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The Cell’s View of Animal Body Plan Evolution: a symposium at the annual meeting of the Society for Integrative and Comparative Biology January 3-7, 2014 Austin, TX

Posted by , on 14 August 2013

Symposium: The cell’s view of animal body plan evolution

Society for Integrative and Comparative Biology (SICB) Annual Meeting

January 3-7, 2014  Austin, TX

http://www.sicb.org/meetings/2014/symposia/cellevo.php

Abstract submission deadline: August 26 2013

http://www.sicb.org/meetings/2014/abstracts/

Registration deadline: November 9, 2013

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Understanding how diverse animal body plans evolved remains one of the most exciting and challenging goals for evolutionary and developmental biologists alike. Over the past few decades, genomic and molecular genetic approaches have provided insights into which gene networks regulate cell fate specification.  It is less well understood how specification states launch specific cell biological properties, such as polarity, migration, and adhesion.  Yet, cells are the fundamental unit of all biological structures and phenomena – evolution shapes phenotypes by ultimately tinkering with cellular characteristics.  With recent advances in applying modern molecular, live-imaging, and modeling techniques to a broader range of experimental systems, can we now compare cell types across animal species to understand how they have mediated organismal evolution?  This symposium will bring together researchers who use varied approaches to test hypotheses at multiple levels of biological organization, ranging from systems-level studies of gene regulatory networks for cell behaviors to modeling cytoskeletal dynamics that drive tissue morphogenesis.

“Cellular Evolutionary Developmental Biology” does not exist as a codified field. Because of recent breakthroughs in research methods, this is the ideal time to discuss what it will look like in the near future. The diversity of expertise and perspectives present at the annual SICB meeting makes it an ideal venue to consider such an integrative topic. We hope that this symposium will stimulate a  synthesis that can inform new directions in the field in the future. The invited speaker symposium covers topics including cytoskeletal dynamics underlying patterning and morphogenesis of tissues, specification and gene regulatory networks leading to cellular behaviors and comparative cell biology of regeneration.

A poster session will follow this day long symposium. A complementary session of shorter contributed talks will be held on a different day. We encourage researchers to submit abstracts on a broad range of research topics pertaining to the evolution of development and developmental cell biology. We will select 10-15 short (15 minute) talks from submitted abstracts. We have a limited number of travel scholarships available to support the participation of students, postdoctoral researchers, and earl-career professors.

Make sure to select our symposium from the pull down menu when you submit your abstract (http://www.sicb.org/meetings/2014/). Feel free to contact the organizers if you have any questions.

Organizers:

Deirdre Lyons, Postdoctoral Researcher, Duke University (deirdre.lyons@duke.edu)

Mansi Srivastava, Postdoctoral Fellow, Whitehead Institute (mansi@wi.mit.edu)

Mark Martindale, Directory, Whitney Marine Laboratory (mqmartin@whitney.ufl.edu)

 

Funding Opportunities:

Some funding is available for those who present a poster or talk as part of this symposium to help defray the cost of attending the meeting. Preference will be given on a primarily need basis to junior scientists (students, post-docs and junior faculty), current members of the Society for Developmental Biology (SDB), and those from under-represented minorities and those with disabilities.  To apply, send an email by September 1, 2013 to Dede Lyons (deirdre.lyons@duke.edu) with the following information:

1) Name, institution, lab and position (student, post-doc, etc.)

2) The title and abstract of your poster or talk. Please indicate if you requested a talk or poster

3) Indicate whether you are a current SDB member and/or belong to an under-represented minority or have a disability

3) Cost of attending the meeting, broken down by travel, lodging, and registration costs

4) Alternative funding sources and amounts available to you

5) The amount you are requesting for funding from the symposium

 

Other sources of funding are available through SICB:

http://www.sicb.org/students/awards.php3#support

http://www.sicb.org/students/skinner.php3

Confirmed Speakers:

Sally Horne-Badovinac 

Assistant Professor, Molecular Genetics and Cell Biology University of Chicago)

(http://shb-lab.org/)

Title: “Mechanisms of egg chamber elongation in Drosophila”

 

Ed Munro 

Professor, Molecular Genetics and Cell Biology University of Chicago

(http://munrolab.bsd.uchicago.edu/index.html)

Title: “Dynamics of tissue morphogenesis in ascidians”

 

Jennifer Zallen 

SICB_CellEvoDevoAssociate Member, Sloan-Kettering Institute

(http://www.mskcc.org/research/lab/jennifer-zallen)

Title: “Co-ordination of cell movements to shape tissue morphology in Drosophila”

 

Dave McClay 

Professor, Department of Biology Duke University

(http://fds.duke.edu/db/aas/Biology/david.mcclay)

Title: “Sequential control of morphogenesis and pattern formation in the sea urchin embryo”

 

Bob Goldstein 

Professor, Biology Department UNC Chapel Hill

(http://labs.bio.unc.edu/Goldstein/index.html)

Title: “Using C. elegans and other organisms to understand conserved mechanisms of morphogenesis”

 

Matt Gibson 

Associate Investigator, Stowers Institute for Medical Research

Assistant Professor, Anatomy and Cell Biology University of Kansas School of Medicine

(http://research.stowers.org/gibsonlab/)

Title: “Cellular and molecular mechanisms of tentacle morphogenesis in the sea anemone Nematostella vectensis”

 

Reiko Kuroda 

Professor, Department of Life Science University of Tokyo

(http://bio.c.u-tokyo.ac.jp/labs/kuroda/englishpage.htm)

Title: “How a single gene twists a snail”

 

Leslie Babonis 

Postdoctoral Researcher, Kewalo Marine Laboratory

(http://www.kewalo.hawaii.edu/martindale/mmpeople.html)

Title: “The influence of the extracellular matrix on differentiation of cnidocytes”

 

Josien van Wolfswinkel 

Postdoctoral Associate, Whitehead Institute for Biomedical Research

(http://jura.wi.mit.edu/reddien/)

Title: Heterogeneity in planarian neoblasts by single cell analysis

 

Alexa Bely 

Associate Professor, Department of Biology, University of Maryland

(http://www.life.umd.edu/biology/bely/web/belylab/home.html)

Title: “Using live imaging to probe the cellular basis of annelid regeneration”

 

John Wallingford 

Associate Professor, Molecular Cell and Developmental Biology University of Texas Austin

(http://www.bio.utexas.edu/faculty/wallingford/)

Title: TBD

 

Supported by:

SICB Divisions: DEDB, DIZ, DNB, DPCB, DVM

American Microscopical Society

Society for Developmental Biology

Company of Biologists
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An interview with François Guillemot

Posted by , on 13 August 2013

This interview first appeared in Development.

François Guillemot heads the Division of Molecular Neurobiology at the MRC National Institute of Medical Research (NIMR) in London. His research focuses on the transcriptional control of neurogenesis, adult neurogenesis and the epigenetic regulation of gene expression in neural development. François recently became an editor for Development, and we asked him about his research and career, as well as his lab’s future move to the Crick Institute.

 

Francois Guillemot photoWhen did you first become interested in developmental biology?

I have always been interested in biology, but my first interest was zoology. I spent a lot of time on the French coast, in Brittany, observing little animals at low tide. That was really a great passion of mine when I was young. As developmental biology is closely linked to zoology, the move was quite logical.

 

What projects are your lab working on at the moment?

My lab’s research focuses on neural stem cells and how their fate is regulated at the molecular level. We have two main current directions. One of these is to examine the gene regulatory networks that control neural stem cell decisions: to self-renew, to differentiate into one cell type or another, or to remain quiescent. This work is mostly performed in neural stem cell cultures. Our other focus is on understanding the function of individual genes in neural stem cell fate decisions in vivo, either in the developing or the adult brain.

 

There has been some controversy as to whether the mouse brain is a good model for the human brain. Do you think it is a good model for the particular questions that you are asking?

The mouse is obviously the closest animal model to humans and the easiest one to work with. It is a good system by default. But it is far from being a perfect model, particularly for the development of the cerebral cortex. Great work has been done looking at the cellular organisation of the human foetal cortex, and there are very striking differences to the mouse. But for other aspects, such as adult neurogenesis, I can’t really answer the question of how close the mouse is to the human because there is still so little known about neurogenesis in the adult human brain. I think that an important future direction of research in the field is to better understand the human brain and to develop tools to achieve this, such as in vitro systems that can be used to probe human brain development. Some great progress is being made in that direction at the moment.

 

You started your career working on the development of the immune system and then moved to developmental neurobiology. Why did you change fields, and what kind of parallels are there between the immune system and the nervous system?

I think I am far from being the only one who changed from an early career in the immune field to neuroscience. My feeling at the end of my PhD was that many of the key discoveries in the immunology field had been made, and what remained to be done was to acquire a deeper understanding of the details, rather than the big picture. At the time, being young and naïve, I wanted to address the big questions that remained unanswered. The neuroscience field seemed to be the most appropriate for this kind of research.

The transition was not that difficult because immunology and neuroscience have in common the fact that the two systems encompass substantial diversity in cell types and cellular responses. You become used to dealing with very complex systems, and in trying to understand where this diversity comes from. However, in practice most of the things that I learned in my PhD and applied later on are maybe more technical. My knowledge of molecular biology (although maybe a bit outdated now!) comes from my PhD work, and I applied that molecular approach to my work in neurodevelopment.

 

You did your undergraduate and postgraduate studies in France, then you moved to the USA and Canada, and then you came back to Europe. How does the research environment differ between France, North America and the UK?

It is obviously very different and I always try to avoid grading the different systems because every system has its advantages and disadvantages. I think that the British system, where I am now, is very well balanced. I really enjoy the flexibility that it has, giving you the ability to adapt and move on in terms of topics and techniques, probably more than in France. In the UK there is a greater turnover of PhD students and postdocs in the lab than in France, where a larger fraction of the lab is usually considered permanent staff. This stability is great in that it provides continuity, but it is harder to renew, to find new approaches, questions, or to decide to change direction – you need to convince not just yourself and the new people you recruit, but also everyone you are working with already. The British system also provides a good balance between competitiveness and still being collaborative and convivial.

 

Was it useful for you to move countries?

Certainly, both intellectually and personally. Moving allows you to take a step back and make what you think at the time is the right decision. You are not influenced by earlier decisions that you are obliged to follow because you remain in the same system. By moving countries you start anew, and you can really decide what the question is that you really want to address. Whenever I have the opportunity to recommend something to a young scientist, I encourage them to take full advantage of the great opportunity that scientists have to be able to move around to do research in the best conditions.

 

Did you have a mentor or someone who inspired you or gave you good advice during your early career?

Not a single person. I have taken advice by asking specific questions of the people around me. But Nicole Le Douarin, who was my first thesis supervisor, was a great figure. She was very inspiring, of brilliant intellect and with a real understanding of her system. It made me realise that understanding your experimental model in depth is a great strength, as well as asking the right questions and addressing them with the right techniques. But in terms of career advice, I am more of an improviser: I ask around and then follow my opinion.

 

How did you find your first months as a Development editor?

I was looking forward to it. It was very attractive to work with a great group of colleagues and for a journal that I respect a lot. But I was a little apprehensive of the amount of work, and how much of a distraction it would be to my main occupation. But I have really enjoyed it actually. The volume is manageable and it is different from the daily lab work, so I can easily do it at different times and almost as a diversion from mainstream work. It is quite diverse, and the interactions with authors through their research is something that I enjoy a lot. To see a manuscript, which has real potential but clearly can be improved, to read the diversity of opinions of reviewers and to see the improvements through the revisions: I find this process interesting and most of the time it ends very positively. Another concern I had was how often you have to deal with complicated situations in which people really disagree and you have to arbitrate, but fortunately I haven’t encountered this kind of situation yet.

 

Are there any particular papers that you would like to see submitted to Development?

I am fully behind the current effort by the Development team to increase the visibility of the journal in the stem cell field. My work is partly brain development, partly stem cells, so I am aware of the need for Development to raise its profile further in the stem cell field, so that it becomes as recognised and important in this area as it is in neural development. Another obvious direction in the mid to long-term is to move more towards the human as a model of development. Papers that describe human development, such as those using in vitro models of organ development, would be very welcome.

 

Your lab will be moving to the new Crick Institute in the near future. What are your expectations?

My understanding of the vision of the director, Paul Nurse, of how an institute should be run is that you should hire the best scientists and let them decide what they want to work on. I am very happy with this way of thinking. What I am really looking forward to is to have new colleagues. The Crick Institute is a merger of our institute (NIMR) with Cancer Research UK institutes in London together with contributions from three London universities. That will greatly increase the number, but also the diversity, of research that is being done. I look forward to having more contact with cell biology and disease model groups. The NIMR is currently a very interactive place, so it is both our wish and our challenge to make the Crick Institute, which will be at least twice as big, as collaborative as the NIMR is at the moment.

 

What advice would you give to young researchers?

I think the best research is done by people who get ideas that other people don’t get. So, follow your intuitions and desires, and don’t follow advice if it goes against these. And don’t hesitate to move, both geographically and in topic, between your PhD and postdoc. Basically, don’t be too conservative.

 

What would people be surprised to find out about you?

Unfortunately, I am not great at cooking which, given that I am French, can sometimes take people by surprise. I love nature and wildlife, and when I moved to the UK I discovered gardening. I have taken my own approach to gardening, and I mostly take care of the weeds that happen to land in my garden. I use my garden as a way to get closer to nature and watch animal behaviour and plant growth – a place for daily observations of wildlife. I enjoy it a lot and it is my way to relax.

 

 

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In Development this week (Vol. 140, Issue 17)

Posted by , on 13 August 2013

Here are the highlights from the current issue of Development:

GDNF’s got a nerve

F1.smallInnervation of the mammalian pancreas is crucial for endocrine and exocrine function. Neural crest cells that give rise to neural progenitor cells are responsible for intrinsic pancreatic innervation, but the specific cues that guide this process in the developing embryo are largely unknown. Now, on page 3669, David Cano and colleagues identify glial cell line-derived neurotrophic factor (GDNF) as a key player in this process. They show that GDNF is expressed in the developing pancreatic epithelium and that conditional GDNF inactivation results in a marked reduction of neuronal and glial cells in both newborn and juvenile mice. In juveniles, parasympathetic innervation density decreased by just over half and appeared to be selectively reduced in pancreatic islets. Using wild-type E11.5 pancreatic explants, the authors demonstrate that GDNF can induce neural progenitor expansion and functions to promote the migration and differentiation of these progenitors. These results present a previously unappreciated role for GDNF in the regulation of neural crest-derived neural progenitor cells and the subsequent intrinsic innervation of the developing pancreas.

Ser2-ious changes in the germline-soma

F1.small-1Transcriptional elongation via RNA polymerase II (Pol II) is an essential component of gene expression. It has long been thought that a necessary step of elongation is the serine 2 phosphorylation (Ser2-P) of Pol II, which is catalysed by a CDK-9/cyclin T complex called P-TEFb. Although this dogma holds true in the soma, Elizabeth Bowman, William Kelly and colleagues now present evidence (see p. 3703) that Ser2-P of Pol II in the C. elegans germline occurs via a P-TEFb-independent mechanism primarily involving CDK-12, not CDK-9, activity. Nonetheless, CDK-9 is required for C. elegans germline development, raising the possibility of an alternative essential function for CDK-9. Conversely, loss of CDK-12 and subsequent Ser2-P had little effect on germline development, suggesting a possible alternative mechanism for regulation of Pol II transcriptional elongation in the germline. These data demonstrate that Ser2-P can occur independently of P-TEFb in at least one context, and further suggest that alternative mechanisms of Pol II elongation activity might be important in establishing and/or maintaining the germline-soma distinction.

 

In good sTEAD4 energy homeostasis

F1.small-2The blastocoel of mammalian embryos is a fluid-filled cavity surrounded by a monolayer of trophectoderm, and its formation marks one of the earliest stages of embryonic development. During this process, the trophectoderm undergoes a metabolic shift toward oxidative phosphorylation, which increases the level of reactive oxygen species (ROS) and places the blastocyst under oxidative stress. In this issue (p. 3680), Melvin DePamphilis and Kotaro Kaneko uncover a role for TEAD4, which was previously thought to specify trophectoderm, in managing oxidative stress and establishing energy homeostasis during murine blastocoel formation. The authors show that under conditions that mimic the in vivo environment, TEAD4 is necessary for trophectoderm and blastocoel formation, but that this requirement is lost when conditions are manipulated to minimise oxidative stress. The authors demonstrate that Tead4-/- mitochondria have a reduced membrane potential in trophoblast giant cells, and furthermore that TEAD4 could localise to mitochondria, possibly to prevent accumulation of ROS. These data reveal a metabolic requirement for TEAD4 in the developing mouse embryo, rather than in trophectoderm lineage specification.

 

Regeneration reoriented

F1.small-3The Drosophila wing primordium is a simple epithelial structure with significant regenerative capacity. As in any regenerative system, it is essential to maintain correct tissue size and shape during the repair process, yet little is known about the mechanisms that enable such control. In this issue (p. 3541), Florenci Serras and colleagues demonstrate that regeneration of the Drosophila wing involves respecification of cell fate as well as reorientation of cell division in order to drive intercalary growth. Following genetic ablation of wing cells, the authors observed a respecification of vein and intervein fates, which was independent of Hedgehog and Decapentaplegic morphogen activity. The authors identified the proteins Fat (Ft) and Crumbs (Crb) as required for the reorientation of cell division, and showed that mutations in ft or crb lead to misorientation of the mitotic spindle as well as to Yorkie-driven excessive proliferation, resulting in malformed wings. This elegant Drosophila model provides novel insight into the mechanisms of epithelial regeneration and wound repair.

 

Hoi Polloi muscles in on myogenesis

F1.small-4The proper formation of somatic muscle depends on morphological and molecular events that orchestrate the specification, maturation and terminal differentiation of muscle precursor cells during development. Many of the transcriptional regulatory networks that regulate these processes have been defined, but little is known about the possible post-transcriptional mechanisms that might also be involved. In this issue (p. 3645), Eric Olson, Aaron Johnson and colleagues conduct a genetic screen for regulators of muscle morphology in Drosophila and identify Hoi Polloi (Hoip), a putative RNA-binding protein with two distinct roles in myogenesis. First, the authors show that Hoip is required for myotube elongation, since elongation failed to initiate in hoip mutants. Second, they show that Hoip is necessary for the expression of sarcomeric proteins Myosin heavy chain (MHC) and Tropomyosin. Importantly, MHC protein expression was restored in the hoip mutant via delivery of a prespliced MHC transcript, suggesting a role for Hoip in pre-mRNA splicing. These data demonstrate a novel and tissue-specific, post-transcriptional role for Hoip in Drosophila development.

 

Ubiquitin depletion stirs up sterility

F1.small-5The ubiquitin proteasome system regulates protein expression at the post-translational level by tagging certain proteins with ubiquitin and thereby marking them for degradation by the proteasome complex. This system is highly conserved and is used by almost every eukaryotic cell to degrade and recycle proteins. In this issue (p. 3522), Margaret Fuller and colleagues uncover a surprisingly specific role for the polyubiquitin Ubi-p63E, encoded by magellan (magn), in the Drosophila spermatogenetic programme. Loss-of-function magn mutants fail to maintain the free ubiquitin pool specifically in the testes, which ultimately results in meiotic arrest and sterility. The authors show that Ubi-p63E is required for normal meiotic chromatin condensation, cell cycle progression and spermatid differentiation, whereas the expression of spermatocyte genes was largely unaffected in the magn mutant. The observed phenotype is likely to be specific to the magn mutant, as knockdown of proteasome subunits had more widespread and severe effects. These data uncover a novel and highly specific mechanism of post-translational regulation via ubiquitin homeostasis in the developing male germline.

 

PLUS…

 

A molecular basis for developmental plasticity in early mammalian embryos

F4crop.largeEarly mammalian embryos exhibit remarkable plasticity, and recent studies of mouse embryos implicate a network of transcription factors in governing this plasticity and the establishment of embryonic lineages. Here, Alfonso Martinez Arias and colleagues summarise this information, link it to classical embryology and propose a molecular framework for the establishment and regulation of developmental plasticity. See the Hypothesis article on p. 3499

 

An interview with François Guillemot

F1FG.largeFrançois Guillemot heads the Division of Molecular Neurobiology at the MRC National Institute of Medical Research in London, where his research focuses on the transcriptional control of neurogenesis and the epigenetic regulation of gene expression in neural development. François recently became an editor for Development, and we asked him about his research and career, as well as his lab’s future move to the Crick Institute. See the Spotlight article on p. 3497

 

 

 

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silicoCROSS: a help in genetic crosses

Posted by , on 12 August 2013

I’m quite a lazy person, and as such I like to find solutions to boring and repetitive tasks.

One of those is the drawing of punnett squares in Drosophila genetics.

I wrote a little software (accessible here: silicocross.molecular.ch), that does basically that: drawing punnett squares.

When you access the software you are asked how many chromosomes you want to track:

1

 

Let’s say we have a quite easy cross: on the second chromosome we have a mutant gene, that we want to have homozygous, and on the third we want to have a gal4 driver and a uas:GFP reporter.
So the number of chromosomes we want to track is two.

At this point you are asked for the model organism you are using, this is only relevant for the balancer chromosomes you are using. As at the moment I’m working only with flies, I suppose this will work better for basic tasks.

2

 

After you choose your favorite pet, it’s time to add it’s genotype:

3

There is just one thing left to do now: we have to specify the balancer chromosome in Optional settings:

4

 

After pressing the submit button, the punnett square appears. At this point one could choose two genotypes for further crossing, this is not necessary in our case. Notice how death fly genotypes are highlighted in red. Sadly the gal4 system is not implemented yet, so in the phenotype you don’t see the GFP popping out (this is definitely in the to do list).

final

 

 

The system is still in heavy development (whenever I have some spare time and motivation), but I still use it in daily work when setting up crosses to have a nice graphic to glue in my fly-notebook or for teaching reasons. Hope it will be useful for the community as well.

At the moment I’m rewriting the core in python, as in my opinion this will give a less messed up code compared to the actual PHP core.

If you find bugs, have suggestions or else, don’t hesitate to contact me.

 

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PhD Positions at IRB Barcelona

Posted by , on 12 August 2013

Closing Date: 15 March 2021

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Description: One key objective of IRB Barcelona is to train future scientific leaders in a competitive international and multidisciplinary scientific environment. IRB Barcelona focuses its efforts on developing the scientific careers of more than 130 PhD students. The advanced research training programme includes specific scientific and technology courses and seminars, lab management workshops, media training and career development sessions.

Funded by the MINECO (Ministerio de Economía y Competitividad), the FPI Programme (Formación de Personal Investigador – Research Personnel Training) offers predoctoral positions covering a 48-month period. The PhD is performed in subjects associated with research projects (financed through the MINECO’s R+D+i National Plan call).

Candidates Eligibility:
Students who qualify to be admitted into a doctorate program in the 2013-2014 academic course or who are in a position to be enrolled or accepted on a doctoral program in Biology, Biochemistry, Pharmacy, Physics, Medicine, Chemistry or related areas at the time the formalization of the contract.

Some of the research projects that are expected to be granted a 2013 FPI Predoctoral position are:

  • Epigenetic Regulation of Chromatin Functions * PI: Dr. Ferran Azorín
  • Individual cell features and supracellular organisation in Drosophila morphogenesis * PI: Dr. Jordi Casanova
  • The Molecular Bases of Stem Cell Polarity and Malignant Transformation in Drosophila * PI: Dr. Cayetano Gonzalez
  • Spatio-temporal regulation of microtubule formation during cell division and cell differentiation * PI: Jens Lüders
  • Biomedical aspects of protein synthesis * PI: Dr. Lluis Ribas de Pouplana

To apply, please visit our vacancies webpage:
http://www.irbbarcelona.org/index.php/en/training-and-jobs/phd-fellowships/expression-of-interest

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The Company of Biologists YouTube channel

Posted by , on 8 August 2013

COB2cAs you may know, the Node is run by the Company of Biologists, a UK-based charity and non-for-profit publisher funded in 1925. The Company of Biologists publishes 5 scientific journals: the well established Development, Journal of Cell Science (JCS) and The Journal of Experimental Biology, and the two open access journals Disease Models & Mechanisms (DMM) and Biology Open (BiO).

One of the main aims of the The Company is to promote research and study across all branches of Biology, and it does this by providing grants for scientific meetings, workshops and conferences. The Company also provides fellowships for students and postdocs to visit other laboratories and attend conferences and runs a series of trans-disciplinary workshops. The Node has featured many posts and reports from these activities.
 
 
This week, the Company of Biologists has launched its latest initiative- a company youtube channel. In this youtube channel you can find a variety of interesting movies:

 

– Movies on the history and activities of the Company:
 

 
 

– Interesting supplementary movies and animations featured in papers published by the journals of the company. Here is an example of a beautiful movie in the Development playlist:
 

 
 

The Node will obviously not be left out, and we have plans for some great content- so keep an eye out for Node movies on The Company of Biologists youtube channel!

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Categories: News, Resources, Video

Travelling Fellowships

Posted by , on 6 August 2013

Do you need to learn a new technique?  Are you planning a collaborative visit?  If so please have a look at The Company of Biologist’s Travelling Fellowships – http://www.biologists.com/fellowships.html. The next deadline is the 31st August 2013.

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Categories: Funding, News

PhD scholarship at UNSW, Sydney, Australia

Posted by , on 2 August 2013

Closing Date: 15 March 2021

 

UNSW logo

Developmental and Regenerative Dermatology Unit

School of Medical Sciences, University of New South Wales, Sydney Australia

 

PhD Scholarship

The Developmental and Regenerative Dermatology Unit is seeking a highly motivated and enthusiastic postgraduate student for a research project in skin (cancer) biology.

Recently, we made the pivotal discovery that Yes-associated protein (YAP) functions as a key molecular switch in epidermal stem/progenitor cell proliferation and differentiation (Beverdam et al., JID 2013). Currently, we are investigating the developmental genetic context in which YAP functions to control skin stem/progenitor cells in normal and in disrupted skin biology, and the PhD student will participate in this research.

We employ genetically manipulated mouse models, human skin samples, advanced imaging technology such as confocal microscopy and whole mouse in vivo imaging, gene and protein expression analyses and whole genome approaches to address our research questions.

Outcomes of our research will open up exciting new avenues for translational research and the development of treatments for human regenerative skin disease.

More information on the lab can be found here.

 

Award: Scholarships are valued at $24,653 per annum (tax exempt), and may be renewed for up to three years, subject to satisfactory progress.

Eligibility: All applicants must hold an Honours degree or equivalent in a related biological science (e.g. Developmental Biology, Genetics, Cell Biology, Pathology) and have a particular interest in the project on offer and have experience in histology, molecular biology techniques, cell culture, bioinformatics and mouse handling.

Application Process: Applicants should include the following documents

• Cover Letter

• Curriculum Vitae

• Copy of an academic transcript

• Names and contact details (email address and phone number) for at least 3 referees.

 

All applications should be emailed to Dr. Annemiek Beverdam: A.Beverdam@unsw.edu.au

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This month on the Node- July 2013

Posted by , on 1 August 2013

Another busy month on the Node, with a particular focus on zebrafish. Plenty of meeting reports, research, interviews and more, as well as new job posts. Here are the highlights:

 

Meeting Reports

With conference season well underway, the Node saw several meeting reports this month:

Zebrafish node cropped– Leonardo and Joaquin posted several reports from the 8th european zebrafish meeting: an excellent summary of the talks on developmental biology topics, and 2 posts on the workshops preceeding the conference: the genome resources workshop and the morphogenesis workshop. Cat also posted on the lighter side of the conference, commenting on her first attendance of a fish meeting.

 

– Students from this year’s Woods Hole Embryology course wrote on their experience after 4 weeks and at the end of the course.

– And Alfonso shared his thoughts on the Morphogen Gradients meeting that took place in Oxford.

 

Research

image1– Keeping with the fish theme, we had several fish research posts on the Node this month: Neil wrote about his paper on a model of Fetal Alcohol Spectrum Disorder; while Megan wrote on a recent paper focusing on sex reversal in fish 

– Gary described a paper showing that waves of Cdk1 might be involved in the quick cell division of the early frog embryo

 and Mike Levin wrote about his recent paper showing that planaria can recall memories after decapitation, suggesting that memory storage can happen outside the brain

 

Interviews

Photo of Maria LeptinThis month also featured interesting interviews:

– The Node interviewed developmental biologist and EMBO director Maria Leptin

– Megan started her series of posts on developmental biology in New Zealand by interviewing clinical geneticist and developmental biology Stephen Robertson

– And the BSDB-SDB poster winner chain continues with an interview with the winner of the SDB poster prize at the ISDB meeting Kara Nordin

 

 

Also on the Node:

– Thomas gave his take on the new Crick institute in London and what it reveals about research in the UK

– Xujiang described his visit to a lab in Sydney to study honey bee behaviour, sponsored by a Travelling Fellowship from the Company of Biologists

– The Node followed the #sciconfessions discussion on twitter, and collated the best lab confessions (don’t tell Health & Safety!)

– and T.H.Morgan’s 1920s fly room was reconstructed for a new exhibition in New York

Reconstructed fly room

 Happy Reading!

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Categories: Highlights

Confess your lab sins

Posted by , on 31 July 2013

Remember the hashtag #overlyhonestmethods that was trending on Twitter a few months ago? Well, the new science hashtag to follow is #sciconfessions : a collection of the lab sins that you never told anyone (and definitely not to your Health & Safety officer!).

We storified our favourites, but why don’t join the discussion on Twitter and add your own confession? If you are not a Twitter user, why not leave a comment below and let us know your lab confession?

 
 
 

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Categories: Lab Life, News