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Off and On: it's more complicated than we thought.

Posted by , on 23 January 2020

We learn fairly early on when becoming biologists that both development and an organism’s response to environmental stressors require turning the right set of genes on in the right cells, ...
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What might evolutionary muscle loss and pathological atrophies have in common?

Posted by , on 8 January 2020

By Mai P. Tran and Kimberly L. Cooper “It’s the cutest rodent I have ever seen, even cuter than a cuddly hamster, and it would be fun doing a rotation for ...
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A domino effect on brain developmental evolution

Posted by , on 6 December 2019

The discipline “Evo-devo” studies the developmental basis of morphological evolution. In the field, some original animal models are emerging as interesting model organisms, enriching the knowledge in the field more ...
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How do new cell types evolve? Sea urchins show the way….

Posted by , on 21 November 2019

We know surprisingly little about how evolution has created new cell types. One of the best examples of a recently evolved cell type comes from early sea urchin development. Most ...
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A biology-modeling crosstalk to uncover feather pattern evolution

Posted by , on 20 November 2019

Richard Bailleul, Jonathan Touboul and Marie Manceau   Patterning in question: 60 years of mathematical and biological studies The coat of Vertebrates displays a stunning diversity of motifs created by ...
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How do cells know their future and forget their past

Posted by , on 7 November 2019

All cells in the body contain the same genetic material. The difference between cells therefore depends solely on which genes are expressed or ‘turned on’. Now, researchers from the University ...
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Secret talk between epithelium and endothelium determines hair follicle stem cell fate

Posted by , on 6 November 2019

By Kefei Nina Li and Prachi Jain   Stem cells are typically defined by their ability to self-renew and differentiate. These activities are tightly controlled by both intrinsic cues and ...
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“My balance comes from instability” thought Herzog (Saul Bellow, Herzog)

Posted by , on 28 October 2019

A bit of background The dependence of a protein’s function on its structure is a well-known phenomenon. Back in 1970’s, it was suggested that most proteins would fold into one ...
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A gnawing question: which cells are responsible for tooth renewal and regeneration?

Posted by , on 23 October 2019

By Amnon Sharir (UCSF), Allon M Klein (HMS), Ophir D Klein (UCSF) As most mouse geneticists know, treating a rodent with malocclusion of its front teeth can be a Sisyphean task: ...
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The serpent's maw: mouth function and the dynamics of Hydra regeneration

Posted by , on 30 September 2019

One of the biggest open questions in biology is how organisms can form complex patterns (limbs, organs, entire body plans) from initially disordered or very simple states. Every animal does ...
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