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An interview with Christiane Nüsslein-Volhard

Posted by on November 3rd, 2017

This interview by Katherine Brown originally appeared in Development, Vol 144 Issue 21 Christiane Nüsslein-Volhard is Director Emeritus at the Max Planck Institute for Developmental Biology in Tübingen, Germany. In 1995, she was awarded the Nobel Prize for Physiology and Medicine, along with Eric Wieschaus and Edward Lewis, for her work on the genetic control[…]

Glia lead the way for pioneers to build the brain neuropil in C. elegans

Posted by on October 20th, 2017

It’s all about the wires. But what about the glue? Networks make us who we are. I am not talking about social networks but about neural networks that define how we perceive the world and how we act. For a century, neuroscientists have sought to understand functions of neural networks in condition and how such[…]

Manchester PhD position on neuronal development, ageing & degeneration

Posted by on October 17th, 2017

The University of Manchester, 2018/19 BBSRC DTP PhD Project Understanding tubulin regulation during neuronal development, ageing and degeneration Axons are slender, up-to-a-meter long, cable-like extensions of neurons which form the nerves and nerve tracts that wire our bodies and brain. These delicate cellular structures have to be maintained for an organism’s life time and are[…]

Layered patterning systems in hair development

Posted by on September 28th, 2017

The story behind our recent paper  ‘Hierarchical patterning modes orchestrate hair follicle morphogenesis‘ , finding that distinct patterning mechanisms can co-exist during embryonic organ formation.   From the spots of a leopard and stripes on a zebra to the pigmentation of sea shells and arrangement of sand dunes in a desert, repeating patterns are present[…]

An interview with George Daley

Posted by on September 22nd, 2017

This interview by Aidan Maartens appeared in Development, Vol 144 Issue 18 George Daley is Dean of the Faculty of Medicine, Professor of Biological Chemistry and Molecular Pharmacology, and Caroline Shields Walker Professor of Medicine at Harvard Medical School. A former Howard Hughes Medical Institute Investigator and President of the International Society for Stem Cell[…]

In Development this Week (Vol. 144, Issue 17)

Posted by on August 29th, 2017

Here are the highlights from the current issue of Development:   AdamTS-A keeps the CNS in shape The Drosophila central nervous system (CNS) is covered by a thick basement membrane that mediates interactions with glial cells and governs the shape of the tissue. Basement membranes are formed from a meshwork of secreted extracellular matrix (ECM) proteins and must be[…]

In Development this Week (Vol. 144, Issue 16)

Posted by on August 15th, 2017

Here are the highlights from the current issue of Development:   PLCζ ‘waves in’ mammalian oocyte activation At fertilisation, fusion of the sperm with the oocyte activates a slew of downstream processes to kick-start embryogenesis. This ‘oocyte activation’ event induces the cortical reaction to prevent polyspermy, triggers oocyte metabolic and DNA synthesis pathways, and reactivates meiosis. In[…]

In Development this Week (Vol. 144, Issue 15)

Posted by on August 1st, 2017

Here are the highlights from the current issue of Development:   X-citing insights into dosage compensation The non-coding RNA Xist plays a key role in the process of X chromosome inactivation (XCI) and is thus essential for dosage compensation of X-linked genes in females. The 5′ region of Xist RNA contains a conserved element termed the A-repeat that is required for[…]

The Drosophila fly brings to light the role of morphogens in limb growth

Posted by on July 5th, 2017

• Scientists at IRB Barcelona clarify the function of the genes that drive wing development in the fruit fly Drosophila melanogaster. • Published in the journal eLife, this study unveils that the Dpp morphogen is necessary for wing growth but that its gradient does not govern this process. • Understanding the development of limbs in[…]

Going format-free

Posted by on May 30th, 2017

This Editorial originally appeared in Development, Volume 144, Issue 11   Katherine Brown, Olivier Pourquié   As some readers will already be aware, we have recently introduced a new ‘format-free’ submission policy. We’ve been delighted by the early feedback on this – from what we’re hearing, this has been a popular move and will help make[…]