://www.biology.ox.ac.uk/people/berta-verd#tab-2779371

‪@sebgauvrit.bsky.social 🇨🇦 (MSc/PhD) 

https://jobrxiv.org/job/university-of-saskatchewan-college-of-medicine-27778-msc-phd/

@bakkerslab.bsky.social‬ 🇳🇱 (PhD)

https://www.hubrecht.eu/job/phd-student-drive-rm-38-hours-p-w

@yhcarolyang.bsky.social‬ 🇬🇧 (PhD)

https://www.exeter.ac.uk/research/institutes/livingsystems/lsiphdprogramme

@zfinmod.bsky.social‬ 🇺🇸 (Tech)

https://zfin.atlassian.net/wiki/spaces/jobs/blog/2025/05/15/6339821596/Zebrafish+Facility+Technician+Prober+Lab+California+Institute+of+Technology+Pasadena+CA

Helen Eachus via online submission 🇬🇧 (Research Assistant)
https://www.jobs.ac.uk/job/DND643/research-assistant-zebrafish-models-and-neuroendocrine-research

Publications:

Embryogenesis/ Development

‪@lovelessradio.bsky.social‬ (Cell proliferation/ Mitotic events/ Kupffer’s vesicle)

doi.org/10.1242/dev.204687 

Behaviour

@icouzin.bsky.social  (Collective behaviour/ Schooling /Virtual reality)

doi.org/10.1126/scirobotics.adq6784 

‪@noimthemary.bsky.social‬ & #NelsonLab at CU-Anschutz (Behaviour/ Larvae startle response/ Cadherin-16)

doi.org/10.1371/journal.pbio.3003164 

@wonglab.bsky.social‬ (Learning/ Behaviour/ Conditioned place preference)

doi.org/10.1038/s41598-025-00423-6 

@parkerlab.bsky.social‬ (Husbandry/ Housing/ Novel Tank Test)

doi.org/10.1038/s41684-025-01548-x 

Cell Biology

@kkostova.bsky.social‬ (Ribosome assembly/ Ubiquitin-proteasome system/ Ribosomopathy)

doi.org/10.1016/j.molcel.2025.04.017 

DNA Elements

@miskalab.bsky.social‬ (Cichlids/ Pangenome/ Transposable elements)

doi.org/10.1101/gr.279674.124 

@migueldvalmeida.bsky.social‬ (Transposable elements/ Genome evolution/ F-box genes)

doi.org/10.1093/molbev/msaf097 

Organogenesis

@nordenlab.bsky.social‬ (Organogenesis/ Psuedostratified epithelia/ Retinal development)
doi.org/10.1126/sciadv.adu6843 

@wittbrodtlab.bsky.social  & @ewanbirney.bsky.social  (Heart development/ Medaka)

doi.org/10.1038/s41467-025-59425-7 

Disease Models

#GiepmansLab at Uni-Groningen (Diabetes/ Endocrine System/ Pancreas)

doi.org/10.1007/s00125-025-06432-4 

#LongZhengLab at UKMC (ANKRD26/ Thrombocytopenia/ Inflammation)

doi.org/10.1242/dmm.052222 

@labmoons.bsky.social‬ (Optic neuropathies/ Retinal ganglion cell/ Killifish)

doi.org/10.3389/fnins.2025.1596464 

Neuroscience

#LippmanBellLab at PCOM (Early-life seizures/ Memory/ Seizure susceptibility)

doi.org/10.1016/j.nbd.2025.106978 

#HaroldBurgessLab at NIH (Alternative splicing/ Microexon/ Neural development)

doi.org/10.1093/g3journal/jkaf052 

‪@lyons-lab.bsky.social‬ (Myelination/ Oligodendrocytes/ mGluR5)

doi.org/10.1038/s41593-025-01956-9 

@alexbchen.bsky.social‬ & @mishaahrens@bsky.social (Diffusible neuromodulators/ Norepinephrine/ Behavioral suppression)

doi.org/10.1126/science.adq5233 

Physiology

‪@jutfelt.bsky.social‬ (Warming & cooling tolerance/ Climate change)

doi.org/10.1038/s41558-025-02332-y 

@taphonomist.bsky.social‬ (XCT/ Tissue decay)

doi.org/10.1111/pala.70007 

Regeneration

‪@ejvillablanca.bsky.social‬‬ (Genetic ablation/ Intestinal regeneration/ Barrier permeability)

doi.org/10.1016/j.mucimm.2025.04.004

Infection/ Immunity

#HallLab at @aucklanduni.bsky.social (circadian rhythmicity/  cellular antibacterial defense)

doi.org/10.1126/sciimmunol.adn3080 

CRISPR

#LawsonLab at UMass (homology dependant repair, CRISPR parameters)

doi.org/10.1242/dev.204571 

Preprints:

Regeneration

@balciunaslab.bsky.social & @kenposs.bsky.social (heart regeneration/ Epicardium/ tcf21)

doi.org/10.1101/2025.05.15.654216 

Behaviour

@kherrera.bsky.social & Fishman Lab at @harvard.edu (Optomotor response/ behaviour/ heart rate)

doi.org/10.1101/2025.04.25.650721 

Neuroscience

@lyons-lab.bsky.social (axon diameter/ Mauthner neuron/ discovery screen)

doi.org/10.1101/2025.04.29.651302 

@nathaliejuya.bsky.social‬ (cerebral spinal fluid/ motile cilia/ diffusion)

doi.org/10.1101/2025.04.15.648743 

Evolution

@bertaverd.bsky.social (vertebrae, hox gene, African Cichlids)

doi.org/10.1101/2025.05.23.655800

@bertaverd.bsky.social  (African Cichlids/ axial skeleton/ phylogenetic comparative analyses)

doi.org/10.1101/2025.05.13.653847 

@ben-moran.bsky.social‬ (swordtail fish/ reproductive isolation/ anthropogenic environmental disturbance)

doi.org/10.1101/2025.04.22.649978 

@adrian-kalchhauser.bsky.social‬ (Brown Trout/ scRNAseq/ non-traditional model organisms)

doi.org/10.1101/2025.05.04.652114 

#KawamuraLab at Saitama University (Medaka/ Phenotypic Variation/ environmental influences/fin rays/ hox12a)

doi.org/10.1101/2025.04.28.651082 

Vasculature

@karinayaniv.bsky.social (Inferiour vena cava/ venous remodeling)

doi.org/10.1101/2025.04.28.650985 

Embryogenesis

@flomarlow.bsky.social  (Primordial germ cells/ Cre-based lineage tracing/ gonad development)

doi.org/10.1101/2025.04.30.651497 

@bowmaniacs.bsky.social (embryogenesis/ hematopoietic stem cells / HSC-independent progenitor cells)

doi.org/10.1101/2025.05.12.653589 

Organogenesis

#SquareLab at Uni-Florida (Organ initiation/ Teeth/ Ectodysplasin)

doi.org/10.1101/2025.05.01.651241 

@vlecaudey.bsky.social  (Organ size/ Development/ Hippo Signalling pathway/ Lateral line)

doi.org/10.1101/2025.05.08.652796 

Infection/ Immunity

@oehlerslab.org‬ (Tuberculosis mycobacterial granulomas)

doi.org/10.1101/2025.05.05.652332 

#GaulkeLab at Uni-Illinois Urbana Champaign (Host-microbiome interactions/ microbiome variation/ housing strategy/ sampling location) 

doi.org/10.1101/2025.05.08.652836 

Disease Models

@chiaraman.bsky.social (genetic compensation/ phenotypic interpretation/ congenital muscular dystrophy)

doi.org/10.1101/2025.05.13.653769 

@thomthum.bsky.social‬ (hypomorphic mutations, glycosylation, congenital disorders of glycosylation)

doi.org/10.1101/2025.05.23.655727 

Cell Biology

#ChitnisLab at NIH (Fgf signaling/ protoneuromasts/ Posterior Lateral Line primordium)

doi.org/10.1101/2025.05.17.650326 

Physiology

#JonzLab at‪ @uottawa.ca (oxygen sensing/ gills/ oxygen-chemoreceptive neuroepithelial cells)

doi.org/10.1101/2025.05.15.654070

Ageing

@miguelgf.bsky.social‬ (progressive telomere shortening, telomere erosion, DNA damage response)

doi.org/10.1101/2025.05.23.655694 


Back to top

Reviews:

@tobinlab.bsky.social  (Mycobacterium marinum)
doi.org/10.1128/jb.00047-25 

@simoesfilipa.bsky.social‬ (Heart/ Immune Cells/ Development/ Regeneration/ Cardiac Niche)

doi.org/10.1016/j.semcdb.2025.103613 

@abeisaw.bsky.social‬ (Cell-cell interaction/ Intercellular crosstalk/ Cardiac regeneration/ Zebrafish/ Mouse/ Inter-organ communication)

doi.org/10.1016/j.semcdb.2025.103619 

#BruceLab at Uni-Toronto (epithelial spreading)

doi.org/10.1242/dev.204890 

@ryosuketanaka.bsky.social (Visual systems/ Outside visual motion detection/ Visual structures)

doi.org/10.1038/s41583-025-00932-3 

@yap-lab.bsky.social (Mechanobiology/ Cell-cell adhesion junctions/ Epithelia)

doi.org/10.1016/j.ceb.2025.102536 

Protocols and Tools:

‪@adamezracohen.bsky.social‬ (Nodal signaling/ Optogenetics/ Morphogen/ Mesendodermal patterning/ Gastrulation)

doi.org/10.1242/dev.204506

@scekker.bsky.social‬ (Genotyping/ Mitochondrial DNA editing/ Heteroplasmy)

doi.org/10.1101/2025.04.30.651585 

@nadlerlab.bsky.social‬ (GEQO/ quantitative biosensors)

doi.org/10.1101/2025.05.05.652245 

‪@burgesslab.bsky.social‬ (Zebrafish reference sequence GRCz12tu)

www.ncbi.nlm.nih.gov/refseq/annotation_euk/Danio_rerio/GCF_049306965.1-RS_2025_04/

@scekker.bsky.social (Zebrafishology, Study design guidelines for rigorous and reproducible data using zebrafish)

doi.org/10.1038/s42003-025-07496-z 

@kurakulabmsm.bsky.social (MedakaBase)

medakabase.nbrp.jp/

doi.org/10.1101/2025.05.13.653297 

@kevinthiessen.bsky.social‬ (Bioinformatics Bootcamp)

thenode.biologists.com/bioinformatics-bootcamp-zebrafish-special-edition/education/ 

‪@benjulab.bsky.social‬ (Warpfield/ Image Correction)

github.com/danionella/warpfield

‪@singhlab.bsky.social‬ (Regeneration/ CellCousin2)

doi.org/10.1101/2025.05.23.655316 

Special thanks to Maddie Ryan, Charli Corcoran & Michaela Noskova Fairley for putting this digest together! If you would like to thank the Zebrafish Rock! team for their time & effort, you can buy us a strong cuppa at the link below. Every little bit keeps us caffeinated and motivated! We appreciate your support 🙂
Link to donate: https://buymeacoffee.com/zebrafishrock 
Do you have news, jobs or research that you want to add to the next digest but don’t have a social media account? Use the submission form at our website below: https://linktr.ee/zebrafishrock

Fin!

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Development presents… early embryogenesis

Posted by , on 19 June 2025

Poster for the webinar. Text included in the poster is written in text below the image.


Our July webinar features three early-career researchers working on early embryogenesis and will be chaired by Development’s Executive Editor, Alex Eve.

Wednesday 9 July – 15:00 BST

Lakshmi Balasubramaniam (Gurdon Institute)
‘Tissue spreading couples matrix remodelling during avian gastrulation’

André Dias (Universitat Pompeu Fabra)
‘Opposing Nodal and Wnt signalling activities govern the emergence of the mammalian body plan’

Nikhil Mishra (Institute of Science and Technology Austria)
‘Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo’

At the speakers’ discretion, the webinar will be recorded for viewing on demand. To see the other webinars scheduled in our series, and to catch up on previous talks, please visit: thenode.biologists.com/devpres

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