From 4PM UK time on Wednesday September 22nd, the Node’s server is going down for some maintenance. Work will continue for several hours, and will cover most of the working day in North and South America. Apologies for the inconvenience. I’ll schedule some things to appear on the Node’s Twitter account to read while the site is down.

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I’m going to collect dates from my travel journal and batch post the most interesting bits.  See this post for my introduction and an explanation for all of this. Enjoy!

May 12, 2007 Beijing, China

The flight was outrageously long, but uneventful once I boarded. I didn’t find out until I got to Logan airport that my flight was to La Guardia but connecting out of JFK, so I had to catch a cab across Brooklyn. Then it was a bit of a game of musical chairs to get my seat. I boarded late so that I didn’t have to take part in the herd of passengers. Since my first trip to China as a tourist, I’ve observed a collective rush to board flights in no particular boarding order, so I routinely wait until everyone else has settled and board nearly last. On this flight, I was supposed to be in Seat 42A, but there was a guy in that seat. He was supposed to be in 41A, but there was someone in his seat who was supposed to be in 40A. I decided “screw it” and ended up in 40A. That apparently very much confused my graduate student companion when he came looking for me midflight and I was not the person in 42A. I was dead to the world for most of the flight anyway, so I didn’t notice much of a thing. My brain is sort of mush right now from the jetlag, and we’ve started right to work in our colleague’s lab getting things ready. I got to see the Olympic stadiums this morning. They’re super cool. And the institute of zoology is really nice. It’s a new building with new lab space. I love new lab space. We’re going to finish getting things ready today and tomorrow and maybe have a bit of time to see the Great Wall and the Imperial Palace before we head off for Inner Mongolia. No Jerboas yet, but there is a great big Tibetan rabbit sitting in the corner of the desk watching me type. It’s Dr. Yang’s pet, and it’s a little snotty and keeps sneezing. Kind of funny to see a rabbit sneeze.

May 13, 2007 Beijing, China

All I’ve managed to do so far is eat and sleep, and I have been wonderful at that. Ms. Xia (a research associate in our collaborating lab) brought me to lab yesterday morning to get started on the preparations for the fieldwork. That didn’t take very long, so she took me to an outdoor recreation store (like REI) and then to a tourist souvenir market. I quickly decided that I needed lunch and sleep, so after trying to choke down a bacon, egg, and pickle (!) sandwich, she took me back to the hotel for a “nap”. Said “nap” turned into a 5 hour sleep. I woke up in time to catch dinner, read a bit of my book, and go back to sleep for a full night. I think I’ve shown that jetlag what’s for though. I will have to say that Shaoyuan, my graduate student, knows good food. With the exception of that questionable sandwich (for which he wasn’t present, and I should have known better since the menu was in English), all of our meals have been fantastic. I had a really beautiful pork and tofu dish last night, and brunch today was a bowl of spicy chow mein noodles with mushrooms and chicken. I may still lose a little weight on this trip, but it won’t be for lack of trying to keep myself full at all times. I’ve also learned from every country I’ve visited that it’s better to go to places with no English menus and point at other people’s plates if you have to. If you’re willing to risk eating calf intestine, you’re likely to get a fantastic meal.

May 14, 2007 Beijing, China

Yesterday I made enough paraformaldehyde to fix a horse. That excites me in a weird way. We’re pretty much ready to go now. Traps, lots of food (for us and rodents), DEPC water, PFA, tubes and tubes and tubes… After the prep work, I caught the train downtown and walked for about 2 hours to get to the Forbidden City to meet Shaoyuan. If it’s true that the best way to learn a city is to get lost in it, then I must know Beijing pretty well by now. I had no idea how EVERYTHING on the map is very very very tiny compared to real life. And to you Texans out there – you aint got nuthin on China. Nothing is bigger in Texas compared to this place.

I was doing fine on time until I got to Tiananmen Square. The Chinese flag in the square is lowered every day at sunset and is cause for a huge spectacle. They shut down all foot traffic past the flag as a crowd of several thousand forms. I had to take the underground passages to get around everyone. But not until after I snapped a fantastic shot of a guy posing in front of the police formation. That’s one thing I love about Asia. People here will pose for a picture in front of just about anything. As a result, I’ve started a bit of a collection of my own pictures of people having their pictures taken in front of random things :) So after a bit of a walk around, Shaoyuan took me to some famous restaurant where we had the most AMAZING duck I’ve ever eaten in my life. It was so juicy, and the skin was the most perfect brown crispy deliciousness.That’s it for now. I’m going to help get things ready to leave tomorrow and then we’re going back down to see the inside of the Forbidden City and visit Chairman Mao’s preserved remains. More later…

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Hello Node Community:
I would like to inform you about the Development Travelling Fellowships. Are you a Graduate student or Post-doc wishing to make a collaborative visit to another lab?

You can apply to Development to fund your travelling expenses. Development offers up to £2,500, you do of course have to be working in the field of developmental biology and intend to visit another lab.

All the information you need can be found at http://dev.biologists.org/site/misc/fellowships.xhtml along with an application form.

See a report from one of our previous recipients here

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I am a graduate student from Indian Institute for Science Education and Research (IISER), Pune, India. I wish to share some of my work and life experiences in Japan from a recent visit. Our lab works on development and evolution of insect wings. I am interested in understanding the development of lepidopteran wings using Bombyx mori ( silkmoth) as a model system. Initially at my place it was an ordeal working experiments mostly for the lack of technical expertise on silkmoth experiments and lack of availability of resources.

We decided to carry out some experiments in the University of Tokyo, Kashiwa campus to study the development and evolution of insect wings, specifically lepidopteran wing development, using the silkmoth as a model organism. Expertise on studies in silkworm development is abundant in Japan as there are many research groups working on this various aspects of silkworm development. To be housed in one of the best universities in asia was a privilege and the facilities and research truly matched the stature of one of the best institutes in the world.

I was in Prof. Haruhiko Fujiwara’s lab which works on Silkworms, Butterflies and different aspects of their genetics and development. The facilities in the lab were really state of the art, organization of the lab was immaculate and expertise vast which helped my work progress smoothly. One hurdle was definitely that of the language which I should admit was a more than what I anticipated, most people in the campus speak in Japanese, study and even discuss science in Japanese, but it seemed trivial with the kind nature of the people, every time they put an effort beyond their way to help you in every situation in lab or on outside. A little Japanese learned beforehand came in handy at times and also got a smile across people there who always appreciated generously for every one of my efforts to speak their language.

I started experiments here as soon as I came in but for a week or so they really did not work as I had to get adjusted to the setup and find the reagents and understand the instruments (some of which had complete Japanese menus!). With the help of the friendly lab members things moved rapidly and was able to understand the techniques they used and apply to solve issues which had troubled me in research so far. In a lab of around 20 people everyone chipped in whenever I had problems to trouble shoot with the best they could and made work progress fast and life easier. The discussions with my sensei (used to address professor in Japanese) were very helpful to understand the development of silkworm and to apply techniques like immuno histochemistry and RNA in situs. As these experiments were done in the lab on a regular basis and also the worms were studied extensively here, hence work moved smoothly and results were easy to come once I was settled in. I could work out all the standardization of Chromatin Immunoprecipitaion (ChIP) with the abundant silkworm resource which was excellently maintained. There wasn’t a single hindrance for an experiment no matter when I wanted to perform them because of the excellent maintenance of the larvae and the whole-hearted support of the lab.

During this trip I also had a golden opportunity to interact with other developmental biologists at the JSDB 2010 meeting at Kyoto. The discussions in the conference included various interesting aspects of developmental biology ranging from growth control, organogenesis to mathematical modeling. The meeting had over 300 poster presentations, where I also got an opportunity to present my work so far and discuss with the best researches in japan and also world-over. It was interesting to discuss with various interesting research projects from japan and other places, also helping understand our own research problems better and flashing some new and interesting insights.

The talks by Prof Eric Wieschaus and Prof Roel Nusse were enlightening and it was really a great opportunity to interact with these scientists, who were very encouraging and made the science more interesting , by inducing many new questions in the mind and also helping our research interests through superlative discussions.  apart from the conference Kyoto as a citywas serene and beautiful, having been to Tokyo this part of the world seemed a page from the ancient and rich traditional Japan and a wholly different landscape from what I had seen or imagined.

People in Japan were very kind, polite, peace loving and sweet who helped in every step of my stay. There a lot of international students around especially in my residence where they were very cooperative and were as kind as Japanese themselves. They organized various events from the art of wearing Japanese yukata (traditional Japanese dress) to that of attending the local city festival on weekends. They helped with every problem and also make stay fun filled and enjoyable in every way.  Cycling was the best transport in Japan for there were free lanes; it was always fun riding to university through a very beautiful park. For being a vegetarian the other constant problem was food, which I had to cook to survive in a land where nothing was vegetarian. The versatile kitchen facility eased out cooking for my survival and sometimes the vibrant community joined in usually watching football worldcup cheering for Japan or South Korea. It was the charm of the place and people around that made problems gradually melt away etching wonderful memories, easing life and making work enjoyable in a very pleasant ambience.

This visit helped move rapid strides in answering my research question and allowed me to learn newer methods to apply and progress in my research work. I am sure a lot of research problems will be solved and this work will raise new and interesting questions for me to pursue further ahead in research. I hope my experience will encourage more people to work across borders to learn the best from all the great learning centers and Japan in particular, which has people who work really hard and help each other to reach greater heights in their endeavors.

I would like to thank the Development and APDBN fellowships for their encouragement and generous support for my travel and stay in Japan. I would like to thank the Prof Fujiwara and University of Tokyo for the kind invite, support and warm welcome into their facility. My sincere thanks to the lab members of his lab and also other labs which helped and supported to the fullest, whose untiring help and encouragement helped me enjoy both work and stay in Japan. I would like to thank my supervisor Prof. Shashidhara and IISER pune for initiating this interaction and supporting all the way in my graduate study. I would like to thank node for allowing me to share my unforgettable memories of  Japan.

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Here’s an uplifting story about how a farmer and a developmental biologist met online and started a collaboration.

Earlier this month, I attended the annual Science Online conference in London. This year’s speakers included Sir Martin Rees of the Royal Society, former Member of UK Parliament Evan Harris, and a good selection of people who are involved in using the Internet to either communicate or facilitate scientific research.

One of the speakers in several panels was science writer and blogger Ed Yong, of the blog Not Exactly Rocket Science. On the first day of the meeting he spoke on a panel about science journalism, and on the second day he was on involved in a discussion about interacting with your readers online. He gave some good advice there, about communicating with your readers and knowing who they are. In Ed’s case, his audience is very general, including scientists as well as non-scientists, so his readers could very well be anyone.

On Saturday, Ed posted an anecdote that shows exactly how broad his readership is, and what he does to engage them. Since one of his tips at the Science Online meeting was to simply link to other blogs when they write it just so much better, I’ll send you back to his place for the full story, and will just summarize it here:

Several months ago, a paper came out about gynandromorph chickens. To refresh your memory: these chickens are female on one side of their body and male on the other side, and by studying them the group of Mike Clinton in Edinburgh revealed that in chickens sex identity is determined early in development and is autonomous for all cells (rather than being regulated by hormone levels). Ed wrote about the paper on his blog, and recently Paul Sanders, a farmer in Missouri, found that very post when he was looking for information on a curious-looking chicken (pictured left) that was born on his farm. Ed then put him in touch with Mike Clinton, and the resulting e-mail conversation between Sanders and Clinton shows how they’re going to collaborate to further investigate the development of gynandromorphic chickens. Since Sanders has access to the bird as well as the parents of the bird, Clinton can carry out more detailed genetic analysis. According to one of Clinton’s e-mails, Sanders’ observations about the size of the egg alone are already an indication that one of the theories about gynandromorphic development — that these animals originate from eggs with a double yolk — is not likely to hold ground!

It’s good to see the reader interaction that Ed mentioned at Science Online in action, and leading to collaborations in developmental biology! Do you know of any other examples of interesting collaborations in the field? We’d love to hear!

(Image credit: Paul Sanders.)

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The RIKEN CDB seeks laboratory heads to lead independent laboratories under the following two Programs. Applicants can choose to apply for a specific position, or allow the search committee to assign them to an appropriate position during the course of the evaluation.

1. Position

・Team Leaders (Creative Research Promoting Program)
The CDB is looking for creative young researchers (preferably those who have obtained a PhD within the last 10 years) who aspire to break new ground within areas of animal development and regeneration, and related research areas.
・Unit Leaders (Center Director’s Strategic Program)
The Unit Leader position is for scientists in the early stages of their career to conduct research in a small-scale laboratory. Highly motivated scientists eager to achieve breakthroughs in next-generation developmental biology in the areas listed are encouraged to apply.

2. Selection Process

Research proposals should be focused on the specific field of research for each program. The initial screening process will be based on the applicant’s application and 5-year research proposal. This will be followed by a final selection process, which includes an interview and seminar. Strong emphasis will be placed on the quality, feasibility and originality of the research proposal; priority will be given to proposals that take full advantage of the CDB’s facilities and resources, and advance challenging new concepts. Female and foreign scientists are strongly encouraged to apply.

The selection process will begin November 1, and will continue until suitable candidates have been selected.

Please visit our website for more detail: http://www.cdb.riken.jp/en/index.html

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Hello Node folks.  My name is Kim Cooper, and I’m a postdoctoral fellow with Cliff Tabin at Harvard Medical School.  I recently spoke at the SDB meeting in Albuquerque, and Eva Amsen approached me about contributing to the Node.  The primary reason is because I’m working on a fun animal that takes me off to China for field collections and has sent me down a rough road of learning to breed an exotic in captivity.  The animal is a jerboa.  It’s a bipedal desert rodent related to rats and mice.  They’re native to northern Africa through the Middle East, Central Asia, and northern China.

I’m interested in this adorably bizarre animal because it is an excellent model for evolutionary novelty in the limbs.  They have elongated hindlimbs with enormous feet that have only three toes and metatarsals that are fused into a single bone.  This gives them a long bounding stride upright on their hindlimbs, and they really only use their forepaws for feeding, digging, and grooming.  They are very efficient movers – they can hop three meters in a single leap and a meter straight in the air when startled.

The gist of what I’m doing with these animals involves collecting embryos from pregnant females soon after the come out of hibernation and breed more or less synchronously in northern China. The embryos are fixed and preserved in methanol and then shipped back to Boston for further developmental studies. I’m taking a two-pronged approach by candidate gene analysis and RNASeq to identify genes that are expressed differently in the three-toed hindlimb of the jerboa compared to the five-toed forelimbs and fore and hindlimbs of a near relative – the mouse.

I’m excited to share field collection stories from China and experiences with starting the colony.  The field stories are easy since I’ve been keeping a travel blog for about 5 years now and can cross post from previous years until the next field season starts again in the spring.  So stay tuned.  As a teaser I can tell you I’ve been chased by camel ticks in the desert, slept in a yurt near the border with Pakistan, and come home with typhoid.  But I’ve had some great times and met a lot of wonderful people along the way.  And collected a lot of jerboas.

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(This interview by Kathryn Senior originally appeared in Development on September 7, 2010)

Ken Zaret is Joseph Leidy Professor in the Department of Cell and Developmental Biology, the Associate Director of the Institute for Regenerative Medicine, and the Co-Director of the Epigenetics Program at the University of Pennsylvania School of Medicine. He agreed to be interviewed by Development and talks about his life as a scientist.

What originally set you on the road towards a career in science?

As a teenager, I loved puzzles of all kinds, and doing science is about solving puzzles. I have also always enjoyed being out of doors. Hiking is one of my favorites, and I originally wanted to be a naturalist; traveling the world and studying different forms of life was really appealing. In high school, I received a fellowship from the National Science Foundation to do research at a medical school in Philadelphia, which exposed me to laboratory science. Then, in college, I had several inspiring biology professors. When I took biochemistry, it all came together and I knew I wanted to do research.

How has your career progressed and what has influenced your decisions about institutions and locations?

When I was 30, I started my own lab at Brown University, which attracts great students, has a highly collegial faculty and, being located near Boston, is part of a larger scientific community. I benefited from the stimulating environment – and I learned developmental biology. After about 13 years, I was recruited to the Basic Science Division at the Fox Chase Cancer Center in Philadelphia. This was a good move for me, as I enjoyed the focus of being at a research institute instead of a university but, after 10 years, Fox Chase began to pursue mainly translational research and I felt it was right for me to move back to academia. I have been at the University of Pennsylvania since then and I greatly enjoy the diverse and active research life that it offers; working there is highly stimulating.
(more…)

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The server that the Node runs on is going to receive some general maintenance between 6:30 PM UK time tonight and early tomorrow morning. This may affect our visitors in North America (and the early risers at the other end of the Pacific) so please be patient if anything seems to not be working during this period.
The down time could be as brief as 30 minutes, and everything should work again on Friday. Thanks for your understanding!

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New format for job postings
You may have noticed some job ads for postdocs appearing on the Node. Until today, these ads appeared with the rest of the posts, but we now changed how job ads are displayed on the Node, to make them stand out from the rest of the content. This makes it easier for people who are looking for jobs to find the ads, and less intrusive for those who aren’t looking for work.

Job ads no longer appear in the main body of the site, with the rest of the posts, but are accessible in three other ways;
-The three most recently posted ads are listed by title in the sidebar (between “recent comments” and “events”) on all pages of the Node. They can also be accessed from the archive in the sidebar
-The Jobs category lists all job ads
-Jobs have their own RSS feed, which can be reached from the page containing all the different feeds on the Node. If you want to receive both regular Node content and job ads, you need to subscribe to both feeds.

Adding an announcement for a job opening in your lab works exactly the same as writing a post. Make sure that you have the title field filled in, and that you select the category “Jobs”. Job postings don’t show up in the main body of the site, but in the sidebar only. There is also a separate RSS feed for job postings.
(The previous paragraph has also been added to the e-mail that new authors receive.)

Finally, the Help page has been updated to reflect these changes.

E-mail updates about the Node
Currently, e-mail updates about new Node posts arrive as a “daily digest”, and will probably still include job ads. It’s also possible to set these updates to occur after every post (which is approximately once per day at the moment anyway) and have users select which categories they would like to receive in e-mail. In that case, if you only want e-mail notifications of interviews, or everything except job ads, you can change those settings.
The choice between digest or per-post cannot be made at the individual user level, unfortunately, so we have to make one decision for everyone. Let us know please, in the comments, what you would like: the option to select which categories to receive in e-mail, OR the daily digest. (In both cases, you have the option to turn notifications off entirely through the WordPress dashboard.)

(2 votes)

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