Disease Models & Mechanisms has launched its latest Special Issue ‘The RAS Pathway: Diseases, Therapeutics and Beyond‘, which was guest edited by Donita Brady and Arvin Dar. In the accompanying Editorial, the guest editors summarize this collection and discuss the potential impact of the articles within this evolving area of research.
Guest editors Donita C. Brady (Perelman School of Medicine, University of Pennsylvania) and Arvin C. Dar (Icahn School of Medicine at Mount Sinai)
All articles in this Special Issue are freely available to read and share.
The RAS superfamily of small GTPases includes over 150 members that generally function as molecular switches and regulators of cellular communication, linking cues from the cell surface to changes in gene expression. These proteins have prominent roles in cancer, but have also been implicated in other diseases, including Mendelian disorders referred to as RASopathies and non-neoplastic cerebral disorders such as Alzheimer’s and Parkinson’s disease.
2022 marks the 40th anniversary of the initial discovery of RAS mutations in human cancers. Over this time, RAS family members – in particular K-RAS due to the prevalence of the mutants – have been intensively studied and have captivated scientists from a range of disciplines.
The story of RAS from human genetics through to the first direct inhibitors represents a long and winding road of discovery that has been greatly accelerated by a focused community. However, we are likely only at the tip of the iceberg. Under the surface, much remains to be understood about different RAS family members and about targeting the dysregulated pathways with therapeutic interventions. This Special Issue of Disease Models & Mechanisms was thus conceived to collate cutting-edge research on the roles of RAS in cancer and developmental disorders, and on approaches to treat and modify the disease course in model systems.
Browse this rich collection here and share it with your colleagues!
Please register for this upcoming event and consider joining the ISRB! Click on the poster for more information. The deadline for speaker abstract submission is March 15th – Scientist at all levels are invited to apply.. (No Ratings Yet) Loading...
Read on for our news roundup of the past month, with an emphasis on what has caught our eyes from our twitter feed.
#ScienceForUkraine – many labs are offering internships for scientists suffering in the conflict in Ukraine. For more information check out the tweet below:
— Ulrike Endesfelder/uendesfelder.bsky.social (@UEndesfelder) February 27, 2022
#Single-CellSequencing – what would Darwin think of single-cell sequencing? And would his grant be funded?
If Darwin went on his voyage of the Beagle today his research would've ended with a t-SNE of the bird specimens that he collected instead of a theory of evolution
#preLights turns 4!! And to help them celebrate we hosted a joint event on ‘Promoting yourself as an ECR’ on Wednesday 23 February. The recordings from the event and our panellists answers to the questions that we didn’t have time to address will be available soon. Thanks to everyone involved, especially our panellists, Maria Abou Chakra, Pablo Sáez and Sarvenaz Sarabipour.
#DiversityinScience – one of the landmarks we are celebrating at our ECR event, is the 2nd birthday of the Node Network. It was launched to help promote diversity in selection of reviewers, panellist and speakers for event in developmental and stem cell biology. Read the interesting twitter thread from Michelle Facette on why she thinks it is important.
Why is it important we feature Black and Indigenous scholars for things like keynote positions at International conferences? I want to earnestly speak to why *I* think it is important. I am not speaking for anyone else. These are some reasons and expectations that I have. (1/n)🧵
#preprints – why do you preprint, or not? – Check out the thread started by Prachee Avasthi to find out the views from the twitterverse:
Settle an argument for me: What prevents a greater proportion of scientists from preprinting? Lack of info, fear/distaste of sharing work prior to peer review, perceived lack of benefit/reward/credit, what else? Muting replies so I can work, but thanks in advance! 🙏
Our first DEAR (Drop Everything And Read) day! The concept: a full day for reading up to date science and whatever is on your reading list, as a lab, with food 🥐
Note to self: next time, instead of sitting in front of the laptop for 6 hours with nothing to show for it other than 3 badly written sentences that do not even connect, accept it's a bad writing day, close the laptop and go do something else. #phdlife@PhDVoice
If you would like to contribute to our ‘Developing news’ blog, please get in touch at thenode@biologists.com. If you are interested in writing preLights, you can find more information here.
Launched in 2020, FocalPlane is a curated and centralised platform for the microscopy community to share news and techniques, discuss issues relevant to the field and read about the latest research and events. We are now looking for an enthusiastic and motivated person with fresh ideas and a willingness to learn to join us to develop and maintain this site.
Core responsibilities of the position include: • Creating and commissioning content for FocalPlane, including writing posts and soliciting content from the academic community, societies, companies and other organisations • Providing user support and ensuring site functionality on a day-to-day basis • Providing creative and practical input into the development of the site • Maintaining and developing the site’s presence on social networking sites such as Facebook, Twitter and Instagram • Representing Journal of Cell Science and FocalPlane at relevant conferences
Essential skills: • PhD in a relevant scientific field, ideally with experience of microscopy • Familiar with current trends and hot topics in microscopy and image analysis • Willingness to grow and develop knowledge of microscopy • Demonstrable ability to write for an online audience and/or produce social media content • Clear understanding of the online environment as it applies to scientists • Excellent interpersonal and communication skills • Strong networking abilities online and in person
Desirable: • Experience with additional media (e.g. video or podcasting) • Experience with WordPress • Contacts within the microscopy community
This is an exciting opportunity to further develop this hub for the microscopy community – in a similar vein to the Company’s established community site for developmental biologists, the Node – and to engage with relevant people at all levels: academics, developers, facilities, institutes and companies. The Community Manager will work alongside an experienced in-house team, including the Executive Editor of Journal of Cell Science. Additional responsibilities may be provided for the right candidate.
The Company of Biologists exists to support biologists and inspire advances in biology. At the heart of what we do are our five specialist journals – Development, Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open. All are edited by expert researchers in the field, and all articles are subjected to rigorous peer review. We believe that the profits from publishing the hard work of biologists should support scientific discovery and help develop future scientists. Our grants help support societies, meetings and individuals. Our workshops and meetings give the opportunity to network and collaborate.
Applicants should send a CV along with a covering letter that summarises their relevant experience, and in particular any specific microscopy/image analysis skills. Please also include links to any online activities, salary expectations, and details about why you are enthusiastic about this opportunity. Applications and informal queries should be sent by email to recruitment@biologists.com by 18 March 2022.
We may request written tests in advance of any interview. Applicants should be eligible to work in the UK.
23,000 year old fossilised human footprints from White Sands National Park, Image courtesy of National Parks Service
If these dates are correct, it means people must have gotten into North America sometime before 25,000 years ago. And that opens up this whole new avenue of exploration and understanding in both the archaeological record and genetics.
It really makes for a whole new story.
Professor Jennifer Raff
In the latest episode of the Genetics Unzipped podcast, we’re looking at a genetic history of the Americas. We chat with Jennifer Raff about her new book, Origin: The Genetic History of the Americas, covering the controversies surrounding how humans first migrated to the continent. plus Krystal Tsosie tells us about some of the modern day issues about how Native American genomes are used in genetic research.
If you enjoy the show, please do rate and review on Apple podcasts and help to spread the word on social media. And you can always send feedback and suggestions for future episodes and guests to podcast@geneticsunzipped.com Follow us on Twitter – @geneticsunzip
As lockdowns ease and the prospect of attending a conference in person rises on the horizon, it might be time to take stock of what conferences offer that virtual meetings have fallen behind on: networking. Although networking is an important part of the conference experience, it can be daunting for some. I hope that these “Top ten tips” can help make networking a more enjoyable experience for those that aren’t feeling so confident. I don’t – by any means – consider myself an expert but I think that because I’ve actively had to work at my networking skills in my role as a Reviews Editor for Development, I’ve thought a lot about how to improve. I hope to share what I’ve learned through trial and error.
1. Cut yourself some slack
First, and most importantly, go easy on yourself! I can’t stress this enough. Big conferences can be overwhelming – even if you’re a natural communicator. It can be difficult to interact, especially when you are new to the field, jet-lagged, speaking a language that isn’t your mother tongue in a noisy room where other people might be speaking with unfamiliar accents. All these components can add up and it’s difficult! However, as with most things, the beginning is always the most challenging; it will get easier with time and better with practice.
2. Plan ahead
If you’re interested in speaking to someone in particular you can email them in advance of the meeting to arrange a time and place to meet. This way, you don’t need to worry about bumping into them by chance or spending time hunting them down. You can also use the conference Twitter hashtag, or a meeting app, to let other people know you’ll be at the meeting.
3. Start small
When meeting new people, don’t feel like every interaction needs to be revolutionary. For example, don’t feel pressure to start a 40-minute conversation about the minutiae of your research project, ending with a collaboration or a job offer. Set small goals. Sometimes, it’s enough just to introduce yourself to someone and catch up with them again later. Once they know who you are, you begin to lay the groundwork for a longer-term relationship. It’s enough to say who you are and that you’re looking forward to/enjoyed their talk. You can then leave it there for the time being.
4. The first impression
That being said, an introduction is quite important and it’s often the hardest thing to do. Personally, it’s something I still struggle with a lot and for many people with speech problems, such as stammers and stutters, saying your own name is often a trigger. Overall, my advice here is to practice and find something that works for you. If your introduction doesn’t go as planned, just carry on with the conversation; there’s no harm done, it just means you spend a bit of time correcting any misunderstanding. Don’t put pressure on yourself (remember Tip 1 above).
5. Keep it light
For me, one of the barriers to starting a conversation is a fear that I’ll be perceived as ignorant or stupid if I don’t know something or someone that I feel I should. This can be especially prevalent if you’re not confident about the scientific topic of the meeting. In these cases, make some small talk and find some common ground until you feel more comfortable. There are supposedly six degrees of separation between everyone in the world. I expect in scientific circles – developmental biology in particular – it’s probably half that. You’ll probably find it won’t take much time to find a colleague or institute in common.
Some fail-safe questions, which are obvious to some, include:
“Have you been to this meeting before?”
“Where are you coming from?”
“How was your journey here?”
“Do you get to spend some time visiting the local area?”
“What other meetings do you plan to go to?”
“Is anyone else from your group here?”
On the other hand, there are some questions I’d advise people to avoid, primarily about assuming someone’s academic position. I think it’s important to address our unconscious biases; even if you’re fairly confident of someone’s position (for example, if you’re attending a meeting for graduate students only), it’s still better to treat everyone equally.
Instead of…
Why not try…
“Are you a student/postdoc?”
“What is your background?”
“What do you work on?”
“What are you interested in?”
“What’s your project?”
“What are your research questions?”
“Who’s lab are you in?”
“Where are you based?”
“Who is your supervisor?”
“How long have you been there?”
6. Be genuine
I find developmental biology amazing and I can sometimes find myself getting a bit over excited. I used to worry that this would come across as being unprofessional but – as the cliché goes – be yourself. We are people first and scientists second. Commit to things that interest you and don’t feel apologetic for things you are (or aren’t) enthusiastic about.
7. Team up
Networking with a friend, colleague or even someone you met on the conference bus, can be a useful way of meeting new people without the pressure of trying to keep a conversation moving by yourself. You can ‘tag out’ and get some time to find your feet. Just make sure you don’t end up too reliant on support or only staying part of a group because you want to develop a unique identity and stay approachable (see Tip 8 below).
8. Be approachable
A reciprocal part of being a “good networker” is allowing others to network with you. Be conscious and aware of your surroundings; open the conversation circle when new people want to engage in your group discussion, or move aside if someone wants to listen in on a poster talk. Although travelling as a lab is great for bonding, and meeting old friends can be the personal highlight of a meeting, be careful not to come across as cliquey or exclusive. Talk to poster presenters and ask them questions – you never know what opportunities might arise out of a chance encounter.
9. Participate
Presenting a poster or a talk, or being a meeting organiser, is a great ice breaker and provides an opportunity for people to initiate a conversation with you.
10. Know when to call it a day
At the first opportunity for networking, it could be that you’ve been travelling halfway around the world and been awake for more than 24 hours. Know when to stop and get some rest; the harder the push yourself the more exhausted you will be and the harder it will become to keep up a conversation. Sometimes, knowing your limits is a really useful skill and there’s no shame in leaving the welcome drinks a little early.
Share your own wisdom
So, those are my suggestions! Do you have any other tips for networking? Share them in the comments below!
Semi-aquatic bugs (or Gerromorpha) likely derived from a terrestrial ancestor that evolved the ability to stand and move on the water-air interface about 200 million years ago. Access to previously unexploited ecological opportunities is associated with phenotypic evolution and often results in significant lineage diversification [2]. Our favorite bugs are no exception to the rule. Early-diverging lineages of semi-aquatic bugs occupy transitional zones and walk both on land and water, whereas derived lineages evolved rowing as a novel mode of locomotion on open-water surface [3,4]. Water surface invasion is commonly viewed as a stepwise process that involved both the diversification of leg morphologies and the evolution of densely arranged water-repellent ‘hairs’ that allow the insects to exploit surface tension. However, the mechanisms by which species develop traits adapted to the new ecological niche are not well understood.
Previous studies having predominantly focused on leg morphologies, we decided to explore the other side of the coin — the leg ‘hairs’. We first shown that the leg ‘hairs’ are nothing else than bristles [5]. Then the central question remains still on the table: how do semi-aquatic bugs evolve such a high density of bristles on their legs? Here started our investigation to find out what makes a water strider so hairy. After several years of leg-focused research, the Khila lab was quite excited and well determined to enter the bristle world.
Figure 1. The water strider Gerris buenoi resting on water surface. Image: courtesy of Abderrahman Khila.
Candidate gene approach
We first compiled a list of more than 120 genes known to play a role in bristle development in Drosophila, and searched for gene duplication events in the Gerromorpha. We found that the gene Beadex has two copies in the Gerromorpha. Whereas the copie BxA plays a role in bristle development in Gerris buenoi (= species with high bristle density), BxA is not significantly expressed during embryogenesis in Mesovelia mulsanti (= species with low bristle density). This result suggests that differences in leg bristle density might be partly attributable to differential expression level of BxA. We also identified two copies of the gene taxi in the semi-aquatic bugs that result from a duplication in the lineage leading to the Gerromorpha. We found that the gene taxiB evolves faster than taxiA and we detected positive selection along the taxiB lineage, suggesting functional divergence of the two copies. We depleted taxiA or taxiB transcripts using RNAi, and we observed defects in the development of leg bristles. However, we found that only ds-taxiB knockdown individuals exhibited shorter legs. Again, we were here to focus on the bristles, so we did not linger on the leg phenotype.
Genes involved leg bristle development in Gerromorpha…
By combining comparative transcriptomics and RNA interference, we identified six genes whose role in bristle development had never been documented in model organisms. We unraveled the role of the GPN-loop GTPase 2, the c-Myc binding protein MYCBP, and a protein-glutamate O-methyltransferase in bristle patterning; the role of the bHLH transcription factor Net and the MAP kinase signal responder protein Dodo in bristle elongation; and the role of the actin binding protein Simiate in bristle orientation and size.
… played also a role in leg growth!
Looking for bristle genes, finding bristle genes! It sounded like a pretty straightforward research project. Well, the truth turned out to be much more complicated and exciting. We found that suppressing the expression of bristle-related genes resulted in a leg shortening. This time, the leg phenotype was so predominant that we could not overlook it. We spent a substantial number of hours with our pictures of legs and our ruler. The quantification was unequivocal: most of the legs in the knockdown individuals were shorter. In brief, shorter and barer, or barer and shorter!
Cell division as a shared molecular mechanism
This hypothesis remained to be verified. To this end, we stained all nuclei with DAPI, and M-phase nuclei with anti-PH3 antibodies in the developing embryonic legs. We then compared the cell division rate between control and ds-taxiB knockdown individuals. We found that the legs T2, which are shorter in ds-taxiB individuals, showed a reduced mitotic activity. By doing so, we noticed that the orientation of cell division might also be affected. Thus, we measured the angle of division relative to the proximo-distal (PD) axis of the leg. We found that epithelial cells bias their orientation perpendicular to the PD axis in knockdown individuals, whereas these cells predominantly orient their divisions parallel to the PD axis in the control embryos.
Pleiotropy as a facilitator of diversification
The key message of the project began to take shape: leg length and bristle density, both necessary for water surface locomotion, are genetically correlated in the semi-aquatic bugs. We had the feeling we could go even a bit further. We plotted the bristle density against the leg length for controls and knockdown individuals of G. buenoi: linear correlation, checked! Because bristle density and leg length vary a lot across the semi-aquatic bugs, we extended our correlation analysis to all the species we had in the laboratory. The correlation between our two favorite traits still stands at the infraorder level.
The classical view of the origin of the semi-aquatic bugs implies the stepwise evolution of longer legs and denser leg bristles. Our findings suggest that the invasion of water surface might have been more ‘straightforward’ because of genetic pleiotropy. However, even if leg length and bristle density are both necessary for water surface locomotion, it does not necessarily mean these two traits have been selected for. Indeed, we cannot exclude that only one trait was selected whereas the other trait was simply a spandrel or by-product [6]. Our study represents the first step towards the deciphering of the molecular mechanism of high bristle density in the Gerromorpha, and further investigation will be needed to build a better picture of this ecologically relevant trait. Nevertheless, one thing is certain: in Gerromorpha, it is all about leg length!
[2] Schluter D. (2000). The ecology of adaptive radiation. Oxford University Press, Oxford.
[3] Andersen NM. (1976). A Comparative Study of Locomotion on the Water Surface in Semiaquatic Bugs (Insecta, Hemiptera, Gerromorpha). Vidensk. Meddel. Dansk Naturhist. Foren. Kjobenhavn 139: 337-396.
TEX13B is important for germ cell development and male fertility Umesh Kumar, Digumarthi V S Sudhakar, Nithyapriya Kumar, Hanuman T Kale, Rajan Kumar Jha, Nalini J Gupta, B N Chakravarthy, Mamata Deenadayal, Aarti Deenadayal Tolani, Swasti Raychaudhuri, P Chandra Shekar, Kumarasamy Thangaraj
Effects of α-crystallin gene knockout on zebrafish lens development Mason Posner, Kelly L. Murray, Brandon Andrew, Stuart Brdicka, Alexis Butterbaugh-Roberts, Kirstan Franklin, Adil Hussen, Taylor Kaye, Emmaline Kepp, Mathew S. McDonald, Tyler Snodgrass, Keith Zientek, Larry David
hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function Homa Majd, Ryan M Samuel, Jonathan T Ramirez, Ali Kalantari, Kevin Barber, Zaniar Ghazizadeh, Angeline K Chemel, Andrius Cesiulis, Mikayla N Richter, Subhamoy Das, Matthew G Keefe, Jeffrey Wang, Rahul K Shiv, Conor J McCann, Samyukta Bhat, Matvei Khoroshkin, Johnny Yu, Tomasz J Nowakowski, Hani Goodarzi, Nikhil Thapar, Julia A Kaltschmidt, Faranak Fattahi
Vascular buds of Botryllus schlosseri from Ricci, et al.
Coupled myovascular expansion directs cardiac growth and regeneration Paige DeBenedittis, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, Yoshihiko Kobayashi, Svati H. Shah, Christopher D. Kontos, Purushothama Rao Tata, R. Thomas Lumbers, Ravi Karra
Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs Saeideh Nakhaei-Rad, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Andrea Borchardt, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian
Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia Jimmy Hom, Theodoros Karnavas, Emily Hartman, Julien Papoin, Yuefeng Tang, Brian M. Dulmovits, Mushran Khan, Hiren Patel, Jedediah Bondy, Morris Edelman, Renaud Touraine, Geneviève Chanoz-Poulard, Gregory Ottenberg, Robert Maynard, Douglas J. Adams, Raymond F. Robledo, Daniel A Grande, Philippe Marambaud, Betsy J Barnes, Sébastien Durand, Anupama Narla, Steven Ellis, Leonard I. Zon, Luanne L. Peters, Lydie Da Costa, Jeffrey M. Lipton, Cheryl L. Ackert-Bicknell, Lionel Blanc
Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence Dorsa Toghani, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian Burns, David Gravano, Stefan Radtke, Hans-Peter Kiem, Sonia Rodriguez, Nadia Carlesso, Amogh Pradeep, Nicola K. Wilson, Sarah J. Kinston, Berthold Göttgens, Claus Nerlov, Eric Pietras, Marion Mesnieres, Christa Maes, Atsushi Kumanogoh, Thomas Worzfeld, Peter Kharchenko, David T. Scadden, Antonio Scialdone, Joel A Spencer, Lev Silberstein
Developmental origins of cell heterogeneity in the human lung Alexandros Sountoulidis, Sergio Marco Salas, Emelie Braun, Christophe Avenel, Joseph Bergenstråhle, Marco Vicari, Paulo Czarnewski, Jonas Theelke, Andreas Liontos, Xesus Abalo, Žaneta Andrusivová, Michaela Asp, Xiaofei Li, Lijuan Hu, Sanem Sariyar, Anna Martinez Casals, Burcu Ayoglu, Alexandra Firsova, Jakob Michaëlsson, Emma Lundberg, Carolina Wählby, Erik Sundström, Sten Linnarsson, Joakim Lundeberg, Mats Nilsson, Christos Samakovlis
A remote lecture series roadmap to equity, diversity, and inclusion in STEM Evan A. Boyle, Gabriela Goldberg, Jonathan C. Schmok, Jillybeth Burgado, Fabiana Izidro Layng, Hannah A. Grunwald, Kylie M. Balotin, Michael S. Cuoco, Keng-Chi Chang, Gertrude Ecklu-Mensah, Aleena K. S. Arakaki, Noorsher Ahmed, Ximena Garcia Arceo, Pratibha Jagannatha, Jonathan Pekar, Mallika Iyer, DASL Alliance, Gene W. Yeo
Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences Riley A. Hess, Olivia A. Erickson, Rebecca B. Cole, Jared M. Isaacs, Silvia Alvarez-Clare, Jonathan Arnold, Allison Augustus-Wallace, Joseph C. Ayoob, Alan Berkowitz, Janet Branchaw, Kevin R. Burgio, Charles H. Cannon, Ruben Michael Ceballos, C. Sarah Cohen, Hilary Coller, Jane Disney, Van A. Doze, Margaret J. Eggers, Edwin L. Ferguson, Jeffrey J. Gray, Jean T. Greenberg, Alexander Hoffmann, Danielle Jensen-Ryan, Robert M. Kao, Alex C. Keene, Johanna E. Kowalko, Steven A. Lopez, Camille Mathis, Mona Minkara, Courtney J. Murren, Mary Jo Ondrechen, Patricia Ordoñez, Anne Osano, Elizabeth Padilla-Crespo, Soubantika Palchoudhury, Hong Qin, Juan Ramírez-Lugo, Jennifer Reithel, Colin A. Shaw, Amber Smith, Rosemary J. Smith, Fern Tsien, Erin L. Dolan
One of the key objectives of the Node Network is to allow scientists, especially early-career researchers (ECRs), to raise their profiles in the developmental and stem cell biology community. With this in mind, and as part of our second birthday celebrations, we are delighted to launch our discussion and networking event, ‘Promoting yourself as an ECR’ hosted with our sister community sites FocalPlane and preLights. The interactive event will begin with a panel discussion with our three invited panellists Maria Abou Chakra, Pablo Sáez and Sarvenaz Sarabipour and then continue with a networking event where you can meet the panellists, representatives from The Company of Biologists and other ECRs.
Dr Maria Abou Chakra is a research associate at the University of Toronto, where her research focuses on mathematical modelling of stem cell development. She is the organiser of the Modelling Cell Development & Regeneration Discussion Group, as well as having been involved in outreach, mentorship and EDI events.
Professor Pablo J. Sáez is a new PI at UKE, Hamburg, where his international team is studying the role of cell communication and migration, with a particular focus on immune cells. Pablo is a regular contributor to our preprint posts on FocalPlane, and is an advocate for better representation for ECRs in academic conferences.
Dr Sarvenaz Sarabipour is an assistant research scientist at Johns Hopkins University, where her research focuses on receptor signalling networks at the cell and tissue level. As well as her scientific interests, she is an active advocate for ECRs, open science, mentorship, and diversity in science.
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